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Research Article

Potential mechanism of Qinggong Shoutao pill alleviating age-associated memory decline based on integration strategy

, , , , , , , , , , , , , & show all
Pages 105-119 | Received 30 Dec 2022, Accepted 30 Nov 2023, Published online: 25 Dec 2023

References

  • Abd-Elrahman KS, Ferguson SSG. 2022. Noncanonical metabotropic glutamate receptor 5 signaling in Alzheimer’s disease. Annu Rev Pharmacol Toxicol. 62(1):235–254. doi: 10.1146/annurev-pharmtox-021821-091747.
  • Altarejos JY, Montminy M. 2011. CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. Nat Rev Mol Cell Biol. 12(3):141–151. doi: 10.1038/nrm3072.
  • Amberger JS, Bocchini CA, Schiettecatte F, Scott AF, Hamosh A. 2015. OMIM.org: online Mendelian inheritance in man (OMIM®), an online catalog of human genes and genetic disorders. Nucleic Acids Res. 43(Database issue):D789–98. doi: 10.1093/nar/gku1205.
  • Amini M, Abdolmaleki Z. 2022. The effect of cannabidiol coated by nano-chitosan on learning and memory, hippocampal CB1 and CB2 levels, and amyloid plaques in an Alzheimer’s disease rat model. Neuropsychobiology. 81(3):171–183. doi: 10.1159/000519534.
  • Anitha P, Anbarasu A, Ramaiah S. 2016. Gene network analysis reveals the association of important functional partners involved in antibiotic resistance: a report on an important pathogenic bacterium Staphylococcus aureus. Gene. 575(2 Pt 1):253–263. doi: 10.1016/j.gene.2015.08.068.
  • Baltaci SB, Mogulkoc R, Baltaci AK. 2019. Molecular mechanisms of early and late LTP. Neurochem Res. 44(2):281–296. doi: 10.1007/s11064-018-2695-4.
  • Bartsch D, Casadio A, Karl KA, Serodio P, Kandel ER. 1998. CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation. Cell. 95(2):211–223. doi: 10.1016/s0092-8674(00)81752-3.
  • Bishop NA, Lu T, Yankner BA. 2010. Neural mechanisms of ageing and cognitive decline. Nature. 464(7288):529–535. doi: 10.1038/nature08983.
  • Bliss TV, Collingridge GL. 2013. Expression of NMDA receptor-dependent LTP in the hippocampus: bridging the divide. Mol Brain. 6(1):5–18. doi: 10.1186/1756-6606-6-5.
  • Bliss TV, Collingridge GL, Morris RG. 2013. Synaptic plasticity in health and disease: introduction and overview. Philos Trans R Soc Lond B Biol Sci. 369(1633):20130129. doi: 10.1098/rstb.2013.0129.
  • Borroto-Escuela DO, Tarakanov AO, Brito I, Fuxe K. 2018. Glutamate heteroreceptor complexes in the brain. Pharmacol Rep. 70(5):936–950. doi: 10.1016/j.pharep.2018.04.002.
  • Bourtchuladze R, Frenguelli B, Blendy J, Cioffi D, Schutz G, Silva AJ. 1994. Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell. 79(1):59–68. doi: 10.1016/0092-8674(94)90400-6.
  • Briggs CA, Chakroborty S, Stutzmann GE. 2017. Emerging pathways driving early synaptic pathology in Alzheimer’s disease. Biochem Biophys Res Commun. 483(4):988–997. doi: 10.1016/j.bbrc.2016.09.088.
  • Buriani A, Fortinguerra S, Sorrenti V, Caudullo G, Carrara M. 2020. Essential oil phytocomplex activity, a review with a focus on multivariate analysis for a network pharmacology-informed phytogenomic approach. Molecules. 25(8):1833. doi: 10.3390/molecules25081833.
  • Busquets-Garcia A, Gomis-González M, Guegan T, Agustín-Pavón C, Pastor A, Mato S, Pérez-Samartín A, Matute C, de la Torre R, Dierssen M, et al. 2013. Targeting the endocannabinoid system in the treatment of fragile X syndrome. Nat Med. 19(5):603–607. doi: 10.1038/nm.3127.
  • Chen KJ, Zhou WQ, Li CS, Shi TR, Lei SP, Li XH, et al. 1984. Clinical study of Qinggong Shoutao Pill on delaying senility – clinical effect and effect on plasma lipid peroxidation level. Chin J Integr Trad West Med. 4(11):658–659 + 642. Chinese.
  • Chen KJ, Zhou WQ, Li CS, Shi TR, Wang W, Wang JS, et al. 1985. Clinical and experimental study of Qinggong Shoutao Pill on delaying senility. J Trad Chin Med. 26:25–28.
  • Contestabile A, Greco B, Ghezzi D, Tucci V, Benfenati F, Gasparini L. 2013. Lithium rescues synaptic plasticity and memory in Down syndrome mice. J Clin Invest. 123(1):348–361. doi: 10.1172/JCI64650.
  • Cosconati S, Forli S, Perryman AL, Harris R, Goodsell DS, Olson AJ. 2010. Virtual screening with AutoDock: theory and practice. Expert Opin Drug Discov. 5(6):597–607. doi: 10.1517/17460441.2010.484460.
  • Daina A, Michielin O, Zoete V. 2017. SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Sci Rep. 7(1):42717. doi: 10.1038/srep42717.
  • Daina A, Michielin O, Zoete V. 2019. SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules. Nucleic Acids Res. 47(W1):W357–W364. doi: 10.1093/nar/gkz382.
  • Datta D, Leslie SN, Wang M, Morozov YM, Yang S, Mentone S, Zeiss C, Duque A, Rakic P, Horvath TL, et al. 2021. Age-related calcium dysregulation linked with tau pathology and impaired cognition in non-human primates. Alzheimers Dement. 17(6):920–932. doi: 10.1002/alz.12325.
  • Del Blanco B, Guiretti D, Tomasoni R, Lopez-Cascales MT, Muñoz-Viana R, Lipinski M, Scandaglia M, Coca Y, Olivares R, Valor LM, et al. 2019. CBP and SRF co-regulate dendritic growth and synaptic maturation. Cell Death Differ. 26(11):2208–2222. doi: 10.1038/s41418-019-0285-x.
  • Deng JL, Xu YH, Wang G. 2019. Identification of potential crucial genes and key pathways in breast cancer using bioinformatic analysis. Front Genet. 10:695–711. doi: 10.3389/fgene.2019.00695.
  • Fang S, Dong L, Liu L, Guo J, Zhao L, Zhang J, Bu D, Liu X, Huo P, Cao W, et al. 2021. HERB: a high-throughput experiment- and reference-guided database of traditional Chinese medicine. Nucleic Acids Res. 49(D1):D1197–D1206. doi: 10.1093/nar/gkaa1063.
  • Ghafarimoghadam M, Mashayekh R, Gholami M, Fereydani P, Shelley-Tremblay J, Kandezi N, Sabouri E, Motaghinejad M. 2022. A review of behavioral methods for the evaluation of cognitive performance in animal models: current techniques and links to human cognition. Physiol Behav. 244:113652. doi: 10.1016/j.physbeh.2021.113652.
  • Grasing M, Kenned K, Sarnak MJ, Burns JM, Gupta A. 2021. Mild to moderate decrease in eGFR and cognitive decline in older adults. Nephrol Dial Transplant. 37(8):1499–1506. doi: 10.1093/ndt/gfab226.
  • Griffin RJ, Moloney A, Kelliher M, Johnston JA, Ravid R, Dockery P, O’Connor R, O’Neill C. 2005. Activation of Akt/P KB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and P T EN are features of Alzheimer’s disease pathology. J Neurochem. 93(1):105–117. doi: 10.1111/j.1471-4159.2004.02949.x.
  • Guo S, Wang J, Xu H, Rong W, Gao C, Yuan Z, Xie F, Bi K, Zhang Z, Li Q. 2019. Classic prescription, Kai-Xin-San, ameliorates Alzheimer’s disease as an effective multitarget treatment: from neurotransmitter to protein signaling pathway. Oxid Med Cell Longev. 2019:9096409.
  • Guzowski JF. 2002. Insights into immediate-early gene function in hippocampal memory consolidation using antisense oligonucleotide and fluorescent imaging approaches. Hippocampus. 12(1):86–104. doi: 10.1002/hipo.10010.
  • Harada CN, Natelson Love MC, Triebel KL. 2013. Normal cognitive aging. Clin Geriatr Med. 29(4):737–752. doi: 10.1016/j.cger.2013.07.002.
  • He J, Yamada K, Nabeshima T. 2002. A role of Fos expression in the CA3 region of the hippocampus in spatial memory formation in rats. Neuropsychopharmacology. 26(2):259–268. doi: 10.1016/S0893-133X(01)00332-3.
  • Heyser CJ, Chemero A. 2012. Novel object exploration in mice: not all objects are created equal. Behav Processes. 89(3):232–238. doi: 10.1016/j.beproc.2011.12.004.
  • Hou Z, Yang X, Li Y, Chen J, Shang H. 2022. Electroacupuncture enhances neuroplasticity by regulating the orexin a-mediated cAMP/PKA/CREB signaling pathway in senescence-accelerated mouse prone 8 (SAMP8) mice. Oxid Med Cell Longev. 2022:8694462.
  • Huang da W, Sherman BT, Lempicki RA. 2009. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4(1):44–57. doi: 10.1038/nprot.2008.211.
  • Huganir RL, Nicoll RA. 2013. AMPARs and synaptic plasticity: the last 25 years. Neuron. 80(3):704–717. doi: 10.1016/j.neuron.2013.10.025.
  • Izquierdo I, Medina JH. 1997. Memory formation: the sequence of biochemical events in the hippocampus and its connection to activity in other brain structures. Neurobiol Learn Mem. 68(3):285–316. doi: 10.1006/nlme.1997.3799.
  • Jin SX, Liu L, Li S, Meunier AL, Selkoe DJ. 2022. Aβ oligomers from human brain impair mossy fiber LTP in CA3 of hippocampus, but activating cAMP-PKA and cGMP-PKG prevents this. Neurobiol Dis. 172:105816. doi: 10.1016/j.nbd.2022.105816.
  • Josselyn SA, Köhler S, Frankland PW. 2015. Finding the engram. Nat Rev Neurosci. 16(9):521–534. doi: 10.1038/nrn4000.
  • Jovanovic JN, Czernik AJ, Fienberg AA, Greengard P, Sihra T S. 2000. Synapsins as mediators of BDNF-enhanced neurotransmitter release. Nat Neurosci. 3(4):323–329. doi: 10.1038/73888.
  • Kandel ER. 2012. The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB. Mol Brain. 5(1):14–25. doi: 10.1186/1756-6606-5-14.
  • Kessels HW, Malinow R. 2009. Synaptic AMPA receptor plasticity and behavior. Neuron. 61(3):340–350. doi: 10.1016/j.neuron.2009.01.015.
  • Kim YJ, Lee JS, Kim H, Jang JH, Choung YH. 2021. Gap junction-mediated intercellular communication of cAMP prevents CDDP-induced ototoxicity via cAMP/PKA/CREB pathway. Int J Mol Sci. 22(12):6327. doi: 10.3390/ijms22126327.
  • Kim S, Thiessen PA, Bolton EE, Chen J, Fu G, Gindulyte A, Han L, He J, He S, Shoemaker BA, et al. 2016. PubChem substance and compound databases. Nucleic Acids Res. 44(D1):D1202–13. doi: 10.1093/nar/gkv951.
  • Kubik S, Miyashita T, Guzowski JF. 2007. Using immediate-early genes to map hippocampal subregional functions. Learn Mem. 14(11):758–770. doi: 10.1101/lm.698107.
  • Laha K, Zhu M, Gemperline E, Rau V, Li L, Fanselow MS, Lennertz R, Pearce RA. 2022. CPP impairs contextual learning at concentrations below those that block pyramidal neuron NMDARs and LTP in the CA1 region of the hippocampus. Neuropharmacology. 202:108846. doi: 10.1016/j.neuropharm.2021.108846.
  • Lamberty Y, Gower AJ. 1990. Age-related changes in spontaneous behavior and learning in NMRI mice from maturity to middle age. Physiol Behav. 47(6):1137–1144. doi: 10.1016/0031-9384(90)90364-a.
  • Lamprecht R, Dudai Y. 1996. Transient expression of c-Fos in rat amygdala during training is required for encoding conditioned taste aversion memory. Learn Mem. 3(1):31–41. doi: 10.1101/lm.3.1.31.
  • Lee E, Kim S, Chung KC, Choo MK, Kim DH, Nam G, Rhim H. 2006. 20(S)-ginsenoside Rh2, a newly identified active ingredient of ginseng, inhibits NMDA receptors in cultured rat hippocampal neurons. Eur J Pharmacol. 536(1–2):69–77. doi: 10.1016/j.ejphar.2006.02.038.
  • León R, Garcia AG, Marco-Contelles J. 2013. Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer’s disease. Med Res Rev. 33(1):139–189. doi: 10.1002/med.20248.
  • Lu J, Wu DM, Hu B, Zheng YL, Zhang ZF, Wang YJ. 2010. NGF-dependent activation of TrkA pathway: a mechanism for the neuroprotective effect of troxerutin in d-galactose-treated mice. Brain Pathol. 20(5):952–965. doi: 10.1111/j.1750-3639.2010.00397.x.
  • Lynch G, Seubert P. 1989. Links between long-term potentiation and neuropathology. An hypothesis involving calcium-activated proteases. Ann N Y Acad Sci. 568(1):171–180. doi: 10.1111/j.1749-6632.1989.tb12505.x.
  • Marks CR, Shonesy BC, Wang X, Stephenson JR, Niswender CM, Colbran RJ. 2018. Activated CaMKIIα binds to the mGlu5 metabotropic glutamate receptor and modulates calcium mobilization. Mol Pharmacol. 94(6):1352–1362. doi: 10.1124/mol.118.113142.
  • Mirza FJ, Zahid S. 2018. The Role of Synapsins in Neurological Disorders. Neurosci Bull. 34(2):349–358. doi: 10.1007/s12264-017-0201-7.
  • Miyashita T, Kikuchi E, Horiuchi J, Saitoe M. 2018. Long-term memory engram cells are established by c-Fos/CREB transcriptional cycling. Cell Rep. 25(10):2716–2728.e3. doi: 10.1016/j.celrep.2018.11.022.
  • Mo H, Wang L, Chen Y, Zhang X, Huang N, Liu T, Hu W, Zhong Y, Li Q. 2022. Age-related memory vulnerability to interfering stimuli is caused by gradual loss of MAPK-dependent protection in Drosophila. Aging Cell. 21(6):e13628. doi: 10.1111/acel.13628.
  • Moloney AM, Griffin RJ, Timmons S, O’Connor R, Ravid R, O’Neill C. 2010. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer’s disease indicate possible resistance to IGF-1 and insulin signaling. Neurobiol Aging. 31(2):224–243. doi: 10.1016/j.neurobiolaging.2008.04.002.
  • Nicoll RA. 2017. A brief history of long-term potentiation. Neuron. 93(2):281–290. doi: 10.1016/j.neuron.2016.12.015.
  • O’Neill C, Kiely AP, Coakley MF, Manning S, Long-Smith CM. 2012. Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer’s disease. Biochem Soc Trans. 40(4):721–727. doi: 10.1042/BST20120080.
  • Park P, Georgiou J, Sanderson TM, Ko KH, Kang H, Kim JI, Bradley CA, Bortolotto ZA, Zhuo M, Kaang BK, et al. 2021. PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus. Nat Commun. 12(1):413–427. doi: 10.1038/s41467-020-20523-3.
  • Pchitskaya E, Popugaeva E, Bezprozvanny I. 2018. Calcium signaling and molecular mechanisms underlying neurodegenerative diseases. Cell Calcium. 70:87–94. doi: 10.1016/j.ceca.2017.06.008.
  • Peng LL, Shen HM, Jiang ZL, Li X, Wang GH, Zhang YF, Ke KF. 2009. Inhibition of NMDA receptors underlies the neuroprotective effect of ginsenoside Rb3. Am J Chin Med. 37(4):759–770. doi: 10.1142/S0192415X09007223.
  • Perfitt TL, Wang X, Dickerson MT, Stephenson JR, Nakagawa T, Jacobson DA, Colbran RJ. 2020. Neuronal L-type calcium channel signaling to the nucleus requires a novel CaMKIIα-shank3 interaction. J Neurosci. 40(10):2000–2014. doi: 10.1523/JNEUROSCI.0893-19.2020.
  • Purkey AM, Dell’Acqua ML. 2020. Phosphorylation-dependent regulation of Ca2+-permeable AMPA receptors during hippocampal synaptic plasticity. Front Synaptic Neurosci. 12:8–31. doi: 10.3389/fnsyn.2020.00008.
  • Qian YF, Wang H, Yao WB, Gao XD. 2008. Aqueous extract of the Chinese medicine, Danggui-Shaoyao-San, inhibits apoptosis in hydrogen peroxide-induced PC12 cells by preventing cytochrome c release and inactivating of caspase cascade. Cell Biol Int. 32(2):304–311. doi: 10.1016/j.cellbi.2007.10.004.
  • Remigante A, Morabito R, Spinelli S, Trichilo V, Loddo S, Sarikas A, Dossena S, Marino A. 2020. d-galactose decreases anion exchange capability through band 3 protein in human erythrocytes. Antioxidants. 9(8):689–705. doi: 10.3390/antiox9080689.
  • Ricciarelli R, Fedele E. 2015. Phosphodiesterase 4D: an enzyme to remember. Br J Pharmacol. 172(20):4785–4789. doi: 10.1111/bph.13257.
  • Ru J, Li P, Wang J, Zhou W, Li B, Huang C, Li P, Guo Z, Tao W, Yang Y, et al. 2014. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J Cheminform. 6(1):13–18. doi: 10.1186/1758-2946-6-13.
  • Salery M, Godino A, Nestler EJ. 2021. Drug-activated cells: from immediate early genes to neuronal ensembles in addiction. Adv Pharmacol. 90:173–216. doi: 10.1016/bs.apha.2020.09.006.
  • Sanderson JL, Gorski JA, Dell’Acqua ML. 2016. NMDA receptor-dependent LTD requires transient synaptic incorporation of Ca2+-permeable AMPARs mediated by AKAP150-anchored PKA and calcineurin. Neuron. 89(5):1000–1015. doi: 10.1016/j.neuron.2016.01.043.
  • Satpathy R. 2020. Application of molecular docking methods on endocrine disrupting chemicals: a review. J Appl Biotechnol Rep. 7:74–80.
  • Schmid LC, Mittag M, Poll S, Steffen J, Wagner J, Geis HR, Schwarz I, Schmidt B, Schwarz MK, Remy S, et al. 2016. Dysfunction of somatostatin-positive interneurons associated with memory deficits in an Alzheimer’s disease model. Neuron. 92(1):114–125. doi: 10.1016/j.neuron.2016.08.034.
  • Seeliger D, de Groot BL. 2010. Ligand docking and binding site analysis with PyMOL and Autodock/Vina. J Comput Aided Mol Des. 24(5):417–422. doi: 10.1007/s10822-010-9352-6.
  • Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T. 2003. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13(11):2498–2504. doi: 10.1101/gr.1239303.
  • Shonesy BC, Jalan-Sakrikar N, Cavener VS, Colbran RJ. 2014. CaMKII: a molecular substrate for synaptic plasticity and memory. Prog Mol Biol Transl Sci. 122:61–87. doi: 10.1016/B978-0-12-420170-5.00003-9.
  • Sonoda Y, Mukai H, Matsuo K, Takahashi M, Ono Y, Maeda K, et al. 2016. Accumulation of tumor-suppressor P T EN in Alzheimer neurofibrillary tangles. Neurosci Lett. 471(1):20–24. doi: 10.1016/j.neulet.2009.12.078.
  • Stelzer G, Rosen N, Plaschkes I, Zimmerman S, Twik M, Fishilevich S, Stein TI, Nudel R, Lieder I, Mazor Y, et al. 2016. The GeneCards suite: from gene data mining to disease genome sequence analyses. Curr Protoc Bioinformatics. 54:1.30.1–1.30.33.
  • Strack S, McNeill RB, Colbran RJ. 2000. Mechanism and regulation of calcium/calmodulin-dependent protein kinase II targeting to the NR2B subunit of the N-methyl-d-aspartate receptor. J Biol Chem. 275(31):23798–23806. doi: 10.1074/jbc.M001471200.
  • Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, Simonovic M, Doncheva NT, Morris JH, Bork P, et al. 2019. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 47(D1):D607–D613. doi: 10.1093/nar/gky1131.
  • Tian J, Shi J, Wei M, Ni J, Fang Z, Gao J, Wang H, Yao H, Zhang J, Li J, et al. 2019. Chinese herbal medicine Qinggongshoutao for the treatment of amnestic mild cognitive impairment: a 52-week randomized controlled trial. Alzheimers Dement. 5(1):441–449. doi: 10.1016/j.trci.2019.03.001.
  • Tischmeyer W, Grimm R. 1999. Activation of immediate early genes and memory formation. Cell Mol Life Sci. 55(4):564–574. doi: 10.1007/s000180050315.
  • Tonegawa S, Pignatelli M, Roy DS, Ryan TJ. 2015. Memory engram storage and retrieval. Curr Opin Neurobiol. 35:101–109. doi: 10.1016/j.conb.2015.07.009.
  • Tong H, Chen GH, Liu RY, Zhou JN. 2007. Age-related learning and memory impairments in adult-onset hypothyroidism in Kunming mice. Physiol Behav. 91(2–3):290–298. doi: 10.1016/j.physbeh.2007.03.008.
  • Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, Dingledine R. 2010. Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev. 62(3):405–496. doi: 10.1124/pr.109.002451.
  • Vugmeyster Y, Harrold J, Xu X. 2012. Absorption, distribution, metabolism, and excretion (ADME) studies of biotherapeutics for autoimmune and inflammatory conditions. AAPS J. 14(4):714–727. doi: 10.1208/s12248-012-9385-y.
  • Wei W, Dong Q, Jiang W, Wang Y, Chen Y, Han T, Sun C. 2021. Dichloroacetic acid-induced dysfunction in rat hippocampus and the protective effect of curcumin. Metab Brain Dis. 36(4):545–556. doi: 10.1007/s11011-020-00657-5.
  • Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, et al. 2018. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 46(D1):D1074–D1082. doi: 10.1093/nar/gkx1037.
  • Wu L, Zhang T, Chen K, Lu C, Liu XF, Zhou JL, Huang YK, Yan H, Chen Y, Zhang CJ, et al. 2021. Rapid antidepressant-like effect of Fructus Aurantii depends on cAMP-response element binding protein/brain-derived neurotrophic facto by mediating synaptic transmission. Phytother Res. 35(1):404–414. doi: 10.1002/ptr.6812.
  • Xiang X, Yu Y, Tang X, Chen M, Zheng Y, Zhu S. 2019. Transcriptome profile in hippocampus during acute inflammatory response to surgery: toward early stage of PND. Front Immunol. 10:149–157. doi: 10.3389/fimmu.2019.00149.
  • Xie Y, Song A, Zhu Y, Jiang A, Peng W, Zhang C, Meng X. 2021. Effects and mechanisms of probucol on aging-related hippocampus-dependent cognitive impairment. Biomed Pharmacother. 144:112266. doi: 10.1016/j.biopha.2021.112266.
  • Yang S, Du Y, Zhao X, Wu C, Yu P. 2022. Reducing PDK1/Akt activity: an effective therapeutic target in the treatment of Alzheimer’s disease. Cells. 11(11):1735–1755. doi: 10.3390/cells11111735.
  • Yin JC, Del Vecchio M, Zhou H, Tully T. 1995. CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. Cell. 81(1):107–115. doi: 10.1016/0092-8674(95)90375-5.
  • Yin JC, Wallach JS, Del Vecchio M, Wilder EL, Zhou H, Quinn WG, Tully T. 1994. Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila. Cell. 79(1):49–58. doi: 10.1016/0092-8674(94)90399-9.
  • Yu CC, He C, Du YJ, Gao S, Lin YF, Wang SQ, Wang L, Wang J, Wang XS, Jiang T, et al. 2021. Preventive electroacupuncture reduces cognitive deficits in a rat model of d-galactose-induced aging. Neural Regen Res. 16(5):916–923. doi: 10.4103/1673-5374.297090.
  • Yuan L, Zhang J, Guo JH, Holscher C, Yang JT, Wu MN, Wang ZJ, Cai HY, Han LN, Shi H, et al. 2021. DAla2-GIP-GLU-PAL protects against cognitive deficits and pathology in APP/PS1 mice by inhibiting neuroinflammation and upregulating cAMP/PKA/CREB signaling pathways. J Alzheimers Dis. 80(2):695–713. doi: 10.3233/JAD-201262.
  • Zeng L, Lin L, Peng Y, Yuan D, Zhang S, Gong Z, Xiao W. 2020. L-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation. Exp Gerontol. 131:110823. doi: 10.1016/j.exger.2019.110823.
  • Zhang C, Du F, Shi M, Ye R, Cheng H, Han J, Ma L, Cao R, Rao Z, Zhao G. 2012. Ginsenoside Rd protects neurons against glutamate-induced excitotoxicity by inhibiting Ca2+ influx. Cell Mol Neurobiol. 32(1):121–128. doi: 10.1007/s10571-011-9742-x.
  • Zhang B, Lian W, Zhao J, Wang Z, Liu A, Du G. 2021. DL0410 alleviates memory impairment in d-galactose-induced aging rats by suppressing neuroinflammation via the TLR4/MyD88/NF-κB pathway. Oxid Med Cell Longev. 2021:6521146. doi: 10.1155/2021/6521146.
  • Zhang HL, Zhao B, Han W, Sun YB, Yang P, Chen Y, Ni D, Zhang J, Yin DM. 2021. Acetylation of calmodulin regulates synaptic plasticity and fear learning. J Biol Chem. 297(3):101034. doi: 10.1016/j.jbc.2021.101034.