Homogeneous Polyporus polysaccharide exerts anti-bladder cancer effects via autophagy induction

References

• Anderson NM, Simon MC. 2020. The tumor microenvironment. Curr Biol. 30(16):R921–R925. doi: 10.1016/j.cub.2020.06.081.
   PubMed Web of Science ®Google Scholar
• Buffen K, Oosting M, Quintin J, Ng A, Kleinnijenhuis J, Kumar V, van de Vosse E, Wijmenga C, van Crevel R, Oosterwijk E, et al. 2014. Autophagy controls BCG-induced trained immunity and the response to intravesical BCG therapy for bladder cancer. PLoS Pathog. 10(10):e1004485. doi: 10.1371/journal.ppat.1004485.
   PubMed Web of Science ®Google Scholar
• Cao R, Ma B, Wang G, Xiong Y, Tian Y, Yuan L. 2021. Identification of autophagy-related genes signature predicts chemotherapeutic and immunotherapeutic efficiency in bladder cancer (BLCA). J Cell Mol Med. 25(12):5417–5433. doi: 10.1111/jcmm.16552.
   PubMed Web of Science ®Google Scholar
• Casey SC, Amedei A, Aquilano K, Azmi AS, Benencia F, Bhakta D, Bilsland AE, Boosani CS, Chen S, Ciriolo MR, et al. 2015. Cancer prevention and therapy through the modulation of the tumor microenvironment. Semin Cancer Biol. 35 Suppl(Suppl):S199–S223. doi: 10.1016/j.semcancer.2015.02.007.
   PubMedGoogle Scholar
• Crispen PL, Kusmartsev S. 2020. Mechanisms of immune evasion in bladder cancer. Cancer Immunol Immunother. 69(1):3–14. doi: 10.1007/s00262-019-02443-4.
   PubMed Web of Science ®Google Scholar
• Denton D, Kumar S. 2019. Autophagy-dependent cell death. Cell Death Differ. 26(4):605–616. doi: 10.1038/s41418-018-0252-y.
   PubMed Web of Science ®Google Scholar
• Gao W, Wang X, Zhou Y, Wang X, Yu Y. 2022. Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy. Signal Transduct Target Ther. 7(1):196.
   PubMed Web of Science ®Google Scholar
• Ge Y, Huang M, Yao YM. 2018. Autophagy and proinflammatory cytokines: interactions and clinical implications. Cytokine Growth Factor Rev. 43:38–46. doi: 10.1016/j.cytogfr.2018.07.001.
   PubMed Web of Science ®Google Scholar
• Guo N, Bai Z, Jia W, Sun J, Wang W, Chen S, Wang H. 2019. Quantitative analysis of polysaccharide composition in Polyporus umbellatus by HPLC-ESI-TOF-MS. Molecules. 24(14):2526. doi: 10.3390/molecules24142526.
   PubMed Web of Science ®Google Scholar
• He PF, Zhang AQ, Wang XL, Qu L, Li GL, Li YP, Sun PL. 2016. Structure elucidation and antioxidant activity of a novel polysaccharide from Polyporus umbellatus sclerotia. Int J Biol Macromol. 82:411–417. doi: 10.1016/j.ijbiomac.2015.10.032.
   PubMed Web of Science ®Google Scholar
• Heras-Sandoval D, Pérez-Rojas JM, Hernández-Damián J, Pedraza-Chaverri J. 2014. The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration. Cell Signal. 26(12):2694–2701. doi: 10.1016/j.cellsig.2014.08.019.
   PubMed Web of Science ®Google Scholar
• Hu F, Song D, Yan Y, Huang C, Shen C, Lan J, Chen Y, Liu A, Wu Q, Sun L, et al. 2021. IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation. Nat Commun. 12(1):3651. doi: 10.1038/s41467-021-23923-1.
   PubMed Web of Science ®Google Scholar
• Huang Z, Gan S, Zhuang X, Chen Y, Lu L, Wang Y, Qi X, Feng Q, Huang Q, Du B, et al. 2022. Artesunate inhibits the cell growth in colorectal cancer by promoting ROS-dependent cell senescence and autophagy. Cells. 11(16):2472. doi: 10.3390/cells11162472.
   PubMed Web of Science ®Google Scholar
• Jia W, Luo S, Lai G, Li S, Huo S, Li M, Zeng X. 2021. Homogeneous Polyporus polysaccharide inhibits bladder cancer by polarizing macrophages to M1 subtype in tumor microenvironment. BMC Complement Med Ther. 21(1):150. doi: 10.1186/s12906-021-03318-x.
   PubMedGoogle Scholar
• Jiang GM, Tan Y, Wang H, Peng L, Chen HT, Meng XJ, Li LL, Liu Y, Li WF, Shan H. 2019. The relationship between autophagy and the immune system and its applications for tumor immunotherapy. Mol Cancer. 18(1):17. doi: 10.1186/s12943-019-0944-z.
   PubMed Web of Science ®Google Scholar
• Konac E, Kurman Y, Baltaci S. 2021. Contrast effects of autophagy in the treatment of bladder cancer. Exp Biol Med (Maywood). 246(3):354–367. doi: 10.1177/1535370220959336.
   PubMed Web of Science ®Google Scholar
• Leblond MM, Zdimerova H, Desponds E, Verdeil G. 2021. Tumor-associated macrophages in bladder cancer: biological role, impact on therapeutic response and perspectives for immunotherapy. Cancers (Basel). 13(18):4712. doi: 10.3390/cancers13184712.
   PubMed Web of Science ®Google Scholar
• Lenis AT, Lec PM, Chamie K, Mshs MD. 2020. Bladder cancer: a review. JAMA. 324(19):1980–1991. doi: 10.1001/jama.2020.17598.
   PubMed Web of Science ®Google Scholar
• Levy JMM, Towers CG, Thorburn A. 2017. Targeting autophagy in cancer. Nat Rev Cancer. 17(9):528–542. doi: 10.1038/nrc.2017.53.
   PubMed Web of Science ®Google Scholar
• Li F, Guo H, Yang Y, Feng M, Liu B, Ren X, Zhou H. 2019. Autophagy modulation in bladder cancer development and treatment (Review). Oncol Rep. 42(5):1647–1655. doi: 10.3892/or.2019.7286.
   PubMed Web of Science ®Google Scholar
• Li X, He S, Ma B. 2020. Autophagy and autophagy-related proteins in cancer. Mol Cancer. 19(1):12. doi: 10.1186/s12943-020-1138-4.
   PubMed Web of Science ®Google Scholar
• Liu CP, Zhang X, Tan QL, Xu WX, Zhou CY, Luo M, Li X, Huang RY, Zeng X. 2017. NF-κB pathways are involved in M1 polarization of RAW 264.7 macrophage by Polyporus polysaccharide in the tumor microenvironment. PLoS One. 12(11):e0188317. doi: 10.1371/journal.pone.0188317.
   PubMed Web of Science ®Google Scholar
• Liu CP, Li X, Lai GN, Li JH, Jia WY, Cao YY, Xu WX, Tan QL, Zhou CY, Luo M, et al. 2020. Mechanisms of macrophage immunomodulatory activity induced by a new polysaccharide isolated from Polyporus umbellatus (Pers.) Fries. Front Chem. 8:581. doi: 10.3389/fchem.2020.00581.
   PubMed Web of Science ®Google Scholar
• Liu C, He D, Zhang S, Chen H, Zhao J, Li X, Zeng X. 2022. Homogeneous Polyporus polysaccharide inhibit bladder cancer by resetting tumor-associated macrophages toward M1 through NF-κB/NLRP3 signaling. Front Immunol. 13:839460. doi: 10.3389/fimmu.2022.839460.
   PubMedGoogle Scholar
• Lv S, Liu H, Wang H. 2021. Exogenous hydrogen sulfide plays an important role by regulating autophagy in diabetic-related diseases. Int J Mol Sci. 22(13):6715. doi: 10.3390/ijms22136715.
   PubMed Web of Science ®Google Scholar
• Marinković M, Šprung M, Buljubašić M, Novak I. 2018. Autophagy modulation in cancer: current knowledge on action and therapy. Oxid Med Cell Longev. 2018:8023821–8023818. doi: 10.1155/2018/8023821.
   PubMed Web of Science ®Google Scholar
• Mizushima N, Komatsu M. 2011. Autophagy: renovation of cells and tissues. Cell. 147(4):728–741. doi: 10.1016/j.cell.2011.10.026.
   PubMed Web of Science ®Google Scholar
• Nielsen SR, Schmid MC. 2017. Macrophages as key drivers of cancer progression and metastasis. Mediators Inflamm. 2017:9624760–9624711. doi: 10.1155/2017/9624760.
   PubMed Web of Science ®Google Scholar
• Parzych KR, Klionsky DJ. 2014. An overview of autophagy: morphology, mechanism, and regulation. Antioxid Redox Signal. 20(3):460–473. doi: 10.1089/ars.2013.5371.
   PubMed Web of Science ®Google Scholar
• Polivka J, Jr, Janku F. 2014. Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway. Pharmacol Ther. 142(2):164–175. doi: 10.1016/j.pharmthera.2013.12.004.
   PubMed Web of Science ®Google Scholar
• Roma-Rodrigues C, Mendes R, Baptista PV, Fernandes AR. 2019. Targeting tumor microenvironment for cancer therapy. Int J Mol Sci. 20(4):840. doi: 10.3390/ijms20040840.
   PubMed Web of Science ®Google Scholar
• Shen J, Xu S, Zhou H, Liu H, Jiang W, Hao J, Hu Z. 2017. IL-1β induces apoptosis and autophagy via mitochondria pathway in human degenerative nucleus pulposus cells. Sci Rep. 7(1):41067. doi: 10.1038/srep41067.
   PubMedGoogle Scholar
• Sun H, Wang Z, Yakisich JS. 2013. Natural products targeting autophagy via the PI3K/Akt/mTOR pathway as anticancer agents. Anticancer Agents Med Chem. 13(7):1048–1056. doi: 10.2174/18715206113139990130.
   PubMed Web of Science ®Google Scholar
• Towers CG, Wodetzki D, Thorburn A. 2020. Autophagy and cancer: modulation of cell death pathways and cancer cell adaptations. J Cell Biol. 219(1):e201909033. doi: 10.1083/jcb.201909033.
   PubMed Web of Science ®Google Scholar
• Tsai TF, Chang AC, Chen PC, Ho CY, Chen HE, Chou KY, Hwang TI. 2022. Autophagy blockade potentiates cancer-associated immunosuppression through programmed death ligand-1 upregulation in bladder cancer. J Cell Physiol. 237(9):3587–3597. doi: 10.1002/jcp.30817.
   PubMed Web of Science ®Google Scholar
• Udristioiu A, Nica-Badea D. 2019. Autophagy dysfunctions associated with cancer cells and their therapeutic implications. Biomed Pharmacother. 115:108892. doi: 10.1016/j.biopha.2019.108892.
   PubMed Web of Science ®Google Scholar
• van Wilpe S, Gerretsen ECF, van der Heijden AG, de Vries IJM, Gerritsen WR, Mehra N. 2020. Prognostic and predictive value of tumor-infiltrating immune cells in urothelial cancer of the bladder. Cancers (Basel). 12(9):2692. doi: 10.3390/cancers12092692.
   PubMed Web of Science ®Google Scholar
• Vitto VAM, Bianchin S, Zolondick AA, Pellielo G, Rimessi A, Chianese D, Yang H, Carbone M, Pinton P, Giorgi C, et al. 2022. Molecular mechanisms of autophagy in cancer development, progression, and therapy. Biomedicines. 10(7):1596. doi: 10.3390/biomedicines10071596.
   PubMed Web of Science ®Google Scholar
• Xiang Y, Guo Z, Zhu P, Chen J, Huang Y. 2019. Traditional Chinese medicine as a cancer treatment: modern perspectives of ancient but advanced science. Cancer Med. 8(5):1958–1975. doi: 10.1002/cam4.2108.
   PubMed Web of Science ®Google Scholar
• Xiao Y, Yu D. 2021. Tumor microenvironment as a therapeutic target in cancer. Pharmacol Ther. 221:107753. doi: 10.1016/j.pharmthera.2020.107753.
   PubMed Web of Science ®Google Scholar
• Xue JF, Shi ZM, Zou J, Li XL. 2017. Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis. Biomed Pharmacother. 89:1252–1261. doi: 10.1016/j.biopha.2017.01.130.
   PubMed Web of Science ®Google Scholar
• Yuan Y, Ding D, Zhang N, Xia Z, Wang J, Yang H, Guo F, Li B. 2018. TNF-α induces autophagy through ERK1/2 pathway to regulate apoptosis in neonatal necrotizing enterocolitis model cells IEC-6. Cell Cycle. 17(11):1390–1402. doi: 10.1080/15384101.2018.1482150.
   PubMed Web of Science ®Google Scholar
• Zhang G, Zeng X, Li C, Li J, Huang Y, Han L, Wei JA, Huang H. 2011. Inhibition of urinary bladder carcinogenesis by aqueous extract of sclerotia of Polyporus umbellatus Fries and Polyporus polysaccharide. Am J Chin Med. 39(1):135–144. doi: 10.1142/S0192415X11008701.
   PubMed Web of Science ®Google Scholar
• Zhang GW, Qin GF, Han B, Li CX, Yang HG, Nie PH, Zeng X. 2015. Efficacy of Zhuling Polyporus polysaccharide with BCG to inhibit bladder carcinoma. Carbohydr Polym. 118:30–35. doi: 10.1016/j.carbpol.2014.11.012.
   PubMed Web of Science ®Google Scholar
• Zhang Y, He N, Zhou X, Wang F, Cai H, Huang SH, Chen X, Hu Z, Jin X. 2021. Betulinic acid induces autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in human bladder cancer cells. Aging (Albany NY). 13(17):21251–21267. doi: 10.18632/aging.203441.
   PubMedGoogle Scholar
• Zhen Y, Zhao R, Wang M, Jiang X, Gao F, Fu L, Zhang L, Zhou XL. 2020. Flubendazole elicits anti-cancer effects via targeting EVA1A-modulated autophagy and apoptosis in Triple-negative Breast Cancer. Theranostics. 10(18):8080–8097. doi: 10.7150/thno.43473.
   PubMed Web of Science ®Google Scholar