Diagnosing epileptic seizures in patients with Alzheimer’s disease and deciding on the appropriate treatment plan

References

• Scheltens P, De Strooper B, Kivipelto M, et al. WM. Alzheimer’s disease. Lancet. 2021;397(10284):1577–1590. doi: 10.1016/S0140-6736(20)32205-4
   PubMed Web of Science ®Google Scholar
• Brigo F, Nardone R. Epilepsy associated with Alzheimer’s disease and other adult neurodegenerative disorders. In: Shorvon S, Guerrini R, Schachter S Trinka E, editors The causes of epilepsy: common and uncommon causes in adults and children. Cambridge: Cambridge University Press; 2019. p. 783–789.
   Google Scholar
• Sosa-Ortiz AL, Acosta-Castillo I, Prince MJ. Epidemiology of dementias and Alzheimer’s disease. Arch Med Res. 2012;43(8):600–8. doi: 10.1016/j.arcmed.2012.11.003
   PubMed Web of Science ®Google Scholar
• Meng XF, Yu JT, Wang HF, et al. Midlife vascular risk factors and the risk of Alzheimer’s disease: a systematic review and meta-analysis. J Alzheimers Dis. 2014;42(4):1295–310. doi: 10.3233/JAD-140954
   PubMed Web of Science ®Google Scholar
• Davis KAS, Bishara D, Perera G, et al. Benefits and harms of statins in people with dementia: a systematic review and meta-analysis. J Am Geriatr Soc. 2020;68(3):650–658. doi: 10.1111/jgs.16342
   PubMed Web of Science ®Google Scholar
• Hyman BT, Phelps CH, Beach TG, et al. National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease. Alzheimer’s Dementia. 2012;8(1):1–13. doi: 10.1016/j.jalz.2011.10.007
   PubMed Web of Science ®Google Scholar
• Cheng X, Wei Y, Qian Z, et al. Autophagy balances neuroinflammation in Alzheimer’s disease. Cell Mol Neurobiol. 2023;43(4):1537–1549. doi: 10.1007/s10571-022-01269-6
   PubMed Web of Science ®Google Scholar
• Montembeault M, Migliaccio R. Atypical forms of Alzheimer’s disease: patients not to forget. Curr Opin Neurol. 2023;36(4):245–252. doi: 10.1097/WCO.0000000000001182
   PubMed Web of Science ®Google Scholar
• Kumfor F, Halliday GM, Piguet O. Clinical aspects of Alzheimer’s disease. Adv Neurobiol. 2017;15:31–53.
   PubMedGoogle Scholar
• Villain N, Dubois B. Alzheimer’s disease including focal presentations. Semin Neurol. 2019;39(2):213–226. doi: 10.1055/s-0039-1681041
   PubMed Web of Science ®Google Scholar
• Liang CS, Li DJ, Yang FC, et al. Mortality rates in Alzheimer’s disease and non-Alzheimer’s dementias: a systematic review and meta-analysis. Lancet Healthy Longev. 2021;2(8):e479–e488. doi: 10.1016/S2666-7568(21)00140-9
   PubMedGoogle Scholar
• Romanelli MF, Morris JC, Ashkin K, et al. Advanced Alzheimer’s disease is a risk factor for late-onset seizures. Arch Neurol. 1990;47(8):847–850. doi: 10.1001/archneur.1990.00530080029006
   PubMedGoogle Scholar
• Hesdorffer DC, Hauser WA, Annegers JF, et al. Dementia and adult-onset unprovoked seizures. Neurology. 1996;46(3):727–730. doi: 10.1212/WNL.46.3.727
   PubMed Web of Science ®Google Scholar
• Pandis D, Scarmeas N. Seizures in Alzheimer disease: clinical and epidemiological data. Epilepsy Curr. 2012;12(5):184–187. doi: 10.5698/1535-7511-12.5.184
   PubMed Web of Science ®Google Scholar
• Nicastro N, Assal F, Seeck M. From here to epilepsy: the risk of seizure in patients with Alzheimer’s disease. Epileptic Disord. 2016;18(1):1–12. doi: 10.1684/epd.2016.0808
   PubMed Web of Science ®Google Scholar
• Sen A, Jette N, Husain M, et al. Epilepsy in older people. Lancet. 2020;395(10225):735–748. doi: 10.1016/S0140-6736(19)33064-8
   PubMed Web of Science ®Google Scholar
• Scarmeas N, Honig LS, Choi H, et al. Seizures in Alzheimer disease: who, when, and how common? Arch Neurol. 2009;66(8):992–997. doi: 10.1001/archneurol.2009.130
   PubMedGoogle Scholar
• Irizarry MC, Jin S, He F, et al. Incidence of new-onset seizures in mild to moderate Alzheimer disease. Arch Neurol. 2012;69(3):368–372. doi: 10.1001/archneurol.2011.830
   PubMedGoogle Scholar
• Mendez MF, Catanzaro P, Doss RC, et al. Seizures in Alzheimer’s disease: clinicopathologic study. J Geriatr Psychiatry Neurol. 1994;7(4):230–233. doi: 10.1177/089198879400700407
   PubMedGoogle Scholar
• Larner AJ, Doran M. Clinical phenotypic heterogeneity of Alzheimer’s disease associated with mutations of the presenilin–1 gene. J Neurol. 2006;253(2):139–158. doi: 10.1007/s00415-005-0019-5
   PubMed Web of Science ®Google Scholar
• Zarea A, Charbonnier C, Rovelet-Lecrux A, et al. PHRC GMAJ Collaborators. Seizures in dominantly inherited Alzheimer disease. Neurology. 2016 30;87(9):912–919. doi: 10.1212/WNL.0000000000003048
   PubMed Web of Science ®Google Scholar
• Johnson EL, Krauss GL, Lee AK, et al. Association between midlife risk factors and late-onset epilepsy: results from the atherosclerosis risk in communities study. JAMA Neurol. 2018;75(11):1375–1382. doi: 10.1001/jamaneurol.2018.1935
   PubMed Web of Science ®Google Scholar
• Chan J, Jones NC, Bush AI, et al. A mouse model of Alzheimer’s disease displays increased susceptibility to kindling and seizure-associated death. Epilepsia. 2015;56(6):e73–7. doi: 10.1111/epi.12993
   PubMed Web of Science ®Google Scholar
• Palop JJ, Mucke L. Network abnormalities and interneuron dysfunction in Alzheimer disease. Nat Rev Neurosci. 2016;17(12):777–792. doi: 10.1038/nrn.2016.141
   PubMed Web of Science ®Google Scholar
• Heggland I, Kvello P, Witter MP. Electrophysiological characterization of networks and single cells in the hippocampal region of a transgenic rat model of Alzheimer’s disease. eNeuro. 2019;6(1):ENEURO.0448–17.2019. doi: 10.1523/ENEURO.0448-17.2019
   PubMed Web of Science ®Google Scholar
• Kang JQ. Epileptic mechanisms shared by Alzheimer’s disease: viewed via the Unique lens of genetic epilepsy. Int J Mol Sci. 2021;22(13):7133. doi: 10.3390/ijms22137133
   PubMed Web of Science ®Google Scholar
• Rao SC, Dove G, Cascino GD, et al. Recurrent seizures in patients with dementia: frequency, seizure types, and treatment outcome. Epilepsy Behav. 2009;14(1):118–120. doi: 10.1016/j.yebeh.2008.08.012
   PubMed Web of Science ®Google Scholar
• Bernardi S, Scaldaferri N, Vanacore N, et al. Seizures in Alzheimer’s disease: a retrospective study of a cohort of outpatients. Epileptic Disord. 2010;12(1):16–21. doi: 10.1684/epd.2010.0290
   PubMed Web of Science ®Google Scholar
• Hauser WA, Morris ML, Heston LL, et al. Seizures and myoclonus in patients with Alzheimer’s disease. Neurology. 1986;36(9):1226–1230. doi: 10.1212/WNL.36.9.1226
   PubMed Web of Science ®Google Scholar
• Beagle AJ, Darwish SM, Ranasinghe KG, et al. Relative incidence of seizures and myoclonus in Alzheimer’s disease, dementia with Lewy Bodies, and frontotemporal dementia. J Alzheimers Dis. 2017;60(1):211–223. doi: 10.3233/JAD-170031
   PubMed Web of Science ®Google Scholar
• Brigo F, Mecarelli O. Aging and degenerative disorders. In: Mecarelli O, editor. Clinical electroencephalography. Cham, Switzerland: Springer; 2019. p. 661–676.
   Google Scholar
• Silveira DC, Jehi L, Chapin J, et al. Seizure semiology and aging. Epilepsy Behav. 2011;20(2):375–377. doi: 10.1016/j.yebeh.2010.12.033
   PubMed Web of Science ®Google Scholar
• Kellinghaus C, Loddenkemper T, Dinner DS, et al. Seizure semiology in the elderly: a video analysis. Epilepsia. 2004;45(3):263–267. doi: 10.1111/j.0013-9580.2004.29003.x
   PubMed Web of Science ®Google Scholar
• Brodie MJ, Elder AT, Kwan P. Epilepsy in later life. Lancet Neurol. 2009;8(11):1019–1030. doi: 10.1016/S1474-4422(09)70240-6
   PubMed Web of Science ®Google Scholar
• Kinney MO, Craig JJ, Kaplan PW. Non-convulsive status epilepticus: mimics and chameleons. Pract Neurol. 2018;18(4):291–305. doi: 10.1136/practneurol-2017-001796
   PubMedGoogle Scholar
• Kinney MO, Craig JJ, Kaplan PW. Hidden in plain sight: Non-convulsive status epilepticus-Recognition and management. Acta Neurol Scand. 2017;136(4):280–292. doi: 10.1111/ane.12732
   PubMed Web of Science ®Google Scholar
• Cretin B, Sellal F, Philippi N, et al. Epileptic prodromal Alzheimer’s disease, a retrospective study of 13 new cases: expanding the spectrum of Alzheimer’s disease to an epileptic variant? J Alzheimers Dis. 2016;52(3):1125–1133. doi: 10.3233/JAD-150096
   PubMed Web of Science ®Google Scholar
• Horváth A, Szűcs A, Barcs G, et al. Epileptic Seizures in Alzheimer Disease: A Review. Alzheimer Dis Assoc Disord. 2016;30(2):186–92. doi: 10.1097/WAD.0000000000000134
   PubMed Web of Science ®Google Scholar
• Vossel KA, Beagle AJ, Rabinovici GD, et al. Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurol. 2013;70(9):1158–1166. doi: 10.1001/jamaneurol.2013.136
   PubMed Web of Science ®Google Scholar
• Horváth A, Szűcs A, Hidasi Z, et al. Prevalence, semiology, and risk factors of epilepsy in Alzheimer’s disease: an ambulatory EEG study. J Alzheimers Dis. 2018;63(3):1045–1054. doi: 10.3233/JAD-170925
   PubMed Web of Science ®Google Scholar
• Vossel KA, Ranasinghe KG, Beagle AJ, et al. Incidence and impact of subclinical epileptiform activity in Alzheimer’s disease. Ann Neurol. 2016;80(6):858–870. doi: 10.1002/ana.24794
   PubMed Web of Science ®Google Scholar
• Ciliento R, Gjini K, Dabbs K, et al. Prevalence and localization of nocturnal epileptiform discharges in mild cognitive impairment. Brain Commun. 2023;5(6):fcad302. doi: 10.1093/braincomms/fcad302
   PubMedGoogle Scholar
• Lam AD, Deck G, Goldman A, et al. Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer’s disease. Nat Med. 2017;23(6):678–680. doi: 10.1038/nm.4330
   PubMed Web of Science ®Google Scholar
• Ranasinghe KG, Kudo K, Hinkley, et al. Neuronal synchrony abnormalities associated with subclinical epileptiform activity in early-onset Alzheimer’s disease. Brain. 2022;145(2):744–753. doi: 10.1093/brain/awab442
   PubMed Web of Science ®Google Scholar
• Brick JF, Gutierrez AR, Cheek JC, et al. Transient appearance of periodic EEG discharges in senile dementia. Clin Electroencephalogr. 1991;22(2):108–111. doi: 10.1177/155005949102200211
   PubMedGoogle Scholar
• Tschampa HJ, Neumann M, Zerr I, et al. Patients with Alzheimer’s disease and dementia with Lewy bodies mistaken for Creutzfeldt-Jakob disease. J Neurol Neurosurg Psychiatry. 2001;71(1):33–39. 10.1136/jnnp.71.1.33
   PubMed Web of Science ®Google Scholar
• Doran M, Larner AJ. EEG findings in dementia with Lewy bodies causing diagnostic confusion with sporadic Creutzfeldt-Jakob disease. Eur J Neurol. 2004;11(12):838–841. doi: 10.1111/j.1468-1331.2004.00895.x
   PubMed Web of Science ®Google Scholar
• Musaeus CS, Kjaer TW, Cacic Hribljan M, et al. Subclinical epileptiform activity in dementia with Lewy Bodies. Mov Disord. 2023;38(10):1861–1870. doi: 10.1002/mds.29531
   PubMed Web of Science ®Google Scholar
• Brigo F, Storti M. Triphasic waves. Am J Electroneurodiagnostic Technol. 2011;51(1):16. doi: 10.1080/1086508X.2011.11079796
   PubMedGoogle Scholar
• Brigo F. An evidence-based approach to proper diagnostic use of the electroencephalogram for suspected seizures. Epilepsy Behav. 2011;21(3):219–222. doi: 10.1016/j.yebeh.2011.04.004
   PubMed Web of Science ®Google Scholar
• Vossel KA, Tartaglia MC, Nygaard HB, et al. Epileptic activity in Alzheimer’s disease: causes and clinical relevance. Lancet Neurol. 2017;16(4):311–322. doi: 10.1016/S1474-4422(17)30044-3
   PubMed Web of Science ®Google Scholar
• McAreavey MJ, Ballinger BR, Fenton GW. Epileptic seizures in elderly patients with dementia. Epilepsia. 1992;33(4):657–660. doi: 10.1111/j.1528-1157.1992.tb02343.x
   PubMed Web of Science ®Google Scholar
• Vercueil L. Epilepsy and neurodegenerative diseases in adults: a clinical review. Epileptic Disord. 2006;8:S44–S54.
   Web of Science ®Google Scholar
• Salinsky M, Kanter R, Dasheiff RM. Effectiveness of multiple EEGs in supporting the diagnosis of epilepsy: an operational curve. Epilepsia. 1987;28(4):331–334. doi: 10.1111/j.1528-1157.1987.tb03652.x
   PubMed Web of Science ®Google Scholar
• Burkholder DB, Britton JW, Rajasekaran V, et al. Routine vs extended outpatient EEG for the detection of interictal epileptiform discharges. Neurology. 2016;86(16):1524–1530. doi: 10.1212/WNL.0000000000002592
   PubMed Web of Science ®Google Scholar
• Lam AD, Sarkis RA, Pellerin KR, et al. Association of epileptiform abnormalities and seizures in Alzheimer disease. Neurology. 2020;95(16):e2259–e2270. doi: 10.1212/WNL.0000000000010612
   PubMed Web of Science ®Google Scholar
• Ghosh S, Jehi LE. New-onset epilepsy in the elderly: challenges for the internist. Cleve Clin J Med. 2014;81(8):490–498. doi: 10.3949/ccjm.81a.13148
   PubMed Web of Science ®Google Scholar
• Howland RH. Drug therapies for cognitive impairment and dementia. J Psychosoc Nurs Ment Health Serv. 2010;48(4):11–14. doi: 10.3928/02793695-20100311-01
   Web of Science ®Google Scholar
• Kumlien E, Lundberg PO. Seizure risk associated with neuroactive drugs: data from the WHO adverse drug reactions database. Seizure. 2010;19(2):69–73. doi: 10.1016/j.seizure.2009.11.005
   PubMed Web of Science ®Google Scholar
• McShane R, Areosa Sastre A, Minakaran N. Memantine for dementia. Cochrane Database Syst Rev. 2006 2. CD003154. doi: 10.1002/14651858.CD003154.pub5
   Web of Science ®Google Scholar
• Harms SL, Garrard J, Schwinghammer P, et al. Ginkgo biloba use in nursing home elderly with epilepsy or seizure disorder. Epilepsia. 2006;47(2):323–329. doi: 10.1111/j.1528-1167.2006.00424.x
   PubMed Web of Science ®Google Scholar
• Zhai Y, Yin S, Zhang D, et al. Association between Antipsychotic drugs and mortality in older persons with Alzheimer’s disease: a systematic review and meta-analysis. J Alzheimers Dis. 2016;52(2):631–639. doi: 10.3233/JAD-151207
   PubMed Web of Science ®Google Scholar
• Bloechliger M, Rüegg S, Jick SS, et al. Antipsychotic drug use and the risk of seizures: follow-up study with a nested case–control analysis. CNS Drugs. 2015;29(7):591–603. doi: 10.1007/s40263-015-0262-y
   PubMed Web of Science ®Google Scholar
• Ruffmann C, Bogliun G, Beghi E. Epileptogenic drugs: a systematic review. Expert Rev Neurother. 2006;6(4):575–589. doi: 10.1586/14737175.6.4.575
   PubMedGoogle Scholar
• Lertxundi U, Hernandez R, Medrano J, et al. Antipsychotics and seizures: higher risk with atypicals? Seizure. 2013;22(2):141–143. doi: 10.1016/j.seizure.2012.10.009
   PubMed Web of Science ®Google Scholar
• Montgomery SA. Antidepressants and seizures: emphasis on newer agents and clinical implications. Int J Clin Pract. 2005;59(12):1435–1440. doi: 10.1111/j.1368-5031.2005.00731.x
   PubMed Web of Science ®Google Scholar
• Hill T, Coupland C, Morriss R, et al. Antidepressant use and risk of epilepsy and seizures in people aged 20 to 64 years: cohort study using a primary care database. BMC Psychiatry. 2015;15(1):315. doi: 10.1186/s12888-015-0701-9
   PubMedGoogle Scholar
• Chandra V, Bharucha NE, Schoenberg BS. Conditions associated with Alzheimer’s disease at death: case-control study. Neurology. 1987;36(2):209–211. doi: 10.1212/WNL.36.2.209
   Web of Science ®Google Scholar
• Volicer L, Smith S, Volicer BJ. Effect of seizures on progression of dementia of the Alzheimer type. Dementia. 1995;6(5):258–263. doi: 10.1159/000106956
   PubMedGoogle Scholar
• Brigo F, Lattanzi S, Zelano J, et al. Randomized controlled trials of antiepileptic drugs for the treatment of post-stroke seizures: a systematic review with network meta-analysis. Seizure. 2018;61:57–62. doi: 10.1016/j.seizure.2018.08.001
   PubMed Web of Science ®Google Scholar
• Belcastro V, Costa C, Galletti F, et al. Levetiracetam monotherapy in Alzheimer patients with late-onset seizures: a prospective observational study. Eur J Neurol. 2007;14(10):1176–1178. doi: 10.1111/j.1468-1331.2007.01907.x
   PubMed Web of Science ®Google Scholar
• Liu J, Wang LN. Treatment of epilepsy for people with Alzheimer’s disease. Cochrane Database Syst Rev. 2021 May 11;5(5):CD011922. doi: 10.1002/14651858.CD011922.pub4
   PubMedGoogle Scholar
• Cumbo E, Ligori LD. Levetiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and Alzheimer’s disease. Epilepsy Behav. 2010;17(4):461–466.
   PubMed Web of Science ®Google Scholar
• SANAD II collaborators, Marson A, Burnside G, et al. The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. Lancet. 2021;397(10282):1363–1374.
   PubMed Web of Science ®Google Scholar
• Larner AJ, Marson AG. Epileptic seizures in Alzheimer’s disease: what are the implications of SANAD II? J Alzheimers Dis. 2022;85(2):527–529. doi: 10.3233/JAD-215154
   PubMed Web of Science ®Google Scholar
• Lattanzi S, Trinka E, Del Giovane C, et al. Antiepileptic drug monotherapy for epilepsy in the elderly: a systematic review and network meta-analysis. Epilepsia. 2019;60(11):2245–2254. doi: 10.1111/epi.16366
   PubMed Web of Science ®Google Scholar
• Rohracher A, Kalss G, Kuchukhidze G, et al. New anti-seizure medication for elderly epilepsy patients - a critical narrative review. Expert Opin Pharmacother. 2021;22(5):621–634. doi: 10.1080/14656566.2020.1843636
   PubMed Web of Science ®Google Scholar
• Piccenna L, O’Dwyer R, Leppik I, et al. Management of epilepsy in older adults: a critical review by the ILAE task force on epilepsy in the elderly. Epilepsia. 2023;64(3):567–585. doi: 10.1111/epi.17426
   PubMed Web of Science ®Google Scholar
• Minkeviciene R, Rheims S, Dobszay MB, et al. Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy. J Neurosci. 2009;29(11):3453–3462. doi: 10.1523/JNEUROSCI.5215-08.2009
   PubMed Web of Science ®Google Scholar
• Liao WP, Shi YW, Long YS, et al. Partial epilepsy with antecedent febrile seizures and seizure aggravation by antiepileptic drugs: associated with loss of function of Na(v) 1.1. Epilepsia. 2010;51(9):1669–1678. doi: 10.1111/j.1528-1167.2010.02645.x
   PubMed Web of Science ®Google Scholar
• Bakker A, Krauss GL, Albert MS, et al. Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment. Neuron. 2012;74(3):467–474. doi: 10.1016/j.neuron.2012.03.023
   PubMed Web of Science ®Google Scholar
• Sanchez PE, Zhu L, Verret L, et al. Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model. Proc Natl Acad Sci U S A. 2012;109(42):E2895–903. doi: 10.1073/pnas.1121081109
   PubMed Web of Science ®Google Scholar
• Bakker A, Albert MS, Krauss G, et al. Response of the medial temporal lobe network in amnestic mild cognitive impairment to therapeutic intervention assessed by fMRI and memory task performance. NeuroImage Clin. 2015;7:688–698. doi: 10.1016/j.nicl.2015.02.009
   PubMed Web of Science ®Google Scholar
• Vossel K, Ranasinghe KG, Beagle AJ, et al. Effect of Levetiracetam on cognition in patients with Alzheimer disease with and without epileptiform activity: a randomized clinical trial. JAMA Neurol. 2021;78(11):1345–1354. doi: 10.1001/jamaneurol.2021.3310
   PubMed Web of Science ®Google Scholar
• Hautecloque-Raysz G, Sellal F, Bousiges O, et al. Epileptic prodromal Alzheimer’s disease treated with antiseizure medications: medium-term outcome of seizures and cognition. J Alzheimers Dis. 2023;94(3):1057–1074. doi: 10.3233/JAD-221197
   PubMed Web of Science ®Google Scholar
• Hesdorffer DC, Benn EK, Cascino GD, et al. Is a first acute symptomatic seizure epilepsy? Mortality and risk for recurrent seizure. Epilepsia. 2009;50(5):1102–1108. doi: 10.1111/j.1528-1167.2008.01945.x
   PubMed Web of Science ®Google Scholar
• Mauritz M, Hirsch LJ, Camfield P, et al. Acute symptomatic seizures: an educational, evidence-based review. Epileptic Disord. 2022;24(1):26–49. doi: 10.1684/epd.2021.1376
   PubMed Web of Science ®Google Scholar
• Mahamud Z, Mononen CP, Brigo F, et al. Risk of epilepsy diagnosis after a first unprovoked seizure in dementia. Seizure. 2020;82:118–124. doi: 10.1016/j.seizure.2020.09.001
   PubMed Web of Science ®Google Scholar
• Zelano J, Brigo F, Garcia-Patek S. Increased risk of epilepsy in patients registered in the Swedish dementia registry. Eur J Neurol. 2020;27(1):129–135. doi: 10.1111/ene.14043
   PubMed Web of Science ®Google Scholar
• Johnson EL, Krauss GL, Kucharska-Newton A, et al. Mortality in patients with late-onset epilepsy: results from the atherosclerosis risk in communities study. Neurology. 2021;97(11):e1132–e1140. doi: 10.1212/WNL.0000000000012483
   PubMed Web of Science ®Google Scholar
• Hesdorffer DC, Tomson T. Sudden unexpected death in epilepsy. Potential role of antiepileptic drugs. CNS Drugs. 2013;27(2):113–119. doi: 10.1007/s40263-012-0006-1
   PubMed Web of Science ®Google Scholar
• Opeskin K, Berkovic SF. Risk factors for sudden unexpected death in epilepsy: a controlled prospective study based on coroners cases. Seizure. 2003;12(7):456–464. doi: 10.1016/S1059-1311(02)00352-7
   PubMed Web of Science ®Google Scholar
• Bergey GK. Initial treatment of epilepsy. Special issues in treating the elderly. Neurology. 2004;63(10 suppl 4):S40–S48. doi: 10.1212/WNL.63.10_suppl_4.S40
   PubMed Web of Science ®Google Scholar
• Zelano J, Holtkamp M, Agarwal N, et al. How to diagnose and treat post-stroke seizures and epilepsy. Epileptic Disord. 2020;22(3):252–263. doi: 10.1684/epd.2020.1159
   PubMed Web of Science ®Google Scholar
• Galovic M, Ferreira-Atuesta C, Abraira L, et al. Seizures and epilepsy after stroke: epidemiology biomarkers and management. Drugs Aging. 2021;38(4):285–299. doi: 10.1007/s40266-021-00837-7
   PubMed Web of Science ®Google Scholar
• Seo JG, Cho YW, Kim KT, et al. Pharmacological treatment of epilepsy in elderly patients. J Clin Neurol. 2020;16(4):556–561. doi: 10.3988/jcn.2020.16.4.556
   PubMed Web of Science ®Google Scholar
• Josephson CB, Wiebe S, Delgado-Garcia G, et al. Association of enzyme-inducing antiseizure drug use with Long-term cardiovascular disease. JAMA Neurol. 2021;78(11):1367–1374. doi: 10.1001/jamaneurol.2021.3424
   PubMed Web of Science ®Google Scholar
• Huang R. Alzheimer’s disease diagnosis based on the EEG analysis. Stud Health Technol Inform. 2023;308:574–582. doi: 10.3233/SHTI230887
   PubMedGoogle Scholar
• Tveit J, Aurlien H, Plis S, et al. Automated interpretation of clinical electroencephalograms using artificial intelligence. JAMA Neurol. 2023;80(8):805–812. doi: 10.1001/jamaneurol.2023.1645
   PubMed Web of Science ®Google Scholar
• AlSharabi K, Salamah YB, Aljalal M, et al. EEG-based clinical decision support system for Alzheimer’s disorders diagnosis using EMD and deep learning techniques. Front Hum Neurosci. 2023;17:1190203. doi: 10.3389/fnhum.2023.1190203
   PubMed Web of Science ®Google Scholar
• Dogan S, Baygin M, Tasci B, et al. Primate brain pattern-based automated Alzheimer’s disease detection model using EEG signals. Cogn Neurodyn. 2023;17(3):647–659. doi: 10.1007/s11571-022-09859-2
   PubMed Web of Science ®Google Scholar
• Chen Y, Wang H, Zhang D, et al. Multi-feature fusion learning for Alzheimer’s disease prediction using EEG signals in resting state. Front Neurosci. 2023;17:1272834. doi: 10.3389/fnins.2023.1272834
   PubMed Web of Science ®Google Scholar
• Illakiya T, Karthik R. Automatic detection of Alzheimer’s disease using deep learning models and neuro-imaging: Current trends and future perspectives. Neuroinformatics. 2023;21(2):339–364. doi: 10.1007/s12021-023-09625-7
   PubMed Web of Science ®Google Scholar
• Lattanzi S, Zaccara G, Giovannelli F, et al. Antiepileptic monotherapy in newly diagnosed focal epilepsy. A network meta-analysis. Acta Neurol Scand. 2019;139(1):33–41. doi: 10.1111/ane.13025
   PubMed Web of Science ®Google Scholar
• Bosco F, Guarnieri L, Rania V, et al. Antiseizure Medications in Alzheimer’s Disease from Preclinical to Clinical Evidence. Int J Mol Sci. 2023;24(16):12639. doi: 10.3390/ijms241612639
   PubMed Web of Science ®Google Scholar