Research Progress and Prospect Analysis of the Application of Flax Lignans

References

• Aarestrup, J., C. Kyro, K. E. B. Knudsen, E. Weiderpass, J. Christensen, M. Kristensen, A. M. L. Würtz , et al. 2013. “Plasma Enterolactone and Incidence of Endometrial Cancer in a Case-Cohort Study of Danish Women.” British Journal of Nutrition 109 (12): 2269–15. https://doi.org/10.1017/s0007114512004424.
   PubMed Web of Science ®Google Scholar
• Aid, T., M. Kaljurand, and M. Vaher. 2015. “Colorimetric Determination of Total Phenolic Contents in Ionic Liquid Extracts by Paper Microzones and Digital Camera.” Analytical Methods 7 (7): 3193–3199. https://doi.org/10.1039/c5ay00194c.
   Web of Science ®Google Scholar
• Ayella, A., S. Lim, Y. Jiang, T. Iwamoto, D. Lin, J. Tomich, and W. Wang. 2010. “Cytostatic Inhibition of Cancer Cell Growth by Lignan Secoisolariciresinol Diglucoside.” Nutrition Research 30 (11): 762–769. https://doi.org/10.1016/j.nutres.2010.10.002.
   PubMed Web of Science ®Google Scholar
• Boengler, K., D. Hilfiker-Kleiner, H. Drexler, G. Heusch, and R. Schulz. 2008. “The Myocardial JAK/STAT Pathway: From Protection to Failure.” Pharmacology & Therapeutics 120 (2): 172–185. https://doi.org/10.1016/j.pharmthera.2008.08.002.
   PubMed Web of Science ®Google Scholar
• Bowers, L. W., C. G. Lineberger, N. A. Ford, E. L. Rossi, A. Punjala, K. K. Camp, B. K. Kimler, C. J. Fabian, and S. D. Hursting. 2019. “The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFB signaling, and inhibits mammary tumor growth.” Breast Cancer Research and Treatment 173 (3): 545–557. https://doi.org/10.1007/s10549-018-5021-6.
   PubMed Web of Science ®Google Scholar
• Brandao, H. N., H. H. S. Medrado, J. P. David, J. M. David, J. F. B. Pastore, and M. Meira. 2017. “Determination of Podophyllotoxin and Related Aryltetralin Lignans by HPLC/DAD/MS from Lamiaceae Species.” Microchemical Journal 130:179–184. https://doi.org/10.1016/j.microc.2016.09.002.
   Web of Science ®Google Scholar
• Chen, J. M., and L. U. Thompson. 2003. “Lignans and Tamoxifen, Alone or in Combination, Reduce Human Breast Cancer Cell Adhesion, Invasion and Migration in vitro.” Breast Cancer Research and Treatment 80 (2): 163–170. https://doi.org/10.1023/a:1024513815374.
   PubMed Web of Science ®Google Scholar
• Chhillar, H., P. Chopra, and M. A. Ashfaq. 2021. “Lignans from Linseed (Linum Usitatissimum L.) and Its Allied Species: Retrospect, Introspect and Prospect.” Critical Reviews in Food Science and Nutrition 61 (16): 2719–2741. https://doi.org/10.1080/10408398.2020.1784840.
   PubMed Web of Science ®Google Scholar
• Cornish, S. M., P. D. Chilibeck, L. Paus-Jennsen, H. J. Biem, T. Khozani, V. Senanayake, H. Vatanparast, J. P. Little, S. J. Whiting, and P. Pahwa. 2009. “A Randomized Controlled Trial of the Effects of Flaxseed Lignan Complex on Metabolic Syndrome Composite Score and Bone Mineral in Older Adults.” Applied Physiology, Nutrition, and Metabolism 34 (2): 89–98. https://doi.org/10.1139/h08-142.
   PubMed Web of Science ®Google Scholar
• Dang, Z. C., and C. Lowik. 2005. “Dose-dependent effects of phytoestrogens on bone.” Trends in Endocrinology and Metabolism 16 (5): 207–213. https://doi.org/10.1016/j.tem.2005.05.001.
   PubMed Web of Science ®Google Scholar
• De Silva, S. F., and J. Alcorn. 2019. “Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets.” Pharmaceuticals 12 (2): 68. https://doi.org/10.3390/ph12020068.
   Web of Science ®Google Scholar
• Dudarev, I. 2022. “A Review of Fibre Flax Harvesting: Conditions, Technologies, Processes and Machines.” Journal of Natural Fibers 19 (12): 4496–4508. https://doi.org/10.1080/15440478.2020.1863296.
   Web of Science ®Google Scholar
• Dupasquier, C. M. C., E. Dibrov, A. L. Kneesh, P. K. M. Cheung, K. G. Y. Lee, H. K. Alexander, B. K. Yeganeh, M. H. Moghadasian, and G. N. Pierce. 2007. “Dietary Flaxseed Inhibits Atherosclerosis in the LDL Receptor-Deficient Mouse in Part Through Antiproliferative and Anti-Inflammatory Actions.” American Journal of Physiology-Heart and Circulatory Physiology 293 (4): H2394–H2402. https://doi.org/10.1152/ajpheart.01104.2006.
   PubMed Web of Science ®Google Scholar
• Ebrahimi, B., Z. Nazmara, N. Hassanzadeh, A. Yarahmadi, N. Ghaffari, F. Hassani, A. Liagh, L. Noori, and G. Hasanzadeh. 2021. “Biomedical Features of Flaxseed Against Different Pathologic Situations: A Narrative Review.” Iranian Journal of Basic Medical Sciences 24 (5): 551–560. https://doi.org/10.22038/ijbms.2021.49821.11378.
   PubMed Web of Science ®Google Scholar
• Eklund, P. C., O. K. Langvik, J. P. Warna, T. O. Salmi, S. M. Willfor, and R. E. Sjoholm. 2005. “Chemical Studies on Antioxidant Mechanisms and Free Radical Scavenging Properties of Lignans.” Organic & Biomolecular Chemistry 3 (18): 3336–3347. https://doi.org/10.1039/b506739a.
   PubMed Web of Science ®Google Scholar
• Flower, G., H. Fritz, L. G. Balneaves, S. Verma, B. Skidmore, R. Fernandes, D. Kennedy, et al. 2014. “Flax and Breast Cancer: A Systematic Review.” Integrative Cancer Therapies 13 (3): 181–192. https://doi.org/10.1177/1534735413502076.
   PubMed Web of Science ®Google Scholar
• Gao, C., Y. Ding, J. Li, Z. Ma, Y. Xia, Z. Xue, Y. Zhang, and Z. Wang. 2014. Agent, Useful for Preserving Food, Comprises Sodium Alginate, Gelatin, Carrageenan, Xanthan Gum, Lysozyme, Chinese Magnoliavine Fruit Lignan Extract, Flax Seed Wood Resin Extract and Water, CN103462174-A, Filed September 27, 2013, and Issued December 25, 2013.
   Google Scholar
• Gaoshun, L. I., Y. E. Zhaoming, and Y. Disheng. 2011. “Biphasic Effect of Lignanoid Decomposition Products: Enterolactone and Enterodiol on Osteoblast-Like MG63 Cells.” Chinese Journal of Clinical Pharmacology and Therapeutics 16 (1): 46–50.
   Google Scholar
• Gao, Q., Y. Wang, M. Kuang, T. Zhuo, and W. Zhang. 2020. “Microwave-Assisted Extraction Process of Lignan from Flaxseed Cake and Its Antioxidant Activity.” Food Research and Development 41 (16): 75–81. https://doi.org/10.12161/j.issn.1005-6521.2020.16.012.
   Google Scholar
• Goyal, A., V. Sharma, N. Upadhyay, S. Gill, and M. Sihag. 2014. “Flax and Flaxseed Oil: An Ancient Medicine & Modern Functional Food.” Journal of Food Science and Technology-Mysore 51 (9): 1633–1653. https://doi.org/10.1007/s13197-013-1247-9.
   Web of Science ®Google Scholar
• Hano, C., C. Corbin, S. Drouet, A. Quero, N. Rombaut, R. Savoire, R. Molinie, B. Thomasset, F. Mesnard, and E. Laine. 2017. “The Lignan (+)-Secoisolariciresinol Extracted from Flax Hulls is an Effective Protectant of Linseed Oil and Its Emulsion Against Oxidative Damage.” European Journal of Lipid Science & Technology 119 (8): 1600219. https://doi.org/10.1002/ejlt.201600219.
   Web of Science ®Google Scholar
• Hong, M., Q. Huang, J. Xu, and Q. Deng. 2018. “Research and Application Status of Antioxidant Activity of Flaxseed Lignan.” China Oils & Fats 43 (11): 122–126.
   Google Scholar
• Hu, T., K. Linghu, S. Huang, M. Battino, M. I. Georgiev, G. Zengin, D. Li, Y. Deng, Y. T. Wang, and H. Cao. 2019. “Flaxseed Extract Induces Apoptosis in Human Breast Cancer MCF-7 Cells.” Food & Chemical Toxicology 127:188–196. https://doi.org/10.1016/j.fct.2019.03.029.
   PubMed Web of Science ®Google Scholar
• Hu, Y., T. J. Tse, Y. Y. Shim, S. K. Purdy, Y. J. Kim, V. Meda, and M. J. T. Reaney. 2022. “A Review of Flaxseed Lignan and the Extraction and Refinement of Secoisolariciresinol Diglucoside.” Critical Reviews in Food Science and Nutrition 1–16. https://doi.org/10.1080/10408398.2022.2148627.
   Web of Science ®Google Scholar
• Hu, C., Y. V. Yuan, and D. D. Kitts. 2007. “Antioxidant activities of the flaxseed lignan secoisolariciresinol diglucoside, its aglycone secoisolariciresinol and the mammalian lignans enterodiol and enterolactone in vitro.” Food and Chemical Toxicology 45 (11): 2219–2227. https://doi.org/10.1016/j.fct.2007.05.017.
   PubMed Web of Science ®Google Scholar
• Imran, M., N. Ahmad, F. M. Anjum, M. K. Khan, Z. Mushtaq, M. Nadeem, and S. Hussain. 2015. “Potential protective properties of flax lignan secoisolariciresinol diglucoside.” Nutrition Journal 14 (1): 71. https://doi.org/10.1186/s12937-015-0059-3.
   PubMedGoogle Scholar
• Kardinaal, A. F. M., M. S. Morton, I. E. M. Bruggemann-Rotgans, and E. C. H. van Beresteijn. 1998. “Phyto-Oestrogen Excretion and Rate of Bone Loss in Postmenopausal Women.” European Journal of Clinical Nutrition 52 (11): 850–855. https://doi.org/10.1038/sj.ejcn.1600659.
   PubMed Web of Science ®Google Scholar
• Kaur, V., M. Singh, D. P. Wankhede, K. Gupta, S. Langyan, J. Aravind, B. Thangavel, et al. 2023. “Diversity of Linum Genetic Resources in Global Genebanks: From Agro-Morphological Characterisation to Novel Genomic Technologies - a Review.” Frontiers in Nutrition 10:1165580. https://doi.org/10.3389/fnut.2023.1165580.
   PubMed Web of Science ®Google Scholar
• Kezimana, P., A. A. Dmitriev, A. V. Kudryavtseva, E. V. Romanova, and N. V. Melnikova. 2018. “Secoisolariciresinol Diglucoside of Flaxseed and Its Metabolites: Biosynthesis and Potential for Nutraceuticals.” Frontiers in Genetics 9:641. https://doi.org/10.3389/fgene.2018.00641.
   PubMed Web of Science ®Google Scholar
• Kitts, D. D., Y. V. Yuan, A. N. Wijewickreme, and L. U. Thompson. 1999. “Antioxidant Activity of the Flaxseed Lignan Secoisolariciresinol Diglycoside and Its Mammalian Lignan Metabolites Enterodiol and Enterolactone.” Molecular and Cellular Biochemistry 202 (1–2): 91–100. https://doi.org/10.1023/a:1007022329660.
   PubMed Web of Science ®Google Scholar
• Liang, G.-H., Y. Xie, Y.-P. Guo, W.-P. Xing, and Y.-Y. Pei. 2022. “Effect of Flax Lignans on Apoptosis of Growth Plate Chondrocytes in Rats.” Zhongguo Gu Shang = China Journal of Orthopaedics and Traumatology 35 (11): 1087–1094. https://doi.org/10.12200/j.issn.1003-0034.2022.11.015.
   PubMedGoogle Scholar
• Li, Y., L. Li, X. Li, B. Luo, Q. Ye, H. Wang, L. Yang, et al. 2022. “A Mechanistic Review of Chinese Medicine Polyphenols on Bone Formation and Resorption.” Frontiers in Pharmacology 13:1017538. https://doi.org/10.3389/fphar.2022.1017538.
   PubMed Web of Science ®Google Scholar
• Liu, Y. Capsule or Tablet Used for Treating Aging in Middle-Aged Female, Comprises Flax Lignan, Resin, Starch, Xylitol, Aspartame and Magnesium Stearate, CN103585272-A, Filed November 14, 2013, and Issued February 19, 2014. 2014.
   Google Scholar
• Liu, H., Y. Guo, Y. Zhao, J. Ren, J. Zhou, and E. Ji. 2020. “Secoisolariciresinol diglucoside attenuates renal inflammatory injury of mice induced by chronic intermittent hypoxia via inhibiting TXNIP and activating NLRP3 inflammasome.” Chinese Journal of Pathophysiology 36 (9): 1631–1638.
   Google Scholar
• Matumoto-Pintro, P. T., H. V. Petit, H. J. Giroux, C. Cortes, N. Gagnon, and M. Britten. 2011. “Effect of Flaxseed Lignans Added to Milk or Fed to Cows on Oxidative Degradation of Dairy Beverages Enriched with Polyunsaturated Fatty Acids.” Journal of Dairy Research 78 (1): 111–117. https://doi.org/10.1017/s0022029910000853.
   PubMed Web of Science ®Google Scholar
• Mazur, W., T. Fotsis, K. Wahala, S. Ojala, A. Salakka, and H. Adlercreutz. 1996. “Isotope dilution gas chromatographic mass spectrometric method for the determination of isoflavonoids, coumestrol, and lignans in food samples.” Analytical Biochemistry 233 (2): 169–180. https://doi.org/10.1006/abio.1996.0025.
   PubMed Web of Science ®Google Scholar
• Michalak, M. 2022. “Plant-Derived Antioxidants: Significance in Skin Health and the Ageing Process.” International Journal of Molecular Sciences 23 (2): 585. https://doi.org/10.3390/ijms23020585.
   PubMed Web of Science ®Google Scholar
• Morton, M., O. Arisaka, A. Miyake, and B. Evans. 1999. “Analysis of Phyto-Oestrogens by Gas Chromatography-Mass Spectrometry.” Environmental Toxicology and Pharmacology 7 (3): 221–225. https://doi.org/10.1016/s1382-6689(99)00018-6.
   PubMed Web of Science ®Google Scholar
• Morton, M. S., A. MatosFerreira, L. AbranchesMonteiro, R. Correia, N. Blacklock, P. S. F. Chan, C. Cheng, S. Lloyd, W. Chiehping, and K. Griffiths. 1997. “Measurement and Metabolism of Isoflavonoids and Lignans in the Human Male.” Cancer Letters 114 (1–2): 145–151. https://doi.org/10.1016/s0304-3835(97)04646-6.
   PubMed Web of Science ®Google Scholar
• Mueed, A., Z. Deng, S. A. Korma, S. Shibli, and M. Jahangir. 2023. “Anticancer Potential of Flaxseed Lignans, Their Metabolites and Synthetic Counterparts in Relation with Molecular Targets: Current Challenges and Future Perspectives.” Food & Function 14 (5): 2286–2303. https://doi.org/10.1039/d2fo02208g.
   PubMed Web of Science ®Google Scholar
• Mueed, A., S. Shibli, M. Jahangir, S. Jabbar, and Z. Deng. 2022. “A Comprehensive Review of Flaxseed (Linum Usitatissimum L.): Health-Affecting Compounds, Mechanism of Toxicity, Detoxification, Anticancer and Potential Risk.” Critical Reviews in Food Science and Nutrition 63 (32): 11081–11104. https://doi.org/10.1080/10408398.2022.2092718.
   PubMed Web of Science ®Google Scholar
• Mullens, D. A., I. Ivanov, M. A. J. Hullar, T. W. Randolph, J. W. Lampe, and R. S. Chapkin. 2022. “Personalized Nutrition Using Microbial Metabolite Phenotype to Stratify Participants and Non-Invasive Host Exfoliomics Reveal the Effects of Flaxseed Lignan Supplementation in a Placebo-Controlled Crossover Trial.” Nutrients 14 (12): 2377. https://doi.org/10.3390/nu14122377.
   PubMed Web of Science ®Google Scholar
• Niedzwiedz-Siegien, I. 1998. “Cyanogenic glucosides in Linum usitatissimum.” Phytochemistry 49 (1): 59–63. https://doi.org/10.1016/s0031-9422(97)00953-9.
   Web of Science ®Google Scholar
• Pan, A., W. Demark-Wahnefried, X. Ye, Z. Yu, H. Li, Q. Qi, J. Sun, et al. 2009. “Effects of a Flaxseed-Derived Lignan Supplement on C-Reactive Protein, IL-6 and Retinol-Binding Protein 4 in Type 2 Diabetic Patients.” The British Journal of Nutrition 101 (8): 1145–1149. https://doi.org/10.1017/s0007114508061527.
   PubMed Web of Science ®Google Scholar
• Parikh, M., T. Netticadan, and G. N. Pierce. 2018. “Flaxseed: Its Bioactive Components and Their Cardiovascular Benefits.” American Journal of Physiology-Heart and Circulatory Physiology 314 (2): H146–H159. https://doi.org/10.1152/ajpheart.00400.2017.
   PubMed Web of Science ®Google Scholar
• Patyra, A., M. Koltun-Jasion, O. Jakubiak, and A. K. Kiss. 2022. “Extraction Techniques and Analytical Methods for Isolation and Characterization of Lignans.” Plants-Basel 11 (17): 2323. https://doi.org/10.3390/plants11172323.
   Web of Science ®Google Scholar
• Pellegrini, N., S. Valtuena, D. Ardigo, F. Brighenti, L. Franzini, D. Del Rio, F. Scazzina, P. M. Piatti, and I. Zavaroni. 2010. “Intake of the Plant Lignans Matairesinol, Secoisolariciresinol, Pinoresinol, and Lariciresinol in Relation to Vascular Inflammation and Endothelial Dysfunction in Middle Age-Elderly Men and Post-Menopausal Women Living in Northern Italy.” Nutrition, Metabolism, and Cardiovascular Diseases 20 (1): 64–71. https://doi.org/10.1016/j.numecd.2009.02.003.
   PubMed Web of Science ®Google Scholar
• Pietrofesa, R. A., S. Chatterjee, K. Park, E. Arguiri, S. M. Albelda, and M. Christofidou-Solomidou. 2018. “Synthetic Lignan Secoisolariciresinol Diglucoside (Lgm2605) Reduces Asbestos-Induced Cytotoxicity in an Nrf2-Dependent and -Independent Manner.” Antioxidants 7 (3): 38. https://doi.org/10.3390/antiox7030038.
   Web of Science ®Google Scholar
• Pilar, B., A. Gullich, P. Oliveira, D. Stroher, J. Piccoli, and V. Manfredini. 2017. “Protective Role of Flaxseed Oil and Flaxseed Lignan Secoisolariciresinol Diglucoside Against Oxidative Stress in Rats with Metabolic Syndrome.” Journal of Food Science 82 (12): 3029–3036. https://doi.org/10.1111/1750-3841.13964.
   PubMed Web of Science ®Google Scholar
• Prasad, K. 1997. “Hydroxyl Radical-Scavenging Property of Secoisolariciresinol Diglucoside (SDG) Isolated from Flax-Seed.” Molecular and Cellular Biochemistry 168 (1–2): 117–123. https://doi.org/10.1023/a:1006847310741.
   PubMed Web of Science ®Google Scholar
• Prasad, K. 2000. “Oxidative stress as a mechanism of diabetes in diabetic BB prone rats: Effect of secoisolariciresinol diglucoside (SDG).” Molecular and Cellular Biochemistry 209 (1–2): 89–96. https://doi.org/10.1023/a:1007079802459.
   PubMed Web of Science ®Google Scholar
• Prasad, K. 2019. “Importance of Flaxseed and Its Components in the Management of Hypertension.” International Journal of Angiology 28 (3): 153–160. https://doi.org/10.1055/s-0039-1678691.
   PubMed Web of Science ®Google Scholar
• Prasad, K., and A. Jadhav. 2016. “Prevention and Treatment of Atherosclerosis with Flaxseed-Derived Compound Secoisolariciresinol Diglucoside.” Current Pharmaceutical Design 22 (2): 214–220. https://doi.org/10.2174/1381612822666151112151130.
   PubMed Web of Science ®Google Scholar
• Razgonova, M., A. Zakharenko, K. Pikula, E. Kim, V. Chernyshev, S. Ercisli, G. Cravotto, and K. Golokhvast. 2020. “Rapid Mass Spectrometric Study of a Supercritical Co2-Extract from Woody Liana Schisandra Chinensis by Hplc-Spd-Esi-Ms/ms.” Molecules 25 (11): 2689. https://doi.org/10.3390/molecules25112689.
   PubMed Web of Science ®Google Scholar
• Razna, K., L. U. Harencar, and M. Kucka. 2022. “The Involvement of microRNAs in Plant Lignan Biosynthesis-Current View.” Cells 11 (14): 2151. https://doi.org/10.3390/cells11142151.
   PubMed Web of Science ®Google Scholar
• Renault, B., and P. Catroux. Cosmetic Use of at Least One Lignan or Plant Extract Containing It in Composition for Topical Application to the Skin to Prevent or Treat Dryness of the Skin, Rough Skin And/Or Dull Complexion, And/Or for Moisturizing or Softening Skin, WO2004012697-A1, Filed July 18, 2003, and Issued February 12, 2004. 2004.
   Google Scholar
• Ren, G.-Y., C.-Y. Chen, W.-G. Chen, Y. Huang, L.-Q. Qin, and L.-H. Chen. 2016. “The Treatment Effects of Flaxseed-Derived Secoisolariciresinol Diglycoside and Its Metabolite Enterolactone on Benign Prostatic Hyperplasia Involve the G Protein-Coupled Estrogen Receptor 1.” Applied Physiology, Nutrition, and Metabolism 41 (12): 1303–1310. https://doi.org/10.1139/apnm-2016-0332.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Garcia, C., C. Sanchez-Quesada, E. Toledo, M. Delgado-Rodriguez, and J. J. Gaforio. 2019. “Naturally Lignan-Rich Foods: A Dietary Tool for Health Promotion?” Molecules 24 (5): 917. https://doi.org/10.3390/molecules24050917.
   PubMed Web of Science ®Google Scholar
• Saarinen, N. M., J. Tuominen, L. Pylkkanen, and R. Santti. 2010. “Assessment of Information to Substantiate a Health Claim on the Prevention of Prostate Cancer by Lignans.” Nutrients 2 (2): 99–115. https://doi.org/10.3390/nu2020099.
   PubMed Web of Science ®Google Scholar
• Saggar, J. K., J. Chen, P. Corey, and L. U. Thompson. 2010. “Dietary Flaxseed Lignan or Oil Combined with Tamoxifen Treatment Affects MCF-7 Tumor Growth Through Estrogen Receptor- and Growth Factor-Signaling Pathways.” Molecular Nutrition & Food Research 54 (3): 415–425. https://doi.org/10.1002/mnfr.200900068.
   PubMed Web of Science ®Google Scholar
• Schmidt, T. J., S. Hemmati, E. Fuss, and A. W. Alfermann. 2006. “A Combined HPLC-UV and HPLC-MS Method for the Identification of Lignans and Its Application to the Lignans of Linum Usitatissimum L. and L-Bienne Mill.” Phytochemical Analysis 17 (5): 299–311. https://doi.org/10.1002/pca.918.
   PubMed Web of Science ®Google Scholar
• Sharma, M., K. Dadhwal, Y. Gat, V. Kumar, A. Panghal, R. Prasad, S. Kaur, and P. Gat. 2019. “A review on newer techniques in extraction of oleaginous flaxseed constituents.” OCL-Oilseeds and Fats Crops and Lipids 26:14. https://doi.org/10.1051/ocl/2019006.
   Web of Science ®Google Scholar
• Shim, Y. Y., C. M. Olivia, J. Liu, R. Boonen, J. Shen, and M. J. T. Reaney. 2016. “Secoisolariciresinol Diglucoside and Cyanogenic Glycosides in Gluten-Free Bread Fortified with Flaxseed Meal.” Journal of Agricultural and Food Chemistry 64 (50): 9551–9558. https://doi.org/10.1021/acs.jafc.6b03962.
   PubMed Web of Science ®Google Scholar
• Shi, X., and G. Sun. 2020. “Recent Progress in the Regulation of Glycolipid Metabolism by Flaxseeds.” Shipin Kexue/Food Science 41 (13): 242–248. https://doi.org/10.7506/spkx1002-6630-20190423-309.
   Google Scholar
• Siegien, I., M. Filoc, A. M. Staszak, and I. Ciereszko. 2021. “Cyanogenic glycosides can function as nitrogen reservoir for flax plants cultured under N-deficient conditions.” Soil and Environment 67 (4): 245–253. https://doi.org/10.17221/573/2020-pse.
   Web of Science ®Google Scholar
• Snyman, L. 2014. “Menopause-related osteoporosis.” South African Family Practice 56 (3): 174–177. https://doi.org/10.1080/20786204.2014.932549.
   Google Scholar
• Soleymani, S., S. Habtemariam, R. Rahimi, and S. M. Nabavi. 2020. “The What and Who of Dietary Lignans in Human Health: Special Focus on Prooxidant and Antioxidant Effects.” Trends in Food Science & Technology 106:382–390. https://doi.org/10.1016/j.tifs.2020.10.015.
   Web of Science ®Google Scholar
• Tang, Z.-X., L.-E. Shi, X.-M. Wang, G.-W. Dai, L.-A. Cheng, Z.-X. Wan, H. He, Q. Wu, Y.-B. Wang, X.-Y. Jin, et al. 2020. “Whole Flaxseed-Based Products and Their Health Benefits.” Food Science and Technology Research 26 (5): 561–578. https://doi.org/10.3136/fstr.26.561.
   Web of Science ®Google Scholar
• Tannous, S., T. Haykal, J. Dhaini, M. H. Hodroj, and S. Rizk. 2020. “The Anti-Cancer Effect of Flaxseed Lignan Derivatives on Different Acute Myeloid Leukemia Cancer Cells.” Biomedicine & Pharmacotherapy 132:110884. https://doi.org/10.1016/j.biopha.2020.110884.
   PubMed Web of Science ®Google Scholar
• Terao, J. 2015. “A Perspective of the Research on Food Factors in Human Health: A Return to the Mechanistic Approach.” Journal of Nutritional Science and Vitaminology 61 (Supplement): S98–S99. https://doi.org/10.3177/jnsv.61.S98.
   PubMedGoogle Scholar
• Thompson, L. U., J. M. Chen, T. Li, K. Strasser-Weippl, and P. E. Goss. 2005. “Dietary flaxseed alters tumor biological markers in postmenopausal breast cancer.” Clinical Cancer Research 11 (10): 3828–3835. https://doi.org/10.1158/1078-0432.Ccr-04-2326.
   PubMed Web of Science ®Google Scholar
• Tian, G., C. Ma, and J. Xu. 2017. “Advance in Improvement of Flaxseed Lignan on Atherosclerosis.” China Oils & Fats 42 (1): 35–39.
   Google Scholar
• Tripodo, G., E. Ibanez, A. Cifuentes, B. Gilbert-Lopez, and C. Fanali. 2018. “Optimization of pressurized liquid extraction by response surface methodology of Goji berry (Lycium barbarum L.) phenolic bioactive compounds.” Electrophoresis 39 (13): 1673–1682. https://doi.org/10.1002/elps.201700448.
   PubMed Web of Science ®Google Scholar
• Velalopoulou, A., S. Tyagi, R. A. Pietrofesa, E. Arguiri, and M. Christofidou-Solomidou. 2016. “The Flaxseed-Derived Lignan Phenolic Secoisolariciresinol Diglucoside (Sdg) Protects Non-Malignant Lung Cells from Radiation Damage.” International Journal of Molecular Sciences 17 (1): 7. https://doi.org/10.3390/ijms17010007.
   Web of Science ®Google Scholar
• Vil’chinskaya, A. S. 1955. “Effect of Linamarin on the Secretory and Motor Function of the Intestines of Sheep.” Trudy Moskovskoi veterinarnoi Academii 9:152–166.
   Google Scholar
• Wang, H., X. Guo, Y. Wu, Y. Wang, R. H. Liu, L. Chen, Y. Liang, and C. Qiu. 2020. “Dynamic Changes of Phytochemical Profiles Identified Key Points of Flaxseed Capsule Maturation for Lignan Accumulation.” Industrial Crops and Products 147:112219. https://doi.org/10.1016/j.indcrop.2020.112219.
   Web of Science ®Google Scholar
• Wang, Y., Q. J. Yan, C. M. Fan, Y. Z. Mo, Y. M. Wang, X. Y. Li, Q. J. Liao , et al. 2023. “Overview and Countermeasures of Cancer Burden in China.” Science China-Life Sciences 66 (11): 2515–2526. https://doi.org/10.1007/s11427-022-2240-6.
   PubMed Web of Science ®Google Scholar
• Wang, R., K. Yang, C. Chen, X. Zhao, Q. Yuan, and B. Qin. 2019. “Protection Effect of Flax Lignan on AAPH-Induced Oxidative Stress in Erythrocytes and Liver Tissue.” China Oils & Fats 44 (7): 98–102.
   Google Scholar
• Ward, W. E., Y. V. Yuan, A. M. Cheung, and L. U. Thompson. 2001. “Exposure to Purified Lignan from Flaxseed (Linum Usitatissimum) Alters Bone Development in Female Rats.” British Journal of Nutrition 86 (4): 499–505. https://doi.org/10.1079/bjn2001429.
   PubMed Web of Science ®Google Scholar
• Willfor, S. M., A. I. Smeds, and B. R. Holmbom. 2006. “Chromatographic Analysis of Lignans.” Journal of Chromatography A 1112 (1–2): 64–77. https://doi.org/10.1016/j.chroma.2005.11.054.
   PubMed Web of Science ®Google Scholar
• Wu, Y., H. Wang, F. Gao, Y. Wang, X. Guo, and C. Qiu. 2022. “Effect of Ultrasonic Pretreatment for Lignan Accumulation in Flax Sprouts (Linum Usitatissimum L.).” Food Chemistry 370:131067. https://doi.org/10.1016/j.foodchem.2021.131067.
   PubMed Web of Science ®Google Scholar
• Wu, Y., H. Wang, Y. Wang, C. S. Brennan, M. A. Brennan, C. Qiu, and X. Guo. 2021. “Comparison of Lignans and Phenolic Acids in Different Varieties of Germinated Flaxseed (Linum Usitatissimum L.).” International Journal of Food Science & Technology 56 (1): 196–204. https://doi.org/10.1111/ijfs.14619.
   Web of Science ®Google Scholar
• Yang, J. J., L. Y. Cho, K.-P. Ko, A. Shin, S. H. Ma, B. Y. Choi, D. S. Han, et al. 2012. “Genetic Susceptibility on Caga-Interacting Molecules and Gene-Environment Interaction with Phytoestrogens: A Putative Risk Factor for Gastric Cancer.” Plos One 7 (2): e31020. https://doi.org/10.1371/journal.pone.0031020.
   PubMed Web of Science ®Google Scholar
• Yaribeygi, H., T. Sathyapalan, S. L. Atkin, and A. Sahebkar. 2020. “Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus.” Oxidative Medicine and Cellular Longevity 2020:8609213. https://doi.org/10.1155/2020/8609213.
   PubMed Web of Science ®Google Scholar
• Ye, X.-P., M.-F. Xu, Z.-X. Tang, H.-J. Chen, D.-T. Wu, Z.-Y. Wang, Y.-X. Songzhen, J. Hao, L.-M. Wu, and L.-E. Shi. 2022. “Flaxseed Protein: Extraction, Functionalities and Applications.” Food Science & Technology 42:e22021. https://doi.org/10.1590/fst.22021.
   Google Scholar
• Yi, L., B. Siqin, X. Feng, X. Jia, F. Gao, Y. Zhou, and H. Zhang. 2020. “Genome-Wide Association Analysis of Lignan Content in Flax.” Molecular Plant Breeding 18 (3): 765–771.
   Google Scholar
• Yu, X., S. Huang, C. Nie, Q. Xiang, Y. Zhai, R. Shen, and Q. Deng. 2019. “Research Progress on Antioxidant Potential and Migration Characteristics into Oil Phase for Flaxseed Phenolic Compounds.” Chinese Journal of Oil Crop Sciences 41 (4): 643–649.
   Google Scholar
• Zamora-Ros, R., N. G. Forouhi, S. J. Sharp, C. A. González, B. Buijsse, M. Guevara, and Y. T. van der Schouw. 2013. “The Association Between Dietary Flavonoid and Lignan Intakes and Incident Type 2 Diabetes in European Populations the Epic-Interact Study.” Diabetes Care 36 (12): 3961–3970. https://doi.org/10.2337/dc13-0877.
   PubMed Web of Science ®Google Scholar
• Zhang, X., S. Heinonen, and E. Levanen. 2014. “Applications of Supercritical Carbon Dioxide in Materials Processing and Synthesis.” RSC advances 4 (105): 61137–61152. https://doi.org/10.1039/c4ra10662h.
   Web of Science ®Google Scholar
• Zhao, B., Y. Gao, B. Yan, Z. Cui, H. Wang, and Z. Cao. 2020. “Varied Previous Crops on Improving Oilseed Flax Productivity in Semiarid Loess Plateau in China.” Oil Crop Science 4 (5): 187–193. https://doi.org/10.1016/j.ocsci.2020.12.002.
   Google Scholar
• Zhou, Y., H. Pan, Z. Fan, and Y. Wu. 2020. “Antioxidant Activity and Postprandial Glycemic Response Mitigating Effect of Homogenized Seed/Nut Milk.” Shipin Kexue / Food Science 41 (9): 113–118. https://doi.org/10.7506/spkx1002-6630-20190508-062.
   Google Scholar
• Zuk, M., K. Pelc, J. Szperlik, A. Sawula, and J. Szopa. 2020. “Metabolism of the Cyanogenic Glucosides in Developing Flax: Metabolic Analysis, and Expression Pattern of Genes.” Metabolites 10 (7). https://doi.org/10.3390/metabo10070288.
   PubMed Web of Science ®Google Scholar