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3rd ICSGAD: Research Paper

Insulin and Insulin-like growth factor-1 can activate the phosphoinositide-3-kinase /Akt/FoxO1 pathway in T cells in vitro

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Article: e1356518 | Received 25 Apr 2017, Accepted 11 Jul 2017, Published online: 04 Oct 2017

References

  • Taylor M, Gonzalez M, Porter R. Pathways to inflammation: Acne pathophysiology. Eur J Dermatol. 2011;21:323-33. doi:10.1684/ejd.2011.1357. PMID:21609898
  • Do TT, Zarkhin S, Orringer JS, Nemeth S, Hamilton T, Sachs D, Voorhees JJ, Kang S. Computer-assisted alignment and tracking of acne lesions indicate that most inflammatory lesions arise from comedones and de novo. J Am Acad Dermatol. 2008;58:603-8. doi:10.1016/j.jaad.2007.12.024. PMID:18249468
  • Tochio T, Tanaka H, Nakata S, Ikeno H. Accumulation of lipid peroxide in the content of comedones may be involved in the progression of comedogenesis and inflammatory changes in comedones. J Cosmet Dermatol. 2009;8:152-8. doi:10.1111/j.1473-2165.2009.00437.x. PMID:19527342
  • Tanghetti EA. The role of inflammation in the pathology of acne. J Clin Aesthet Dermatol. 2013;6:27. PMID:24062871
  • Shehadeh N, Kligman AM. The bacteriology of acne. Arch Dermatol. 1963;88:829-31. doi:10.1001/archderm.1963.01590240153025. PMID:14071456
  • Marples RR, Mcginley KJ, Mills OH. Microbiology of comedones in acne vulgaris. J Invest Dermatol. 1973;60:80-3. doi:10.1111/1523-1747.ep12724149. PMID:4266324
  • Puhvel S, AMIRIAN DA. Bacterial flora of comedones. Br J Dermatol. 1979;101:543-8. doi:10.1111/j.1365-2133.1979.tb11883.x. PMID:160242
  • Shaheen B, Gonzalez M. A microbial aetiology of acne: what is the evidence? Br J Dermatol. 2011;165:474-85. doi:10.1111/j.1365-2133.2011.10375.x. PMID:21495996
  • Boehm KD, Yun JK, StrohI KP, Elmets CA. Messenger RNAs for the multifunctional cytokines interleukin‐1α, interleukin‐1β and tumor necrosis factor‐α are present in adnexal tissues and in dermis of normal human skin. Exp Dermatol. 1995;4:335-41. doi:10.1111/j.1600-0625.1995.tb00057.x. PMID:8608340
  • Anttila H, Reitamo S, SAURAT JH. Interleukin 1 immunoreactivity in sebaceous glands. Br J Dermatol. 1992;127:585-8. doi:10.1111/j.1365-2133.1992.tb14870.x. PMID:1476918
  • Das S, Reynolds RV. Recent advances in acne pathogenesis: Implications for therapy. Am J Clin Dermatol. 2014;15:479-88. doi:10.1007/s40257-014-0099-z. PMID:25388823
  • Mirdamadi Y, Thielitz A, Wiede A, Goihl A, Papakonstantinou E, Hartig R, Zouboulis CC, Reinhold D, Simeoni L, Bommhardt U. Insulin and insulin-like growth factor-1 can modulate the phosphoinositide-3-kinase/Akt/FoxO1 pathway in SZ95 sebocytes in vitro. Mol Cell Endocrinol. 2015;415:32-44. doi:10.1016/j.mce.2015.08.001. PMID:26257240
  • Kurokawa I, Danby FW, Ju Q, Wang X, Xiang LF, Xia L, Chen W, Nagy I, Picardo M, Suh DH. New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol. 2009;18:821-32. doi:10.1111/j.1600-0625.2009.00890.x. PMID:19555434
  • Dreno B, Gollnick H, Kang S, Thiboutot D, Bettoli V, Torres V, Leyden J. Understanding innate immunity and inflammation in acne: Implications for management. J Eur Acad Dermatol Venereol. 2015;29:3-11. doi:10.1111/jdv.13190. PMID:26059728
  • Gollnick H, Dreno B. Pathophysiology and management of acne. Journal of the European J Eur Acad Dermatol Venereol. 2015;29:1-2. doi:10.1111/jdv.13190. PMID:26059728
  • Clark RA. Skin-resident T cells: The ups and downs of on site immunity. J Invest Dermatol. 2010;130:362-70. doi:10.1038/jid.2009.247. PMID:19675575
  • Lorenz B, von Stebut E. Isolation of T Cells from the Skin. Methods Mol Biol. 2014:3-13. doi:10.1007/978-1-4939-1212-4_1. PMID:25150991
  • Norris J, Cunliffe W. A histological and immunocytochemical study of early acne lesions. Br J Dermatol. 1988;118:651-9. doi:10.1111/j.1365-2133.1988.tb02566.x. PMID:2969256
  • Layton A, Morris C, Cunliffe W, Ingham E. Immunohistochemical investigation of evolving inflammation in lesions of acne vulgaris. Exp Dermatol. 1998;7:191-7. doi:10.1111/j.1600-0625.1998.tb00323.x. PMID:9758417
  • Jeremy AH, Holland DB, Roberts SG, Thomson KF, Cunliffe WJ. Inflammatory events are involved in acne lesion initiation. J Invest Dermatol. 2003;121:20-7. doi:10.1046/j.1523-1747.2003.12321.x. PMID:12839559
  • Cordain L, Lindeberg S, Hurtado M, Hill K, Eaton SB, Brand-Miller J. Acne vulgaris: A disease of Western civilization. Arch Dermatol. 2002;138:1584-90. doi:10.1001/archderm.138.12.1584. PMID:12472346
  • Cordain L, Eades MR, Eades MD. Hyperinsulinemic diseases of civilization: more than just Syndrome X. Comp Biochem Physiol A Mol Integr Physiol. 2003;136:95-112. doi:10.1016/S1095-6433(03)00011-4. PMID:14527633
  • Cappel M, Mauger D, Thiboutot D. Correlation between serum levels of insulin-like growth factor 1, dehydroepiandrosterone sulfate, and dihydrotestosterone and acne lesion counts in adult women. Arch Dermatol. 2005;141:333-8. doi:10.1001/archderm.141.3.333. PMID:15781674
  • Melnik BC, Schmitz G. Role of insulin, insulin‐like growth factor‐1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris. Exp Dermatol. 2009;18:833-41. doi:10.1111/j.1600-0625.2009.00924.x. PMID:19709092
  • Vora S, Ovhal A, Jerajani H, Nair N, Chakrabortty A. Correlation of facial sebum to serum insulin-like growth factor-1 in patients with acne. Br J Dermatol. 2008;159:990-1. doi:10.1111/j.1365-2133.2008.08764.x. PMID:18652583
  • LaRosa CL, Quach KA, Koons K, Kunselman AR, Zhu J, Thiboutot DM, Zaenglein AL. Consumption of dairy in teenagers with and without acne. J Am Acad Dermatol. 2016;75:318-22. doi:10.1016/j.jaad.2016.04.030. PMID:27241803
  • Melnik BC. FoxO1–the key for the pathogenesis and therapy of acne? J Dtsch Dermatol Ges. 2010;8:105-14. doi:10.1111/j.1610-0387.2010.07344.x. PMID:20151947
  • Coffer PJ, Burgering BM. Forkhead-box transcription factors and their role in the immune system. Nat Rev Immunol. 2004;4:889-99. doi:10.1038/nri1488. PMID:15516968
  • Birkenkamp KU, Coffer PJ. FOXO transcription factors as regulators of immune homeostasis: molecules to die for? J Immunol. 2003;171:1623-9. doi:10.4049/jimmunol.171.4.1623. PMID:12902457
  • Helderman JH, Strom TB. Specific insulin binding site on T and B lymphocytes as a marker of cell activation. Nature. 1978;274:62. doi:10.1038/274062a0. PMID:26882
  • Kooijman R, Scholtens L, Rijkers G, Zegers B. Type I insulin-like growth factor receptor expression in different developmental stages of human thymocytes. J Endocrinol. 1995;147:203-9. doi:10.1677/joe.0.1470203. PMID:7490549
  • Kooijman R, Scholtens LE, Rijkers GT, Zegers BJ. Differential expression of type I insulin‐like growth factor receptors in different stages of human T cells. Eur J Immunol. 1995;25:931-5. doi:10.1002/eji.1830250411. PMID:7737296
  • Braciale VL, Gavin J, Braciale TJ. Inducible expression of insulin receptors on T lymphocyte clones. J Exp Med. 1982;156:664-9. doi:10.1084/jem.156.2.664. PMID:7047673
  • DeBenedette M, Snow E. Insulin modulates the interleukin 2 responsiveness of T lymphocytes. Reg Immunol. 1990;3:82-7. PMID:2150918
  • Brocardo MG, Schillaci R, Galeano A, Radrizzani M, White V, Guerrico AG, Santa-Coloma TA, Roldán A. Early effects of insulin-like growth factor-1 in activated human T lymphocytes. J Leukoc Biol. 2001;70:297-305. PMID:11493623
  • Kecha O, Brilot F, Martens H, Franchimont N, Renard C, Greimers R, Defresne M-P, Winkler R, Geenen V. Involvement of Insulin-Like Growth Factors in Early T Cell Development: A Study Using Fetal Thymic Organ Cultures 1. Endocrinology. 2000;141:1209-17. doi:10.1210/endo.141.3.7360. PMID:10698198
  • Fabre S, Lang V, Harriague J, Jobart A, Unterman TG, Trautmann A, Bismuth G. Stable activation of phosphatidylinositol 3-kinase in the T cell immunological synapse stimulates Akt signaling to FoxO1 nuclear exclusion and cell growth control. J Immunol. 2005;174:4161-71. doi:10.4049/jimmunol.174.7.4161. PMID:15778376
  • Charvet C, Canonigo AJ, Bécart S, Maurer U, Miletic AV, Swat W, Deckert M, Altman A. Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression. J Immunol. 2006;177:5024-31. doi:10.4049/jimmunol.177.8.5024. PMID:17015685
  • Walsh PT, Smith LM, O'Connor R. Insulin‐like growth factor‐1 activates Akt and Jun N‐terminal kinases (JNKs) in promoting the survival of T lymphocytes. Immunology. 2002;107:461-71. doi:10.1046/j.1365-2567.2002.01525.x. PMID:12460191
  • Han JM, Patterson SJ, Speck M, Ehses JA, Levings MK. Insulin Inhibits IL-10–Mediated Regulatory T Cell Function: Implications for Obesity. J Immunol. 2014;192:623-9.doi:10.4049/jimmunol.1302181. PMID:24323581
  • Inoki K, Ouyang H, Li Y, Guan K-L. Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev. 2005;69:79-100. doi:10.1128/MMBR.69.1.79-100.2005. PMID:15755954
  • Wang X, Proud CG. Nutrient control of TORC1, a cell-cycle regulator. Trends Cell Biol. 2009;19:260-7. doi:10.1016/j.tcb.2009.03.005. PMID:19419870
  • Suzuki T, Inoki K. Spatial regulation of the mTORC1 system in amino acids sensing pathway. Acta Biochim Biophys Sin (Shanghai). 2011;43:671-9. doi:10.1093/abbs/gmr066. PMID:21785113
  • Wang X, Proud CG. mTORC1 signaling: what we still don't know. J Mol Cell Biol. 2010;3(4):206–220. doi:10.1093/jmcb/mjq038. PMID:21138990
  • Monfrecola G, Lembo S, Caiazzo G, De Vita V, Di Caprio R, Balato A, Fabbrocini G. Mechanistic target of rapamycin (mTOR) expression is increased in acne patients' skin. Exp Dermatol. 2016;25:153-5. doi:10.1111/exd.12885. PMID:26477999
  • Pierdominici M, Vacirca D, Delunardo F, Ortona E. mTOR signaling and metabolic regulation of T cells: New potential therapeutic targets in autoimmune diseases. Curr Pharm Des. 2011;17:3888-97. doi:10.2174/138161211798357809. PMID:21933144
  • Powell JD, Pollizzi KN, Heikamp EB, Horton MR. Regulation of immune responses by mTOR. Annu Rev Immunol. 2012;30:39-68. doi:10.1146/annurev-immunol-020711-075024. PMID:22136167
  • Yang K, Chi H. mTOR and metabolic pathways in T cell quiescence and functional activation. Semin Immunol. 2012:421-8.doi:10.1016/j.smim.2012.12.004. PMID:23375549
  • Almeida L, Lochner M, Berod L, Sparwasser T. Metabolic pathways in T cell activation and lineage differentiation. Semin Immunol. 2016:514-24. doi:10.1016/j.smim.2016.10.009. PMID:27825556
  • Reynolds LF, Smyth LA, Norton T, Freshney N, Downward J, Kioussis D, Tybulewicz VL. Vav1 transduces T cell receptor signals to the activation of phospholipase C-γ1 via phosphoinositide 3-kinase-dependent and-independent pathways. J Exp Med. 2002;195:1103-14. doi:10.1084/jem.20011663. PMID:11994416
  • Na S-Y, Patra A, Scheuring Y, Marx A, Tolaini M, Kioussis D, Hemmings B, Hünig T, Bommhardt U. Constitutively active protein kinase B enhances Lck and Erk activities and influences thymocyte selection and activation. J Immunol. 2003;171:1285-96. doi:10.4049/jimmunol.171.3.1285. PMID:12874217
  • Janeway Jr CA, Medzhitov R. Innate immune recognition. Annu Rev Immunol. 2002;20:197-216. doi:10.1146/annurev.immunol.20.083001.084359. PMID:11861602
  • MacLeod H, Wetzler LM. T cell activation by TLRs: a role for TLRs in the adaptive immune response. Sci STKE. 2007;2007:pe48-pe.
  • Komai-Koma M, Jones L, Ogg GS, Xu D, Liew FY. TLR2 is expressed on activated T cells as a costimulatory receptor. Proc Natl Acad Sci U S A. 2004;101:3029-34. doi:10.1073/pnas.0400171101. PMID:14981245
  • Mercier BC, Cottalorda A, Coupet C-A, Marvel J, Bonnefoy-Bérard N. TLR2 engagement on CD8 T cells enables generation of functional memory cells in response to a suboptimal TCR signal. J Immunol. 2009;182:1860-7. doi:10.4049/jimmunol.0801167. PMID:19201838
  • Reynolds JM, Martinez GJ, Chung Y, Dong C. Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation. Proc Natl Acad Sci U S A. 2012;109:13064-9. doi:10.1073/pnas.1120585109. PMID:22826216
  • Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG. Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway. Nat Immunol. 2000;1:533-40. doi:10.1038/82797. PMID:11101877
  • Laird MH, Rhee SH, Perkins DJ, Medvedev AE, Piao W, Fenton MJ, Vogel SN. TLR4/MyD88/PI3K interactions regulate TLR4 signaling. J Leukoc Biol. 2009;85:966-77. doi:10.1189/jlb.1208763. PMID:19289601
  • Li X, Jiang S, Tapping RI. Toll-like receptor signaling in cell proliferation and survival. Cytokine. 2010;49:1-9. doi:10.1016/j.cyto.2009.08.010. PMID:19775907
  • Ojaniemi M, Glumoff V, Harju K, Liljeroos M, Vuori K, Hallman M. Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages. Eur J Immunol. 2003;33:597-605. doi:10.1002/eji.200323376. PMID:12616480
  • Hazeki K, Nigorikawa K, Hazeki O. Role of phosphoinositide 3-kinase in innate immunity. Biol Pharm Bull. 2007;30:1617-23. doi:10.1248/bpb.30.1617. PMID:17827709
  • Martinasso G, Oraldi M, Trombetta A, Maggiora M, Bertetto O, Canuto R, Muzio G. Involvement of PPARs in cell proliferation and apoptosis in human colon cancer specimens and in normal and cancer cell lines. PPAR Res. 2007;2007:93416. doi:10.1155/2007/93416. PMID:17389773
  • Fan W, Imamura T, Sonoda N, Sears DD, Patsouris D, Kim JJ, Olefsky JM. FOXO1 transrepresses peroxisome proliferator-activated receptor γ transactivation, coordinating an insulin-induced feed-forward response in adipocytes. J Biol Chem. 2009;284:12188-97. doi:10.1074/jbc.M808915200. PMID:19246449
  • Fan W, Yanase T, Morinaga H, Okabe T, Nomura M, Daitoku H, Fukamizu A, Kato S, Takayanagi R, Nawata H. Insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor. J Biol Chem. 2007;282:7329-38. doi:10.1074/jbc.M610447200. PMID:17202144
  • Chen W, Yang CC, Sheu HM, Seltmann H, Zouboulis CC. Expression of peroxisome proliferator-activated receptor and CCAAT/enhancer binding protein transcription factors in cultured human sebocytes. J Invest Dermatol. 2003;121:441-7. doi:10.1046/j.1523-1747.2003.12411.x. PMID:12925198