Publication Cover
Mycology
An International Journal on Fungal Biology
Volume 14, 2023 - Issue 4
571
Views
0
CrossRef citations to date
0
Altmetric
Research Article

The disulphide cleavage derivative (C42-4) of 11′-deoxyverticillin A (C42) fails to induce apoptosis and genomic instability in HeLa cells

, , &
Pages 358-370 | Received 08 May 2023, Accepted 09 Aug 2023, Published online: 13 Sep 2023

References

  • Amaravadi R, Kimmelman AC, White E. 2016. Recent insights into the function of autophagy in cancer. Genes Dev. 30(17):1913–1930. doi: 10.1101/gad.287524.116.
  • Atkin-Smith GK, Poon IKH. 2017. Disassembly of the dying: mechanisms and functions. Trends Cell Biol. 27(2):151–162. doi: 10.1016/j.tcb.2016.08.011.
  • Battistelli M, Falcieri E. 2020. Apoptotic bodies: particular extracellular vesicles involved in intercellular communication. Biology (Basel). 9(1):21. doi: 10.3390/biology9010021.
  • Bjorkoy G, Lamark T, Pankiv S, Overvatn A, Brech A, Johansen T. 2009. Monitoring autophagic degradation of p62/SQSTM1. Methods Enzymol. 452:181–197.
  • Booth LA, Tavallai S, Hamed HA, Cruickshanks N, Dent P. 2014. The role of cell signalling in the crosstalk between autophagy and apoptosis. Cell Signal. 26(3):549–555. doi: 10.1016/j.cellsig.2013.11.028.
  • Chen H, Wang S, Sun Y, Wang J. 2020. Mitomycin C induces fibroblast apoptosis and reduces intra-articular scar adhesion by regulating miR-21 and its target programmed cell death 4. Fitoterapia. 142:104392. doi:10.1016/j.fitote.2019.104392.
  • Chen Y, Guo H, Du Z, Liu XZ, Che Y, Ye X. 2009. Ecology-based screen identifies new metabolites from a Cordyceps-colonizing fungus as cancer cell proliferation inhibitors and apoptosis inducers. Cell Prolif. 42(6):838–847. doi: 10.1111/j.1365-2184.2009.00636.x.
  • Crighton D, Wilkinson S, O’Prey J, Syed N, Smith P, Harrison PR, Gasco M, Garrone O, Crook T, Ryan KM. 2006. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell. 126(1):121–134. doi: 10.1016/j.cell.2006.05.034.
  • Elmore S. 2007. Apoptosis: a review of programmed cell death. Toxicol Pathol. 35(4):495–516. doi: 10.1080/01926230701320337.
  • Fernandez-Capetillo O, Lee A, Nussenzweig M, Nussenzweig A. 2004. H2AX: the histone guardian of the genome. DNA Repair (Amst). 3(8–9):959–967. doi: 10.1016/j.dnarep.2004.03.024.
  • Guo L, Zhang C, Gao Q, Hou B, Liu L, Yang H, Jiang X. 2020. Chloropupukeananin and pestalofone C regulate autophagy through AMPK and glycolytic pathway. Chem Biodivers. 17(3):e1900583. doi: 10.1002/cbdv.201900583.
  • Han WD, Xie JS, Li L, Liu Z, Hu X. 2009. Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis. Apoptosis. 14(5):674–686. doi: 10.1007/s10495-009-0334-x.
  • Hays SL, Firmenich AA, Berg P. 1995. Complex formation in yeast double-strand break repair: participation of Rad51, Rad52, Rad55, and Rad57 proteins. Proc Natl Acad Sci U S A. 92(15):6925–6929. doi: 10.1073/pnas.92.15.6925.
  • Hoffelder DR, Luo L, Burke NA, Watkins SC, Gollin SM, Saunders WS. 2004. Resolution of anaphase bridges in cancer cells. Chromosoma. 112(8):389–397. doi: 10.1007/s00412-004-0284-6.
  • Hou B, Liu S, Li E, Jiang X. 2020. Different role of raptor and rictor in regulating rasfonin-induced autophagy and apoptosis in renal carcinoma cells. Chem Biodivers. 17(12):e2000743. doi: 10.1002/cbdv.202000743.
  • Hou B, Wang G, Gao Q, Wei Y, Zhang C, Wang Y, Huo Y, Yang H, Jiang X, Xi Z. 2019. SQSTM1/p62 loss reverses the inhibitory effect of sunitinib on autophagy independent of AMPK signaling. Sci Rep. 9(1):11087. doi: 10.1038/s41598-019-47597-4.
  • Hou B, Xu S, Xu Y, Gao Q, Zhang C, Liu L, Yang H, Jiang X, Che Y. 2019. Grb2 binds to PTEN and regulates its nuclear translocation to maintain the genomic stability in DNA damage response. Cell Death Disease. 10(8):546. doi: 10.1038/s41419-019-1762-3.
  • Jackson SP, Bartek J. 2009. The DNA-damage response in human biology and disease. Nature. 461(7267):1071–1078. doi: 10.1038/nature08467.
  • Kerr JF, Wyllie AH, Currie AR. 1972. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 26(4):239–257. doi: 10.1038/bjc.1972.33.
  • Klionsky DJ. 2012. A human autophagy interaction network. Autophagy. 8(4):439–441. doi: 10.4161/auto.19926.
  • Levine B, Klionsky DJ. 2004. Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Dev Cell. 6(4):463–477. doi: 10.1016/S1534-5807(04)00099-1.
  • Li E, Hou B, Gao Q, Xu Y, Zhang C, Liu X, Jiang X, Che Y. 2020. Disulfide cleavage in a dimeric epipolythiodioxopiperazine natural product diminishes its apoptosis-inducing effect but enhances autophagy in tumor cells. J Nat Prod. 83(3):601–609. doi: 10.1021/acs.jnatprod.9b00994.
  • Lu Q, Yan S, Sun H, Wang W, Li Y, Yang X, Jiang X, Che Y, Xi Z. 2015. Akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells. Cell Death Disease. 6(12):e2005. doi: 10.1038/cddis.2015.344.
  • Macintosh RL, Ryan KM. 2013. Autophagy in tumour cell death. Semin Cancer Biol. 23(5):344–351. doi: 10.1016/j.semcancer.2013.05.006.
  • Nikoletopoulou V, Markaki M, Palikaras K, Tavernarakis N. 2013. Crosstalk between apoptosis, necrosis and autophagy. Bba-Mol Cell Res. 1833(12):3448–3459. doi: 10.1016/j.bbamcr.2013.06.001.
  • Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD, Levine B. 2005. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell. 122(6):927–939. doi: 10.1016/j.cell.2005.07.002.
  • Poon IK, Lucas CD, Rossi AG, Ravichandran KS. 2014. Apoptotic cell clearance: basic biology and therapeutic potential. Nat Rev Immunol. 14(3):166–180. doi: 10.1038/nri3607.
  • Ren FX, Chen SX, Zhang Y, Zhu SM, Xiao JH, Liu XZ, Su RB, Che YS. 2018. Hawaiienols A-D, Highly oxygenated p-terphenyls from an insect-associated fungus. Paraconiothyrium Hawaiiense J Nat Prod. 81(8):1752–1759. doi: 10.1021/acs.jnatprod.8b00106.
  • Shinohara A, Ogawa H, Ogawa T. 1992. Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein. Cell. 69(3):457–470. doi: 10.1016/0092-8674(92)90447-K.
  • Son BW, Jensen PR, Kauffman CA, Fenical W. 1999. New cytotoxic epidithiodioxopiperazines related to verticillin a from a marine isolate of the fungus Penicillium. Nat Prod Lett. 13(3):213–222. doi: 10.1080/10575639908048788.
  • Sridhar S, Botbol Y, Macian F, Cuervo AM. 2012. Autophagy and disease: always two sides to a problem. J Pathol. 226(2):255–273. doi: 10.1002/path.3025.
  • Thacker J. 2005. The RAD51 gene family, genetic instability and cancer. Cancer Lett. 219(2):125–135. doi: 10.1016/j.canlet.2004.08.018.
  • Wang Y, Hu P, Pan Y, Zhu Y, Liu X, Che Y, Liu G. 2017. Identification and characterization of the verticillin biosynthetic gene cluster in Clonostachys rogersoniana. Fungal Genet Biol. 103:25–33. doi:10.1016/j.fgb.2017.03.007.
  • Wilson AJ, Stubbs M, Liu P, Ruggeri B, Khabele D. 2018. The BET inhibitor INCB054329 reduces homologous recombination efficiency and augments PARP inhibitor activity in ovarian cancer. Gynecol Oncol. 149(3):575–584. doi: 10.1016/j.ygyno.2018.03.049.
  • Yamada T, Iwamoto C, Yamagaki N, Yamanouchi T, Minoura K, Yamori T, Uehara Y, Andoh T, Umemura K, Numata A. 2002. Leptosins M-N-1, cytotoxic metabolites from a Leptosphaeria species separated from a marine alga. Structure determination and biological activities. Tetrahedron. 58(3):479–487. doi: 10.1016/S0040-4020(01)01170-X.
  • Yan S, Che Y, Jiang X. 2016. Proteasome inhibition attenuates rasfonin-induced autophagy concurring with the upregulation of caspase-dependent apoptosis. Mycology. 7(1):29–35. doi: 10.1080/21501203.2016.1147091.
  • Yan SY, Liu L, Ren FX, Gao Q, Xu SS, Hou BL, Wang YG, Jiang XJ, Che YS. 2017. Sunitinib induces genomic instability of renal carcinoma cells through affecting the interaction of LC3-II and PARP-1. Cell Death Disease. 8(8):e2988. doi: 10.1038/cddis.2017.387.
  • Yan X, Zhou R, Ma Z. 2019. Autophagy-cell survival and death. Adv Exp Med Biol. 1206:667–696.
  • Zhang CZ, Spektor A, Cornils H, Francis JM, Jackson EK, Liu S, Meyerson M, Pellman D. 2015. Chromothripsis from DNA damage in micronuclei. Nature. 522(7555):179–184. doi: 10.1038/nature14493.
  • Zhang N, Chen Y, Jiang R, Li E, Chen X, Xi Z, Guo Y, Liu X, Zhou Y, Che Y, et al. 2011. PARP and RIP 1 are required for autophagy induced by 11’-deoxyverticillin A, which precedes caspase-dependent apoptosis. Autophagy. 7(6):598–612. doi:10.4161/auto.7.6.15103.
  • Zong L, Bartolami E, Abegg D, Adibekian A, Sakai N, Matile S. 2017. Epidithiodiketopiperazines: Strain-promoted thiol-mediated cellular uptake at the highest tension. ACS Cent Sci. 3(5):449–453. doi: 10.1021/acscentsci.7b00080.