Long term neuropsychological outcomes of a pediatric ETANTR brain tumor: A case study

References

• Antonini, T. N., Ris, M. D., Grosshans, D. R., Mahajan, A., Okcu, M. F., Chintagumpala, M., Paulino, A., Child, A. E., Orobio, J., Stancel, H. H., & Kahalley, L. S. (2017). Attention, processing speed, and executive functioning in pediatric brain tumor survivors treated with proton beam radiation therapy. Radiotherapy and Oncology: journal of the European Society for Therapeutic Radiology and Oncology, 124(1), 89–97. https://doi.org/10.1016/j.radonc.2017.06.010
   PubMed Web of Science ®Google Scholar
• Brinkman, T. M., Krasin, M. J., Liu, W., Armstrong, G. T., Ojha, R. P., Sadighi, Z. S., Gupta, P., Kimberg, C., Srivastava, D., Merchant, T. E., Gajjar, A., Robison, L. L., Hudson, M. M., & Krull, K. R. (2016). Long-term neurocognitive functioning and social attainment in adult survivors of pediatric CNS tumors: Results from the St Jude Lifetime Cohort Study. Journal of Clinical Oncology: official Journal of the American Society of Clinical Oncology, 34(12), 1358–1367. https://doi.org/10.1200/JCO.2015.62.2589
   PubMed Web of Science ®Google Scholar
• Cámara, S., Fournier, M. C., Cordero, P., Melero, J., Robles, F., Esteso, B., Vara, M. T., Rodríguez, S., Lassaletta, Á., & Budke, M. (2020). Neuropsychological profile in children with posterior fossa tumors with or without postoperative cerebellar mutism syndrome (CMS). Cerebellum (London, England), 19(1), 78–88. https://doi.org/10.1007/s12311-019-01088-4
   PubMed Web of Science ®Google Scholar
• Child, A. E., Warren, E. A., Grosshans, D. R., Paulino, A. C., Okcu, M. F., Ris, M. D., Mahajan, A., Orobio, J., Cirino, P. T., Minard, C. G., Viana, A. G., Bick, J., Woods, S. P., Chintagumpala, M., & Kahalley, L. S. (2021). Long-term cognitive and academic outcomes among pediatric brain tumor survivors treated with proton versus photon radiotherapy. Pediatric Blood & Cancer, 68(9), e28125. https://doi.org/10.1002/pbc.29125
   Web of Science ®Google Scholar
• Clark, S. V., Semmel, E. S., Aleksonis, H. A., Steinberg, S. N., & King, T. Z. (2021). Cerebellar-Subcortical-Cortical Systems as Modulators of Cognitive Functions. Neuropsychology Review, 31(3), 422–446. 10.1007/s11065-020-09465-1
   PubMed Web of Science ®Google Scholar
• Ferguson, H. J., Brunsdon, V. E. A., & Bradford, E. E. F. (2021). The developmental trajectories of executive function from adolescence to old age. Scientific Reports, 11(1), 1382. https://doi.org/10.1038/s41598-020-80866-1
   PubMed Web of Science ®Google Scholar
• Fiske, A., & Holmboe, K. (2019). Neural substrates of early executive function development. Developmental Review: DR, 52, 42–62. https://doi.org/10.1016/j.dr.2019.100866
   PubMed Web of Science ®Google Scholar
• Gessi, M., Giangaspero, F., Lauriola, L., Gardiman, M., Scheithauer, B., Halliday, W., Hawkins, C., Rosenblum, M. K., Burger, P. C., & Eberhart, C. G. (2009). Embryonal tumors with abundant neuropil and true rosettes. The American Journal of Surgical Pathology, 33(2), 211–217. https://doi.org/10.1097/PAS.0b013e318186235b
   PubMed Web of Science ®Google Scholar
• Glass, J. O., Ogg, R. J., Hyun, J. W., Harreld, J. H., Schreiber, J. E., Palmer, S. L., Li, Y., Gajjar, A. J., & Reddick, W. E. (2017). Disrupted development and integrity of frontal white matter in patients treated for pediatric medulloblastoma. Neuro-oncology, 19(10), 1408–1418. https://doi.org/10.1093/neuonc/nox062
   PubMed Web of Science ®Google Scholar
• Heitzer, A. M., Raghubar, K., Ris, M. D., Minard, C. G., Gragert, M. N., Stancel, H. H., Orobio, J., Xue, J., Whitehead, W., Okcu, M. F., Chintagumpala, M., & Kahalley, L. S. (2020). Neuropsychological functioning following surgery for pediatric low-grade glioma: a prospective longitudinal study. Journal of Neurosurgery. Pediatrics, 25(3), 1–9. https://doi.org/10.3171/2019.9.PEDS19357
   Web of Science ®Google Scholar
• Hoveyan, J., Avagyan, M., Avagyan, A., Papyan, R., Iskanyan, S., Danielyan, S., Hovhannisyan, G., Khachatryan, P., Tamamyan, G., & Bardakhchyan, S. (2020). ETMR-07. ETANTR: A RARE TUMOR IN A RESOURCE-LIMITED SETTING. Neuro-Oncology, 22(Supplement_3), iii324–iii324. 10.1093/neuonc/noaa222.211
   Google Scholar
• Jaramillo, S., Grosshans, D. R., Philip, N., Varan, A., Akyüz, C., McAleer, M. F., Mahajan, A., & McGovern, S. L. (2019). Radiation for ETMR: Literature review and case series of patients treated with proton therapy. Clinical and Translational Radiation Oncology, 15, 31–37. https://doi.org/10.1016/j.ctro.2018.11.002
   PubMed Web of Science ®Google Scholar
• Juhnke, B. O., Gessi, M., Gerber, N. U., Friedrich, C., Mynarek, M., von Bueren, A. O., Haberler, C., Schüller, U., Kortmann, R. D., Timmermann, B., Bison, B., Warmuth-Metz, M., Kwiecien, R., Pfister, S. M., Spix, C., Pietsch, T., Kool, M., Rutkowski, S., & von Hoff, K. (2022). Treatment of embryonal tumors with multilayered rosettes with carboplatin/etoposide induction and high-dose chemotherapy within the prospective P-HIT trial. Neuro-oncology, 24(1), 127–137. https://doi.org/10.1093/neuonc/noab100
   PubMed Web of Science ®Google Scholar
• Kahalley, L. S., Douglas Ris, M., Mahajan, A., Fatih Okcu, M., Chintagumpala, M., Paulino, A. C., Whitehead, W. E., Minard, C. G., Stancel, H. H., Orobio, J., Xue, J. J., Warren, E. A., & Grosshans, D. R. (2019). Prospective, longitudinal comparison of neurocognitive change in pediatric brain tumor patients treated with proton radiotherapy versus surgery only. Neuro-oncology, 21(6), 809–818. https://doi.org/10.1093/neuonc/noz041
   PubMed Web of Science ®Google Scholar
• Kahalley, L. S., Winter-Greenberg, A., Stancel, H., Ris, M. D., & Gragert, M. (2016). Utility of the general ability index (GAI) and cognitive proficiency index (CPI) with survivors of pediatric brain tumors: Comparison to Full Scale IQ and premorbid IQ estimates. Journal of Clinical and Experimental Neuropsychology, 38(10), 1065–1076. https://doi.org/10.1080/13803395.2016.1189883
   PubMed Web of Science ®Google Scholar
• King, T. Z., Ailion, A. S., Fox, M. E., & Hufstetler, S. M. (2019). Neurodevelopmental model of long-term outcomes of adult survivors of childhood brain tumors. Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence, 25(1), 1–21. https://doi.org/10.1080/09297049.2017.1380178
   PubMed Web of Science ®Google Scholar
• King, T. Z., Wang, L., & Mao, H. (2015). Disruption of white matter integrity in adult survivors of childhood brain tumors: correlates with long-term intellectual outcomes. PloS One, 10(7), e0131744. https://doi.org/10.1371/journal.pone.0131744
   PubMed Web of Science ®Google Scholar
• Korshunov, A., Sturm, D., Ryzhova, M., Hovestadt, V., Gessi, M., Jones, D. T. W., Remke, M., Northcott, P., Perry, A., Picard, D., Rosenblum, M., Antonelli, M., Aronica, E., Schüller, U., Hasselblatt, M., Woehrer, A., Zheludkova, O., Kumirova, E., Puget, S., … Kool, M. (2014). Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity. Acta Neuropathologica, 128(2), 279–289. https://doi.org/10.1007/s00401-013-1228-0
   PubMed Web of Science ®Google Scholar
• Lambo, S., von Hoff, K., Korshunov, A., Pfister, S. M., & Kool, M. (2020). ETMR: A tumor entity in its infancy. Acta Neuropathologica, 140(3), 249–266. https://doi.org/10.1007/s00401-020-02182-2
   PubMed Web of Science ®Google Scholar
• Levitch, C. F., Holland, A. A., Bledsoe, J., Kim, S. Y., Barnett, M., Ramjan, S., & Sands, S. A. (2021). Comparison of neuropsychological functioning in pediatric posterior fossa tumor survivors: Medulloblastoma, low-grade astrocytoma, and healthy controls. Pediatric Blood & Cancer, 69(2), e29491. https://doi.org/10.1002/pbc.29491
   PubMed Web of Science ®Google Scholar
• Li, B. K., Al-Karmi, S., Huang, A., & Bouffet, E. (2020). Pediatric embryonal brain tumors in the molecular era. Expert Review of Molecular Diagnostics, 20(3), 293–303. https://doi.org/10.1080/14737159.2020.1714439
   PubMed Web of Science ®Google Scholar
• Mannarelli, D., Pauletti, C., Missori, P., Trompetto, C., Cotellessa, F., Fattapposta, F., & Currà, A. (2023). Cerebellum’s Contribution to Attention, Executive Functions and Timing: Psychophysiological Evidence from Event-Related Potentials. Brain Sciences, 13(12), 1683 10.3390/brainsci13121683
   PubMed Web of Science ®Google Scholar
• Mulhern, R. K., Palmer, S. L., Reddick, W. E., Glass, J. O., Kun, L. E., Taylor, J., Langston, J., & Gajjar, A. (2001). Risks of young age for selected neurocognitive deficits in medulloblastoma are associated with white matter loss. Journal of Clinical Oncology: official Journal of the American Society of Clinical Oncology, 19(2), 472–479. https://doi.org/10.1200/JCO.2001.19.2.472
   PubMed Web of Science ®Google Scholar
• Na, S., Li, L., Crosson, B., Dotson, V., MacDonald, T. J., Mao, H., & King, T. Z. (2018). White matter network topology relates to cognitive flexibility and cumulative neurological risk in adult survivors of pediatric brain tumors. NeuroImage. Clinical, 20, 485–497. https://doi.org/10.1016/j.nicl.2018.08.015
   PubMed Web of Science ®Google Scholar
• Nemade, D., Knowles, P., Payne, M., & Nahar, N. (2019). A case of embryonal tumor with abundant neuropil and true rosettes (ETANTR): a distinct genetic locus with an excellent outcome (P3.6-010). Neurology, 92(15_supplement), P3.6–010. http://n.neurology.org/content/92/15_Supplement/P3.6-010.abstract https://doi.org/10.1212/WNL.92.15_supplement.P3.6-010
   Web of Science ®Google Scholar
• Ostrom, Q. T., Price, M., Ryan, K., Edelson, J., Neff, C., Cioffi, G., Waite, K. A., Kruchko, C., & Barnholtz-Sloan, J. S. (2022). CBTRUS statistical report: Pediatric brain tumor foundation childhood and adolescent primary brain and other central nervous system tumors diagnosed in the United States in 2014–2018. Neuro-oncology, 24(Suppl 3), iii1–iii38. https://doi.org/10.1093/neuonc/noac161
   PubMedGoogle Scholar
• Oyefiade, A., Paltin, I., De Luca, C., Hardy, K., Grosshans, D., Chintagumpala, M., Mabbott, D. J., & Kahalley, L. S. (2021). Cognitive risk in survivors of pediatric brain tumors. Journal of Clinical Oncology: official Journal of the American Society of Clinical Oncology, 39(16), 1718–1726. https://doi.org/10.1200/jco.20.02338
   PubMed Web of Science ®Google Scholar
• Palmer, S. L. (2008). Neurodevelopmental impacts on children treated for medulloblastoma: A review and proposed conceptual model. Developmental Disabilities Research Reviews, 14(3), 203–210. https://doi.org/10.1002/ddrr.32
   PubMed Web of Science ®Google Scholar
• Pancaldi, A., Pugliese, M., Migliozzi, C., Blom, J., Cellini, M., & Iughetti, L. (2023). Neuropsychological outcomes of children treated for brain tumors. Children (Basel, Switzerland), 10(3), 472. https://doi.org/10.3390/children10030472
   PubMed Web of Science ®Google Scholar
• Peterson, R. K., Ludwig, N. N., Rowena Ng, & Jacobson, L. A. (2023). The interaction of age at diagnosis and neurological risk predicts adaptive functioning changes in pediatric brain tumor survivors.Developmental Neuropsychology, 48(5), 203–214. https://doi.org/10.1080/87565641.2023.2222325
   PubMed Web of Science ®Google Scholar
• Phillips, N. S., Khan, R. B., Li, C., Mirzaei Salehabadi, S., Brinkman, T. M., Srivastava, D., Robison, L. L., Hudson, M. M., Krull, K. R., & Sadighi, Z. S. (2022). Seizures’ impact on cognition and quality of life in childhood cancer survivors. Cancer, 128(1), 180–191. https://doi.org/10.1002/cncr.33879
   PubMed Web of Science ®Google Scholar
• Puhr, A., Ruud, E., Anderson, V., Due-Tønnessen, B. J., Skarbø, A.-B., Finset, A., & Andersson, S. (2021). Social attainment in physically well-functioning long-term survivors of pediatric brain tumour; the role of executive dysfunction, fatigue, and psychological and emotional symptoms. Neuropsychological Rehabilitation, 31(1), 129–153. https://doi.org/10.1080/09602011.2019.1677480
   PubMed Web of Science ®Google Scholar
• Pulsifer, M. B., Duncanson, H., Grieco, J., Evans, C., Tseretopoulos, I. D., MacDonald, S., Tarbell, N. J., & Yock, T. I. (2018). Cognitive and Adaptive Outcomes After Proton Radiation for Pediatric Patients With Brain Tumors. International Journal of Radiation Oncology, Biology, Physics, 102(2), 391–398. https://doi.org/10.1016/j.ijrobp.2018.05.069
   PubMed Web of Science ®Google Scholar
• Rey-Casserly, C., & Diver, T. (2019). Late effects of pediatric brain tumors. Current Opinion in Pediatrics, 31(6), 789–796. https://doi.org/10.1097/MOP.0000000000000837
   PubMed Web of Science ®Google Scholar
• Ris, D. M., Beebe, D. W., Armstrong, D. F., Fontanesi, J., Holmes, E., Sanford, R. A., & Wisoff, J. H., Children’s Oncology Group. (2008). Cognitive and adaptive outcome in extracerebellar low-grade brain tumors in children: A report from the children’s oncology group. Journal of Clinical Oncology: official Journal of the American Society of Clinical Oncology, 26(29), 4765–4770. https://doi.org/10.1200/JCO.2008.17.1371
   PubMed Web of Science ®Google Scholar
• Robinson, K., Fraley, C., Pearson, M., Kuttesch, J., & Compas, B. (2013). Neurocognitive late effects of pediatric brain tumors of the posterior fossa: A quantitative review. Journal of the International Neuropsychological Society: JINS, 19(1), 44–53. https://doi.org/10.1017/S1355617712000987
   PubMed Web of Science ®Google Scholar
• Robinson, K., Kuttesch, J. F., Champion, J. E., Andreotti, C. F., Hipp, D. W., Bettis, A., Barnwell, A., & Compas, B. E. (2010). A quantitative meta-analysis of neurocognitive sequelae in survivors of pediatric brain tumors. Pediatric Blood & Cancer, 55(3), 525–531. https://doi.org/10.1002/pbc.22568
   PubMed Web of Science ®Google Scholar
• Roth, A. K., Ris, M. D., Orobio, J., Xue, J., Mahajan, A., Paulino, A. C., Grosshans, D., Okcu, M. F., Chintagumpala, M., & Kahalley, L. S. (2019). Cognitive mediators of adaptive functioning outcomes in survivors of pediatric brain tumors treated with proton radiotherapy. Pediatric Blood & Cancer, 67(2), e28064. https://doi.org/10.1002/pbc.28064
   PubMed Web of Science ®Google Scholar
• Schreiber, J. E., Palmer, S. L., Conklin, H. M., Mabbott, D. J., Swain, M. A., Bonner, M. J., Chapieski, M. L., Huang, L., Zhang, H., & Gajjar, A. (2017). Posterior fossa syndrome and long-term neuropsychological outcomes among children treated for medulloblastoma on a multi-institutional, prospective study. Neuro-oncology, 19(12), 1673–1682. https://doi.org/10.1093/neuonc/nox135
   PubMed Web of Science ®Google Scholar
• Sowell, E. R., Thompson, P. M., Holmes, C. J., Batth, R., Jernigan, T. L., & Toga, A. W. (1999). Localizing age-related changes in brain structure between childhood and adolescence using statistical parametric mapping. NeuroImage, 9(6 Pt 1), 587–597. https://doi.org/10.1006/nimg.1999.0436
   PubMed Web of Science ®Google Scholar
• Ullrich, N. J., Pomeroy, S. L., Kapur, K., Manley, P. E., Goumnerova, L. C., & Loddenkemper, T. (2015). Incidence, risk factors, and longitudinal outcome of seizures in long-term survivors of pediatric brain tumors. Epilepsia, 56(10), 1599–1604. https://doi.org/10.1111/epi.13112
   PubMed Web of Science ®Google Scholar
• Verity, S. J., Halliday, G., Hill, R. M., Ryles, J., & Bailey, S. (2022). Methylphenidate improves cognitive function and health-related quality of life in survivors of childhood brain tumours. Neuropsychological Rehabilitation, 34(1), 133–153. https://doi.org/10.1080/09602011.2022.2157446
   PubMed Web of Science ®Google Scholar
• Willard, V. W., Allen, T. M., Hardy, K. K., & Bonner, M. J. (2017). Social functioning in survivors of pediatric brain tumors: Contribution of neurocognitive and social-cognitive skills. Children’s Health Care, 46(2), 181–195. https://doi.org/10.1080/02739615.2015.1124769
   Web of Science ®Google Scholar
• Winter, A. L., Conklin, H. M., Tyc, V. L., Stancel, H., Hinds, P. S., Hudson, M. M., & Kahalley, L. S. (2014). Executive function late effects in survivors of pediatric brain tumors and acute lymphoblastic leukemia. Journal of Clinical and Experimental Neuropsychology, 36(8), 818–830. https://doi.org/10.1080/13803395.2014.943695
   PubMed Web of Science ®Google Scholar
• Wolfe, K. R., Madan-Swain, A., & Kana, R. K. (2012). Executive dysfunction in pediatric posterior fossa tumor survivors: a systematic literature review of neurocognitive deficits and interventions. Developmental Neuropsychology, 37(2), 153–175. https://doi.org/10.1080/87565641.2011.632462
   PubMed Web of Science ®Google Scholar