Identification of major hub genes involved in high-fat diet-induced obese visceral adipose tissue based on bioinformatics approach

References

• Collaboration NCDRF. Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants. Lancet. 2016;387(10026):1377–14.
   PubMed Web of Science ®Google Scholar
• Ahmed B, Sultana R, Greene MW. Adipose tissue and insulin resistance in obese. Biomed Pharmacother. 2021;137:111315.
   PubMed Web of Science ®Google Scholar
• Jayedi A, Khan TA, Aune D, et al. Body fat and risk of all-cause mortality: a systematic review and dose-response meta-analysis of prospective cohort studies. Int J Obes (Lond). 2022;46(9):1573–1581.
   PubMed Web of Science ®Google Scholar
• Gugliucci A. Biomarkers of dysfunctional visceral fat. Adv Clin Chem. 2022;109:1–30.
   PubMedGoogle Scholar
• Sun Y, Chen S, Zhang X, et al. Significance of cellular cross-talk in stromal vascular fraction of adipose tissue in neovascularization. Arterioscler Thromb Vasc Biol. 2019;39(6):1034–1044.
   PubMed Web of Science ®Google Scholar
• Ibrahim MM. Subcutaneous and visceral adipose tissue: structural and functional differences. Obes Rev. 2010;11(1):11–18.
   PubMed Web of Science ®Google Scholar
• Jeffery E, Wing A, Holtrup B, Sebo Z, Kaplan JL, Saavedra-Pena R, et al. The adipose tissue microenvironment regulates depot-specific adipogenesis in obesity. Cell Metab. 2016;24(1):142–150.
   PubMed Web of Science ®Google Scholar
• Vague J. The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. Am J Clin Nutr. 1956;4(1):20–34.
   PubMed Web of Science ®Google Scholar
• Unamuno X, Gomez-Ambrosi J, Rodriguez A, et al. Adipokine dysregulation and adipose tissue inflammation in human obesity. Eur J Clin Invest. 2018;48(9):e12997.
   PubMed Web of Science ®Google Scholar
• Sarafidis M, Lambrou GI, Zoumpourlis V, et al. An integrated bioinformatics analysis towards the identification of diagnostic, prognostic, and predictive key biomarkers for urinary bladder cancer. Cancers (Basel). 2022;15(1):14.
   PubMedGoogle Scholar
• Sai Swaroop R, Akhil PS, Sai Sanwid P, et al. Integrated multi-omic data analysis and validation with yeast model show oxidative phosphorylation modulates protein aggregation in amyotrophic lateral sclerosis. J Biomol Struct Dyn. 2022;1–20. doi: 10.1080/07391102.2022.2090441.
   PubMed Web of Science ®Google Scholar
• Haim Y, Bluher M, Slutsky N, et al. Elevated autophagy gene expression in adipose tissue of obese humans: a potential non-cell-cycle-dependent function of E2F1. Autophagy. 2015;11(11):2074–2088.
   PubMed Web of Science ®Google Scholar
• Aflaki E, Balenga NA, Luschnig-Schratl P, et al. Impaired Rho GTPase activation abrogates cell polarization and migration in macrophages with defective lipolysis. Cell Mol Life Sci. 2011;68(23):3933–3947.
   PubMed Web of Science ®Google Scholar
• Ko SH, Lee JK, Lee HJ, et al. 8-Oxo-2’-deoxyguanosine ameliorates features of metabolic syndrome in obese mice. Biochem Biophys Res Commun. 2014;443(2):610–616.
   PubMed Web of Science ®Google Scholar
• Sun H, Hu L, Fan Z. β2 integrin activation and signal transduction in leukocyte recruitment. Am J Physiol Cell Physiol. 2021;321(2):C308–C16.
   PubMed Web of Science ®Google Scholar
• Nair S, Lee YH, Rousseau E, et al. Increased expression of inflammation-related genes in cultured preadipocytes/stromal vascular cells from obese compared with non-obese Pima Indians. Diabetologia. 2005;48(9):1784–1788.
   PubMed Web of Science ®Google Scholar
• Chen Q, Ruedl C. Obesity retunes turnover kinetics of tissue-resident macrophages in fat. J Leukoc Biol. 2020;107(5):773–782.
   PubMed Web of Science ®Google Scholar
• Haure-Mirande JV, Audrain M, Ehrlich ME, et al. TYROBP/DAP12 in Alzheimer’s disease: transduction of physiological and pathological signals across TREM2. Mol Neurodegener. 2022;17(1):55.
   PubMed Web of Science ®Google Scholar
• Yan K, Zhang P, Jin J, et al. Integrative analyses of hub genes and their association with immune infiltration in adipose tissue, liver tissue and skeletal muscle of obese patients after bariatric surgery. Adipocyte. 2022;11(1):190–201.
   PubMed Web of Science ®Google Scholar
• Sletta KY, Castells O, Gjertsen BT. Colony stimulating factor 1 receptor in acute myeloid leukemia. Front Oncol. 2021;11:654817.
   PubMedGoogle Scholar
• Cox N, Crozet L, Holtman IR, et al. Diet-regulated production of PDGFcc by macrophages controls energy storage. Science. 2021;373(6553):373.
   PubMedGoogle Scholar
• Lecoutre S, Lambert M, Drygalski K, et al. Importance of the Microenvironment and Mechanosensing in Adipose Tissue Biology. Cells. 2022;12(1):11.
   PubMedGoogle Scholar
• Hachiya R, Tanaka M, Itoh M, et al. Molecular mechanism of crosstalk between immune and metabolic systems in metabolic syndrome. Inflamm Regen. 2022;42(1):13.
   PubMed Web of Science ®Google Scholar
• Kanda H, Tateya S, Tamori Y, et al. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest. 2006;116(6):1494–1505.
   PubMed Web of Science ®Google Scholar
• Weisberg SP, Hunter D, Huber R, et al. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest. 2006;116(1):115–124.
   PubMed Web of Science ®Google Scholar
• Lindhorst A, Raulien N, Wieghofer P, et al. Adipocyte death triggers a pro-inflammatory response and induces metabolic activation of resident macrophages. Cell Death Dis. 2021;12(6):579.
   PubMed Web of Science ®Google Scholar
• Cinti S, Mitchell G, Barbatelli G, et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res. 2005;46(11):2347–2355.
   PubMed Web of Science ®Google Scholar
• Datta R, Podolsky MJ, Atabai K. Fat fibrosis: friend or foe?. JCI Insight. 2018;3(19). doi:10.1172/jci.insight.122289.
   Web of Science ®Google Scholar
• Marcelin G, Gautier EL, Clement K. Adipose tissue fibrosis in obesity: etiology and challenges. Annu Rev Physiol. 2022;84(1):135–155.
   PubMedGoogle Scholar
• Marcelin G, Clement K. The multifaceted progenitor fates in healthy or unhealthy adipose tissue during obesity. Rev Endocr Metab Disord. 2021;22(4):1111–1119.
   PubMed Web of Science ®Google Scholar
• Ji JJ, Qian LL, Zhu Y, et al. Kallistatin/Serpina3c inhibits cardiac fibrosis after myocardial infarction by regulating glycolysis via Nr4a1 activation. Biochim Biophys Acta Mol Basis Dis. 2022;1868(9):166441.
   PubMed Web of Science ®Google Scholar
• Guo J, Qian L, Ji J, et al. Serpina3c regulates adipose differentiation via the Wnt/beta-catenin-PPARgamma pathway. Cell Signal. 2022;93:110299.
   PubMed Web of Science ®Google Scholar