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Research Paper

IL-27 increases energy storage in white adipocytes by enhancing glucose uptake and fatty acid esterification

ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Article: 2276346 | Received 29 Jun 2023, Accepted 19 Oct 2023, Published online: 10 Nov 2023

References

  • Beizavi Z, Zohouri M, Asadipour M, et al. IL-27, a pleiotropic cytokine for fine-tuning the immune response in cancer. Int Rev Immunol. 2021;40(5):319–10. doi: 10.1080/08830185.2020.1840565
  • Shahi A, Afzali S, Salehi S, et al. IL-27 and autoimmune rheumatologic diseases: the good, the bad, and the ugly. Int Immunopharmacol. 2020;84:106538. doi: 10.1016/j.intimp.2020.106538
  • Nam H, Ferguson BS, Stephens JM, et al. Modulation of IL-27 in adipocytes during inflammatory stress. Obesity (Silver Spring). 2016;24:157–166. doi: 10.1002/oby.21351
  • Cani PD, Amar J, Iglesias MA, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56:1761–1772. doi: 10.2337/db06-1491
  • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science. 1993;259(5091):87–91. doi: 10.1126/science.7678183
  • Nam H, Ferguson BS, Stephens JM, et al. Impact of obesity on IL-12 family gene expression in insulin responsive tissues. Biochim Biophys Acta. 2013;1832(1):11–19. doi: 10.1016/j.bbadis.2012.08.011
  • Greenberg AS, Shen WJ, Muliro K, et al. Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway. J Biol Chem. 2001;276(48):45456–45461. doi: 10.1074/jbc.M104436200
  • Leiva M, Matesanz N, Pulgarin-Alfaro M, et al. Uncovering the role of p38 family members in adipose tissue physiology. Front Endocrinol. 2020;11:572089. doi: 10.3389/fendo.2020.572089
  • van Krieken PP, Roos J, Fischer-Posovszky P, et al. Oncostatin M promotes lipolysis in white adipocytes. Adipocyte. 2022;11:315–324. doi: 10.1080/21623945.2022.2075129
  • Banks AS, McAllister FE, Camporez JP, et al. An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ. Nature. 2015;517(7534):391–395. doi: 10.1038/nature13887
  • Hotamisligil GS. Inflammation, metaflammation and immunometabolic disorders. Nature. 2017;542:177–185. doi: 10.1038/nature21363
  • Wang Q, Li D, Cao G, et al. IL-27 signalling promotes adipocyte thermogenesis and energy expenditure. Nature. 2021;600:314–318. doi: 10.1038/s41586-021-04127-5
  • Li Y, Fromme T, Klingenspor M. Meaningful respirometric measurements of UCP1-mediated thermogenesis. Biochimie. 2017;134:56–61. doi: 10.1016/j.biochi.2016.12.005
  • Li Y, Fromme T, Schweizer S, et al. Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes. EMBO Rep. 2014;15(10):1069–1076. doi: 10.15252/embr.201438775
  • Schweiger M, Schreiber R, Haemmerle G, et al. Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism. J Biol Chem. 2006;281(52):40236–40241. doi: 10.1074/jbc.M608048200
  • Ricquier D. Respiration uncoupling and metabolism in the control of energy expenditure. Proc Nutr Soc. 2005;64(1):47–52. doi: 10.1079/PNS2004408
  • Tews D, Pula T, Funcke JB, et al. Elevated UCP1 levels are sufficient to improve glucose uptake in human white adipocytes. Redox Biol. 2019;26:101286. doi: 10.1016/j.redox.2019.101286
  • Clenet ML, Laurent C, Lemaitre F, et al. The IL-27/IL-27R axis is altered in CD4 + and CD8 + T lymphocytes from multiple sclerosis patients. Clin Trans Imm. 2021;10(3):e1262. doi: 10.1002/cti2.1262
  • Frangieh M, McHenry A, Phillips R, et al. IL-27: an endogenous constitutive repressor of human monocytes. Clin Immunol. 2020;217:108498. doi: 10.1016/j.clim.2020.108498
  • Kovsan J, Osnis A, Maissel A, et al. Depot-specific adipocyte cell lines reveal differential drug-induced responses of white adipocytes—relevance for partial lipodystrophy. Am J Physiol Endocrinol Metab. 2009;296(2):E315–22. doi: 10.1152/ajpendo.90486.2008
  • Zimmermann R, Strauss JG, Haemmerle G, et al. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science. 2004;306:1383–1386. doi: 10.1126/science.1100747
  • Kralisch S, Klein J, Lossner U, et al. Isoproterenol, TNFα, and insulin downregulate adipose triglyceride lipase in 3T3-L1 adipocytes. Mol Cell Endocrinol. 2005;240(1–2):43–49. doi: 10.1016/j.mce.2005.06.002
  • Edens NK, Leibel RL, Hirsch J. Mechanism of free fatty acid re-esterification in human adipocytes in vitro. J Lipid Res. 1990;31(8):1423–1431. doi: 10.1016/S0022-2275(20)42613-6
  • Tan GD, Debard C, Tiraby C, et al. A “futile cycle” induced by thiazolidinediones in human adipose tissue? Nat Med. 2003;9:811–812. author reply 2. doi: 10.1038/nm0703-811
  • Vaughan M. The production and release of glycerol by adipose tissue incubated in vitro. J Biol Chem. 1962;237(11):3354–3358. doi: 10.1016/S0021-9258(19)70821-7
  • Bluher M. Metabolically healthy obesity. Endocr Rev. 2020;41(3):41. doi: 10.1210/endrev/bnaa004
  • Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2006;444:881–887. doi: 10.1038/nature05488
  • Diehl AM, Cause DC. Pathogenesis, and treatment of Nonalcoholic Steatohepatitis. N Engl J Med. 2017;377(21):2063–2072. doi: 10.1056/NEJMra1503519
  • Dokmak A, Lizaola-Mayo B, Trivedi HD. The impact of nonalcoholic fatty liver disease in primary care: a population health perspective. Am J Med. 2021;134(1):23–29. doi: 10.1016/j.amjmed.2020.08.010
  • Yang Y, Liu H, Liu D. Preventing high-fat diet-induced obesity and related metabolic disorders by hydrodynamic transfer of il-27 gene. Int J Obes (Lond). 2023;47:413–421. doi: 10.1038/s41366-023-01293-6
  • Foster LJ, Klip A. Mechanism and regulation of GLUT-4 vesicle fusion in muscle and fat cells. Am J Physiol Cell Physiol. 2000;279(4):C877–90. doi: 10.1152/ajpcell.2000.279.4.C877
  • Carpentier AC, Blondin DP, Haman F, et al. Brown adipose tissue—A translational perspective. Endocr Rev. 2023;44(2):143–192. doi: 10.1210/endrev/bnac015
  • Olsen JM, Sato M, Dallner OS, et al. Glucose uptake in brown fat cells is dependent on mTOR complex 2–promoted GLUT1 translocation. J Cell Bio. 2014;207(3):365–374. doi: 10.1083/jcb.201403080
  • van Krieken PP, Odermatt TS, Borsigova M, et al. Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling. Mol Metab. 2021;54:101341. doi: 10.1016/j.molmet.2021.101341