Leptin secreted by adipocytes promotes EMT transition and endometrial cancer progression via the JAK2/STAT3 signalling pathway

References

• Morice P, Leary A, Creutzberg C, et al. Endometrial cancer. Lancet. 2016;387(10023):1094–13. doi: 10.1016/S0140-6736(15)00130-0
   PubMed Web of Science ®Google Scholar
• Urick ME, Bell DW. Clinical actionability of molecular targets in endometrial cancer. Nat Rev Cancer. 2019;19(9):510–521. doi: 10.1038/s41568-019-0177-x
   PubMed Web of Science ®Google Scholar
• Crosbie EJ, Kitson SJ, McAlpine JN, et al. Endometrial cancer. Lancet. 2022;399(10333):1412–28. doi: 10.1016/S0140-6736(22)00323-3
   PubMed Web of Science ®Google Scholar
• Raglan O, Kalliala I, Markozannes G, et al. Risk factors for endometrial cancer: an umbrella review of the literature. Intl J Cancer. 2019;145(7):1719–30. doi: 10.1002/ijc.31961
   PubMed Web of Science ®Google Scholar
• Nagle C, Crosbie E, Brand A, et al. The association between diabetes, comorbidities, body mass index and all-cause and cause-specific mortality among women with endometrial cancer. Gynecol Oncol. 2018;150(1):99–105. doi: 10.1016/j.ygyno.2018.04.006
   PubMed Web of Science ®Google Scholar
• Hazelwood E, Sanderson E, Tan VY, et al. Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis. BMC Med. 2022;20(1):125. doi: 10.1186/s12916-022-02322-3
   PubMed Web of Science ®Google Scholar
• Tzenios N, Chahine M, Tazanios M. Obesity and endometrial cancer: the role insulin resistance and adipokines. SJMAS. 2023;1(2). doi: 10.58676/sjmas.v1i2.12
   Google Scholar
• Wang P-P, He X-Y, Wang R, et al. High leptin level is an independent risk factor of endometrial cancer: a meta-analysis. Cell Physiol Biochem. 2014;34(5):1477–84. doi: 10.1159/000366352
   PubMedGoogle Scholar
• Deng J, Grande F, Neamati N. Small molecule inhibitors of Stat3 signaling pathway. Curr Cancer Drug Targets. 2007;7(1):91–107. doi: 10.2174/156800907780006922
   PubMed Web of Science ®Google Scholar
• Gao J, Tian J, Lv Y, et al. Leptin induces functional activation of cyclooxygenase‐2 through JAK2/STAT3, MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells. Cancer Sci. 2009;100(3):389–395. doi: 10.1111/j.1349-7006.2008.01053.x
   PubMed Web of Science ®Google Scholar
• Ahn J-H, Choi YS, Choi J-H. Leptin promotes human endometriotic cell migration and invasion by up-regulating MMP-2 through the JAK2/STAT3 signaling pathway. Mol Hum Reprod. 2015;21(10):792–802. doi: 10.1093/molehr/gav039
   PubMed Web of Science ®Google Scholar
• Gorrab A, Pagano A, Ayed K, et al. Leptin promotes prostate cancer proliferation and migration by stimulating STAT3 pathway. Nutr Cancer. 2021;73(7):1217–1227. doi: 10.1080/01635581.2020.1792946
   PubMed Web of Science ®Google Scholar
• Chen C, Chang Y-C, Lan MS, et al. Leptin stimulates ovarian cancer cell growth and inhibits apoptosis by increasing cyclin D1 and Mcl-1 expression via the activation of the MEK/ERK1/2 and PI3K/Akt signaling pathways corrigendum in/10.3892/ijo.2013.1789. Int J Oncol. 2013;42(3):1113–9. doi: 10.3892/ijo.2013.1789
   PubMed Web of Science ®Google Scholar
• Boothby-Shoemaker W, Benham V, Paithankar S, et al. The relationship between leptin, the leptin receptor and FGFR1 in primary human breast tumors. Cells. 2020;9(10):2224. doi: 10.3390/cells9102224
   PubMed Web of Science ®Google Scholar
• Wu X, Yan Q, Zhang Z, et al. Acrp30 inhibits leptin-induced metastasis by downregulating the JAK/STAT3 pathway via AMPK activation in aggressive SPEC-2 endometrial cancer cells. Oncol Rep. 2012;27(5):1488–96. doi: 10.3892/or.2012.1670
   PubMed Web of Science ®Google Scholar
• Saglam K, Aydur E, Yilmaz MI, et al. Leptin influences cellular differentiation and progression in prostate cancer. J Urol. 2003;169(4):1308–11. doi: 10.1097/01.ju.0000055903.18400.25
   PubMed Web of Science ®Google Scholar
• Chang S, Hursting SD, Contois JH, et al. Leptin and prostate cancer. Prostate. 2001;46(1):62–67. doi: 10.1002/1097-0045(200101)46:1<62:AID-PROS1009>3.0.CO;2-V
   PubMed Web of Science ®Google Scholar
• Hsing AW, Chua JS, Gao Y-T, et al. Prostate cancer risk and serum levels of insulin and leptin: a population-based study. JNCI. 2001;93(10):783–789. doi: 10.1093/jnci/93.10.783
   PubMedGoogle Scholar
• Lagiou P, Signorello LB, Trichopoulos D, et al. Leptin in relation to prostate cancer and benign prostatic hyperplasia. Int J Cancer. 1998;76(1):25–8.
   PubMed Web of Science ®Google Scholar
• Stattin P, Kaaks R, Johansson R, et al. Plasma leptin is not associated with prostate cancer risk. Cancer Epidemiol Biomark Prev. 2003;12(5):474–5.
   PubMed Web of Science ®Google Scholar
• Yuan K, Ye J, Liu Z, et al. Complement C3 overexpression activates JAK2/STAT3 pathway and correlates with gastric cancer progression. J Exp Clin Cancer Res. 2020;39(1):9. PMID:PMC6956509. doi: 10.1186/s13046-019-1514-3
   PubMed Web of Science ®Google Scholar
• Shen H, Guo M, Wang L, et al. MUC16 facilitates cervical cancer progression via JAK2/STAT3 phosphorylation-mediated cyclooxygenase-2 expression. Genes Genomics. 2020;42(2):127–133. doi: 10.1007/s13258-019-00885-9
   PubMed Web of Science ®Google Scholar
• Oh HK, Choi YS, Yang Y-I, et al. Leptin receptor is induced in endometriosis and leptin stimulates the growth of endometriotic epithelial cells through the JAK2/STAT3 and ERK pathways. Mol Hum Reprod. 2012;19(3):160–8. doi: 10.1093/molehr/gas055
   PubMed Web of Science ®Google Scholar
• Kumar J, Fang H, McCulloch DR, et al. Leptin receptor signaling via Janus kinase 2/Signal transducer and activator of transcription 3 impacts on ovarian cancer cell phenotypes. Oncotarget. 2017;8(55):93530. doi: 10.18632/oncotarget.19873
   PubMedGoogle Scholar
• Reschke L, Afrin S, El Sabah M, et al. Leptin induces leiomyoma cell proliferation and extracellular matrix deposition via JAK2/STAT3 and MAPK/ERK pathways. F S Science. 2022;3(4):383–91. doi: 10.1016/j.xfss.2022.05.001
   PubMedGoogle Scholar
• Olea-Flores M, Juárez-Cruz JC, Zuñiga-Eulogio MD, et al. New actors driving the epithelial–mesenchymal transition in cancer: the role of leptin. Biomolecules. 2020;10(12):1676. doi: 10.3390/biom10121676
   PubMed Web of Science ®Google Scholar
• Wang L, Tang C, Cao H, et al. Activation of IL-8 via PI3K/Akt-dependent pathway is involved in leptin-mediated epithelial-mesenchymal transition in human breast cancer cells. Cancer Biol Ther. 2015;16(8):1220–1230. doi: 10.1080/15384047.2015.1056409
   PubMed Web of Science ®Google Scholar
• Xu C, Dong L, Kang X, et al. Leptin promotes proliferation and inhibits apoptosis of prostate cancer cells by regulating ERK1/2 signaling pathway. Eur Rev Med Pharmacol Sci. 2020;24(16):8341–8348. doi: 10.26355/eurrev_202008_22630
   PubMed Web of Science ®Google Scholar
• Xu M, Cao F-L, Li N, et al. Leptin induces epithelial-to-mesenchymal transition via activation of the ERK signaling pathway in lung cancer cells. Oncol Lett. 2018;16(4):4782–4788. doi: 10.3892/ol.2018.9230
   PubMed Web of Science ®Google Scholar