949
Views
0
CrossRef citations to date
0
Altmetric
Original Research

Humoral complementomics – exploration of noninvasive complement biomarkers as predictors of renal cancer progression

, ORCID Icon, , , , , , , , , , , , , ORCID Icon & ORCID Icon show all
Article: 2328433 | Received 09 Oct 2023, Accepted 06 Mar 2024, Published online: 13 Mar 2024

References

  • Merle NS, Noe R, Halbwachs-Mecarelli L, Fremeaux-Bacchi V, et Roumenina LT. Complement system part II: role in immunity. Front Immunol. 2015;6:257. doi:10.3389/fimmu.2015.00257.
  • Roumenina LT, Daugan MV, Petitprez F, Sautès-Fridman C, et Fridman WH. Context-dependent roles of complement in cancer. Nat Rev Cancer. 2019 déc;19(12):698–14. doi:10.1038/s41568-019-0210-0.
  • Revel M, Daugan MV, Sautés-Fridman C, Fridman WH, et Roumenina LT. Complement system: promoter or suppressor of cancer progression?. Antibodies (Basel). 2020 oct;9(no 4):E57. doi:10.3390/antib9040057.
  • Roumenina LT, Daugan MV, Noé R, Petitprez F, Vano YA, Sanchez-Salas R, Becht E, Meilleroux J, Clec’h BL, Giraldo NA, et al. Tumor cells hijack macrophage-produced complement C1q to promote tumor growth. Cancer Immunol Res. 2019 juill;7(no 7):1091–1105. doi:10.1158/2326-6066.CIR-18-0891.
  • Daugan MV, Revel M, Russick J, Dragon-Durey M-A, Gaboriaud C, Robe-Rybkine T, Poillerat V, Grunenwald A, Lacroix G, Bougouin A, et al. Complement C1s and C4d as prognostic biomarkers in renal cancer: emergence of non-canonical functions of C1s. Cancer Immunol Res. 2021 mai;9(8):891–908. doi:10.1158/2326-6066.CIR-20-0532.
  • Daugan MV, Revel M, Thouenon R, Dragon-Durey M-A, Robe-Rybkine T, Torset C, Merle NS, Noé R, Verkarre V, Oudard SM, et al. Intracellular factor H drives tumor progression independently of the complement cascade. Cancer Immunol Res. 2021;9(8):909–925. mai. doi:10.1158/2326-6066.CIR-20-0787.
  • Ajona D, Okrój M, Pajares MJ, Agorreta J, Lozano MD, Zulueta JJ, Verri C, Roz L, Sozzi G, Pastorino U, et al. Complement C4d-specific antibodies for the diagnosis of lung cancer. Oncotarget. 2018 janv;9(5):6346–6355. doi:10.18632/oncotarget.23690.
  • Klikovits T, Stockhammer P, Laszlo V, Dong Y, Hoda MA, Ghanim B, Opitz I, Frauenfelder T, Nguyen-Kim TDL, Weder W, et al. Circulating complement component 4d (C4d) correlates with tumor volume, chemotherapeutic response and survival in patients with malignant pleural mesothelioma. Sci Rep. 2017 nov;7(no 1 Art.):16456. doi:10.1038/s41598-017-16551-7.
  • Amornsiripanitch N, Hong S, Campa MJ, Frank MM, Gottlin EB, et Patz EF. Complement factor H autoantibodies are associated with early stage NSCLC. Clin Cancer Res. 2010 juin;16(12):3226–3231. doi:10.1158/1078-0432.CCR-10-0321.
  • Bushey RT, Moody MA, Nicely NL, Haynes BF, Alam SM, Keir ST, Bentley RC, Roy Choudhury K, Gottlin EB, Campa MJ, et al. A therapeutic antibody for cancer, derived from single human B cells. Cell Rep. 2016 17;15(7):1505–1513. doi:10.1016/j.celrep.2016.04.038.
  • Campa MJ, Gottlin EB, Bushey RT, et Patz EF. Complement factor H antibodies from lung cancer patients induce complement-dependent lysis of tumor cells, suggesting a novel immunotherapeutic strategy. Cancer Immunol Res. 2015 déc.;3(12):1325–1332. doi:10.1158/2326-6066.CIR-15-0122.
  • King BC, Kulak K, Krus U, Rosberg R, Golec E, Wozniak K, Gomez MF, Zhang E, O’Connell DJ, Renström E, et al. Complement component C3 is highly expressed in human pancreatic islets and prevents β cell death via ATG16L1 interaction and autophagy regulation. Cell Metab. 2019 janv.;29(1):202–210.e6. doi:10.1016/j.cmet.2018.09.009.
  • Niyonzima N, Rahman J, Kunz N, West EE, Freiwald T, Desai JV, Merle NS, Gidon A, Sporsheim B, Lionakis MS, et al. Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation. Sci Immunol. 2021 déc.;6(66):eabf2489. doi:10.1126/sciimmunol.abf2489.
  • Yan B, Freiwald T, Chauss D, Wang L, West E, Mirabelli C, Zhang CJ, Nichols E-M, Malik N, Gregory R, et al. SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation. Sci Immunol. 2021 avr.;6(58):eabg0833. doi:10.1126/sciimmunol.abg0833.
  • Vasilev VV, Noe R, Dragon-Durey M-A, Chauvet S, Lazarov VJ, Deliyska BP, Fremeaux-Bacchi V, Dimitrov JD, Roumenina LT. Functional characterization of autoantibodies against complement component C3 in patients with lupus nephritis. J Biol Chem. 2015 oct;290(42):25343–25355. doi:10.1074/jbc.M115.647008.
  • Vasilev V, Artero MR, Petkova M, Mihaylova G, Dragon-Durey M-A, Radanova M, Roumenina LT. Clinical relevance of anti-C3 and anti-C4 autoantibodies in lupus nephritis. Kidney Int Reports. 2024. doi:10.1016/j.ekir.2024.01.052.
  • Marinozzi MC, Roumenina LT, Chauvet S, Hertig A, Bertrand D, Olagne J, Frimat M, Ulinski T, Deschênes G, Burtey S, et al. Anti-Factor B and Anti-C3b Autoantibodies in C3 Glomerulopathy and Ig-Associated Membranoproliferative GN. J Am Soc Nephrol. 2017;28(5):1603–1613. mai. doi:10.1681/ASN.2016030343.
  • Chauvet S, Berthaud R, Devriese M, Mignotet M, Vieira Martins P, Robe-Rybkine T, Miteva MA, Gyulkhandanyan A, Ryckewaert A, Louillet F, et al. Anti-factor B antibodies and acute postinfectious GN in children. J Am Soc Nephrol. 2020 avr.;31(4):829–840. doi:10.1681/ASN.2019080851.
  • Meuleman M-S, Duval A, Grunenwald A, Rezola Artero M, Dermani M, Peliconi J, Revel M, Vieira-Martins P, Courbebaisse M, Parfait B, et al. Usefulness and analytical performances of complement multiplex assay for measuring complement biomarkers in plasma. Clin Chim Acta. 2024 févr.;554:117750. doi:10.1016/j.cca.2023.117750.
  • Hurler L, Toonen EJM, Kajdácsi E, van Bree B, Brandwijk RJMGE, de Bruin W, Lyons PA, Bergamaschi L, Sinkovits G, Cervenak L, et al. Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs. Front Immunol. 2022;13:1039765. doi:10.3389/fimmu.2022.1039765.
  • Uzonyi B, Szabó Z, Trojnár E, Hyvärinen S, Uray K, Nielsen HH, Erdei A, Jokiranta TS, Prohászka Z, Illes Z, et al. Autoantibodies against the complement regulator factor H in the serum of patients with neuromyelitis optica spectrum disorder. Front Immunol. 2021;12:660382. doi:10.3389/fimmu.2021.660382.
  • Tibshirani R. Regression shrinkage and selection via the lasso. J R Stat Soc. 1996;58(1):267–288. doi:10.1111/j.2517-6161.1996.tb02080.x.
  • Simon N, Friedman J, Hastie T, et Tibshirani R. Regularization Paths for Cox’s Proportional Hazards Model via Coordinate Descent. J Stat Softw. 2011 mars;39(5):1–13. doi:10.18637/jss.v039.i05.
  • Reese B, Silwal A, Daugherity E, Daugherity M, Arabi M, Daly P, Paterson Y, Woolford L, Christie A, Elias R, et al. Complement as prognostic biomarker and potential therapeutic target in renal cell carcinoma. J Immunol. 2020 déc.;205(11):3218–3229. doi:10.4049/jimmunol.2000511.
  • Cooley LS, Rudewicz J, Souleyreau W, Emanuelli A, Alvarez-Arenas A, Clarke K, Falciani F, Dufies M, Lambrechts D, Modave E, et al. Experimental and computational modeling for signature and biomarker discovery of renal cell carcinoma progression. Mol Cancer. 2021 oct.;20(no 1):136. doi:10.1186/s12943-021-01416-5.
  • Zhang L, Jiang H, Xu G, Wen H, Gu B, Liu J, Mao S, Na R, Jing Y, Ding Q, et al. Proteins S100A8 and S100A9 are potential biomarkers for renal cell carcinoma in the early stages: results from a proteomic study integrated with bioinformatics analysis. Mol Med Rep. 2015 juin;11(6):4093–4100. doi:10.3892/mmr.2015.3321.
  • Daugan MV, Revel M, Lacroix L, Sautès-Fridman C, Fridman WH, et Roumenina LT. Complement detection in human tumors by immunohistochemistry and immunofluorescence. Methods Mol Biol. 2021;2227:191–203. doi:10.1007/978-1-0716-1016-9_18.
  • M M, Smoląg KI, Björk A, Gullstrand B, Okrój M, Leffler J, Jönsen A, Bengtsson AA, Blom AM. Plasma C4d as marker for lupus nephritis in systemic lupus erythematosus. Arthritis Res Ther. 2017 juin;19(no 1). doi:10.1186/s13075-017-1470-2.
  • Kraaij T, Nilsson SC, van Kooten C, Okrój M, Blom AM, et Teng YO. Measuring plasma C4D to monitor immune complexes in lupus nephritis, Lupus Sci Med, vol. 6, no 1, p. e000326, 2019, doi: 10.1136/lupus-2019-000326.
  • Kajdácsi E, Jandrasics Z, Veszeli N, Makó V, Koncz A, Gulyás D, Köhalmi KV, Temesszentandrási G, Cervenak L, Gál P, et al. Patterns of C1-Inhibitor/Plasma serine protease complexes in healthy humans and in hereditary angioedema patients. Front Immunol. 2020;11:794. doi:10.3389/fimmu.2020.00794.
  • Bushey RT, Gottlin EB, Campa MJ, et Patz EF Jr. Complement factor H protects tumor cell-derived exosomes from complement-dependent lysis and phagocytosis. PloS One. 2021 juin;16(no 6):e0252577. doi:10.1371/journal.pone.0252577.
  • Vasilev VV, Radanova M, Lazarov VJ, Dragon-Durey M-A, Fremeaux-Bacchi V, et Roumenina LT. Autoantibodies against C3b-functional consequences and disease relevance. Front Immunol. 2019;10:64. doi:10.3389/fimmu.2019.00064.
  • Shalapour S, Font-Burgada J, Di Caro G, Zhong Z, Sanchez-Lopez E, Dhar D, Willimsky G, Ammirante M, Strasner A, Hansel DE, et al. Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy. Nature. 2015 mai;521(7550):94–98. doi:10.1038/nature14395.
  • Teillaud J-L et Dieu-Nosjean M-C. Intratumoral plasma cells: more than a predictive marker of response to anti-PD-L1 treatment in lung cancer?. Cancer Cell. 2022 mars;40(3):240–243. doi:10.1016/j.ccell.2022.02.008.
  • Biswas S, Mandal G, Payne KK, Anadon CM, Gatenbee CD, Chaurio RA, Costich TL, Moran C, Harro CM, Rigolizzo KE, et al. IgA transcytosis and antigen recognition govern ovarian cancer immunity. Nature. 2021 mars;591(7850):464–470. doi:10.1038/s41586-020-03144-0.
  • Mandal G, Biswas S, Anadon CM, Yu X, Gatenbee CD, Prabhakaran S, Payne KK, Chaurio RA, Martin A, Innamarato P, et al. IgA-dominated humoral immune responses govern patients’ outcome in endometrial cancer. Cancer Res. 2022 mars;82(5):859–871. doi:10.1158/0008-5472.CAN-21-2376.
  • Juranić Z, Stanojević-Bakić N, Maletić V, et Borkovacki R. Immune reactive proteins in renal cell carcinoma patients treated by IFN alpha alone or in combination with vinblastine, Neoplasma, vol. 41, no 4, p. 229–232, 1994.
  • Magyarlaki T, Kiss B, Buzogány I, Fazekas A, Sükösd F, et Nagy J. Renal cell carcinoma and paraneoplastic IgA nephropathy. Nephron. 1999 juin;82(no 2):127–130. doi:10.1159/000045388.
  • Netti GS, Lucarelli G, Spadaccino F, Castellano G, Gigante M, Divella C, Rocchetti MT, Rascio F, Mancini V, Stallone G, et al. PTX3 modulates the immunoflogosis in tumor microenvironment and is a prognostic factor for patients with clear cell renal cell carcinoma. Aging (Albany NY). 2020 avr.;12(8):7585–7602. doi:10.18632/aging.103169.
  • Blok VT, Daha MR, Tijsma OM, Weissglas MG, van den Broek LJ, et Gorter A. A possible role of CD46 for the protection in vivo of human renal tumor cells from complement-mediated damage. Lab Invest. 2000 mars;80(3):335–344. doi:10.1038/labinvest.3780038.
  • Lucarelli G, Netti GS, Rutigliano M, Lasorsa F, Loizzo D, Milella M, Schirinzi A, Fontana A, Di Serio F, Tamma R, et al. MUC1 expression affects the immunoflogosis in renal cell carcinoma microenvironment through complement system activation and immune infiltrate modulation. Int J Mol Sci. 2023 mars;24(5):4814. doi:10.3390/ijms24054814.