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Human Vaccines & Immunotherapeutics Volume 20, 2024 - Issue 1
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Coronavirus

Allergy to PEG (polyethylene glycol) – sensitivity of basophil activation test with COVID-19 mRNA-vaccine BNT162B2

Bernadette EberleinDepartment of Dermatology and Allergy Biederstein, School of Medicine, Technical University of Munich, Munich, GermanyCorrespondence[email protected]
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,
Sonja MathesDepartment of Dermatology and Allergy Biederstein, School of Medicine, Technical University of Munich, Munich, GermanyView further author information
,
Ulf DarsowDepartment of Dermatology and Allergy Biederstein, School of Medicine, Technical University of Munich, Munich, GermanyView further author information
,
Tilo BiedermannDepartment of Dermatology and Allergy Biederstein, School of Medicine, Technical University of Munich, Munich, GermanyView further author information
&
Knut BrockowDepartment of Dermatology and Allergy Biederstein, School of Medicine, Technical University of Munich, Munich, GermanyView further author information
Article: 2312600 | Received 28 Dec 2023, Accepted 28 Jan 2024, Published online: 05 Feb 2024

References

  • Ieven T, Coorevits L, Vandebotermet M, Tuyls S, Vanneste H, Santy L, Wets D, Proost P, Frans G, Devolder D. et al. Endotyping of IgE-mediated polyethylene glycol and/or polysorbate 80 allergy. J Allergy Clin Immunol Pract. 2023;11(10):3146–5. doi:10.1016/j.jaip.2023.06.031.
  • Eberlein B, Mathes S, Fischer J, Darsow U, Biedermann T, Brockow K. Do basophil activation tests help elucidate allergic reactions to the ingredients in COVID-19 vaccines? Allergy. 2022;77(10):2924–36. doi:10.1111/all.15278.
  • Mayorga C, Çelik GE, Pascal M, Hoffmann HJ, Eberlein B, Torres MJ, Brockow K, Garvey LH, Barbaud A, Madrigal‐Burgaleta R. et al. Flow-based basophil activation test in drug hypersensitivity. Allergy. 2023 Dec 12. Online ahead of print. doi:10.1111/all.15957.
  • Brockow K, Mathes S, Fischer J, Volc S, Darsow U, Eberlein B, Biedermann T. Experience with polyethylene glycol allergy-guided risk management for COVID-19 vaccine anaphylaxis. Allergy. 2022;77(7):2200–10. doi:10.1111/all.15183.
  • Bruusgaard-Mouritsen MA, Jensen BM, Poulsen LK, Duus Johansen J, Garvey LH. Optimizing investigation of suspected allergy to polyethylene glycols. J Allergy Clin Immunol. 2022;149(1):168–75. doi:10.1016/j.jaci.2021.05.020.
  • Lim XR, Chan GYL, TaN JWL, Ng CYL, Chua CG, Tan GB, Chan SSW, Ong KH, Tan YZ, Tan SHZ. et al. Anaphylatoxin complement 5a in pfizer BNT162b2-induced immediate-type vaccine hypersensitivity reactions. Vaccines (Basel). 2023;11(6):1020. doi:10.3390/vaccines11061020.
  • Labella M, Céspedes JA, Dona I, Shamji MH, Agache I, Mayorga C, Torres MJ. The value of the basophil activation test in the evaluation of patients reporting allergic reactions to the BNT162b2 mRNA COVID-19 vaccine. Allergy. 2022;77(7):2067–79. doi:10.1111/all.15148.
  • Lorentzen CL, Haanan JB, Ö M, Svane IM. Clinical advances and ongoing trials on mRNA vaccines for cancer treatment. Lancet Oncol. 2022;23(10):450–8. doi:10.1016/S1470-2045(22)00372-2.

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