Eliciting specialized metabolites from marine microalgae using abiotic stress

References

• Ahamad, T. S., Brindhadevi, K., Krishnan, R., Phuong, T. N., Alharbi, S. A., Chinnathambi, A., & Mathimani, T. (2022). Invivo detection of triacylglycerols through Nile red staining and quantification of fatty acids in hyper lipid producer Nannochloropsis sp. cultured under adequate nitrogen and deficient nitrogen condition. Fuel, 322, 124179. doi:10.1016/j.fuel.2022.124179
   Web of Science ®Google Scholar
• Aldholmi, M., Ahmad, R., Carretero-Molina, D., Pérez-Victoria, I., Martín, J., and Ganesan, A. (2022). Euglenatides, potent antiproliferative cyclic peptides isolated from the freshwater photosynthetic microalga Euglena gracilis. Angewandte Chemie International Edition Engl, 61, e202203175. doi:10.1002/anie.202203175
   PubMed Web of Science ®Google Scholar
• AntiBase. (2021, 07 05) A bioinformatics tool for natural product databases | chemoinformatics databases. Retrieved from https://omictools.com/antibase-tool
   Google Scholar
• Atlantic Ocean | Definition, Temperature, Weather, & Facts. (2021). Retrieved from https://www.britannica.com/place/Atlantic-Ocean
   Google Scholar
• Baier, T., Wichmann, J., Kruse, O., & Lauersen, K. J. (2018). Intron-containing algal transgenes mediate efficient recombinant gene expression in the green microalga Chlamydomonas reinhardtii. Nucleic Acids Research, 46, 6909–6919. doi:10.1093/nar/gky532
   PubMed Web of Science ®Google Scholar
• Béchemin, C., Grzebyk, D., Hachame, F., Hummert, C., & Maestrini, S. (1999). Effect of different nitrogen/phosphorus nutrient ratios on the toxin content in Alexandrium minutum. Aquatic Microbial Ecology: International Journal, 20, 157–165. doi:10.3354/ame020157
   Web of Science ®Google Scholar
• Bjorn Bode, H.; Bethe, B.; Hofs, R.; Zeeck, A. (2002). Big effects from small changes: Possible ways to explore Nature’s chemical diversity. ChemBiochem, 3, 619–627. doi:10.1002/1439-7633(20020703)3:7
   PubMed Web of Science ®Google Scholar
• Cai, W.-J., Huang, W.-J., Luther, G. W., Pierrot, D., Li, M., … Kemp, W. M. 2017 Redox reactions and weak buffering capacity lead to acidification in the Chesapeake Bay. Nature Communications, 8, 369. doi:10.1038/s41467-017-00417-7
   PubMed Web of Science ®Google Scholar
• Carroll, A. R., Copp, B. R., Davis, R. A., Keyzers, R. A., & Prinsep, M. R. (2023). Marine natural products. Natural Product Reports, 40, 275–325. doi:10.1039/D2NP00083K
   PubMed Web of Science ®Google Scholar
• Chaffin, J. D., Bridgeman, T. B., & Bade, D. L. (2013). Nitrogen constrains the growth of Late Summer cyanobacterial blooms in Lake Erie. Advances in Microbiology, 03, 16–26. doi:10.4236/aim.2013.36A003
   Google Scholar
• Che, Y., Ding, L., Qiu, J., Ji, Y., & Li, A. (2020). Conversion and Stability of New metabolites of Paralytic Shellfish toxins under different Temperature and pH Conditions. Journal of Agricultural and Food Chemistry, 68, 1427–1435. doi:10.1021/acs.jafc.9b07063
   PubMed Web of Science ®Google Scholar
• Dunkel, M. (2006). SuperNatural: A searchable database of available natural compounds. Nucleic Acids Research, 34, D678–D683. doi:10.1093/nar/gkj132
   PubMed Web of Science ®Google Scholar
• Ernst, M., Kang, K. B., Caraballo-Rodríguez, A. M., Nothias, L.-F., Wandy, J.,… van der Hooft, J. J. J. (2019). MolNetEnhancer: Enhanced Molecular Networks by Integrating Metabolome Mining and Annotation Tools. Metabolites, 9(7), 144. doi:10.3390/metabo9070144
   PubMed Web of Science ®Google Scholar
• Falkenberg, L. J., Bellerby, R. G. J., Connell, S. D., Fleming, L. E., Maycock, B. … Dupont, S. (2020). Ocean acidification and human health. International Journal of Environmental Research and Public Health, 17, 4563. doi:10.3390/ijerph17124563
   PubMed Web of Science ®Google Scholar
• Fu, W., Nelson, D. R., Mystikou, A., Daakour, S., & Salehi-Ashtiani, K. (2019). Advances in microalgal Research and engineering development. Current Opinion in Biotechnology, 59, 157–164. doi:10.1016/j.copbio.2019.05.013
   PubMed Web of Science ®Google Scholar
• Horai, H., Arita, M., Kanaya, S., Nihei, Y., Ikeda, T., … Nishioka, T. (2010). MassBank: A public repository for sharing mass spectral data for life sciences. Journal of Mass Spectrometry: JMS, 45, 703–714. doi:10.1002/jms.1777.
   PubMed Web of Science ®Google Scholar
• Hort, V., Abadie, E., Arnich, N., Bottein, M.-Y. D., & Amzil, Z. (2021). Chemodiversity of Brevetoxins and other potentially toxic metabolites produced by Karenia spp. and their metabolic products in marine organisms. Marine Drugs, 19, 656. doi:10.3390/md19120656
   PubMed Web of Science ®Google Scholar
• Hwang, S.-W., Choi, H. I., & Sim, S. J. (2019). Acidic cultivation of Haematococcus pluvialis for improved astaxanthin production in the presence of a lethal fungus. Bioresource Technology, 278, 138–144. doi:10.1016/j.biortech.2019.01.080
   PubMed Web of Science ®Google Scholar
• Liska, A. J., Shevchenko, A., Pick, U., & Katz, A. 2004 Enhanced photosynthesis and redox energy production contribute to salinity tolerance in Dunaliella as revealed by homology-based proteomics. Plant Physiology, 136, 2806–2817. doi:10.1104/pp.104.039438
   PubMed Web of Science ®Google Scholar
• Li, J., Zhang, J., Huang, W., Kong, F., Li, Y., Xi, M., & Zheng, Z. (2016). Comparative bioavailability of ammonium, nitrate, nitrite and urea to typically harmful cyanobacterium Microcystis aeruginosa. Marine Pollution Bulletin, 110, 93–98. doi:10.1016/j.marpolbul.2016.06.077
   PubMed Web of Science ®Google Scholar
• MarinLit. (2021). A database of the marine natural products literature. Retrieved from http://pubs.rsc.org/marinlit/
   Google Scholar
• Mehar, M. U. N., Mudliar, J. G., Shekh, S. N., & Shekh, A. Y. (2019). Recent advances in microalgal bioactives for food, feed, and healthcare products: Commercial potential, market space, and sustainability. Comprehensive Reviews In Food Science And Food Safety, 18, 1882–1897. doi:10.1111/1541-4337.12500
   PubMed Web of Science ®Google Scholar
• Morel, F. M. M., Rueter, J. G., Anderson, D. M., & Guillard, R. R. L. (1979). Aquil: a chemically defined phytoplankton culture medium for trace metal studies. Journal of Phycology, 15, 135–141. doi:10.1111/j.1529-8817.1979.tb02976.x
   Web of Science ®Google Scholar
• Nagappan, S., Devendran, S., Tsai, P.-C., Jayaraman, H., Alagarsamy, V., Pugazhendhi, A., & Ponnusamy, V. K. (2020). Metabolomics Integrated with transcriptomics and proteomics: Evaluation of systems reaction to nitrogen deficiency stress in microalgae. Process Biochemistry, 91, 1–14. doi:10.1016/j.procbio.2019.11.027
   Web of Science ®Google Scholar
• Nothias, L.-F., Nothias-Esposito, M., da Silva, R., Wang, M., Protsyuk, I. , and Dorrestein, P. C. (2018). Bioactivity-based molecular networking for the discovery of drug leads in natural product Bioassay-Guided Fractionation. Journal of Natural Products, 81, 758–767. doi:10.1021/acs.jnatprod.7b00737
   PubMed Web of Science ®Google Scholar
• Nymark, M., Sharma, A. K., Sparstad, T., Bones, A. M., & Winge, P. (2016). A CRISPR/Cas9 system adapted for gene editing in marine algae. Scientific Reports, 6, 24951. doi:10.1038/srep24951
   PubMed Web of Science ®Google Scholar
• Pacific Ocean | Depth. (2021). Temperature, Animals, Location, Map, & Facts. Retrieved from https://www.britannica.com/place/Pacific-Ocean.
   Google Scholar
• Pluskal, T., Castillo, S., Villar-Briones, A., & Orešič, M. (2010). Mzmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data. BMC Bioinformatics, 11, 395. doi:10.1186/1471-2105-11-395
   PubMed Web of Science ®Google Scholar
• Poliner, E., Pulman, J. A., Zienkiewicz, K., Childs, K., Benning, C., & Farré, E. M. (2018). A toolkit for Nannochloropsis oceanica CCMP 1779 enables gene stacking and genetic engineering of the eicosapentaenoic acid pathway for enhanced Long‐chain polyunsaturated fatty acid production. Plant Biotechnology Journal, 16, 298–309. doi:10.1111/pbi.12772
   PubMed Web of Science ®Google Scholar
• Renaud, S. M., & Parry, D. L. (1994). Microalgae for use in tropical aquaculture II: Effect of salinity on growth, gross chemical composition and fatty acid composition of three species of marine microalgae. Journal of Applied Phycology, 6, 347–356. doi:10.1007/BF02181949
   Web of Science ®Google Scholar
• Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., & Schwikowski, B. (2003). Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Research, 13, 2498–2504. doi:10.1101/gr.1239303
   PubMed Web of Science ®Google Scholar
• Smayda, T. J. (2008). Complexity in the eutrophication–harmful algal bloom relationship, with comment on the importance of grazing. Harmful Algae, 8, 140–151. doi:10.1016/j.hal.2008.08.018
   Web of Science ®Google Scholar
• Tett, P., Droop, M. R., & Heaney, S. I. (1985). The Redfield ratio and phytoplankton growth rate. Journal of the Marine Biological Association of the United Kingdom, 65, 487–504. doi:10.1017/S0025315400050566
   Web of Science ®Google Scholar
• Teuma, L., Sanz-Luque, E., Guieysse, B., & Plouviez, M. (2023). Are microalgae new players in nitrous oxide emissions from eutrophic aquatic environments? Phycology, 3, 356–367. doi:10.3390/phycology3030023
   Google Scholar
• Wandy, J., Zhu, Y., van der Hooft, J. J. J., Daly, R., Barrett, M. P., & Rogers, S. M. O. (2018). Web-based topic modelling for substructure discovery in mass spectrometry. Bioinformatics, 34, 317–318. doi:10.1093/bioinformatics/btx582
   PubMed Web of Science ®Google Scholar
• Wang, M., Carver, J. J., Phelan, V. V., Sanchez, L. M., Garg, N. … Bandeira, N. (2016). Sharing and community curation of mass spectrometry data with global natural products social molecular networking. Nature Biotechnology, 34, 828–837. doi:10.1038/nbt.3597
   PubMed Web of Science ®Google Scholar
• Xi, Y., Kong, F., & Chi, Z. (2021). ROS induce β-carotene biosynthesis caused by changes of photosynthesis efficiency and energy metabolism in Dunaliella salina under stress conditions. Frontiers in Bioengineering and Biotechnology, 8, 613768. doi:10.3389/fbioe.2020.613768
   PubMed Web of Science ®Google Scholar
• Xu, Y., & Harvey, P. J. (2019). Carotenoid production by Dunaliella salina under red light. Antioxidants, 8, 123. doi:10.3390/antiox8050123
   Web of Science ®Google Scholar