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Drug Evaluations

Terbinafine: a pharmacological and clinical review

Pages 2723-2733 | Published online: 30 Oct 2009

Bibliography

  • Shear NH, Villars VV, Marsolais C. Terbinafine: an oral and topical antifungal agent. Clin Dermatol 1991;9:487-95
  • Elewski BE, Hay RJ. Update on the management of onychomycosis: highlights of the third annual international summit on cutaneous antifungal therapy. Clin Infect Dis 1996;23:305-13
  • Gupta AK, Cooper EA. Update in antifungal therapy of dermatophytosis. Mycopathologia 2008;166:353-67
  • Ryder NS. Activity of terbinafine against serious fungal pathogens. Mycoses 1999;42(Suppl 2):115-19
  • Gupta AK, Konnikov N, Lynde CW. Single-blind, randomized, prospective study on terbinafine and itraconazole for treatment of dermatophyte toenail onychomycosis in the elderly. J Am Acad Dermatol 2001;44:479-84
  • Elewski BE, Cáceres HW, DeLeon L, Terbinafine hydrochloride oral granules versus oral griseofulvin suspension in children with Tinea capitis: results of two randomized, investigator-blinded, multicenter, international, controlled trials. J Am Acad Dermatol 2008;59:41-54
  • Revankar SG, Nailor MD, Sobel JD. Use of terbinafine in rare and refractory mycoses. Future Microbiol 2008;3:9-17
  • Gupta AK, Ryder JE, Lynch LE, Tavakkol A. The use of terbinafine in the treatment of onychomycosis in adults and special populations: a review of the evidence. J Drugs Dermatol 2005;4:302-8
  • Favre B, Ryder NS. Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents. Antimicrob Agents Chemother 1996;40:443-7
  • Ryder NS. Terbinafine: mode of action and properties of the squalene epoxidase inhibition. Br J Dermatol 1992;126:2-7
  • Jensen JC. Clinical pharmacokinetics of terbinafine (Lamisil). Clin Exp Dermatol 1989;14:110-13
  • Schäfer-Korting M, Schoellmann C, Korting HC. Fungicidal activity plus reservoir effect allow short treatment courses with terbinafine in tinea pedis. Skin Pharmacol Physiol 2008;21:203-10
  • Zehender H, Cabiac MD, Denouël J, Elimination kinetics of terbinafine from human plasma and tissues following multiple-dose administration, and comparison with 3 main metabolites. Drug Invest 1994;8:203-10
  • Balfour JA, Faulds D. Terbinafine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in superficial mycoses. Drugs 1992;43:259-84
  • Kovarik JM, Mueller EA, Zehender H, Multiple-dose pharmacokinetics and distribution in tissue of terbinafine and metabolites. Antimicrob Agents Chemother 1995;39:2738-41
  • Faergemann J, Zehender H, Denouël J, Millerioux L. Levels of terbinafine in plasma, stratum corneum, dermis-epidermis (without stratum corneum), sebum, hair and nails during and after 250 mg terbinafine orally once per day for four weeks. Acta Derm Venereol 1993;73:305-9
  • Nedelman JR, Gibiansky E, Robbins BA, Pharmacokinetics and pharmacodynamics of multiple-dose terbinafine. J Clin Pharmacol 1996;36:452-61
  • Finlay AY. Pharmacokinetics of terbinafine in the nail. Br J Dermatol 1992;126(Suppl 39):28-32
  • Torres-Rodriguez JM, Madrenys-Brunet N, Urrea-Arbeláez A, Lopez-Jodra O. Oral terbinafine for the Tinea unguium of the toenails. Efficacy between 12 and 24 weeks of treament. Rev Iberoam Micol 1998;15:160-2
  • Takahata Y, Hiruma M, Shiraki Y, Treatment of dermatophyte onychomycosis with three pulses of terbinafine (500 mg day for a week). Mycoses 2009;52:72-6
  • Gupta AK, Gover MD, Lynde CW. Pulse itraconazole vs. continuous terbinafine for the treatment of dermatophyte toenail onychomycosis in patients with diabetes mellitus. J Eur Acad Dermatol Venereol 2006;20:1188-93
  • Nardo Zaias MD, Gerbert Rebell MS. The successful treatment of Trichophyton rubrum nail bed (distal subungual) onychomycosis with intermittent pulse-dosed terbinafine. Arch Dermatol 2004;140:691-95
  • Hall M, Monka C, Krupp P, O'Sullivan D. Safety of oral terbinafine: results of a post-marketing surveillance study in 25884 patients. Arch Dermatol 1997;133:1213-19
  • Yülek F, Cagil N, Cakmak HB, Bilateral anterior optic neuropathy associated with use of terbinafine. Clin Exp Ophthalmol 2008;36:488-9
  • Tokuyama Y, Senoh A, Setsu N, Iwatsuki K. Pustular psoriasis induced by terbinafine: differential diagnosis from acute generalized exanthematous pustulosis. Eur J Dermatol 2008;18:725-6
  • Magro CM, Schaefer JT, Waldman J, Terbinafine-induced dermatomyositis: a case report and literature review of drug-induced dermatomyositis. J Cutan Pathol 2008;35:74-81
  • Paredes AH, Lewis JH. Terbinafine-induced acute autoimmune hepatitis in the setting of hepatitis B virus infection. Ann Pharmacother 2007;41:880-4
  • Perveze Z, Johnson MW, Rubin RA, Terbinafine-induced hepatic failure requiring liver transplantation. Liver Transpl 2007;13:162-4
  • Vickers AE, Sinclair JR, Zollinger M, Multiple cytochrome P-450s involved in the metabolism of terbinafine suggest a limited potential for drug-drug interactions. Drug Metab Dispos 1999;27:1029-38
  • Madani S, Barilla D, Cramer J, Effect of terbinafine on the pharmacokinetics and pharmacodynamics of desipramine in healthy volunteers identified as cytochrome P450 2D6 (CYP2D6) extensive metabolizers. J Clin Pharmacol 2002;42:1211-18
  • Tarral A, Francheteau P, Guerret M. Effects of terbinafine on the pharmacokinetics of digoxin in healthy volunteers. Pharmacotherapy 1997;17:791-5
  • Guerret M, Francheteau P, Hubert M. Evaluation of effects of terbinafine on single oral dose pharmacokinetics and anticoagulant actions of warfarin in healthy volunteers. Pharmacotherapy 1997;17:767-73
  • Lo AC, Lui SL, Lo WK, The interaction of terbinafine and cyclosporine A in renal transplant patients. Br J Clin Pharmacol 1997;43:340-1
  • Carrillo-Muñoz AJ, Gustavo Giusiano G, Cárdenes D, Terbinafine susceptibility patterns for onychomycosis-causative dermatophytes and Scopulariopsis brevicaulis. Int J Antimicrob Agents 2008;31:540-3
  • Ghannoum MA, Arthington-Skaggs B, Chaturvedi V, Interlaboratory study of quality control isolates for a broth microdilution method (modified CLSI M38-A) for testing susceptibilities of dermatophytes to antifungals. J Clin Microbiol 2006;44:4353-6
  • Figueiredo VT, de Assis Santos D, Resende MA, Hamdan JS. Identification and in vitro antifungal susceptibility testing of 200 clinical isolates of Candida spp. responsible for fingernail infections. Mycopathologia 2007;164:27-33
  • Córdoba S, Rodero L, Vivot W, In vitro interactions of antifungal agents against clinical isolates of Fusarium spp. Int J Antimicrob Agents 2008;31:171-4
  • Meinerz AR, Nascente Pda S, Schuch LF, In vitro susceptibility of isolates of Sporothrix schenckii to terbinafine and itraconazole. Rev Soc Bras Med Trop 2007;40:60-2
  • Queiroz-Telles F, Esterre P, Perez-Blanco M, Chromoblastomycosis: an overview of clinical manifestations, diagnosis and treatment. Med Mycol 2009;47:3-15
  • Vitale RG, Perez-Blanco M, De Hoog GS. In vitro activity of antifungal drugs against Cladophialophora species associated with human chromoblastomycosis. Med Mycol 2009;47:35-40
  • Ford JG, Agee S, Greenhaw ST. Successful medical treatment of a case of Paecilomyces lilacinus keratitis. Cornea 2008;27:1077-9
  • McGinnis MR, Nordoff NG, Ryder NS, Nunn GB. In vitro comparison of terbinafine and itraconazole against Penicillium marneffei. Antimicrob Agents Chemother 2000;44:1407-8
  • Contini C, Manganaro M, Romani R, Activity of terbinafine against Pneumocystis carinii in vitro and its efficacy in the treatment of experimental pneumonia. J Antimicrob Chemother 1994;34:727-35
  • Jessup CJ, Ghannoum MA, Ryder NS. An evaluation of the in vitro activity of terbinafine. Med Mycol 2000;38:155-9
  • Ryder NS, Wagner S, Leitner I. In vitro activities of terbinafine against cutaneous isolates of Candida albicans and other pathogenic yeasts. Antimicrob Agents Chemother 1998;42:1057-61
  • Dannaoui E, Meletiadis J, Mouton JW, ; Eurofung Network. In vitro susceptibilities of zygomycetes to conventional and new antifungals. J Antimicrob Chemother 2003;51:45-52
  • Ghannoum MA, Long L, Pfister WR. Determination of the efficacy of terbinafine hydrochloride nail solution in the topical treatment of dermatophytosis in a guinea pig model. Mycoses 2009;52:35-43
  • Petranyi G, Meingassner JG, Mieth H. Activity of terbinafine in experimental fungal infections of laboratory animals. Antimicrob Agents Chemother 1987;31:1558-61
  • Walzer PD, Ashbaugh A. Use of terbinafine in mouse and rat models of Pneumocystis carinii pneumonia. Antimicrob Agents Chemother 2002;46:514-16
  • Contini C, Colombo D, Cultrera R, Employment of terbinafine against Pneumocystis carinii infection in rat models. Br J Dermatol 1996;134(Suppl 46):30-2
  • Sorenson KN, Sobel RA, Clemons KV, Comparative efficacies of terbinafine and FLZ in treatment of experimental coccidioidal meningitis in a rabbit model. Antimicrob Agents Chemother 2000;44:3087-91
  • Schmitt HJ, Andrade J, Edwards F, Inactivity of terbinafine in a rat model of pulmonary aspergillosis. Eur J Clin Microbiol Infect Dis 1990;9:832-5
  • Kirkpatrick WR, Vallor AC, McAtee RK, Combination therapy with terbinafine and amphotericin B in a rabbit model of experimental invasive aspergillosis. Antimicrob Agents Chemother 2005;49:4751-3
  • Urbina JA, Lazardi K, Marchan E, Mevinolin (lovastatin) potentiates the antiproliferative effects of ketoconazole and terbinafine against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies. Antimicrob Agents Chemother 1993;37:580-91
  • Ford JG, Agee S, Greenhaw ST. Successful medical treatment of a case of Paecilomyces lilacinus keratitis. Cornea 2008;27:1077-9
  • Chang BP, Sun PL, Huang FY, Paecilomyces lilacinus peritonitis complicating peritoneal dialysis cured by oral voriconazole and terbinafine combination therapy. J Med Microbiol 2008;57:1581-4
  • Kurzai O, Vaeth T, Hamelmann W, Combined surgical and antifungal treatment of a subcutaneous infection due to Paecilomyces lilacinus. Med Mycol 2003;41:253-8
  • Ghannoum MA, Elewski B. Successful treatment of FLZ-resistant oropharyngeal candidiasis by a combination of fluconazole and terbinafine. Clin Diagn Lab Immunol 1999;6:921-3
  • Rothe A, Seibold M, Hoppe T, Combination therapy of disseminated Fusarium oxysporum infection with terbinafine and amphotericin B. Ann Hematol 2004;83:394-7
  • Neuburger S, Massenkeil G, Seibold M, Successful salvage treatment of disseminated cutaneous fusariosis with liposomal amphotericin B and terbinafine after allogeneic stem cell transplantation. Transpl Infect Dis 2008;10:290-3
  • Schiraldi GF, Cicero SL, Colombo MD, Refractory pulmonary aspergillosis: compassionate trial with terbinafine. Br J Dermatol 1996;134(Suppl 46):25-9
  • Schiraldi GF, Colombo MD, Harari S, Terbinafine in the treatment of non-immunocompromised compassionate cases of bronchopulmonary aspergillosis. Mycoses 1996;39:5-12
  • Hiromoto A, Nagano T, Nishigori C. Cutaneous infection caused by Curvularia species in an immunocompetent patient. Br J Dermatol 2008;158:1374-5
  • Sun ST, Wang LY, Xu J, The clinical and pathogenic characteristics of keratitis caused by Alternaria alternata. Zhonghua Yan Ke Za Zhi 2007;43:32-5
  • Rallis E, Frangoulis E. Successful treatment of subcutaneous phaeohyphomycosis owing to Exophiala jeanselmei with oral terbinafine. Int J Dermatol 2006;45:1369-70
  • Zhang J, Xi L, Lu C, Successful treatment for chromoblastomycosis caused by Fonsecaea monophora: a report of three cases in Guangdong, China. Mycoses 2009;52:176-81
  • Gupta AK, Taborda PR, Sanzova AD. Alternate week and combination itraconazole and terbinafine therapy for chromoblastomycosis caused by Fonsecaea pedrosoi in Brazil. Med Mycol 2002;40:529-34
  • Sriaroon C, Vincent AL, Silapunt S, Successful treatment of subcutaneous Scytalidium hyalinum infection with voriconazole and topical terbinafine in a cardiac transplant patient. Transplantation 2008;85:780-2
  • Li JY, Yong TY, Grove DI, Coates PT. Successful control of Scedosporium prolificans septic arthritis and probable osteomyelitis without radical surgery in a long-term renal transplant recipient. Transpl Infect Dis 2008;10:63-5
  • Bhat SV, Paterson DL, Rinaldi MG, Veldkamp PJ. Scedosporium prolificans brain abscess in a patient with chronic granulomatous disease: successful combination therapy with voriconazole and terbinafine. Scand J Infect Dis 2007;39:87-90
  • Gosbell IB, Toumasatos V, Yong J, Cure of orthopaedic infection with Scedosporium prolificans, using voriconazole plus terbinafine, without the need for radical surgery. Mycoses 2003;46:233-6
  • Howden BP, Slavin MA, Schwarer AP, Mijch AM. Successful control of disseminated Scedosporium prolificans infection with a combination of voriconazole and terbinafine. Eur J Clin Microbiol Infect Dis 2003;22:111-13
  • Kesson AM, Bellemore MC, O'Mara TJ, Scedosporium prolificans osteomyelitis in an immunocompetent child treated with a novel agent, hexadecylphospocholine (miltefosine), in combination with terbinafine and voriconazole: a case report. Clin Infect Dis 2009;48:1257-61
  • Perez A. Terbinafine: broad spectrum of indications in several subcutaneous and systemic parasitic diseases. Mycoses 1999;42:111-14
  • Neoh CY, Tan SH, Perera P. Cutaneous phaeohyphomycosis due to Cladophialophora bantiana in an immunocompetent patient. Clin Exp Dermatol 2007;32:539-40
  • Shenep JL, English BK, Kaufman L, Successful medical therapy for deeply invasive facial infection due to Pythium insidiosum in a child. Clin Infect Dis 1998;27:1388-93
  • Meletiadis J, Mouton JW, Rodriguez-Tudela JL, In vitro interaction of terbinafine with itraconazole against clinical isolates of Scedosporium prolificans. Antimicrob Agents Chemother 2000;44:470-2
  • Meletiadis J, Mouton JW, Meis JF, Verweij PE. In vitro drug interaction modeling of combinations of azoles with terbinafine against clinical Scedosporium prolificans isolates. Antimicrob Agents Chemother 2003;47:106-17
  • Meletiadis J, Mouton JW, Meis JF, Verweij PE. Combination chemotherapy for the treatment of invasive infections by Scedosporium prolificans. Clin Microbiol Infect 2000;6:336-7
  • Shalit I, Shadkchan Y, Mircus G, Osherov N. In vitro synergy of caspofungin with licensed and novel antifungal drugs against clinical isolates of Fusarium spp. Med Mycol 2008;13:1-6
  • Li L, Wang Z, Li R, In vitro evaluation of combination antifungal activity against Fusarium species isolated from ocular tissues of keratomycosis patients. Am J Ophthalmol 2008;146:724-8
  • Argenta JS, Santurio JM, Alves SH, In vitro activities of voriconazole, itraconazole, and terbinafine alone or in combination against Pythium insidiosum isolates from Brazil. Antimicrob Agents Chemother 2008;52:767-9
  • Weig M, Müller FM. Synergism of voriconazole and terbinafine against Candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis. Antimicrob Agents Chemother 2001;45:966-8
  • Perea S, Gonzalez G, Fothergill AW, In vitro activities of terbinafine in combination with fluconazole, itraconazole, voriconazole, and posaconazole against clinical isolates of Candida glabrata with decreased susceptibility to azoles. J Clin Microbiol 2002;40:1831-3
  • Barchiesi F, Falconi Di Francesco L, Scalise G. In vitro activities of terbinafine in combination with fluconazole and itraconazole against isolates of Candida albicans with reduced susceptibility to azoles. Antimicrob Agents Chemother 1997;41:1812-14
  • Cantón E, Pemán J, Gobernado M, Synergistic activities of fluconazole and voriconazole with terbinafine against four Candida species determined by checkerboard, time-kill, and Etest methods. Antimicrob Agents Chemother 2005;49:1593-6
  • Gómez-López A, Cuenca-Estrella M, Mellado E, Rodríguez-Tudela JL. In vitro evaluation of combination of terbinafine with itraconazole or amphotericin B against Zygomycota. Diagn Microbiol Infect Dis 2003;45:199-202
  • Dannaoui E, Afeltra J, Meis JF, Verweij PE; Eurofung Network. In vitro susceptibilities of zygomycetes to combinations of antimicrobial agents. Antimicrob Agents Chemother 2002;46:2708-11
  • Mosquera J, Sharp A, Moore CB, In vitro interaction of terbinafine with itraconazole, fluconazole, amphotericin B and 5-flucytosine against Aspergillus spp. J Antimicrob Chemother 2002;50:189-94
  • Ryder NS, Leitner I. Synergistic interaction of terbinafine with triazoles or amphotericin B against Aspergillus species. Med Mycol 2001;39:91-5
  • Cuenca-Estrella M, Gomez-Lopez A, Buitrago MJ, In vitro activities of 10 combinations of antifungal agents against the multiresistant pathogen Scopulariopsis brevicaulis. Antimicrob Agents Chemother 2006;50:2248-50
  • Rangel H, Dagger F, Hernandez A, Naturally azole-resistant Leishmania braziliensis promastigotes are rendered susceptible in the presence of terbinafine: comparative study with azole-susceptible Leishmania mexicana promastigotes. Antimicrob Agents Chemother 1996;40:2785-91
  • Martinez-Rossi NM, Peres NT, Rossi A. Antifungal resistance mechanisms in dermatophytes. Mycopathologia 2008;166:369-83
  • Fachin AL, Ferreira-Nozawa MS, Maccheroni WJr, Martinez-Rossi NM. Role of the ABC transporter TruMDR2 in terbinafine, 4-nitroquinoline N-oxide and ethidium bromide susceptibility in Trichophyton rubrum. J Med Microbiol 2006;55:1093-9
  • Rocha EM, Gardiner RE, Park S, A Phe389Leu substitution in ergA confers terbinafine resistance in Aspergillus fumigatus. Antimicrob Agents Chemother 2006;50:2533-6
  • Osborne CS, Leitner I, Favre B, Ryder NS. Amino acid substitution in Trichophyton rubrum squalene epoxidase associated with resistance to terbinafine. Antimicrob Agents Chemother 2005;49:2840-4
  • Liu W, May GS, Lionakis MS, Extra copies of the Aspergillus fumigatus squalene epoxidase gene confer resistance to terbinafine: genetic approach to studying gene dose-dependent resistance to antifungals in A. fumigatus. Antimicrob Agents Chemother 2004;48:2490-6
  • Mukherjee PK, Leidich SD, Isham N, Clinical Trichophyton rubrum strain exhibiting primary resistance to terbinafine. Antimicrob Agents Chemother 2003;47:82-6
  • de Assis Santos D, de Carvalho Araujo RA, Kohler LM, Molecular typing and antifungal susceptibility of Trichophyton rubrum isolates from patients with onychomycosis pre- and post-treatment. Int J Antimicrob Agents 2007;29:563-9
  • Garcia-Effron G, Gomez-Lopez A, Mellado E, In vitro activity of terbinafine against medically important non-dermatophyte species of filamentous fungi. J Antimicrob Chemother 2004;53:1086-9
  • Krishnan-Natesan S, Chandrasekar PH, Manavathu EK, Revankar SG. Successful treatment of primary cutaneous Aspergillus ustus infection with surgical debridement and a combination of voriconazole and terbinafine. Diagn Microbiol Infect Dis 2008;62:443-6
  • Stiller MJ, Teperman L, Rosenthal SA, Primary cutaneous infection by Aspergillus ustus in a 62-year-old liver transplant recipient. J Am Acad Dermatol 1994;31:344-7
  • Bruynzeel I, Starink TM. Granulomatous skin infection caused by Scopulariopsis brevicularis. J Am Acad Dermatol 1998;39:365-7
  • Destino L, Sutton DA, Helon AL, Severe osteomyelitis caused by Myceliophthora thermophila after a pitchfork injury. Ann Clin Microbiol Antimicrob 2006;5:21

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