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Miscellaneous

Miglitol, a new α-glucosidase inhibitor

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Pages 149-156 | Published online: 24 Feb 2005

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  • ••Extensive review of the pharmocokinetics of miglitol
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  • •Interesting study showing difference of affinities of miglitol for digestive enzymes.
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  • •Compares the effects of acarbose and miglitol on cataract formation in sand rats.
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  • •Assessment of the real risk of long-term use of miglitol.
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  • •This study demonstrates that for the day to day use of miglitol a dietary advice concerning the dietary starch content is not necessary.
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  • •Placebo-controlled study demonstrating that there are no extra-intestinal effects of miglitol.
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  • •Extensive study using an important number of patients and different doses of miglitol. Systemic effects are not present.
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  • •This study demonstrates that miglitol cannot prevent the noctural rise of blood glucose in Type 2 diabetes patients.
  • RENARD E, PARER-RICHARD C, RICHARD J-L, JUREIDINI S, ORSETTI A, MIROUZE J: Effect of miglitol (Bay m 1099) a new a-glucosidase inhibitor, on glucose, insulin, C-peptide and GIP responses to an oral sucrose load in patients with post-prandial hypoglycaemic symptoms. Diab. Metabol (1991) 17:355–362.
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  • ••Placebo-controlled study in a population with highprevalence of Type 2 diabetes.
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  • •This study demonstrated the usefulness of miglitol in this particular population
  • JOHNSTON PS, CONIFF RF, HOOGWERF BJ, SANTIAGOJV, XAVIER PI-SUNYER, KROL A: Effects of the carbohy-drase inhibitor miglitol in sulphonylurea-treated NIDDM patients. Diabetes Care (1994) 17:20–29.
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  • •This study demonstarted that miglitol was not superior to a frequently-used sulphonylurea compound. Glibenclamide gave a greater reduction of HbAl c.
  • SCHNACK C, PRAGER RJF, WINKLER J, KLAUSER RM, SCHNEIDER BG, SCHERNTHANER G: Effects of 8-wk a-glucosidase inhibition on metabolic control, C-peptide secretion, hepatic glucose output, and peripheral insulin sensitivity in poorly controlled Type II diabetic patients. Diabetes Care (1989) 12:537–543.
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  • •Improvement of glycaemic control could increase insulin sensitivity. Smoothing postprandial blood glucose levels by miglitol could have this consequence. This study could not demonstrate a change in insulin sensitivity, probably caused by the limited reduction of blood glucose levels by miglitol.
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