Regulation of CYP1A1 by heavy metals and consequences for drug metabolism

Bibliography

• Nebert DW, Duffy JJ. How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction and development, and in environmental toxicity, cancer, and oxidative stress. Biochem pharmacol 1997;53(3):249-54
   PubMed Web of Science ®Google Scholar
• Rivera SP, Saarikoski ST, Hankinson O. Identification of a novel dioxin-inducible cytochrome P450. Mol pharmacol 2002;61(2):255-9
   PubMed Web of Science ®Google Scholar
• Fukunaga BN, Probst MR, Reisz-Porszasz S, Hankinson O. Identification of functional domains of the aryl hydrocarbon receptor. J Biol Chem 1995;270(49):29270-8
   PubMed Web of Science ®Google Scholar
• Schmidt JV, Bradfield CA. Ah receptor signaling pathways. Annu Rev Cell Dev Biol 1996;12:55-89
   PubMed Web of Science ®Google Scholar
• Schmidt JV, Carver LA, Bradfield CA. Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment. J Biol Chem 1993;268(29):22203-9
   PubMed Web of Science ®Google Scholar
• Schmidt JV, Su GH, Reddy JK, et al. Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development. Proc Natl Acad Sci USA 1996;93(13):6731-6
   PubMed Web of Science ®Google Scholar
• Kazlauskas A, Sundstrom S, Poellinger L, Pongratz I. The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor. Mol Cell Biol 2001;21(7):2594-607
   PubMed Web of Science ®Google Scholar
• Dolwick KM, Swanson HI, Bradfield CA. In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition. Proc Natl Acad Sci USA 1993;90(18):8566-70
   PubMed Web of Science ®Google Scholar
• Kazlauskas A, Poellinger L, Pongratz I. Evidence that the co-chaperone p23 regulates ligand responsiveness of the dioxin (Aryl hydrocarbon) receptor. J Biol Chem 1999;274(19):13519-24
   PubMed Web of Science ®Google Scholar
• Kazlauskas A, Poellinger L, Pongratz I. The immunophilin-like protein XAP2 regulates ubiquitination and subcellular localization of the dioxin receptor. J Biol Chem 2000;275(52):41317-24
   PubMed Web of Science ®Google Scholar
• Ikuta T, Eguchi H, Tachibana T, et al. Nuclear localization and export signals of the human aryl hydrocarbon receptor. J Biol Chem 1998;273(5):2895-904
   PubMed Web of Science ®Google Scholar
• Denison MS, Nagy SR. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol 2003;43:309-34
   PubMed Web of Science ®Google Scholar
• Hines RN, Mathis JM, Jacob CS. Identification of multiple regulatory elements on the human cytochrome P450IA1 gene. Carcinogenesis 1988;9(9):1599-605
   PubMed Web of Science ®Google Scholar
• Monostory K, Kohalmy K, Prough RA, et al. The effect of synthetic glucocorticoid, dexamethasone on CYP1A1 inducibility in adult rat and human hepatocytes. FEBS Lett 2005;579(1):229-35
   PubMed Web of Science ®Google Scholar
• Hazinski TA, Noisin E, Hamon I, DeMatteo A. Sheep lung cytochrome P4501A1 (CYP1A1): cDNA cloning and transcriptional regulation by oxygen tension. J Clin Invest 1995;96(4):2083-9
   PubMed Web of Science ®Google Scholar
• Sadek CM, Allen-Hoffmann BL. Cytochrome P450IA1 is rapidly induced in normal human keratinocytes in the absence of xenobiotics. J Biol Chem 1994;269(23):16067-74
   PubMed Web of Science ®Google Scholar
• Sadek CM, Allen-Hoffmann BL. Suspension-mediated induction of Hepa 1c1c7 Cyp1a-1 expression is dependent on the Ah receptor signal transduction pathway. J Biol Chem 1994;269(50):31505-9
   PubMed Web of Science ®Google Scholar
• Crawford RB, Holsapple MP, Kaminski NE. Leukocyte activation induces aryl hydrocarbon receptor up-regulation, DNA binding, and increased Cyp1a1 expression in the absence of exogenous ligand. Mol pharmacol 1997;52(6):921-7
   PubMed Web of Science ®Google Scholar
• Singh SS, Hord NG, Perdew GH. Characterization of the activated form of the aryl hydrocarbon receptor in the nucleus of HeLa cells in the absence of exogenous ligand. Arch Biochem Biophys 1996;329(1):47-55
   PubMed Web of Science ®Google Scholar
• Richter CA, Tillitt DE, Hannink M. Regulation of subcellular localization of the aryl hydrocarbon receptor (AhR). Arch Biochem Biophys 2001;389(2):207-17
   PubMed Web of Science ®Google Scholar
• Oesch-Bartlomowicz B, Huelster A, Wiss O, et al. Aryl hydrocarbon receptor activation by cAMP vs. dioxin: divergent signaling pathways. Proc Natl Acad Sci USA 2005;102(26):9218-23
   PubMed Web of Science ®Google Scholar
• Ikuta T, Kobayashi Y, Kawajiri K. Phosphorylation of nuclear localization signal inhibits the ligand-dependent nuclear import of aryl hydrocarbon receptor. Biochem Biophys Res Commun 2004;317(2):545-50
   PubMed Web of Science ®Google Scholar
• Adachi J, Mori Y, Matsui S, et al. Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine. J Biol Chem 2001;276(34):31475-8
   PubMed Web of Science ®Google Scholar
• Heath-Pagliuso S, Rogers WJ, Tullis K, et al. Activation of the Ah receptor by tryptophan and tryptophan metabolites. Biochemistry 1998;37(33):11508-15
   PubMed Web of Science ®Google Scholar
• Phelan D, Winter GM, Rogers WJ, et al. Activation of the Ah receptor signal transduction pathway by bilirubin and biliverdin. Arch Biochem Biophys 1998;357(1):155-63
   PubMed Web of Science ®Google Scholar
• Sinal CJ, Bend JR. Aryl hydrocarbon receptor-dependent induction of cyp1a1 by bilirubin in mouse hepatoma hepa 1c1c7 cells. Mol Pharmacol 1997;52(4):590-9
   PubMed Web of Science ®Google Scholar
• Schaldach CM, Riby J, Bjeldanes LF. Lipoxin A4: a new class of ligand for the Ah receptor. Biochemistry 1999;38(23):7594-600
   PubMed Web of Science ®Google Scholar
• Seidel SD, Winters GM, Rogers WJ, et al. Activation of the Ah receptor signaling pathway by prostaglandins. J Biochem Mol Toxicol 2001;15(4):187-96
   PubMed Web of Science ®Google Scholar
• Nebert DW, Gelboin HV. The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states. Arch Biochem Biophys 1969;134(1):76-89
   PubMed Web of Science ®Google Scholar
• Nebert DW, Gielen JE. Genetic regulation of aryl hydrocarbon hydroxylase induction in the mouse. Federation Proc 1972;31(4):1315-25
   PubMedGoogle Scholar
• Nebert DW, Dalton TP, Okey AB, Gonzalez FJ. Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J Biol Chem 2004;279(23):23847-50
   PubMed Web of Science ®Google Scholar
• Hankinson O. Role of coactivators in transcriptional activation by the aryl hydrocarbon receptor. Arch Biochem Biophys 2005;433(2):379-86
   PubMed Web of Science ®Google Scholar
• Kobayashi A, Sogawa K, Fujii-Kuriyama Y. Cooperative interaction between AhR.Arnt and Sp1 for the drug-inducible expression of CYP1A1 gene. J Biol Chem 1996;271(21):12310-6
   PubMed Web of Science ®Google Scholar
• Kumar MB, Tarpey RW, Perdew GH. Differential recruitment of coactivator RIP140 by Ah and estrogen receptors. Absence of a role for LXXLL motifs. J Biol Chem 1999;274(32):22155-64
   PubMed Web of Science ®Google Scholar
• Kumar MB, Perdew GH. Nuclear receptor coactivator SRC-1 interacts with the Q-rich subdomain of the AhR and modulates its transactivation potential. Gene Expr 1999;8(5-6):273-86
   PubMed Web of Science ®Google Scholar
• Beischlag TV, Wang S, Rose DW, et al. Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex. Mol Cell Biol 2002;22(12):4319-33
   PubMed Web of Science ®Google Scholar
• Nguyen TA, Hoivik D, Lee JE, Safe S. Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex. Arch Biochem Biophys 1999;367(2):250-7
   PubMed Web of Science ®Google Scholar
• Rushing SR, Denison MS. The silencing mediator of retinoic acid and thyroid hormone receptors can interact with the aryl hydrocarbon (Ah) receptor but fails to repress Ah receptor-dependent gene expression. Arch Biochem Biophys 2002;403(2):189-201
   PubMed Web of Science ®Google Scholar
• Wang S, Hankinson O. Functional involvement of the Brahma/SWI2-related gene 1 protein in cytochrome P4501A1 transcription mediated by the aryl hydrocarbon receptor complex. J Biol chem 2002;277(14):11821-7
   PubMed Web of Science ®Google Scholar
• Kobayashi A, Numayama-Tsuruta K, Sogawa K, Fujii-Kuriyama Y. CBP/p300 functions as a possible transcriptional coactivator of Ah receptor nuclear translocator (Arnt). J Biochem 1997;122(4):703-10
   PubMed Web of Science ®Google Scholar
• Anwar-Mohamed A, El-Kadi AO. Sulforaphane induces CYP1A1 mRNA, protein, and catalytic activity levels via an AhR-dependent pathway in murine hepatoma Hepa 1c1c7 and human HepG2 cells. Cancer Lett 2009;275(1):93-101
   PubMed Web of Science ®Google Scholar
• Sardana MK, Drummond GS, Sassa S, Kappas A. The potent heme oxygenase inducing action of arsenic and parasiticidal arsenicals. Pharmacology 1981;23(5):247-53
   PubMed Web of Science ®Google Scholar
• Itoh K, Chiba T, Takahashi S, et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 1997;236(2):313-22
   PubMed Web of Science ®Google Scholar
• Ma Q, Kinneer K, Bi Y, et al. Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap ‘n’ collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2): cross-interaction between AhR (aryl hydrocarbon receptor) and Nrf2 signal transduction. Biochem J 2004;377(Pt 1):205-13
   PubMed Web of Science ®Google Scholar
• Miao W, Hu L, Scrivens PJ, Batist G. Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: direct cross-talk between phase I and II drug-metabolizing enzymes. J Biol Chem 2005;280(21):20340-8
   PubMed Web of Science ®Google Scholar
• Kohle C, Bock KW. Activation of coupled Ah receptor and Nrf2 gene batteries by dietary phytochemicals in relation to chemoprevention. Biochem Pharmacol 2006;72(7):795-805
   PubMed Web of Science ®Google Scholar
• Marchand A, Barouki R, Garlatti M. Regulation of NAD(P)H:quinone oxidoreductase 1 gene expression by CYP1A1 activity. Mol Pharmacol 2004;65(4):1029-37
   PubMed Web of Science ®Google Scholar
• Shin S, Wakabayashi N, Misra V, et al. NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis. Mol Cell Biol 2007;27(20):7188-97
   PubMed Web of Science ®Google Scholar
• Ohtake F, Takeyama K, Matsumoto T, et al. Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Nature 2003;423(6939):545-50
   PubMed Web of Science ®Google Scholar
• Hoivik D, Willett K, Wilson C, Safe S. Estrogen does not inhibit 2,3,7, 8-tetrachlorodibenzo-p-dioxin-mediated effects in MCF-7 and Hepa 1c1c7 cells. J Biol Chem 1997;272(48):30270-4
   PubMed Web of Science ®Google Scholar
• Kharat I, Saatcioglu F. Antiestrogenic effects of 2,3,7, 8-tetrachlorodibenzo-p-dioxin are mediated by direct transcriptional interference with the liganded estrogen receptor. Cross-talk between aryl hydrocarbon- and estrogen-mediated signaling. J Biol Chem 1996;271(18):10533-7
   PubMed Web of Science ®Google Scholar
• Ricci MS, Toscano DG, Mattingly CJ, Toscano WA Jr. Estrogen receptor reduces CYP1A1 induction in cultured human endometrial cells. J Biol Chem 1999;274(6):3430-8
   PubMed Web of Science ®Google Scholar
• Safe S, Wang F, Porter W, et al. Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms. Toxicol Lett 1998;102-103:343-7
   PubMed Web of Science ®Google Scholar
• Wang X, Porter W, Krishnan V, et al. Mechanism of 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated decrease of the nuclear estrogen receptor in MCF-7 human breast cancer cells. Mol Cell Endocrinol 1993;96(1-2):159-66
   PubMed Web of Science ®Google Scholar
• Gierthy JF, Spink BC, Figge HL, et al. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate and 17 beta-estradiol on estrogen receptor regulation in MCF-7 human breast cancer cells. J Cell Biochem 1996;60(2):173-84
   PubMed Web of Science ®Google Scholar
• Brake PB, Zhang L, Jefcoate CR. Aryl hydrocarbon receptor regulation of cytochrome P4501B1 in rat mammary fibroblasts: evidence for transcriptional repression by glucocorticoids. Mol Pharmacol 1998;54(5):825-33
   PubMed Web of Science ®Google Scholar
• Konig H, Ponta H, Rahmsdorf HJ, Herrlich P. Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo. EMBO J 1992;11(6):2241-6
   PubMed Web of Science ®Google Scholar
• Gambone CJ, Hutcheson JM, Gabriel JL, et al. Unique property of some synthetic retinoids: activation of the aryl hydrocarbon receptor pathway. Mol Pharmacol 2002;61(2):334-42
   PubMed Web of Science ®Google Scholar
• Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J 1996;10(9):940-54
   PubMed Web of Science ®Google Scholar
• Vecchini F, Lenoir-Viale MC, Cathelineau C, et al. Presence of a retinoid responsive element in the promoter region of the human cytochrome P4501A1 gene. Biochem Biophys Res Commun 1994;201(3):1205-12
   PubMed Web of Science ®Google Scholar
• Mader S, Leroy P, Chen JY, Chambon P. Multiple parameters control the selectivity of nuclear receptors for their response elements. Selectivity and promiscuity in response element recognition by retinoic acid receptors and retinoid X receptors. J Biol Chem 1993;268(1):591-600
   PubMed Web of Science ®Google Scholar
• Jurima-rRomet M, Neigh S, Casley WL. Induction of cytochrome P450 3A by retinoids in rat hepatocyte culture. Hum Exp Toxicol 1997;16(4):198-203
   PubMed Web of Science ®Google Scholar
• Howell SR, Shirley MA, Ulm EH. Effects of retinoid treatment of rats on hepatic microsomal metabolism and cytochromes P450. Correlation between retinoic acid receptor/retinoid x receptor selectivity and effects on metabolic enzymes. Drug Metab Dispos 1998;26(3):234-9
   PubMed Web of Science ®Google Scholar
• Shimada T. Xenobiotic-metabolizing enzymes involved in activation and detoxification of carcinogenic polycyclic aromatic hydrocarbons. Drug Metab Pharmacokinet 2006;21(4):257-76
   PubMed Web of Science ®Google Scholar
• Kapitulnik J, Wislocki PG, Levin W, et al. Tumorigenicity studies with diol-epoxides of benzo(a)pyrene which indicate that (+/-)-trans-7beta, 8alpha-dihydroxy-9alpha, 10alpha-epoxy-7,8,9,10-tetrahydr obenzo(a)pyrene is an ultimate carcinogen in newborn mice. Cancer Res 1978;38(2):354-8
   PubMed Web of Science ®Google Scholar
• Levin W, Wood AW, Yagi H, et al. (+/-)-trans-7,8-dihydroxy-7, 8-dihydrobenzo (a)pyrene: a potent skin carcinogen when applied topically to mice. Proc Natl Acad Sci USA 1976;73(11):3867-71
   PubMed Web of Science ®Google Scholar
• Conney AH. Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. clowes memorial lecture. Cancer Res 1982;42(12):4875-917
   PubMed Web of Science ®Google Scholar
• Pelkonen O, Nebert DW. Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis. Pharmacol Rev 1982;34(2):189-222
   PubMed Web of Science ®Google Scholar
• Shimada T, Hayes CL, Yamazaki H, et al. Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1. Cancer Res 1996;56(13):2979-84
   PubMed Web of Science ®Google Scholar
• Buters JT, Sakai S, Richter T, et al. Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas. Proc Natl Acad Sci USA 1999;96(5):1977-82
   PubMed Web of Science ®Google Scholar
• Fujii-Kuriyama Y, Mimura J. Molecular mechanisms of AhR functions in the regulation of cytochrome P450 genes. Biochem Biophys Res Commun 2005;338(1):311-7
   PubMed Web of Science ®Google Scholar
• Shimada T, Gillam EM, Oda Y, et al. Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase. Chem Res Toxicol 1999;12(7):623-9
   PubMed Web of Science ®Google Scholar
• Amin S, Desai D, Dai W, et al. Tumorigenicity in newborn mice of fjord region and other sterically hindered diol epoxides of benzo[g]chrysene, dibenzo[a,l]pyrene (dibenzo[def,p]chrysene), 4H-cyclopenta[def]chrysene and fluoranthene. Carcinogenesis 1995;16(11):2813-7
   PubMed Web of Science ®Google Scholar
• Barbier O, Jacquillet G, Tauc M, et al. Effect of heavy metals on, and handling by, the kidney. Nephron Physiol 2005;99(4):p105-10
   PubMedGoogle Scholar
• ATSDR.The Agency for Toxic Substances and Disease Registry. Available from: http://wwwatsdrcdcgov/cxcx3html 2005
   Google Scholar
• CEPA.Canadian Environmental Protection Act Registry. Available from: http://wwwecgcca/CEPARegistry/subs_list/Toxicupdatecfm 2006
   Google Scholar
• Monarca S, Crebelli R, Feretti D, et al. Mutagens and carcinogens in size-classified air particulates of a northern Italian town. Sci Total Environ 1997;205(2-3):137-44
   PubMed Web of Science ®Google Scholar
• Sram RJ, Benes I, Binkova B, et al. Teplice program–the impact of air pollution on human health. Environ Health Perspect 1996;104(Suppl 4):699-714
   PubMed Web of Science ®Google Scholar
• Schilderman PA, Moonen EJ, Maas LM, et al. Use of crayfish in biomonitoring studies of environmental pollution of the river Meuse. Ecotoxicol Environ Saf 1999;44(3):241-52
   PubMed Web of Science ®Google Scholar
• Sapozhnikova Y, Zubcov E, Zubcov N, Schlenk D. Occurrence of pesticides, polychlorinated biphenyls (PCBs), and heavy metals in sediments from the Dniester River, Moldova. Arch Environ Contam Toxicol 2005;49(4):439-48
   PubMed Web of Science ®Google Scholar
• Kaminsky L. The role of trace metals in cytochrome P4501 regulation. Drug Metab Rev 2006;38(1-2):227-34
   PubMed Web of Science ®Google Scholar
• Elbekai RH, El-Kadi AO. Arsenite and cadmium, but not chromium, induce NAD(P)H:quinone oxidoreductase 1 through transcriptional mechanisms, in spite of post-transcriptional modifications. Toxicol In Vitro 2008;22(5):1184-90
   PubMed Web of Science ®Google Scholar
• Falkner KC, McCallum GP, Cherian MG, Bend JR. Effects of acute sodium arsenite administration on the pulmonary chemical metabolizing enzymes, cytochrome P-450 monooxygenase, NAD(P)H:quinone acceptor oxidoreductase and glutathione S-transferase in guinea pig: comparison with effects in liver and kidney. Chem Biol Interact 1993;86(1):51-68
   PubMed Web of Science ®Google Scholar
• Siller FR, Quintanilla-Vega B, Cebrian ME, Albores A. Effects of arsenite pretreatment on the acute toxicity of parathion. Toxicology 1997;116(1-3):59-65
   PubMed Web of Science ®Google Scholar
• Jacobs J, Roussel R, Roberts M, et al. Effect of arsenite on induction of CYP1A and CYP2H in primary cultures of chick hepatocytes. Toxicol Appl Pharmacol 1998;150(2):376-82
   PubMed Web of Science ®Google Scholar
• Jacobs JM, Nichols CE, Andrew AS, et al. Effect of arsenite on induction of CYP1A, CYP2B, and CYP3A in primary cultures of rat hepatocytes. Toxicol Appl Pharmacol 1999;157(1):51-9
   PubMed Web of Science ®Google Scholar
• Vakharia DD, Liu N, Pause R, et al. Effect of metals on polycyclic aromatic hydrocarbon induction of CYP1A1 and CYP1A2 in human hepatocyte cultures. Toxicol Appl Pharmacol 2001;170(2):93-103
   PubMed Web of Science ®Google Scholar
• Elbekai RH, El-Kadi AO. Modulation of aryl hydrocarbon receptor-regulated gene expression by arsenite, cadmium, and chromium. Toxicology 2004;202(3):249-69
   PubMed Web of Science ®Google Scholar
• Albores A, Cebrian ME, Bach PH, et al. Sodium arsenite induced alterations in bilirubin excretion and heme metabolism. J Biochem Toxicol 1989 Summer;4(2):73-8
   PubMedGoogle Scholar
• Del Razo LM, Quintanilla-Vega B, Brambila-Colombres E, et al. Stress proteins induced by arsenic. Toxicol Appl Pharmacol 2001;177(2):132-48
   PubMed Web of Science ®Google Scholar
• Kapahi P, Takahashi T, Natoli G, et al. Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem 2000;275(46):36062-6
   PubMed Web of Science ®Google Scholar
• Gonzalez FJ. The molecular biology of cytochrome P450s. Pharmacol Rev 1988;40(4):243-88
   PubMed Web of Science ®Google Scholar
• Vernhet L, Allain N, Le Vee M, et al. Blockage of multidrug resistance-associated proteins potentiates the inhibitory effects of arsenic trioxide on CYP1A1 induction by polycyclic aromatic hydrocarbons. J Pharmacol Exp Ther 2003;304(1):145-55
   PubMed Web of Science ®Google Scholar
• Bogdan C. Nitric oxide and the regulation of gene expression. Trends Cell Biol 2001;11(2):66-75
   PubMed Web of Science ®Google Scholar
• Lowe GM, Hulley CE, Rhodes ES, et al. Free radical stimulation of tyrosine kinase and phosphatase activity in human peripheral blood mononuclear cells. Biochem Biophys Res Commun 1998;245(1):17-22
   PubMed Web of Science ®Google Scholar
• Marilena G. New physiological importance of two classic residual products: carbon monoxide and bilirubin. Biochem Mol Med 1997;61(2):136-42
   PubMedGoogle Scholar
• Schuller DJ, Wilks A, Ortiz de Montellano P, Poulos TL. Crystallization of recombinant human heme oxygenase-1. Protein Sci 1998;7(8):1836-8
   PubMed Web of Science ®Google Scholar
• Elbekai RH, El-Kadi AO. The role of oxidative stress in the modulation of aryl hydrocarbon receptor-regulated genes by As3+, Cd2+, and Cr6+. Free Radic Biol Med 2005;39(11):1499-511
   PubMed Web of Science ®Google Scholar
• Spink DC, Katz BH, Hussain MM, et al. Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[a]pyrene is diminished by arsenite. Drug Metab Dispos 2002;30(3):262-9
   PubMed Web of Science ®Google Scholar
• Elbekai RH, El-Kadi AO. Transcriptional activation and posttranscriptional modification of Cyp1a1 by arsenite, cadmium, and chromium. Toxicology Lett 2007;172(3):106-19
   PubMed Web of Science ®Google Scholar
• Wu SJ, Spink DC, Spink BC, Kaminsky LS. Quantitation of CYP1A1 and 1B1 mRNA in polycyclic aromatic hydrocarbon-treated human T-47D and HepG2 cells by a modified bDNA assay using fluorescence detection. Anal Biochem 2003;312(2):162-6
   PubMed Web of Science ®Google Scholar
• Vakharia DD, Liu N, Pause R, et al. Polycyclic aromatic hydrocarbon/metal mixtures: effect on PAH induction of CYP1A1 in human HEPG2 cells. Drug Metab Dispos 2001;29(7):999-1006
   PubMed Web of Science ®Google Scholar
• Ho IC, Lee TC. Arsenite pretreatment attenuates benzo[a]pyrene cytotoxicity in a human lung adenocarcinoma cell line by decreasing cyclooxygenase-2 levels. J Toxicol Environ Health 2002;65(3-4):245-63
   PubMed Web of Science ®Google Scholar
• Maier A, Dalton TP, Puga A. Disruption of dioxin-inducible phase I and phase II gene expression patterns by cadmium, chromium, and arsenic. Mol Carcinog 2000;28(4):225-35
   PubMed Web of Science ®Google Scholar
• Bessette EE, Fasco MJ, Pentecost BT, Kaminsky LS. Mechanisms of arsenite-mediated decreases in benzo[k]fluoranthene-induced human cytochrome P4501A1 levels in HepG2 cells. Drug Metab Dispos 2005;33(3):312-20
   PubMed Web of Science ®Google Scholar
• Chao HR, Tsou TC, Li LA, et al. Arsenic inhibits induction of cytochrome P450 1A1 by 2,3,7, 8-tetrachlorodibenzo-p-dioxin in human hepatoma cells. J Hazard Mater 2006;137(2):716-22
   PubMed Web of Science ®Google Scholar
• Bonzo JA, Chen S, Galijatovic A, Tukey RH. Arsenite inhibition of CYP1A1 induction by 2,3,7, 8-tetrachlorodibenzo-p-dioxin is independent of cell cycle arrest. Mol Pharmacol 2005;67(4):1247-56
   PubMed Web of Science ®Google Scholar
• Kann S, Huang MY, Estes C, et al. Arsenite-induced aryl hydrocarbon receptor nuclear translocation results in additive induction of phase I genes and synergistic induction of phase II genes. Mol Pharmacol 2005;68(2):336-46
   PubMed Web of Science ®Google Scholar
• Joiakim A, Mathieu PA, Elliott AA, Reiners JJ Jr. Superinduction of CYP1A1 in MCF10A cultures by cycloheximide, anisomycin, and puromycin: a process independent of effects on protein translation and unrelated to suppression of aryl hydrocarbon receptor proteolysis by the proteasome. Mol Pharmacol 2004;66(4):936-47
   PubMed Web of Science ®Google Scholar
• Ma Q, Renzelli AJ, Baldwin KT, Antonini JM. Superinduction of CYP1A1 gene expression. Regulation of 2,3,7, 8-tetrachlorodibenzo-p-dioxin-induced degradation of Ah receptor by cycloheximide. J Biol Chem 2000;275(17):12676-83
   PubMed Web of Science ®Google Scholar
• Seubert JM, Sinal CJ, Bend JR. Acute sodium arsenite administration induces pulmonary CYP1A1 mRNA, protein and activity in the rat. J Biochem Mol Toxicol 2002;16(2):84-95
   PubMed Web of Science ®Google Scholar
• Seubert JM, Webb CD, Bend JR. Acute sodium arsenite treatment induces Cyp2a5 but not Cyp1a1 in the C57Bl/6 mouse in a tissue (kidney) selective manner. J Biochem Mol Toxicol 2002;16(2):96-106
   PubMed Web of Science ®Google Scholar
• Li J, Gorospe M, Hutter D, et al. Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation. Mol Cell Biol 2001;21(23):8213-24
   PubMed Web of Science ®Google Scholar
• He Z, Ma WY, Liu G, et al. Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1. J Biol Chem 2003;278(12):10588-93
   PubMed Web of Science ®Google Scholar
• Shibazaki M, Takeuchi T, Ahmed S, Kikuchi H. Suppression by p38 MAP kinase inhibitors (pyridinyl imidazole compounds) of Ah receptor target gene activation by 2,3,7, 8-tetrachlorodibenzo-p-dioxin and the possible mechanism. J Biol Chem 2004;279(5):3869-76
   PubMed Web of Science ®Google Scholar
• Nakajima M, Iwanari M, Yokoi T. Effects of histone deacetylation and DNA methylation on the constitutive and TCDD-inducible expressions of the human CYP1 family in MCF-7 and HeLa cells. Toxicol Lett 2003;144(2):247-56
   PubMed Web of Science ®Google Scholar
• Hinck JE, Blazer VS, Denslow ND, et al. Chemical contaminants, health indicators, and reproductive biomarker responses in fish from rivers in the Southeastern United States. Sci Total Environ 2008;390(2-3):538-57
   PubMed Web of Science ®Google Scholar
• Randak T, Zlabek V, Kolarova J, et al. Biomarkers detected in Chub (Leuciscus cephalus L.) to evaluate contamination of the Elbe and Vltava rivers, Czech Republic. Bulletin Environ Contam Toxicology 2006;76(2):233-41
   PubMed Web of Science ®Google Scholar
• Schmitt CJ, Hinck JE, Blazer VS, et al. Environmental contaminants and biomarker responses in fish from the Rio Grande and its U.S. tributaries: spatial and temporal trends. Sci Total Environ 2005;350(1-3):161-93
   PubMed Web of Science ®Google Scholar
• Hinck JE, Schmitt CJ, Blazer VS, et al. Environmental contaminants and biomarker responses in fish from the Columbia river and its tributaries: spatial and temporal trends. Sci Total Environ 2006;366(2-3):549-78
   PubMed Web of Science ®Google Scholar
• Jedamski-Grymlas J, Kammann U, Tempelmann A, et al. Biochemical responses and environmental contaminants in breams (Abramis brama L.) caught in the river Elbe. Ecotoxicol Environ Saf 1995;31(1):49-56
   PubMed Web of Science ®Google Scholar
• Ham KD, Adams SM, Peterson MJ. Application of multiple bioindicators to differentiate spatial and temporal variability from the effects of contaminant exposure on fish. Ecotoxicol Environ Saf 1997;37(1):53-61
   PubMed Web of Science ®Google Scholar
• Ferber D. Environmental science. Sperm whales bear testimony to worldwide pollution. Science 2005;309(5738):1166
   PubMedGoogle Scholar
• Ke Q, Yang Y, Ratner M, et al. Intracellular accumulation of mercury enhances P450 CYP1A1 expression and Cl-currents in cultured shark rectal gland cells. Life Sci 2002;70(21):2547-66
   PubMed Web of Science ®Google Scholar
• Oliveira M, Santos MA, Pacheco M. Glutathione protects heavy metal-induced inhibition of hepatic microsomal ethoxyresorufin O-deethylase activity in Dicentrarchus labrax L. Ecotoxicol Environ Saf 2004;58(3):379-85
   PubMed Web of Science ®Google Scholar
• Korashy HM, El-Kadi AO. Differential effects of mercury, lead and copper on the constitutive and inducible expression of aryl hydrocarbon receptor (AHR)-regulated genes in cultured hepatoma Hepa 1c1c7 cells. Toxicology 2004;201(1-3):153-72
   PubMed Web of Science ®Google Scholar
• Korashy HM, El-Kadi AO. Regulatory mechanisms modulating the expression of cytochrome P450 1A1 gene by heavy metals. Toxicol Sci 2005;88(1):39-51
   PubMed Web of Science ®Google Scholar
• Korashy HM, El-Kadi AO. Modulation of TCDD-mediated induction of cytochrome P450 1A1 by mercury, lead, and copper in human HepG2 cell line. Toxicol In Vitro 2008;22(1):154-8
   PubMed Web of Science ®Google Scholar
• Ramadoss P, Petrulis JR, Hollingshead BD, et al. Divergent roles of hepatitis B virus X-associated protein 2 (XAP2) in human versus mouse Ah receptor complexes. Biochemistry 2004;43(3):700-9
   PubMed Web of Science ®Google Scholar
• Ramadoss P, Perdew GH. The transactivation domain of the Ah receptor is a key determinant of cellular localization and ligand-independent nucleocytoplasmic shuttling properties. Biochemistry 2005;44(33):11148-59
   PubMed Web of Science ®Google Scholar
• Suzuki T, Nohara K. Regulatory factors involved in species-specific modulation of arylhydrocarbon receptor (AhR)-dependent gene expression in humans and mice. J Biochem 2007;142(4):443-52
   PubMed Web of Science ®Google Scholar
• Korashy HM, El-Kadi AO. The role of redox-sensitive transcription factors NF-kappaB and AP-1 in the modulation of the Cyp1a1 gene by mercury, lead, and copper. Free Radic Biol Med 2008;44(5):795-806
   PubMed Web of Science ®Google Scholar
• Tian Y, Ke S, Denison MS, et al. Ah receptor and NF-kappaB interactions, a potential mechanism for dioxin toxicity. J Biol Chem 1999;274(1):510-5
   PubMed Web of Science ®Google Scholar
• Ruby CE, Leid M, Kerkvliet NI. 2,3,7,8-Tetrachlorodibenzo-p-dioxin suppresses tumor necrosis factor-alpha and anti-CD40-induced activation of NF-kappaB/Rel in dendritic cells: p50 homodimer activation is not affected. Mol Pharmacol 2002;62(3):722-8
   PubMed Web of Science ®Google Scholar
• Vogel CF, Sciullo E, Li W, et al. RelB, a new partner of aryl hydrocarbon receptor-mediated transcription. Mol Endocrinol 2007;21(12):2941-55
   PubMed Web of Science ®Google Scholar
• Ke S, Rabson AB, Germino JF, et al. Mechanism of suppression of cytochrome P-450 1A1 expression by tumor necrosis factor-alpha and lipopolysaccharide. J Biol Chem 2001;276(43):39638-44
   PubMed Web of Science ®Google Scholar
• Tian Y, Ke S, Chen M, Sheng T. Interactions between the aryl hydrocarbon receptor and P-TEFb. Sequential recruitment of transcription factors and differential phosphorylation of C-terminal domain of RNA polymerase II at cyp1a1 promoter. J Biol chem 2003;278(45):44041-8
   PubMed Web of Science ®Google Scholar
• Tan Z, Chang X, Puga A, Xia Y. Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function. Biochem Pharmacol 2002;64(5-6):771-80
   PubMed Web of Science ®Google Scholar
• Ichim TE, Li M, Qian H, et al. RNA interference: a potent tool for gene-specific therapeutics. Am J Transplant 2004;4(8):1227-36
   PubMed Web of Science ®Google Scholar
• Wagstaff DD. Stimulation of liver detoxication enzymes by dietary cadmium acetate. Bulletin Environ Contam Toxicol 1973;10(6):328-32
   PubMed Web of Science ®Google Scholar
• Eaton DL, Stacey NH, Wong KL, Klaassen CD. Dose-response effects of various metal ions on rat liver metallothionein, glutathione, heme oxygenase, and cytochrome P-450. Toxicol Appl Pharmacol 1980;55(2):393-402
   PubMed Web of Science ®Google Scholar
• Anjum F, Raman A, Shakoori AR, Gorrod JW. An assessment of cadmium toxicity on cytochrome P-450 and flavin monooxygenase-mediated metabolic pathways of dimethylaniline in male rabbits. J Environ Pathol Toxicol Oncol 1992;11(4):191-5
   PubMedGoogle Scholar
• Alexidis AN, Rekka EA, Kourounakis PN. Influence of mercury and cadmium intoxication on hepatic microsomal CYP2E and CYP3A subfamilies. Res Commun Mol Pathol Pharmacol 1994;85(1):67-72
   PubMed Web of Science ®Google Scholar
• Dehn PF, White CM, Conners DE, et al. Characterization of the human hepatocellular carcinoma (hepg2) cell line as an in vitro model for cadmium toxicity studies. In vitro Cell Dev Biol 2004;40(5-6):172-82
   Web of Science ®Google Scholar
• Baker JR, Satarug S, Reilly PE, et al. Relationships between non-occupational cadmium exposure and expression of nine cytochrome P450 forms in human liver and kidney cortex samples. Biochem Pharmacol 2001;62(6):713-21
   PubMed Web of Science ®Google Scholar
• States JC, Quan T, Hines RN, et al. Expression of human cytochrome P450 1A1 in DNA repair deficient and proficient human fibroblasts stably transformed with an inducible expression vector. Carcinogenesis 1993;14(8):1643-9
   PubMed Web of Science ®Google Scholar
• Iscan M, Ada AO, Coban T, et al. Combined effects of cadmium and nickel on testicular xenobiotic metabolizing enzymes in rats. Biol Trace Elem Res 2002;89(2):177-90
   PubMed Web of Science ®Google Scholar
• Rosenberg DW, Kappas A. Induction of heme oxygenase in the small intestinal epithelium: a response to oral cadmium exposure. Toxicology 1991;67(2):199-210
   PubMed Web of Science ®Google Scholar
• Benedetti M, Martuccio G, Fattorini D, et al. Oxidative and modulatory effects of trace metals on metabolism of polycyclic aromatic hydrocarbons in the Antarctic fish Trematomus bernacchii. Aquatic Toxicol 2007;85(3):167-75
   PubMed Web of Science ®Google Scholar
• Risso-de Faverney C, Lafaurie M, Girard JP, Rahmani R. The nitroxide stable radical tempo prevents metal-induced inhibition of CYP1A1 expression and induction. Toxicology Lett 2000;111(3):219-27
   PubMed Web of Science ®Google Scholar
• Lewis NA, Williams TD, Chipman JK. Functional analysis of a metal response element in the regulatory region of flounder cytochrome P450 1A and implications for environmental monitoring of pollutants. Toxicol Sci 2006;92(2):387-93
   PubMed Web of Science ®Google Scholar
• Ahmad I, Maria VL, Oliveira M, et al. Oxidative stress and genotoxic effects in gill and kidney of Anguilla anguilla L. exposed to chromium with or without pre-exposure to beta-naphthoflavone. Mutation Res 2006;608(1):16-28
   PubMed Web of Science ®Google Scholar
• Ye J, Zhang X, Young HA, et al. Chromium(VI)-induced nuclear factor-kappa B activation in intact cells via free radical reactions. Carcinogenesis 1995;16(10):2401-5
   PubMed Web of Science ®Google Scholar
• Kim G, Yurkow EJ. Chromium induces a persistent activation of mitogen-activated protein kinases by a redox-sensitive mechanism in H4 rat hepatoma cells. Cancer Res 1996;56(9):2045-51
   PubMed Web of Science ®Google Scholar
• Chen F, Ye J, Zhang X, et al. One-electron reduction of chromium(VI) by alpha-lipoic acid and related hydroxyl radical generation, dG hydroxylation and nuclear transcription factor-kappaB activation. Arch Biochem Biophys 1997;338(2):165-72
   PubMed Web of Science ®Google Scholar
• Tesfai Y, Davis D, Reinhold D. Chromium can reduce the mutagenic effects of benzo[a]pyrene diolepoxide in normal human fibroblasts via an oxidative stress mechanism. Mutation Res 1998;416(3):159-68
   PubMed Web of Science ®Google Scholar
• Wei YD, Tepperman K, Huang MY, et al. Chromium inhibits transcription from polycyclic aromatic hydrocarbon-inducible promoters by blocking the release of histone deacetylase and preventing the binding of p300 to chromatin. J Biol Chem 2004;279(6):4110-9
   PubMed Web of Science ®Google Scholar
• Geist J, Werner I, Eder KJ, Leutenegger CM. Comparisons of tissue-specific transcription of stress response genes with whole animal endpoints of adverse effect in striped bass (Morone saxatilis) following treatment with copper and esfenvalerate. Aquatic Toxicol 2007;85(1):28-39
   PubMed Web of Science ®Google Scholar
• Song MO, Freedman JH. Expression of copper-responsive genes in HepG2 cells. Mol Cell Biochem 2005;279(1-2):141-7
   PubMed Web of Science ®Google Scholar
• Kim JS, Ahn T, Yim SK, Yun CH. Differential effect of copper (II) on the cytochrome P450 enzymes and NADPH-cytochrome P450 reductase: inhibition of cytochrome P450-catalyzed reactions by copper (II) ion. Biochem 2002;41(30):9438-47
   PubMed Web of Science ®Google Scholar
• Johnson WT, Smith TB. Copper deficiency increases cytochrome P450-dependent 7-ethoxyresorufin-O-deethylase activity in rat small intestine. Proc Soc Exp Biol Med Soc Exp Biol Med 1994;207(3):302-8
   PubMed Web of Science ®Google Scholar
• Li J, Zhao M, He P, et al. Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. Clin Cancer Res 2007;13(12):3731-7
   PubMed Web of Science ®Google Scholar
• Hamilton M, Wolf JL, Rusk J, et al. Effects of smoking on the pharmacokinetics of erlotinib. Clin Cancer Res 2006 Apr 1;12(7 Pt 1):2166-71
   Google Scholar
• Chua MS, Kashiyama E, Bradshaw TD, et al. Role of Cyp1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells. Cancer Res 2000;60(18):5196-203
   PubMed Web of Science ®Google Scholar
• Leong CO, Gaskell M, Martin EA, et al. Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo. Br J Cancer 2003;88(3):470-7
   PubMed Web of Science ®Google Scholar
• Bradshaw TD, Wren JE, Bruce M, et al. Preclinical toxicokinetic evaluation of phortress [2-(4-Amino-3-Methylphenyl)-5-fluorobenzothiazole Lysylamide Dihydrochloride] in Two Rodent Species. Pharmacology 2008;83(2):99-109
   PubMed Web of Science ®Google Scholar
• Crewe HK, Notley LM, Wunsch RM, et al. Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4′-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos 2002;30(8):869-74
   PubMed Web of Science ®Google Scholar
• Bieche I, Girault I, Urbain E, et al. Relationship between intratumoral expression of genes coding for xenobiotic-metabolizing enzymes and benefit from adjuvant tamoxifen in estrogen receptor alpha-positive postmenopausal breast carcinoma. Breast Cancer Res 2004;6(3):R252-63
   PubMed Web of Science ®Google Scholar
• Reid JM, Kuffel MJ, Miller JK, et al. Metabolic activation of dacarbazine by human cytochromes P450: the role of CYP1A1, CYP1A2, and CYP2E1. Clin Cancer Res 1999;5(8):2192-7
   PubMed Web of Science ®Google Scholar
• Stiborova M, Bieler CA, Wiessler M, Frei E. The anticancer agent ellipticine on activation by cytochrome P450 forms covalent DNA adducts. Biochem Pharmacol 2001;62(12):1675-84
   PubMed Web of Science ®Google Scholar
• Lee DY, Kim JW, Lee MG. Pharmacokinetic interaction between oltipraz and omeprazole in rats: competitive inhibition of metabolism of oltipraz by omeprazole via CYP1A1 and 3A2, and of omeprazole by oltipraz via CYP1A1/2, 2D1/2, and 3A1/2. Eur J Pharm Sci 2007;32(4-5):328-39
   PubMed Web of Science ®Google Scholar
• Su QB, He F, Wang XD, et al. Biotransformation and pharmacokinetics of the novel anticancer drug, SYUIQ-5, in the rat. Invest New Drugs 2008;26(2):119-37
   PubMed Web of Science ®Google Scholar
• Patterson LH, McKeown SR. AQ4N: a new approach to hypoxia-activated cancer chemotherapy. Br J Cancer 2000;83(12):1589-93
   PubMed Web of Science ®Google Scholar
• Rintala S, Tammela TL, Tuimala R. CYP1A1 activity in renal cell carcinoma and in adjacent normal renal tissue. Urol Res 1998;26(2):117-21
   PubMed Web of Science ®Google Scholar
• Brockdorff BL, Skouv J, Reiter BE, Lykkesfeldt AE. Increased expression of cytochrome p450 1A1 and 1B1 genes in anti-estrogen-resistant human breast cancer cell lines. Int J Cancer 2000;88(6):902-6
   PubMed Web of Science ®Google Scholar
• Roos TC, Jugert FK, Merk HF, Bickers DR. Retinoid metabolism in the skin. Pharmacol Rev 1998;50(2):315-33
   PubMed Web of Science ®Google Scholar
• Marill J, Idres N, Capron CC, et al. Retinoic acid metabolism and mechanism of action: a review. Curr Drug Metab 2003;4(1):1-10
   PubMed Web of Science ®Google Scholar
• Tsuchiya Y, Nakajima M, Yokoi T. Cytochrome P450-mediated metabolism of estrogens and its regulation in human. Cancer Lett 2005;227(2):115-24
   PubMed Web of Science ®Google Scholar
• Nutter LM, Wu YY, Ngo EO, et al. An o-quinone form of estrogen produces free radicals in human breast cancer cells: correlation with DNA damage. Chemical Res Toxicol 1994;7(1):23-8
   PubMed Web of Science ®Google Scholar
• Sanderink GJ, Bournique B, Stevens J, et al. Involvement of human CYP1A isoenzymes in the metabolism and drug interactions of riluzole in vitro. J Pharmacol Exp Ther 1997;282(3):1465-72
   PubMed Web of Science ®Google Scholar
• Nakamura H, Ariyoshi N, Okada K, et al. CYP1A1 is a major enzyme responsible for the metabolism of granisetron in human liver microsomes. Curr Drug Metab 2005;6(5):469-80
   PubMed Web of Science ®Google Scholar
• Bloomer JC, Baldwin SJ, Smith GJ, et al. Characterisation of the cytochrome P450 enzymes involved in the in vitro metabolism of granisetron. Br J Clin Pharmacol 1994;38(6):557-66
   PubMed Web of Science ®Google Scholar
• de Alwis DP, Aarons L, Palmer JL. Population pharmacokinetics of ondansetron: a covariate analysis. Br J Clin Pharmacol 1998;46(2):117-25
   PubMed Web of Science ®Google Scholar
• Draper AJ, Madan A, Latham J, Parkinson A. Development of a non-high pressure liquid chromatography assay to determine [14C]chlorzoxazone 6-hydroxylase (CYP2E1) activity in human liver microsomes. Drug Metab Dispos 1998;26(4):305-12
   PubMed Web of Science ®Google Scholar
• Zhang ZY, Pelletier RD, Wong YN, et al. Preferential inducibility of CYP1A1 and CYP1A2 by TCDD: differential regulation in primary human hepatocytes versus transformed human cells. Biochem Biophys Res Commun 2006;341(2):399-407
   PubMed Web of Science ®Google Scholar
• Ohyama K, Nakajima M, Nakamura S, et al. A significant role of human cytochrome P450 2C8 in amiodarone N-deethylation: an approach to predict the contribution with relative activity factor. Drug Metab Dispos 2000;28(11):1303-10
   PubMed Web of Science ®Google Scholar
• Ohyama K, Nakajima M, Suzuki M, et al. Inhibitory effects of amiodarone and its N-deethylated metabolite on human cytochrome P450 activities: prediction of in vivo drug interactions. Br J Clin Pharmacol 2000;49(3):244-53
   PubMed Web of Science ®Google Scholar
• Beddows SA, Page SR, Taylor AH, et al. Cytotoxic effects of amiodarone and desethylamiodarone on human thyrocytes. Biochem Pharmacol 1989;38(24):4397-403
   PubMed Web of Science ®Google Scholar
• Elsherbiny ME, El-Kadi AO, Brocks DR. The metabolism of amiodarone by various CYP isoenzymes of human and rat, and the inhibitory influence of ketoconazole. J Pharm Pharm Sci 2008;11(1):147-59
   PubMed Web of Science ®Google Scholar
• Fischer V, Johanson L, Heitz F, et al. The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor fluvastatin: effect on human cytochrome P-450 and implications for metabolic drug interactions. Drug Metab Dispos 1999;27(3):410-6
   PubMed Web of Science ®Google Scholar
• Granvil CP, Krausz KW, Gelboin HV, et al. 4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine. J pharmacol Exp Ther 2002;301(3):1025-32
   PubMed Web of Science ®Google Scholar
• Gage BF. Pharmacogenetics-based coumarin therapy. Hematology / the Education Program of the American Society of Hematology. Am Soc Hematol 2006;467-73
   PubMed Web of Science ®Google Scholar
• Badger C, Preston N, Seers K, Mortimer P. Benzo-pyrones for reducing and controlling lymphoedema of the limbs. Cochrane Database Syst Rev 2004;(2):CD003140
   Google Scholar
• Hussein MA. Arsenic trioxide: a new immunomodulatory agent in the management of multiple myeloma. Med Oncol 2001;18(4):239-42
   PubMed Web of Science ®Google Scholar
• Murgo AJ. Clinical trials of arsenic trioxide in hematologic and solid tumors: overview of the National Cancer Institute Cooperative Research and Development Studies. Oncologist 2001;6(Suppl 2):22-8
   PubMed Web of Science ®Google Scholar
• Yoshisue K, Nagayama S, Shindo T, Kawaguchi Y. Effects of 5-fluorouracil on the drug-metabolizing enzymes of the small intestine and the consequent drug interaction with nifedipine in rats. J Pharmacol Exp Therapeutics 2001;297(3):1166-75
   PubMed Web of Science ®Google Scholar
• Loaiza-Perez AI, Kenney S, Boswell J, et al. Aryl hydrocarbon receptor activation of an antitumor aminoflavone: basis of selective toxicity for MCF-7 breast tumor cells. Mol Cancer Ther 2004;3(6):715-25
   PubMed Web of Science ®Google Scholar
• Sahi J, Reyner EL, Bauman JN, et al. The effect of bergamottin on diazepam plasma levels and P450 enzymes in beagle dogs. Drug Metab Dispos 2002;30(2):135-40
   PubMed Web of Science ®Google Scholar
• Peraza MA, Burdick AD, Marin HE, et al. The toxicology of ligands for peroxisome proliferator-activated receptors (PPAR). Toxicol Sci 2006;90(2):269-95
   PubMed Web of Science ®Google Scholar
• Rinaldi AL, Morse MA, Fields HW, et al. Curcumin activates the aryl hydrocarbon receptor yet significantly inhibits (-)-benzo(a)pyrene-7R-trans-7, 8-dihydrodiol bioactivation in oral squamous cell carcinoma cells and oral mucosa. Cancer Res 2002;62(19):5451-6
   PubMed Web of Science ®Google Scholar
• Vrzal R, Stejskalova L, Monostory K, et al. Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes. Chem Biol Interact 2008
   Google Scholar
• Hose CD, Hollingshead M, Sausville EA, Monks A. Induction of CYP1A1 in tumor cells by the antitumor agent 2-[4-amino-3-methylphenyl]-5-fluoro-benzothiazole: a potential surrogate marker for patient sensitivity. Mol Cancer Ther 2003;2(12):1265-72
   PubMed Web of Science ®Google Scholar
• Aimova D, Svobodova L, Kotrbova V, et al. The anticancer drug ellipticine is a potent inducer of rat cytochromes P450 1A1 and 1A2, thereby modulating its own metabolism. Drug Metab Dispos 2007;35(10):1926-34
   PubMed Web of Science ®Google Scholar
• Coumoul X, Diry M, Robillot C, Barouki R. Differential regulation of cytochrome P450 1A1 and 1B1 by a combination of dioxin and pesticides in the breast tumor cell line MCF-7. Cancer Res 2001;61(10):3942-8
   PubMed Web of Science ®Google Scholar
• Valero F, de la Torre R, Segura J. Selective in-vitro inhibition of hepatic oxidative metabolism by quinolones: 7-ethoxyresorufin and caffeine as model substrates. J Pharm Pharmacol 1991;43(1):17-21
   PubMed Web of Science ®Google Scholar
• Regmi NL, Abd El-Aty AM, Kuroha M, et al. Inhibitory effect of several fluoroquinolones on hepatic microsomal cytochrome P-450 1A activities in dogs. J Vet Pharmacol Ther 2005;28(6):553-7
   PubMed Web of Science ®Google Scholar
• Rochat B, Morsman JM, Murray GI, et al. Human CYP1B1 and anticancer agent metabolism: mechanism for tumor-specific drug inactivation? J Pharmacol Exp Ther 2001;296(2):537-41
   PubMed Web of Science ®Google Scholar
• Rasmussen BB, Maenpaa J, Pelkonen O, et al. Selective serotonin reuptake inhibitors and theophylline metabolism in human liver microsomes: potent inhibition by fluvoxamine. Br J Clin Pharmacol 1995;39(2):151-9
   PubMed Web of Science ®Google Scholar
• Paine MF, Schmiedlin-Ren P, Watkins PB. Cytochrome P-450 1A1 expression in human small bowel: interindividual variation and inhibition by ketoconazole. Drug Metab Dispos 1999;27(3):360-4
   PubMed Web of Science ®Google Scholar
• Curi-Pedrosa R, Daujat M, Pichard L, et al. Omeprazole and lansoprazole are mixed inducers of CYP1A and CYP3A in human hepatocytes in primary culture. J Pharmacol Exp Ther 1994;269(1):384-92
   PubMed Web of Science ®Google Scholar
• Le Ferrec E, Lagadic-Gossmann D, Rauch C, et al. Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent. J Biol Chem 2002;277(27):24780-7
   PubMed Web of Science ®Google Scholar
• Cho IJ, Kim SG. Oltipraz inhibits 3-methylcholanthrene induction of CYP1A1 by CCAAT/enhancer-binding protein activation. J Biol Chem 2003;278(45):44103-12
   PubMed Web of Science ®Google Scholar
• Backlund M, Johansson I, Mkrtchian S, Ingelman-Sundberg M. Signal transduction-mediated activation of the aryl hydrocarbon receptor in rat hepatoma H4IIE cells. J Biol Chem 1997;272(50):31755-63
   PubMed Web of Science ®Google Scholar
• Gerhold D, Lu M, Xu J, et al. Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays. Physiol Genomics 2001;5(4):161-70
   PubMed Web of Science ®Google Scholar
• Wolf DC, Allen JW, George MH, et al. Toxicity profiles in rats treated with tumorigenic and nontumorigenic triazole conazole fungicides: Propiconazole, triadimefon, and myclobutanil. Toxicol Pathol 2006;34(7):895-902
   PubMed Web of Science ®Google Scholar
• Ciolino HP, Yeh GC. Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol. Mol Pharmacol 1999;56(4):760-7
   PubMed Web of Science ®Google Scholar
• MacDonald CJ, Ciolino HP, Yeh GC. The drug salicylamide is an antagonist of the aryl hydrocarbon receptor that inhibits signal transduction induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Cancer Res 2004;64(1):429-34
   PubMed Web of Science ®Google Scholar
• Ciolino HP, Macdonald CJ, Memon OS, et al. Sulindac regulates the aryl hydrocarbon receptor-mediated expression of Phase 1 metabolic enzymes in vivo and in vitro. Carcinogenesis 2006
   Google Scholar
• Yang YM, Huang DY, Liu GF, et al. Inhibitory effects of vitamin A on TCDD-induced cytochrome P-450 1A1 enzyme activity and expression. Toxicol Sci 2005;85(1):727-34
   PubMed Web of Science ®Google Scholar