Cardionomics: a new integrative approach for screening cardiotoxicity of drug candidates

Bibliography

• Boukens BJD, Christoffels VM, Coronel R, et al. Developmental basis for electrophysiological heterogeneity in the ventricular and outflow tract myocardium as a substrate for life-threatening ventricular arrhythmias. Cir Res 2009;104:19-31
   PubMed Web of Science ®Google Scholar
• Packer M, Carver JR, Rodeheffer RJ, et al. Effect of oral milrinone in severe chronic heart failure. The PROMISE study research group. NEJM 1991;325:1468-75
   PubMed Web of Science ®Google Scholar
• Feldman MD, Copelas L, Gwathmey JK, et al. Deficient production of cyclic AMP: pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure. Circulation 1987;75:331-39
   PubMed Web of Science ®Google Scholar
• Schmidt U, Hajjar RJ, Helm PA, et al. Contribution of abnormal sarcoplasmic reticulum ATPase activity to systolic and diastolic dysfunction in human heart failure. J Mol Cell Cardiol 1998;30:1929-37
   PubMed Web of Science ®Google Scholar
• Schmidt U, Hajjar RJ, Kim CS, et al. Human heart failure: cAMP stimulation of sarcoplasmic reticulum Ca2+-ATPase activity and phosphorylation level of phospholamban. Am J Physiol 1999;277:H474-80
   PubMed Web of Science ®Google Scholar
• Gwathmey JK, Slawsky MT, Hajjar RJ, et al. Role of intracellular calcium handling in force-interval relationships of human ventricular myocardium. J Clin Invest 1990;85(5):1599-628
   PubMed Web of Science ®Google Scholar
• del Monte F, Harding S, Schmidt U, et al. Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a. Circulation 1999;100(23):2308-11
   PubMed Web of Science ®Google Scholar
• Gwathmey JK, Copelas L, MacKinnon R, et al. Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure. Circ Res 1987;61:70-6
   PubMed Web of Science ®Google Scholar
• Okafor CC, Liao R, Perrault-Micale C, et al. Mg-ATPase and Ca2+-activated myosin ATPase activity in ventricular myofibrils from non-failing and diseased human hearts: effects of calcium sensitizing agents MCI-154, DPI 201-106 201-106, and caffeine. Mol Cell Biochem 2003;245:77-89
   PubMed Web of Science ®Google Scholar
• Hajjar RJ, Schmidt U, Helm P, et al. Ca2+-Sensitizers impair cardiac relaxation in failing human myocardium. J Pharm Exp Ther 1997;280(1):247-54
   PubMed Web of Science ®Google Scholar
• Hajjar RJ, Gwathmey JK. Calcium-sensitizing inotropic agents in the treatment of heart failure: a critical view. Cardiovasc Drugs Ther 1991;5(6):961-6
   PubMed Web of Science ®Google Scholar
• Hajjar RJ, Schwinger RHG, Schmidt U, et al. Myofilament calcium regulation in human myocardium. Circulation 2000;101(14):1679-85
   PubMed Web of Science ®Google Scholar
• Gwathmey JK, Kim CS, Hajjar RJ, et al. Cellular and molecular remodeling in a heart failure model treated with the β-blocker Carteolol. Am J Physiol 1999;276:H1678-90
   PubMed Web of Science ®Google Scholar
• Okafor CC, Perreault-Micale C, Lebeche D, et al. Chronic treatment with Carvedilol improves ventricular function and reduces myocyte apoptosis in an animal model of heart failure. BMC Physiology 2003;3(6):1-12
   PubMedGoogle Scholar
• Hajjar RJ, Gwathmey JK, Briggs GM, et al. Differential effects of DPI 201-106 on the sensitivity of the myofilaments to Ca2+ in intact and skinned trabeculae from control and myopathic human hearts. J Clin Invest 1988;82(5):1578-84
   PubMed Web of Science ®Google Scholar
• Gwathmey JK, Slawsky MT, Briggs GM, et al. The role of intracellular sodium in the regulation of intracellular calcium and contractility: the effects of DPI 201-106 on excitation-contraction coupling in human ventricular myocardium. J Clin Invest 1988;82:1592-05
   PubMed Web of Science ®Google Scholar
• Haddad GE, Saunders LJ, Carles M, et al. Fingerprint profile of alcohol-associated heart failure in human hearts. Alcohol Clin Exp Res 2008;32(5):814-21
   PubMed Web of Science ®Google Scholar
• Haddad GE, Saunders JL, Crosby SD, et al. Human cardiac-specific cDNA array for idiopathic dilated cardiomyopathy: gender related differences. Physiol Genomics 2008;33:267-77
   PubMed Web of Science ®Google Scholar
• Dykens JA, Will Y. The significance of mitochondrial toxicity testing in drug development. Drug Discov Today 2007;12(17-18):777-85
   PubMed Web of Science ®Google Scholar
• Dykens JA, Will J. Drug-induced mitochondrial toxicity: Drug safety considerations. Mitochondrion 2007;7:430-31
   Google Scholar
• Cannito S, Novo E, Compagnone A, et al. Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells. Carcinogenesis 2008;29(12):2267-78
   PubMed Web of Science ®Google Scholar
• Dykens JA, Jamieson J, Marroquin L, et al. Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro. Toxicol Appl Pharmacol 2008;233(2):203-10
   PubMed Web of Science ®Google Scholar
• Rodríguez-Enríquez S, Juárez O, Rodríguez-Zavala JS, et al. Multisite control of the Crabtree effect in ascites hepatoma cells. Eur J Biochem 2001;268:2512-19
   PubMedGoogle Scholar
• Marroquin LD, Hynes J, Dykens JA, et al. Circumventing the Crabtree effect: Replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants. Tox Sci 2007;97:539-47
   PubMed Web of Science ®Google Scholar
• Jacewicz M, Annand R, Gilbert J, et al. Growth of cells in an optimized medium increases their sensitivity to mitochondrial toxicants. Proc Am Assoc Pharm Sci 2008. p. 3456
   Google Scholar
• Ross R. Cell biology of atherosclerosis. Ann Rev Physiol 1995;57:791-804
   PubMed Web of Science ®Google Scholar
• Lipskaia L, del Monte F, Capiod T, et al. Sarco/endoplasmic reticulum Ca2+-ATPase gene transfer reduces vascular smooth muscle cell proliferation and neointima formation in the rat. Circ Res 2005;97:488-95
   PubMed Web of Science ®Google Scholar
• Lipskaia L, Lompre AM. Alteration in temporal kinetics of Ca2+ signaling and control of growth and proliferation. Biol Cell 2004;96:55-68
   PubMed Web of Science ®Google Scholar
• Vallot O, Combettes L, Jourdon P, et al. Intracellular Ca (2+) handling in vascular smooth muscle cells is affected by proliferation. Arterioscler Thromb Vasc Biol 2000;20:1225-35
   PubMed Web of Science ®Google Scholar
• Gollasch M, Haase H, Ried C, et al. L-type calcium channel expression depends on the differentiated state of vascular smooth muscle cells. FASEB J 1998;12: 593-601
   PubMed Web of Science ®Google Scholar
• Dolmetsch RE, Lewis RS, Goodnow CC, et al. Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Nature 1997;386:855-58
   PubMed Web of Science ®Google Scholar
• Klemm DJ, Watson PA, Frid MG, et al. cAMP response element-binding protein content is a molecular determinant of smooth muscle cell proliferation and migration. J Biol Chem 2001;276:46132-41
   PubMed Web of Science ®Google Scholar
• Cartin L, Lounsbury KM, Nelson MT. Coupling of Ca (2+) to CREB activation and gene expression in intact cerebral arteries from mouse: roles of ryanodine receptors and voltage-dependent Ca (2+) channels. Circ Res 2000;86:760-67
   PubMed Web of Science ®Google Scholar
• Lipskaia L, Pourci ML, Delomenie C, et al. Phosphatidylinositol 3-kinase and calcium-activated transcription pathways are required for VLDL-induced smooth muscle cell proliferation. Circ Res, 2003;92:1115-22
   PubMed Web of Science ®Google Scholar
• Stevenson AS, Gomez MF, Hill-Eubanks DC, et al. NFAT4 movement in native smooth muscle. A role for differential Ca (2+) signaling. J Biol Chem 2001;276:15018-24
   PubMed Web of Science ®Google Scholar
• Park KW, Yang HM, Youn SW, et al. Constitutively active glycogen synthase kinase-3{beta} gene transfer sustains apoptosis, inhibits proliferation of vascular smooth muscle cells, and reduces neointima formation after balloon injury in rats. Arterioscler Thromb Vasc Biol 2003;23:1364-69
   PubMed Web of Science ®Google Scholar
• Morice MC, Serruys PW, Sousa JE, et al. A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization. N Engl J Med 2002;346:1773-80
   PubMed Web of Science ®Google Scholar
• Jenkins NP, Prendergast BD, Thomas M. Drug eluting coronary stents. BMJ, 2002;325:1315-16
   PubMed Web of Science ®Google Scholar
• Bers DM. Cardiac excitation-contraction coupling. Nature 2002;415(6868):198-05
   PubMed Web of Science ®Google Scholar
• Bers DM. Calcium fluxes involved in control of cardiomyocyte contraction. Circ Res 2000;874:275-81
   Google Scholar
• Bers DM. Sarcoplasmic reticulum Ca release in intact ventricular myocytes. Front Biosci 2002;7:1697-11
   Google Scholar
• Bers DM, Weber CR. Na/Ca exchange function in intact ventricular myocytes. Ann NY Acad Sci 2002;976:500-12
   PubMed Web of Science ®Google Scholar
• Pogwizd SM, Bers DM. Na/Ca exchange in heart failure: contractile dysfunction and arrhythmogenesis. Annals of the New York Academy of Sciences 2002;976:454-65
   PubMed Web of Science ®Google Scholar
• Pogwizd SM, Bers DM. Calcium cycling in heart failure: the arrhythmia connection. Journal of Cardiovascular Electrophysiology 2002;131:88-91
   Google Scholar
• Pogwizd SM, Bers DM. Cellular basis of triggered arrhythmias in heart failure. Trends Cardiovasc Med 2004;14(2):61-6
   PubMed Web of Science ®Google Scholar
• Bers DM, Eisner DA, Valdivia HH. Sarcoplasmic reticulum Ca2+ and heart failure: roles of diastolic leak and Ca2+ transport. Circ Res 2003;93(6):487-90
   PubMed Web of Science ®Google Scholar
• Raj SR, Mitchell LB, Sheldon RS. Implantable cardioverter-defibrillators in hypertrophic cardiomyopathy.[comment]. N Engl J Med 2000;343(1):68-9
   PubMedGoogle Scholar
• Maron BJ, Shen WK, Link MS, et al. Efficacy of implantable cardioverter-defibrillators for the prevention of sudden death in patients with hypertrophic cardiomyopathy. [see comment]. N Engl J Med 2000;342(6):365-73
   PubMed Web of Science ®Google Scholar
• Bigger JT Jr. Prophylactic use of implanted cardiac defibrillators in patients at high risk for ventricular arrhythmias after coronary-artery bypass graft surgery. Coronary Artery Bypass Graft (CABG) Patch Trial Investigators.[see comment]. N Engl J Med 1997;337(22):1569-75
   PubMed Web of Science ®Google Scholar
• Mines GR. On circulating excitations in heart muscle and their possible relation to tachycardia and fibrillation. Trans R Soc Can 2001;1914:43-52
   Google Scholar
• Shah M, Akar FG, Tomaselli GF. Molecular basis of arrhythmias. Circulation 2005;112:2517-29
   PubMed Web of Science ®Google Scholar
• Tomaselli GF, Rose J. Molecular aspects of arrhythmias associated with cardiomyopathies. Curr Opin Cardiol 2000;15:202-8
   PubMed Web of Science ®Google Scholar
• Liu XS, Jiang M, Zhang M, et al. Electrical remodeling in a canine model of ischemic cardiomyopathy. Am J Physiol Heart Circ Physiol 2007;292:H560-71
   PubMed Web of Science ®Google Scholar
• Wehrens XH, Lehnart SE, Reiken S, et al. Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proc Nat Acad Sci USA 2005;102(27):9607-12
   PubMed Web of Science ®Google Scholar
• Marx SO, Marks AR. Regulation of the ryanodine receptor in heart failure. Basic Res Cardiol 2002;97(Suppl 1):I49-51
   PubMedGoogle Scholar
• Wehrens XH, Marks AR. Novel therapeutic approaches for heart failure by normalizing calcium cycling. Nat Rev Drug Discov 2004;7:565-73
   Google Scholar
• Wehrens XH, Lehnart SE, Huang F, et al. FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell 2003;113(7):829-40
   PubMed Web of Science ®Google Scholar
• Wehrens XH, Lehnart SE, Reiken S, et al. Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science 2004;304(5668):292-96
   PubMed Web of Science ®Google Scholar
• Lehnart SE, Terrenoire C, Reiken S, et al. Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Nat Acad Sci USA 2006;103(20):7906-10
   PubMed Web of Science ®Google Scholar
• Wehrens XH, Lehnart SE, Reiken S, et al. Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Nat Acad Sci USA 2006;103(3):511-18
   PubMed Web of Science ®Google Scholar
• Wehrens XH, Lehnart SE, Marks AR. Ryanodine receptor-targeted anti-arrhythmic therapy. Ann NY Acad Sci 2005;1047:366-75
   PubMed Web of Science ®Google Scholar
• Akar JG, Akar FG. Mapping arrhythmias in the failing heart: from Langendorff to patient. J Electrocardiology 2006;39(4):S19-23
   PubMed Web of Science ®Google Scholar
• Prunier F, Kawase Y, Gianni D, et al. Prevention of ventricular arrhythmias with sarcoplasmic reticulum Ca2+ ATPase pump overexpression in a porcine model of ischemia reperfusion. Circulation 2008;118:614-24
   PubMed Web of Science ®Google Scholar
• del Monte F, Lebeche D, Guerrero JL, et al. Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cycling. Proc Nat Acad Sci USA 2004;101(15):5622-27
   PubMed Web of Science ®Google Scholar
• Narayan SM, Bayer JD, Lalani G, Trayanova NA. Action potential dynamics explain arrhythmic vulnerability in human heart failure. A clinical and modeling study implicating abnormal calcium handling. JACC 2008;52:1782-92
   Google Scholar
• Gwathmey JK, editor-in-chief; Briggs GM, Allen PD, associate editors. Heart Failure: Basic Research and Clinical Aspects. Marcel Dekker NY 1993
   Google Scholar