81
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

A Low Eosinophil to Platelet Ratio as a Worse Prognostic Index for Emergency Department Attendance in Acute Exacerbation of COPD

ORCID Icon, ORCID Icon, , , , , & show all
Pages 139-147 | Received 24 Oct 2023, Accepted 07 Jan 2024, Published online: 15 Jan 2024

References

  • Christenson SA, Smith BM, Bafadhel M, et al. Chronic obstructive pulmonary disease. Lancet. 2022;399(10342):2227–2242. doi:10.1016/s0140-6736(22)00470-6
  • Soler-Cataluna JJ, Martinez-Garcia MA, Roman Sanchez P, et al. Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease. Thorax. 2005;60(11):925–931. doi:10.1136/thx.2005.040527
  • Xiong W, Xu M, Zhao Y, et al. Can we predict the prognosis of COPD with a routine blood test? Int J Chron Obstruct Pulmon Dis. 2017;12:615–625. doi:10.2147/COPD.S124041
  • Kumar P, Law S, Sriram KB. Evaluation of platelet lymphocyte ratio and 90-day mortality in patients with acute exacerbation of chronic obstructive pulmonary disease. J Thorac Dis. 2017;9(6):1509–1516. doi:10.21037/jtd.2017.05.77
  • Yao C, Liu X, Tang Z. Prognostic role of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio for hospital mortality in patients with AECOPD. Int J Chron Obstruct Pulmon Dis. 2017;12:2285–2290. doi:10.2147/COPD.S141760
  • Abidi K, Khoudri I, Belayachi J, et al. Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units. Crit Care. 2008;12(2):R59. doi:10.1186/cc6883
  • Holland M, Alkhalil M, Chandromouli S, et al. Eosinopenia as a marker of mortality and length of stay in patients admitted with exacerbations of chronic obstructive pulmonary disease. Respirology. 2010;15(1):165–167. doi:10.1111/j.1440-1843.2009.01651.x
  • Yu S, Zhang J, Fang Q, et al. Blood eosinophil levels and prognosis of hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease. Am J Med Sci. 2021;362(1):56–62. doi:10.1016/j.amjms.2021.02.013
  • MacDonald MI, Osadnik CR, Bulfin L, et al. Low and high blood eosinophil counts as biomarkers in hospitalized acute exacerbations of COPD. Chest. 2019;156(1):92–100. doi:10.1016/j.chest.2019.02.406
  • Chan MC, Yeung YC, Elm Y, et al. Blood eosinophil and risk of exacerbation in chronic obstructive pulmonary disease patients: a retrospective cohort analysis. Int J Chron Obstruct Pulmon Dis. 2020;15:2869–2877. doi:10.2147/COPD.S268018
  • Prins HJ, Duijkers R, Lutter R, et al. Blood eosinophilia as a marker of early and late treatment failure in severe acute exacerbations of COPD. Respir Med. 2017;131:118–124. doi:10.1016/j.rmed.2017.07.064
  • Vanderschueren S, De Weerdt A, Malbrain M, et al. Thrombocytopenia and prognosis in intensive care. Crit Care Med. 2000;28(6):1871–1876.
  • Strauss R, Wehler M, Mehler K, et al. Thrombocytopenia in patients in the medical intensive care unit: bleeding prevalence, transfusion requirements, and outcome. Crit Care Med. 2002;30(8):1765–1771.
  • Stéphan F, Hollande J, Richard O, et al. Thrombocytopenia in a surgical ICU. Chest. 1999;115(5):1363–1370.
  • Lopez-Delgado JC, Rovira A, Esteve F, et al. Thrombocytopenia as a mortality risk factor in acute respiratory failure in H1N1 influenza. Swiss Med Wkly. 2013:143:w13788. doi:10.4414/smw.2013.13788
  • Fawzy A, Anderson JA, Cowans NJ, et al. Association of platelet count with all-cause mortality and risk of cardiovascular and respiratory morbidity in stable COPD. Respir Res. 2019;20(1):86. doi:10.1186/s12931-019-1059-1
  • Harrison MT, Short P, Williamson PA, et al. Thrombocytosis is associated with increased short and long term mortality after exacerbation of chronic obstructive pulmonary disease: a role for antiplatelet therapy? Thorax. 2014;69(7):609–615. doi:10.1136/thoraxjnl-2013-203996
  • Steer J, Gibson J, Bourke SC. The DECAF Score: predicting hospital mortality in exacerbations of chronic obstructive pulmonary disease. Thorax. 2012;67(11):970–976. doi:10.1136/thoraxjnl-2012-202103
  • Pascoe S, Locantore N, Dransfield MT, et al. Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials. Lancet Respir Med. 2015;3(6):435–442. doi:10.1016/S2213-2600(15)00106-X
  • Pavord ID, Chanez P, Criner GJ, et al. Mepolizumab for eosinophilic chronic obstructive pulmonary disease. N Engl J Med. 2017;377(17):1613–1629. doi:10.1056/NEJMoa1708208
  • Pavord ID, Korn S, Howarth P, et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet. 2012;380(9842):651–659. doi:10.1016/S0140-6736(12)60988-X
  • Vedel-Krogh S, Nielsen SF, Lange P, et al. Blood eosinophils and exacerbations in chronic obstructive pulmonary disease. the Copenhagen general population study. Am J Respir Crit Care Med. 2016;193(9):965–974. doi:10.1164/rccm.201509-1869OC
  • Lv MY, Qiang LX, Li ZH, et al. The lower the eosinophils, the stronger the inflammatory response? The relationship of different levels of eosinophils with the degree of inflammation in acute exacerbation chronic obstructive pulmonary disease (AECOPD). J Thorac Dis. 2021;13(1):232–243. doi:10.21037/jtd-20-2178
  • Wu H-X, Zhuo K-Q, Cheng D-Y. Peripheral blood eosinophil as a biomarker in outcomes of acute exacerbation of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2019;14:3003–3015. doi:10.2147/COPD.S226783
  • Prudente R, Ferrari R, Mesquita CB, et al. Peripheral blood eosinophils and Nine years mortality in COPD patients. Int J Chron Obstruct Pulmon Dis. 2021;16:979–985. doi:10.2147/COPD.S265275
  • Bartziokas K, Papathanasiou E, Papaioannou AI, et al. Eosinopenia as a prognostic biomarker for noninvasive ventilation use in COPD exacerbations. J Pers Med. 2023;13(4):686.
  • Rahimi-Rad MH, Soltani S, Rabieepour M, et al. Thrombocytopenia as a marker of outcome in patients with acute exacerbation of chronic obstructive pulmonary disease. Pneumonol Alergol Pol. 2015;83(5):348–351. doi:10.5603/PiAP.2015.0056
  • Russell R, Beer S, Pavord ID, et al. The acute wheezy adult with airways disease in the emergency department: a retrospective case-note review of exacerbations of COPD. Int J Chron Obstruct Pulmon Dis. 2019;14:971–977. doi:10.2147/COPD.S190085
  • Linch SN, Kelly AM, Danielson ET, et al. Mouse eosinophils possess potent antibacterial properties in vivo. Infect Immun. 2009;77(11):4976–4982. doi:10.1128/IAI.00306-09
  • Rosenberg HF, Dyer KD, Domachowske JB. Respiratory viruses and eosinophils: exploring the connections. Antiviral Res. 2009;83(1):1–9. doi:10.1016/j.antiviral.2009.04.005
  • Handzel ZT, Busse WW, Sedgwick JB, et al. Eosinophils bind rhinovirus and activate virus-specific T cells. J Immunol. 1998;160(3):1279–1284.
  • Aksoy E, Güngör S, Ağca MÇ, et al. A revised treatment approach for hospitalized patients with eosinophilic and neutrophilic exacerbations of chronic obstructive pulmonary disease. Turk Thorac J. 2018;19(4):193–200. doi:10.5152/TurkThoracJ.2018.18004
  • Rahimirad S, Ghaffary MR, Rahimirad MH, et al. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute exacerbation of chronic obstructive pulmonary disease. Tuberk Toraks. 2017;65(1):25–31.
  • Emami Ardestani M, Alavi-Naeini N. Evaluation of the relationship of neutrophil-to lymphocyte ratio and platelet-to-lymphocyte ratio with in-hospital mortality in patients with acute exacerbation of chronic obstructive pulmonary disease. Clin Respir J. 2021;15(4):382–388. doi:10.1111/crj.13312
  • Chen L, Chen L, Zheng H, et al. Emergency admission parameters for predicting in-hospital mortality in patients with acute exacerbations of chronic obstructive pulmonary disease with hypercapnic respiratory failure. BMC Pulm Med. 2021;21:1.
  • Yang H, Xiang P, Zhang E, et al. Is hypercapnia associated with poor prognosis in chronic obstructive pulmonary disease? A long-term follow-up cohort study. BMJ Open. 2015;5(12):e008909. doi:10.1136/bmjopen-2015-008909
  • Matkovic Z, Huerta A, Soler N, et al. Predictors of adverse outcome in patients hospitalised for exacerbation of chronic obstructive pulmonary disease. Respir Int Rev Thoracic Dis. 2012;84(1):17–26. doi:10.1159/000335467
  • Chen C-W, Chen -Y-Y, C-l L, et al. Severe hypoalbuminemia is a strong independent risk factor for acute respiratory failure in COPD: a nationwide cohort study. Int J Chron Obstruct Pulmon Dis. 2015;10:1147–1154. doi:10.2147/COPD.S85831
  • Lomholt FK, Laulund AS, Bjarnason NH, et al. Meta-analysis of routine blood tests as predictors of mortality in COPD. Eur Clin Respir J. 2014;1. doi:10.3402/ecrj.v1.24110