80
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Association of Frailty with Patient-Report Outcomes and Major Clinical Determinants in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

ORCID Icon, ORCID Icon, ORCID Icon, , , & show all
Pages 907-919 | Received 13 Oct 2023, Accepted 07 Apr 2024, Published online: 12 Apr 2024

References

  • Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol Biol Sci Med Sci. 2001;56(3):M146–M156. doi:10.1093/gerona/56.3.m146
  • Ensrud KE, Ewing SK, Taylor BC, et al. Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. Arch Intern Med. 2008;168(4):382–389. doi:10.1001/archinternmed.2007.113
  • Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–762. doi:10.1016/S0140-6736(12)62167-9
  • Veronese N, Sigeirsdottir K, Eiriksdottir G, et al. Frailty and risk of cardiovascular diseases in older persons: the age, gene/environment susceptibility-Reykjavik study. Rejuvenation Res. 2017;20(6):517–524. doi:10.1089/rej.2016.1905
  • Pollack LR, Litwack-Harrison S, Cawthon PM, et al. Patterns and predictors of frailty transitions in older men: the osteoporotic fractures in men study. J Am Geriatr Soc. 2017;65(11):2473–2479. doi:10.1111/jgs.15003
  • Marengoni A, Vetrano DL, Manes-Gravina E, Bernabei R, Onder G, Palmer K. The relationship between COPD and frailty: a systematic review and meta-analysis of observational studies. Chest. 2018;154(1):21–40. doi:10.1016/j.chest.2018.02.014
  • Yee N, Locke ER, Pike KC, et al. Frailty in chronic obstructive pulmonary disease and risk of exacerbations and hospitalizations. Int J Chron Obstruct Pulmon Dis. 2020;15:1967–1976. doi:10.2147/COPD.S245505
  • Wang L, Zhang X, Liu X. Prevalence and clinical impact of frailty in COPD: a systematic review and meta-analysis. BMC Pulm Med. 2023;23(1):164. doi:10.1186/s12890-023-02454-z
  • Luo J, Zhang D, Tang W, Dou LY, Sun Y. Impact of frailty on the risk of exacerbations and all-cause mortality in elderly patients with stable chronic obstructive pulmonary disease. Clin Interv Aging. 2021;16:593–601. doi:10.2147/CIA.S303852
  • Bernabeu-Mora R, García-Guillamón G, Valera-Novella E, Giménez-Giménez LM, Escolar-Reina P, Medina-Mirapeix F. Frailty is a predictive factor of readmission within 90 days of hospitalization for acute exacerbations of chronic obstructive pulmonary disease: a longitudinal study. Ther Adv Respir Dis. 2017;11(10):383–392. doi:10.1177/1753465817726314
  • Cesari M, Prince M, Thiyagarajan JA, et al. Frailty: an emerging public health priority. J Am Med Dir Assoc. 2016;17(3):188–192. doi:10.1016/j.jamda.2015.12.016
  • Agustí A, Celli BR, Criner GJ, et al. Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary. Eur Respir J. 2023;61(4):2300239. doi:10.1183/13993003.00239-2023
  • Mercieca-Bebber R, King MT, Calvert MJ, Stockler MR, Friedlander M. The importance of patient-reported outcomes in clinical trials and strategies for future optimization. Patient Relat Outcome Meas. 2018;9:353–367. doi:10.2147/PROM.S1562793
  • Machado A, Barusso M, De Brandt J, et al. Impact of acute exacerbations of COPD on patients’ health status beyond pulmonary function: a scoping review. Pulmonology. 2023;29(6):518–534. doi:10.1016/j.pulmoe.2022.04.004
  • Bourbeau J, Ford G, Zackon H, Pinsky N, Lee J, Ruberto G. Impact on patients’ health status following early identification of a COPD exacerbation. Eur Respir J. 2007;30(5):907–913. doi:10.1183/09031936.00166606
  • Casanova C, Marin JM, Martinez-Gonzalez C, et al. Differential effect of modified Medical Research Council dyspnea, COPD assessment test, and clinical COPD questionnaire for symptoms evaluation within the new GOLD staging and mortality in COPD. Chest. 2015;148:159–168. doi:10.1378/chest.14-2449
  • Nishimura K, Kusunose M, Sanda R, Mori M, Shibayama A, Nakayasu K. Comparison of predictive properties between tools of patient-reported outcomes: risk prediction for three future events in subjects with COPD. Diagnostics. 2023;13(13):2269. doi:10.3390/diagnostics13132269
  • Afroz N, Gutzwiller FS, Mackay AJ, Naujoks C, Patalano F, Kostikas K. Patient-reported outcomes (PROs) in COPD clinical trials: trends and gaps. Int J Chron Obstruct Pulmon Dis. 2020;15:1789–1800. doi:10.2147/COPD.S235845
  • Scarlata S, Finamore P, Laudisio A, et al. Association between frailty index, lung function, and major clinical determinants in chronic obstructive pulmonary disease. Aging Clin Exp Res. 2021;33(8):2165–2173. doi:10.1007/s40520-021-01878-z
  • Kusunose M, Oga T, Nakamura S, Hasegawa Y, Nishimura K. Frailty and patient-reported outcomes in subjects with chronic obstructive pulmonary disease: are they independent entities? BMJ Open Respir Res. 2017;4(1):e000196. doi:10.1136/bmjresp-2017-000196
  • Abellan van Kan G, Rolland YM, Morley JE, Vellas B. Frailty: toward a clinical definition. J Am Med Dir Assoc. 2008;9(2):71–72. doi:10.1016/j.jamda.2007.11.005
  • Li J, Wang J, Xie Y, Feng Z. Development and validation of the modified patient-reported outcome scale for chronic obstructive pulmonary disease (mCOPD-PRO). Int J Chron Obstruct Pulmon Dis. 2020;15:661–669. doi:10.2147/COPD.S240842
  • Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for the diagnosis, management and prevention of COPD; 2023. Available from: http://www.goldcopd.org/. Accessed August 24, 2023.
  • Jones PW, Harding G, Berry P, Wiklund I, Chen WH, Kline Leidy N. Development and first validation of the COPD Assessment Test. Eur Respir J. 2009;34(3):648–654. doi:10.1183/09031936.00102509
  • Mahler DA, Wells CK. Evaluation of clinical methods for rating dyspnea. Chest. 1988;93(3):580–586. doi:10.1378/chest.93.3.580
  • Kondrup J, Allison SP, Elia M, et al. ESPEN guidelines for nutrition screening 2002. Clin Nutr. 2003;22(4):415–421. doi:10.1016/s0261-5614(03)00098-0
  • Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–383. doi:10.1016/0021-9681(87)90171-8
  • Zigmond AS, Snaith RP. The Hospital Anxiety and Depression Scale. Acta Psychiatr Scand. 1983;67(6):361–370. doi:10.1111/j.1600-0447.1983.tb09716.x
  • Hanlon P, Guo X, McGhee E, Lewsey J, McAllister D, Mair FS. Systematic review and meta-analysis of prevalence, trajectories, and clinical outcomes for frailty in COPD. NPJ Prim Care Respir Med. 2023;33(1):1. doi:10.1038/s41533-022-00324-5
  • Agustí A, Faner R. COPD beyond smoking: new paradigm, novel opportunities. Lancet Respir Med. 2018;6(5):324–326. doi:10.1016/S2213-2600(18)30060-2
  • Natanek SA, Gosker HR, Slot IG, et al. Heterogeneity of quadriceps muscle phenotype in chronic obstructive pulmonary disease (COPD); implications for stratified medicine? Muscle Nerve. 2013;48(4):488–497. doi:10.1002/mus.23784
  • MacNee W. Accelerated lung aging: a novel pathogenic mechanism of chronic obstructive pulmonary disease (COPD). Biochem Soc Trans. 2009;37(4):819–823. doi:10.1042/BST0370819
  • Chin M, Kendzerska T, Inoue J, et al. Comparing the hospital frailty risk score and the clinical frailty scale among older adults with chronic obstructive pulmonary disease exacerbation. JAMA Network Open. 2023;6(2):e2253692. doi:10.1001/jamanetworkopen.2022.53692
  • Cazzola M, MacNee W, Martinez FJ, et al. Outcomes for COPD pharmacological trials: from lung function to biomarkers. Eur Respir J. 2008;31(2):416–469. doi:10.1183/09031936.00099306
  • Weldam SW, Schuurmans MJ, Liu R, Lammers JW. Evaluation of quality of life instruments for use in COPD care and research: a systematic review. Int J Nurs Stud. 2013;50(5):688–707. doi:10.1016/j.ijnurstu.2012.07.017
  • Oga T, Nishimura K, Tsukino M, Sato S, Hajiro T, Mishima M. Longitudinal deteriorations in patient reported outcomes in patients with COPD. Respir Med. 2007;101(1):146–153. doi:10.1016/j.rmed.2006.04.001
  • Engström CP, Persson LO, Larsson S, Sullivan M. Health-related quality of life in COPD: why both disease-specific and generic measures should be used. Eur Respir J. 2001;18(1):69–76. doi:10.1183/09031936.01.00044901
  • Chen PJ, Yang KY, Perng WC, Lin KC, Wang KY. Effect of dyspnea on frailty stages and related factors in Taiwanese men with COPD. Int J Chron Obstruct Pulmon Dis. 2018;13:2463–2469. doi:10.2147/COPD.S172694
  • Medina-Mirapeix F, Bernabeu-Mora R, Giménez-Giménez LM, Escolar-Reina P, Gacto-Sánchez M, de Oliveira-Sousa SL. Physical frailty characteristics have a differential impact on symptoms as measured by the CAT score: an observational study. Health Qual Life Outcomes. 2018;16(1):140. doi:10.1186/s12955-018-0969-9
  • Park SK, Richardson CR, Holleman RG, Larson JL. Frailty in people with COPD, using the National Health and Nutrition evaluation survey dataset (2003–2006). Heart Lung. 2013;42(3):163–170. doi:10.1016/j.hrtlng.2012.07.004
  • Jones PW, Quirk FH, Baveystock CM, Littlejohns P. A self-complete measure of health status for chronic airflow limitation. The St. George’s respiratory questionnaire. Am Rev Respir Dis. 1992;145(6):1321–1327. doi:10.1164/ajrccm/145.6.1321
  • Yan LC, Lu HY, Wang XY, et al. Prevalence and risk factors of frailty in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis. Eur Geriatr Med. 2023;14(4):789–802. doi:10.1007/s41999-023-00800-2
  • Tanabe N, Sato S. Narrative review of current COPD status in Japan. J Thorac Dis. 2021;13(6):3878–3887. doi:10.21037/jtd-20-2263
  • Brighton LJ, Evans CJ, Farquhar M, et al. Integrating comprehensive geriatric assessment for people with COPD and frailty starting pulmonary rehabilitation: the Breathe Plus feasibility trial protocol. ERJ Open Res. 2021;7(1):00717–2020. doi:10.1183/23120541.00717-2020
  • Andrianopoulos V, Klijn P, Franssen FM, Spruit MA. Exercise training in pulmonary rehabilitation. Clin Chest Med. 2014;35(2):313–322. doi:10.1016/j.ccm.2014.02.013
  • Troosters T, Gosselink R, Janssens W, Decramer M. Exercise training and pulmonary rehabilitation: new insights and remaining challenges. Eur Respir Rev. 2010;19(115):24–29. doi:10.1183/09059180.00007809
  • Gloeckl R, Marinov B, Pitta F. Practical recommendations for exercise training in patients with COPD. Eur Respir Rev. 2013;22(128):178–186. doi:10.1183/09059180.00000513
  • Gloeckl R, Schneeberger T, Jarosch I, Kenn K. Pulmonary rehabilitation and exercise training in chronic obstructive pulmonary disease. Dtsch Ärztebl Int. 2018;115(8):117–123. doi:10.3238/arztebl.2018.0117
  • Zeng Y, Jiang F, Chen Y, Chen P, Cai S. Exercise assessments and trainings of pulmonary rehabilitation in COPD: a literature review. Int J Chron Obstruct Pulmon Dis. 2018;13:2013–2023. doi:10.2147/COPD.S167098
  • Centers for Disease Control and Prevention. Urban-rural differences in chronic obstructive pulmonary disease (COPD). Available from: https://www.cdc.gov/ruralhealth/copd/index.html. Accessed April 21, 2023.
  • Croft JB, Wheaton AG, Liu Y, et al. Urban-rural county and state differences in chronic obstructive pulmonary disease–United States, 2015. MMWR Morb Mortal Wkly Rep. 2018;67(7):205–211. doi:10.15585/mmwr.mm6707a1
  • Raju S, Brigham EP, Paulin LM, et al. The burden of rural chronic obstructive pulmonary disease: analyses from the National health and nutrition examination survey. Am J Respir Crit Care Med. 2020;201(4):488–491. doi:10.1164/rccm.201906-1128LE
  • Barreto P, Greig C, Ferrandez AM. Detecting and categorizing frailty status in older adults using a self-report screening instrument. Arch Gerontol Geriatr. 2012;54(3):e249–e254. doi:10.1016/j.archger.2011.08.003
  • Tazzeo C, Rizzuto D, Calderón-Larrañaga A, et al. Multimorbidity patterns and risk of frailty in older community-dwelling adults: a population-based cohort study. Age Ageing. 2021;50(6):2183–2191. doi:10.1093/ageing/afab138
  • Divo M, Celli BR. Multimorbidity in patients with chronic obstructive pulmonary disease. Clin Chest Med. 2020;41(3):405–419. doi:10.1016/j.ccm.2020.06.002
  • Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol a Biol Sci Med Sci. 2004;59(3):255–263. doi:10.1093/gerona/59.3.m255
  • Hogan D, Lan LT, Diep DT, Gallegos D, Collins PF. Nutritional status of Vietnamese outpatients with chronic obstructive pulmonary disease. J Hum Nutr Diet. 2017;30(1):83–89. doi:10.1111/jhn.12402
  • Nguyen HT, Collins PF, Pavey TG, Nguyen NV, Pham TD, Gallegos DL. Nutritional status, dietary intake, and health-related quality of life in outpatients with COPD. Int J Chron Obstruct Pulmon Dis. 2019;14:215–226. doi:10.2147/COPD.S181322
  • Hoong JM, Ferguson M, Hukins C, Collins PF. Economic and operational burden associated with malnutrition in chronic obstructive pulmonary disease. Clin Nutr. 2017;36(4):1105–1109. doi:10.1016/j.clnu.2016.07.008