64
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Inhibitory Effect of P22077 on Airway Inflammation in Rats with COPD and Its Mechanism

ORCID Icon, , , , &
Pages 779-788 | Received 24 Nov 2023, Accepted 13 Mar 2024, Published online: 19 Mar 2024

References

  • Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global Strategy for Prevention, Diagnosis and Management of COPD: 2023 Report. Available from: https://goldcopd.org/2023-gold-report-2/. Accessed 18 March 2024.
  • World Health Organization. Projections of mortality and causes of death, 2017-2060 【EB/OL】 2018.
  • Zhang X, Xu A, Lv J, et al. Development of small molecule inhibitors targeting NLRP3 inflammasome pathway for inflammatory diseases. Eur J Med Chem. 2020;185:111822. doi:10.1016/j.ejmech.2019.111822
  • Guo H, Callaway JB, Ting JP. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med. 2015;21(7):677–687. doi:10.1038/nm.3893
  • Latz E, Xiao TS, Stutz A. Activation and regulation of the inflammasomes. Nat Rev Immunol. 2013;13(6):397–411. doi:10.1038/nri3452
  • Yang J, Liu Z, Xiao TS. Post-translational regulation of inflammasomes. Cell Mol Immunol. 2017;14(1):65–79. doi:10.1038/cmi.2016.29
  • Juliana C, Fernandes-Alnemri T, Kang S, Farias A, Qin F, Alnemri ES. Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. J Biol Chem. 2012;287(43):36617–36622. doi:10.1074/jbc.M112.407130
  • Zeng M, Zhang X, Xing W, Wang Q, Liang G, He Z. Cigarette smoke extract mediates cell premature senescence in chronic obstructive pulmonary disease patients by up-regulating USP7 to activate p300-p53/p21 pathway. Toxicol Lett. 2022;359:31–45. doi:10.1016/j.toxlet.2022.01.017
  • Palazon-Riquelme P, Worboys JD, Green J, et al. USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation. EMBO Rep. 2018;19(10). doi:10.15252/embr.201744766
  • Cui Y, Luo L, Zeng Z, et al. MFG-E8 stabilized by deubiquitinase USP14 suppresses cigarette smoke-induced ferroptosis in bronchial epithelial cells. Cell Death Dis. 2023;14(1):2. doi:10.1038/s41419-022-05455-8
  • Juliana C, Fernandes-Alnemri T, Wu J, et al. Anti-inflammatory compounds parthenolide and bay 11–7082 are direct inhibitors of the inflammasome. J Biol Chem. 2010;285(13):9792–9802. doi:10.1074/jbc.M109.082305
  • Song X, Wang C, Bai C. Establishment of rat chronic obstructive pulmonary disease model: a comparison between exposure to cigarette smoke alone and in combination with intra-tracheal injection of lipopolysaccharide. Former Acad J Sec Mil Med Univers. 2010;31(03):246–249. doi:10.3724/SP.J.1008.2010.00246
  • Kim RY, Pinkerton JW, Gibson PG, Cooper MA, Horvat JC, Hansbro PM. Inflammasomes in COPD and neutrophilic asthma. Thorax. 2015;70(12):1199–1201. doi:10.1136/thoraxjnl-2014-206736
  • Franklin BS, Bossaller L, De Nardo D, et al. The adaptor ASC has extracellular and ‘prionoid’ activities that propagate inflammation. Nat Immunol. 2014;15(8):727–737. doi:10.1038/ni.2913
  • Nachmias N, Langier S, Brzezinski RY, et al. NLRP3 inflammasome activity is upregulated in an in-vitro model of COPD exacerbation. PLoS One. 2019;14(5):e214622. doi:10.1371/journal.pone.0214622
  • Faner R, Sobradillo P, Noguera A, et al. The inflammasome pathway in stable COPD and acute exacerbations. ERJ Open Res. 2016;2(3):00002–2016. doi:10.1183/23120541.00002-2016
  • Song H, Zhao C, Yu Z, et al. UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression. Nat Commun. 2020;11(1):6042. doi:10.1038/s41467-020-19939-8
  • Mitxitorena I, Somma D, Mitchell JP, et al. The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-kB subunits. J Biol Chem. 2020;295(33):11754–11763. doi:10.1074/jbc.RA120.014113
  • Zhao XB, Ji FY, Li HR, et al. P22077 inhibits LPS-induced inflammatory response by promoting K48-linked ubiquitination and degradation of TRAF6. Aging. 2020;12(11):10969–10982. doi:10.18632/aging.103309
  • Liu G, Liu Q, Yan B, Zhu Z, Xu Y. USP7 inhibition alleviates H(2)O(2)-induced injury in chondrocytes via inhibiting NOX4/NLRP3 pathway. Front Pharmacol. 2020;11:617270. doi:10.3389/fphar.2020.617270