313
Views
0
CrossRef citations to date
0
Altmetric
EXPERT OPINION

Guidelines for Rational Clinical Use of Fentanyl Transdermal Patch

ORCID Icon, , , , , , , & show all
Pages 233-255 | Received 26 Mar 2023, Accepted 11 Jan 2024, Published online: 15 Feb 2024

References

  • World Health Organization. WHO guidelines for the pharmacological and radiotherapeutic management of cancer pain in adults and adolescents. World Health Organization; 2018. Available from: https://apps.who.int/iris/handle/10665/279700. Accessed January 19, 2024.
  • World Health Organization. Model list of essential medicines; 2019. Available from: https://list.essentialmeds.org/. Accessed January 19, 2024.
  • Deng G. Integrative medicine therapies for pain management in cancer patients. Cancer J. 2019;25(5):343–348. doi:10.1097/PPO.0000000000000399
  • Davis MP. Fentanyl for breakthrough pain: a systematic review. Expert Rev Neurother. 2011;11(8):1197–1216. doi:10.1586/ern.11.63
  • Yang M, Z. X, M. M, et al. CSCO guidelines for metastatic colorectal cancer: personalized medicine in clinical practice. Cancer Biol Med. 2023;20:640–645. doi:10.20892/j.issn.2095-3941.2023.0211
  • Hair PI, Keating GM, McKeage K. Transdermal matrix fentanyl membrane patch (matrifen): in severe cancer-related chronic pain. Drugs. 2008;68:2001–2009. doi:10.2165/00003495-200868140-00005
  • Yu SY. New dosage form of fentanyl. Clin J Pract Hosp. 2006;3:94–95.
  • Pathan H, Williams J. Basic opioid pharmacology: an update. Br J Pain. 2012;6:11–16. doi:10.1177/2049463712438493
  • Zhuang Y, Wang Y, He B, et al. Molecular recognition of morphine and fentanyl by the human mu-opioid receptor. Cell. 2022;185:4361–75 e19. doi:10.1016/j.cell.2022.09.041
  • Thompson JP, Bower S, Liddle AM, Rowbotham DJ. Perioperative pharmacokinetics of transdermal fentanyl in elderly and young adult patients. Br J Anaesth. 1998;81(2):152–154. doi:10.1093/bja/81.2.152
  • Collins JJ, Dunkel IJ, Gupta SK. Transdermal fentanyl in children with cancer pain: feasibility, tolerability, and pharmacokinetic correlates. J Pediatr. 1999;134(3):319–323. doi:10.1016/S0022-3476(99)70457-9
  • Grond S, Radbruch L, Lehmann KA. Clinical pharmacokinetics of transdermal opioids: focus on transdermal fentanyl. Clin Pharmacokinet. 2000;38:59–89. doi:10.2165/00003088-200038010-00004
  • Pettifer GR, Hosgood G. The effect of inhalant anesthetic and body temperature on peri-anesthetic serum concentrations of transdermally administered fentanyl in dogs. Vet Anaesth Analg. 2004;31(2):109–120. doi:10.1111/j.1467-2987.2004.00158.x
  • Kyles AE, Papich M, Hardie EM. Disposition of transdermally administered fentanyl in dogs. Am J Vet Res. 1996;57:715–719.
  • Egger CM, Glerum LE, Allen SW, Haag M. Plasma fentanyl concentrations in awake cats and cats undergoing anesthesia and ovariohysterectomy using transdermal administration. Vet Anaesth Analg. 2003;30(4):229–236. doi:10.1046/j.1467-2995.2003.00109.x
  • Mather LE. Clinical pharmacokinetics of fentanyl and its newer derivatives. Clin Pharmacokinet. 1983;8(5):422–446. doi:10.2165/00003088-198308050-00004
  • Hess R, Herz A, Friedel K. Pharmacokinetics of fentanyl in rabbits in view of the importance for limiting the effect. J Pharmacol Exp Ther. 1971;179:474–484.
  • Camu F, Vanlersberghe C. Pharmacology of systemic analgesics. Best Pract Res Clin Anaesthesiol. 2002;16(4):475–488. doi:10.1053/bean.2002.0262
  • FDA. Duragesic: fentanyl transdermal system[EB/OL]; 2005. Available from: http://www.fda.gov/cder/foi/label/2005/19813s039lb.lpdf. Accessed January 19, 2024.
  • Moore RA, Hand CW, McQuay HJ. Opiate metabolism and excretion. Bailliere’s Clin Anaesthesiol. 1987;1:829. doi:10.1016/S0950-3501(87)80038-7
  • Fallon M, Giusti R, Aielli F, et al. Management of cancer pain in adult patients: ESMO clinical practice guidelines. Ann Oncol. 2018;29:iv166–iv91. doi:10.1093/annonc/mdy152
  • 2021 NCCN Adult Cancer Pain. Version 1.2021, 02/26/2021 © 2021 National Comprehensive Cancer Network® (NCCN®). NCCN Clinical Practice Guidelines in Oncology-Adult Cancer Pain. (2021 Version2) [DB/OL]. Available from: https://www.nccn.org/professionals/physician_gls/pdf/pain.pdf. Accessed January 19, 2024.
  • Mercadante S. Options for treating pain in cancer patients with dysphagia. Drugs. 2017;77(6):629–635. doi:10.1007/s40265-017-0710-8
  • Xing S-Z, Zhang Y. Efficacy and safety of transdermal fentanyl for the treatment of oral mucositis pain caused by chemoradiotherapy in patients with esophageal squamous cell carcinoma. Support Care Cancer. 2015;23(3):753–759. doi:10.1007/s00520-014-2419-5
  • Guo S-P, Wu S-G, Zhou J, et al. Transdermal fentanyl for pain due to chemoradiotherapy-induced oral mucositis in nasopharyngeal cancer patients: evaluating efficacy, safety, and improvement in quality of life. Drug Des Devel Ther. 2014;8:497–503. doi:10.2147/DDDT.S60187
  • Wang YQ, Wang MJ, Qiu ZM. Application of transdermal fentanyl patch in cancer pain patients with renal insufficiency. J Pract Cancer. 2012;27:529–53v.
  • Cheng Yi YS. The selective use of opioids in patients with liver and kidney dysfunction and cancer pain. Chin J Cancer. 2020;20:43–47.
  • Yu SY, Qin SK, Xie GR. Expert consensus on the treatment of advanced cancer patients with intestinal obstruction. Chin J Cancer. 2007;29:637–640.
  • Miyoshi T, Yamauchi H, Misumi N. [Efficacy and safety of transdermal fentanyl patches for opioid initiation in patients with gastrointestinal obstruction]. Gan Kagaku Ryoho. 2014;41(11):1401–1405. Japan.
  • Yang Q, Xie D, Jiang ZM. Efficacy and adverse effects of transdermal fentanyl and sustained-release oral morphine in treating moderate-severe cancer pain in Chinese population: a systematic review and meta-analysis. J Exper Clin Cancer Res. 2010;29:67. doi:10.1186/1756-9966-29-67
  • Caraceni A, Hanks G, Kaasa S, et al. Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC. Lancet Oncol. 2012;13(2):e58–e68. doi:10.1016/S1470-2045(12)70040-2
  • Wang DD, Ma TT, Zhu HD, Peng CB. Transdermal fentanyl for cancer pain: trial sequential analysis of 3406 patients from 35 randomized controlled trials. J Cancer Res Ther. 2018;14:S14–S21. doi:10.4103/0973-1482.171368
  • Hadley G, Derry S, Moore RA, Wiffen PJ. Transdermal fentanyl for cancer pain. Cochrane Database Syst Rev. 2013;2013:CD010270. doi:10.1002/14651858.CD010270.pub2
  • Liu JY, Xue J, Zhu T. Risk comparison of morphine sulfate sustained-release tablets, oxycodone hydrochloride sustained-release tablets and fentanyl transdermal patch in the treatment of cancer pain and constipation. China Pharm. 2015;16:316–318.
  • Megens AA, Artois K, Vermeire J, Meert T, Awouters FH. Comparison of the analgesic and intestinal effects of fentanyl and morphine in rats. J Pain Symptom Manage. 1998;15:253–257. doi:10.1016/S0885-3924(97)00371-0
  • 2021 NCCN Adult Cancer Pain. Version 1.2021, 02/26/2021 © 2021 National Comprehensive Cancer Network® (NCCN®). NCCN Clinical Practice Guidelines in Oncology-Adult Cancer Pain. (2021 Version2) [DB/OL]. Available from: https://www.nccn.org/professionals/physician_gls/pdf/pain.pdf.PMID:34551388. Accessed January 19, 2024.
  • Bemard B. Is transdermal fentanyl really better than sustained oral morphine. BMJ. 2015;322:1154–1158.
  • Kang JH, Oh SY, Song S-Y, et al. The efficacy of low-dose transdermal fentanyl in opioid-naive cancer patients with moderate-to-severe pain. Korean J Intern Med. 2015;30(1):88–95. doi:10.3904/kjim.2015.30.1.88
  • Fu Q, Ran FM, Wang JZ. Clinical efficacy and safety of fentanyl transdermal patch in the treatment of moderate to severe cancer pain within 3 days. Cancer Progress. 2014;4:317.
  • Yalcin S, Esin E. Neuropathic cancer pain: what we are dealing with? How to manage it. Oncot Ther. 2014;4:599–618. doi:10.2147/OTT.S60995
  • Vuong C, Van Uum SH, O’Dell LE, Lutfy K, Friedman TC. The effects of opioids and opioid analogs on animal and human endocrine systems. Endocr Rev. 2010;31:98–132. doi:10.1210/er.2009-0009
  • Toru H. Molecular mechanisms of bone cancer pain. ClinCalc. 2014;24:1185–1191.
  • El Mouedden M, Meert TF. The impact of the opioids fentanyl and morphine on nociception and bone destruction in a murine model of bone cancer pain. Pharmacol Biochem Behav. 2007;87:30–40. doi:10.1016/j.pbb.2007.03.017
  • Yu SY, Sun Y, Wu YL. Clinical efficacy analysis of transdermal fentanyl patch in the treatment of 4492 cases of cancer pain. Chin J Cancer. 2005;27:369–372.
  • Cancer Clinical Chemotherapy Committee of China Anti Cancer Association. Cancer Support Therapy Committee of China Anti Cancer Association Chinese expert consensus on the prevention and treatment of nausea and vomiting related to tumor drug therapy (2019 edition). Chin J Med Front. 2019;11:16–26.
  • Jee YS, Yoon HJ, Jang CH. Prophylactic antiemetic effects in gynecologic patients receiving fentanyl IV-patient controlled analgesia: comparison of combined treatment with ondansetron and dexamethasone with metoclopramide and dexamethasone. Korean J Anesthesiol. 2010;59:335–339. doi:10.4097/kjae.2010.59.5.335
  • Nelson AD, Camilleri M. Opioid induced constipation: advances and clinical guidance. Ther Adv Chronic Dis. 2016;7:121–134. doi:10.1177/2040622315627801
  • G. JJ, Akbaral H. Molecular physiology of enteric opioid receptors. Am J Gastroenterol Suppl. 2014;2:17–21. doi:10.1038/ajgsup.2014.5
  • Yan L, Liu H, Yan R, Tan L, Tan J, Lei Y. Effect of traditional Chinese medicine external therapy for functional constipation: a meta-analysis. Am J Transl Res. 2023;15:13–26.
  • Ziesenitz VC, Vaughns JD, Koch G, Mikus G, van den Anker JN. Pharmacokinetics of fentanyl and its derivatives in children: a comprehensive review. Clin Pharmacokinet. 2018;57:125–149. doi:10.1007/s40262-017-0569-6
  • Paut O, Camboulives J, Viard L, Lemoing JP, Levron JC. Pharmacokinetics of transdermal fentanyl in the peri-operative period in young children. Anaesthesia. 2000;55:1202–1207. doi:10.1046/j.1365-2044.2000.01615-3.x
  • Lynn W, Megan A, Gregory S. Modafinil treatment of opioid-induced sedation. Pain Med. 2010;10:135–140.
  • Meng SQ, Shi J. Abuse of pharmaceutical drugs and its prevention. Fa Yi Xue Za Zhi. 2021;37:788–795.
  • Heal DJ, Smith SL, Henningfield JE. CNS stimulants. Neuropharmacology. 2014;87:1–3. doi:10.1016/j.neuropharm.2014.09.025
  • Dackis CA, Gold MS. Addictiveness of central stimulants. Adv Alcohol Subst Abuse. 1990;9:9–26. doi:10.1300/J251v09n01_02
  • Ibrahim AM, Obaidi Z, Ruan G, Adaramola D, Onguti S. Nalbuphine for opioid-induced urine retention. Ann Intern Med. 2018;169:894–895. doi:10.7326/L18-0387
  • Kim B, Sciascia T, Yosipovitch G. The role of kappa- and mu-opioid receptors in pruritus. SKIN J Cutaneous Med. 2021;5:s31.
  • Morita T, Tei Y. Skin reaction to both morphine and fentanyl attenuated by steroids and antihistaminics. J Pain Symptom Manage. 2006;32(2):100–101. doi:10.1016/j.jpainsymman.2006.04.002
  • Vertigo professional committee of Chinese medical education association, emergency physician branch of Chinese medical doctor association guidelines for emergency diagnosis and treatment of vertigo (2021). Chin J Emerg Med. 2021;30:402–406.
  • Sharma V, Simpson SH, Samanani S, Jess E, Eurich DT. Concurrent use of opioids and benzodiazepines/Z-drugs in Alberta, Canada and the risk of hospitalisation and death: a case cross-over study. BMJ Open. 2020;10(11):e038692. doi:10.1136/bmjopen-2020-038692
  • Liu EY, Tamblyn R, Filion KB, Buckeridge DL. Concurrent prescriptions for opioids and benzodiazepines and risk of opioid overdose: protocol for a retrospective cohort study using linked administrative data. BMJ Open. 2021;11(2):e042299. doi:10.1136/bmjopen-2020-042299
  • Ziesenitz VC, Konig SK, Mahlke NS, Skopp G, Haefeli WE, Mikus G. Pharmacokinetic interaction of intravenous fentanyl with ketoconazole. J Clin Pharmacol. 2015;55(6):708–717. doi:10.1002/jcph.469
  • Nozari A, Akeju O, Mirzakhani H, et al. Prolonged therapy with the anticonvulsant carbamazepine leads to increased plasma clearance of fentanyl. J Pharm Pharmacol. 2019;71:982–987. doi:10.1111/jphp.13079
  • Kuip EJ, Zandvliet ML, Koolen SL, Mathijssen RH, van der Rijt CC. A review of factors explaining variability in fentanyl pharmacokinetics; focus on implications for cancer patients. Br J Clin Pharmacol. 2017;83:294–313. doi:10.1111/bcp.13129
  • Geist MJP, Ziesenitz VC, Bardenheuer HJ, Burhenne J, Skopp G, Mikus G. Minor contribution of cytochrome P450 3A activity on fentanyl exposure in palliative care cancer patients. Sci Rep. 2019;9:14635. doi:10.1038/s41598-019-51279-6
  • Baneyx G, Parrott N, Meille C, Iliadis A, Lave T. Physiologically based pharmacokinetic modeling of CYP3A4 induction by rifampicin in human: influence of time between substrate and inducer administration. Eur J Pharm Sci. 2014;56:1–15. doi:10.1016/j.ejps.2014.02.002
  • Kokko H, Hall PD, Afrin LB. Fentanyl-associated syndrome of inappropriate antidiuretic hormone secretion. Pharmacotherapy. 2002;22(9):1188–1192. doi:10.1592/phco.22.13.1188.33526
  • Rastogi R, Swarm RA, Patel TA, Riou B. Case scenario: opioid association with serotonin syndrome: implications to the practitioners. Anesthesiology. 2011;115(6):1291–1298. doi:10.1097/ALN.0b013e31823940c0
  • Kitamura S, Kawano T, Kaminaga S, et al. Effects of fentanyl on serotonin syndrome-like behaviors in rats. J Anesth. 2016;30:178–182. doi:10.1007/s00540-015-2092-y
  • Baldo BA. Opioid analgesic drugs and serotonin toxicity (syndrome): mechanisms, animal models, and links to clinical effects. Arch Toxicol. 2018;92(8):2457–2473. doi:10.1007/s00204-018-2244-6
  • Rickli A, Liakoni E, Hoener MC, Liechti ME. Opioid-induced inhibition of the human 5-HT and noradrenaline transporters in vitro: link to clinical reports of serotonin syndrome. Br J Pharmacol. 2018;175(3):532–543. doi:10.1111/bph.14105
  • Kim JH, Kim M, Sung CW, et al. High-dose fentanyl patch for cancer pain of a patient with cholangiocarcinoma. Korean J Intern Med. 2010;25(3):337–340. doi:10.3904/kjim.2010.25.3.337
  • Dai YM, Cui TJ, Lin GS. Clinical observation of high-dose fentanyl transdermal patch in the treatment of advanced cancer pain. Mod Tumor Med. 2016;24:138–139.
  • Pergolizzi J, H. BR, Budd K, et al. Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone). Pain Pract. 2008;8:287–313. doi:10.1111/j.1533-2500.2008.00204.x
  • Singleton MA, Rosen JI, Fisher DM, Kitamura S, Kawano T, Kaminaga S. Pharmacokinetics of fentanyl in the elderly. Br J Anaesth. 1988;60:178–182. doi:10.1093/bja/60.6.619
  • H. SS, Ghosh P, Newman B, et al. On the road to development of an in Vitro Permeation Test (IVPT) model to compare heat effects on transdermal delivery systems: exploratory studies with nicotine and fentanyl. Pharm Res. 2017;34:1817–1830. doi:10.1007/s11095-017-2189-0
  • Chinese nursing society, expert consensus on nursing guidance for cancer pain patients (2017 edition). Chin J Nurs Manag. 2017;17:1585–1586.
  • Zhang HZ, Yu HY, Wen CD. Application and effect analysis of information-based whole process management in outpatient cancer pain management. Hosp Manag Forum. 2019;272:73–75.
  • Li WJ, Liu JY, Si Q. The development and change of the concept of cancer pain drug treatment. J Med. 2021;40:45–51.