UHPLC-qTOF-MS-Based Nontargeted Metabolomics to Characterize the Effects of Capsaicin on Plasma and Skin Metabolic Profiles of C57BL/6 Mice-An In vivo Experimental Study

References

• Sun F, Xiong S, Zhu Z. Dietary capsaicin protects cardiometabolic organs from dysfunction. Nutrients. 2016;8(5):174. doi:10.3390/nu8050174
   PubMed Web of Science ®Google Scholar
• Tapsell LC, Hemphill I, Cobiac L, et al. Health benefits of herbs and spices: the past, the present, the future. Med j Australia. 2006;185(S4):S1–s24. doi:10.5694/j.1326-5377.2006.tb00548.x
   PubMedGoogle Scholar
• Ahuja KD, Robertson IK, Geraghty DP, Ball MJ. Effects of chili consumption on postprandial glucose, insulin, and energy metabolism. Am j Clin Nutr. 2006;84(1):63–69. doi:10.1093/ajcn/84.1.63
   PubMed Web of Science ®Google Scholar
• Chaiyasit K, Khovidhunkit W, Wittayalertpanya S. Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level. J Med Assoc Thai. 2009;92(1):108–113.
   PubMedGoogle Scholar
• Yuan LJ, Qin Y, Wang L, et al. Capsaicin-containing chili improved postprandial hyperglycemia, hyperinsulinemia, and fasting lipid disorders in women with gestational diabetes mellitus and lowered the incidence of large-for-gestational-age newborns. Clin nutr. 2016;35(2):388–393. doi:10.1016/j.clnu.2015.02.011
   PubMed Web of Science ®Google Scholar
• Lejeune MP, Kovacs EM, Westerterp-Plantenga MS. Effect of capsaicin on substrate oxidation and weight maintenance after modest body-weight loss in human subjects. Brit j Nutr. 2003;90(3):651–659. doi:10.1079/BJN2003938
   PubMed Web of Science ®Google Scholar
• Snitker S, Fujishima Y, Shen H, et al. Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am j Clin Nutr. 2009;89(1):45–50. doi:10.3945/ajcn.2008.26561
   PubMed Web of Science ®Google Scholar
• Peng J, Li YJ. The vanilloid receptor TRPV1: role in cardiovascular and gastrointestinal protection. Eur J Pharmacol. 2010;627(1–3):1–7. doi:10.1016/j.ejphar.2009.10.053
   PubMed Web of Science ®Google Scholar
• Ma L, Zhong J, Zhao Z, et al. Activation of TRPV1 reduces vascular lipid accumulation and attenuates atherosclerosis. Cardiovasc Res. 2011;92(3):504–513. doi:10.1093/cvr/cvr245
   PubMed Web of Science ®Google Scholar
• Zhang R, Humphreys I, Sahu RP, Shi Y, Srivastava SK. In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway. Apoptosis. 2008;13(12):1465–1478. doi:10.1007/s10495-008-0278-6
   PubMed Web of Science ®Google Scholar
• Lu HF, Chen YL, Yang JS, et al. Antitumor activity of capsaicin on human colon cancer cells in vitro and colo 205 tumor xenografts in vivo. J Agr Food Chem. 2010;58(24):12999–13005. doi:10.1021/jf103335w
   PubMed Web of Science ®Google Scholar
• Wang F, Huang X, Chen Y, et al. Study on the effect of capsaicin on the intestinal flora through high-throughput sequencing. ACS Omega. 2020;5(2):1246–1253. doi:10.1021/acsomega.9b03798
   PubMed Web of Science ®Google Scholar
• Surh YJ, Lee SS. Capsaicin in hot chili pepper: carcinogen, co-carcinogen or anticarcinogen? Food Chem Toxicol. 1996;34(3):313–316. doi:10.1016/0278-6915(95)00108-5
   PubMed Web of Science ®Google Scholar
• Liu NC, Hsieh PF, Hsieh MK, et al. Capsaicin-mediated tNOX (ENOX2) up-regulation enhances cell proliferation and migration in vitro and in vivo. J Agr Food Chem. 2012;60(10):2758–2765. doi:10.1021/jf204869w
   PubMed Web of Science ®Google Scholar
• Bode AM, Dong Z. The two faces of capsaicin. Cancer Res. 2011;71(8):2809–2814. doi:10.1158/0008-5472.CAN-10-3756
   PubMed Web of Science ®Google Scholar
• Weiss E, Katta R. Diet and rosacea: the role of dietary change in the management of rosacea. Dermatol Pract Conc. 2017;7(4):31–37. doi:10.5826/dpc.0704a08
   PubMedGoogle Scholar
• Han RT, Kim S, Choi K, et al. Asthma-like airway inflammation and responses in a rat model of atopic dermatitis induced by neonatal capsaicin treatment. J Asthma Allergy. 2017;10:181–189. doi:10.2147/JAA.S124902
   PubMed Web of Science ®Google Scholar
• Roessner U, Bowne J. What is metabolomics all about? Biotechniques. 2009;46(5):363–365. doi:10.2144/000113133
   PubMed Web of Science ®Google Scholar
• Wishart DS. Emerging applications of metabolomics in drug discovery and precision medicine. Nat Rev Drug Discov. 2016;15(7):473–484. doi:10.1038/nrd.2016.32
   PubMed Web of Science ®Google Scholar
• Lin P, Qin Z, Yao Z, et al. Metabolites profile of Gualou Xiebai Baijiu decoction (a classical traditional Chinese medicine prescription) in rats by ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry. J Chromato B-Analyt Technol Biomed Life Sci. 2018;1085:72–88. doi:10.1016/j.jchromb.2018.04.001
   PubMed Web of Science ®Google Scholar
• Saigusa D, Okamura Y, Motoike IN, et al. Establishment of Protocols for Global Metabolomics by LC-MS for Biomarker Discovery. PLoS One. 2016;11(8):e0160555. doi:10.1371/journal.pone.0160555
   PubMed Web of Science ®Google Scholar
• Whiting S, Derbyshire E, Tiwari BK. Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence. Appetite. 2012;59(2):341–348. doi:10.1016/j.appet.2012.05.015
   PubMed Web of Science ®Google Scholar
• Zhang LL, Yan Liu D, Ma LQ, et al. Activation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesity. Circ res. 2007;100(7):1063–1070. doi:10.1161/01.RES.0000262653.84850.8b
   PubMed Web of Science ®Google Scholar
• Vanderperre B, Bender T, Kunji ER, Martinou JC. Mitochondrial pyruvate import and its effects on homeostasis. Curr Opin Cell Biol. 2015;33:35–41. doi:10.1016/j.ceb.2014.10.008
   PubMed Web of Science ®Google Scholar
• Qiang F. Effect of malate-oligosaccharide solution on antioxidant capacity of endurance athletes. Open Biomed Eng J. 2015;9:326–329. doi:10.2174/1874120701509010326
   PubMedGoogle Scholar
• Ashrafi K. Obesity and the Regulation of Fat Metabolism. WormBook; 2007:1–20.
   Google Scholar
• Zhao Z, Wang J, Wang L, et al. capsaicin protects against oxidative insults and alleviates behavioral deficits in rats with 6-OHDA-induced parkinson’s disease via activation of TRPV1. Neurochem Res. 2017;42(12):3431–3438. doi:10.1007/s11064-017-2388-4
   PubMed Web of Science ®Google Scholar
• Srinivasan K. Antioxidant potential of spices and their active constituents. Crit Rev Food Sci. 2014;54(3):352–372. doi:10.1080/10408398.2011.585525
   PubMed Web of Science ®Google Scholar
• Rubió L, Motilva MJ, Romero MP. Recent advances in biologically active compounds in herbs and spices: a review of the most effective antioxidant and anti-inflammatory active principles. Crit Rev Food Sci. 2013;53(9):943–953. doi:10.1080/10408398.2011.574802
   PubMed Web of Science ®Google Scholar
• Dalazen GR, Terra M, Jacques CE, et al. Pipecolic acid induces oxidative stress in vitro in cerebral cortex of young rats and the protective role of lipoic acid. Metab Brain Dis. 2014;29(1):175–183. doi:10.1007/s11011-013-9466-3
   PubMed Web of Science ®Google Scholar
• Pekcetin C, Kiray M, Ergur BU, et al. Carnosine attenuates oxidative stress and apoptosis in transient cerebral ischemia in rats. Acta biol hung. 2009;60(2):137–148. doi:10.1556/ABiol.60.2009.2.1
   PubMed Web of Science ®Google Scholar
• Tsai SJ, Kuo WW, Liu WH, Yin MC. Antioxidative and anti-inflammatory protection from carnosine in the striatum of MPTP-treated mice. J Agr Food Chem. 2010;58(21):11510–11516.
   PubMed Web of Science ®Google Scholar
• Pandey KB, Rizvi SI. Role of red grape polyphenols as antidiabetic agents. Integr Med Res. 2014;3(3):119–125. doi:10.1016/j.imr.2014.06.001
   PubMedGoogle Scholar
• Coleman DN, Lopreiato V, Alharthi A, Loor JJ. Amino acids and the regulation of oxidative stress and immune function in dairy cattle. J Anim Sci. 2020;98(Suppl 1):S175–s193. doi:10.1093/jas/skaa138
   PubMedGoogle Scholar
• Yuan W, Wang Y, Heinecke JW, Fu X. Hypochlorous acid converts the gamma-glutamyl group of glutathione disulfide to 5-hydroxybutyrolactam, a potential marker for neutrophil activation. J Biol Chem. 2009;284(39):26908–26917. doi:10.1074/jbc.M109.005496
   PubMed Web of Science ®Google Scholar
• Huxtable RJ. Physiological actions of taurine. Physiol Rev. 1992;72(1):101–163. doi:10.1152/physrev.1992.72.1.101
   PubMed Web of Science ®Google Scholar
• Woo HA, Chae HZ, Hwang SC, et al. Reversing the inactivation of peroxiredoxins caused by cysteine sulfinic acid formation. Science. 2003;300(5619):653–656. doi:10.1126/science.1080273
   PubMed Web of Science ®Google Scholar
• Terzian AL, Aguiar DC, Guimarães FS, Moreira FA. Modulation of anxiety-like behaviour by transient receptor potential vanilloid type 1 (TRPV1) channels located in the dorsolateral periaqueductal gray. Eur neuropsychopharm. 2009;19(3):188–195. doi:10.1016/j.euroneuro.2008.11.004
   PubMed Web of Science ®Google Scholar
• Xia J, Gu L, Guo Y, et al. Gut microbiota mediates the preventive effects of dietary capsaicin against depression-like behavior induced by lipopolysaccharide in mice. Front Cell Infect Microbiol. 2021;11:627608. doi:10.3389/fcimb.2021.627608
   PubMed Web of Science ®Google Scholar
• Chen KT, Wu CH, Tsai MH, et al. Antidepressant-like effects of long-term sarcosine treatment in rats with or without chronic unpredictable stress. Behav Brain Res. 2017;316:1–10. doi:10.1016/j.bbr.2016.06.004
   PubMed Web of Science ®Google Scholar
• Ou-Yang XL, Zhang D, Wang XP, et al. Nontargeted metabolomics to characterize the effects of isotretinoin on skin metabolism in rabbit with acne. Front Pharmacol. 2022;13:963472. doi:10.3389/fphar.2022.963472
   PubMed Web of Science ®Google Scholar
• Yu S, Xiao Z, Ou Yang X, Wang X, Zhang D, Li C. Untargeted metabolomics analysis of the plasma metabolic signature of moderate-to-severe acne. Clin. Chim. Acta. 2022;533:79–84. doi:10.1016/j.cca.2022.06.012
   PubMed Web of Science ®Google Scholar
• Xiao Z, Yu S, Ou Yang X, et al. Non-targeted metabolomics analysis reveals changes in plasma and skin metabolic profiles after capsaicin gavage in mice. Res Square. 2022. doi:10.21203/rs.3.rs-1719825/v1
   Google Scholar