Nicotine Diminishes Alpha2-Adrenergic Receptor-Dependent Protection Against Oxidative Stress in H9c2 Cardiomyocytes

References

• Anderson JL, Morrow DA, Campion EW. Acute myocardial infarction. N Engl J Med. 2017;376(21):2053–2064. doi:10.1056/NEJMra1606915
   PubMed Web of Science ®Google Scholar
• Zhu H, Sun A. Programmed necrosis in heart disease: molecular mechanisms and clinical implications. J Mol Cell Cardiol. 2018;116:125–134. doi:10.1016/j.yjmcc.2018.01.018
   PubMed Web of Science ®Google Scholar
• Zhou T, Chuang CC, Zuo L. Molecular characterization of reactive oxygen species in myocardial ischemia-reperfusion injury. Biomed Res Int. 2015;2015:864946. doi:10.1155/2015/864946
   PubMed Web of Science ®Google Scholar
• Li D, Wang X, Huang Q, Li S, Zhou Y, Li Z. Cardioprotection of CAPE-oNO2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro. Redox Biol. 2018;15:62–73. doi:10.1016/j.redox.2017.11.023
   PubMed Web of Science ®Google Scholar
• Kung G, Konstantinidis K, Kitsis RN. Programmed necrosis, not apoptosis, in the heart. Circ Res. 2011;108(8):1017–1036. doi:10.1161/CIRCRESAHA.110.225730
   PubMed Web of Science ®Google Scholar
• Khademi F, Totonchi H, Mohammadi N, Zare R, Zal F. Nicotine-induced oxidative stress in human primary endometrial cells. Int J Toxicol. 2019;38(3):202–208. doi:10.1177/1091581819848081
   PubMed Web of Science ®Google Scholar
• Centner AM, Bhide PG, Salazar G. Nicotine in senescence and atherosclerosis. Cells. 2020;9(4):1035. doi:10.3390/cells9041035
   PubMed Web of Science ®Google Scholar
• Yin W, Wang C, Peng Y, et al. Dexmedetomidine alleviates H2O2-induced oxidative stress and cell necroptosis through activating of α2-adrenoceptor in H9C2 cells. Mol Biol Rep. 2020;47(5):3629–3639. doi:10.1007/s11033-020-05456-w
   PubMed Web of Science ®Google Scholar
• Desimine VL, McCrink KA, Parker BM, Wertz SL, Maning J, Lymperopoulos A. Biased agonism/antagonism of cardiovascular GPCRs for heart failure therapy. Int Rev Cell Mol Biol. 2018;339:41–61. doi:10.1016/bs.ircmb.2018.02.007
   PubMed Web of Science ®Google Scholar
• Lymperopoulos A, Cora N, Maning J, Brill AR, Sizova A. Signaling and function of cardiac autonomic nervous system receptors: insights from the GPCR signalling universe. FEBS J. 2021;288(8):2645–2659. doi:10.1111/febs.15771
   PubMed Web of Science ®Google Scholar
• Karkoulias G, McCrink KA, Maning J, et al. Sustained GRK2-dependent CREB activation is essential for α2-adrenergic receptor-induced PC12 neuronal differentiation. Cell Signal. 2020;66:109446. doi:10.1016/j.cellsig.2019.109446
   PubMed Web of Science ®Google Scholar
• Nguyen K, Kassimatis T, Lymperopoulos A. Impaired desensitization of a human polymorphic α2B-adrenergic receptor variant enhances its sympatho-inhibitory activity in chromaffin cells. Cell Commun Signal. 2011;9(1):5. doi:10.1186/1478-811X-9-5
   PubMedGoogle Scholar
• Lymperopoulos A, Brill A, McCrink KA. GPCRs of adrenal chromaffin cells & catecholamines: the plot thickens. Int J Biochem Cell Biol. 2016;77(Pt B):213–219. doi:10.1016/j.biocel.2016.02.003
   PubMedGoogle Scholar
• Lymperopoulos A, Rengo G, Funakoshi H, Eckhart AD, Koch WJ. Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure. Nat Med. 2007;13(3):315–323. doi:10.1038/nm1553
   PubMed Web of Science ®Google Scholar
• Jafferjee M, Reyes Valero T, Marrero C, McCrink KA, Brill A, Lymperopoulos A. GRK2 up-regulation creates a positive feedback loop for catecholamine production in chromaffin cells. Mol Endocrinol. 2016;30(3):372–381. doi:10.1210/me.2015-1305
   PubMedGoogle Scholar
• Zhang Y, Liu X, Zhang L, et al. Metformin protects against H2O2-induced cardiomyocyte injury by inhibiting the mir-1a-3p/GRP94 pathway. Mol Ther Nucleic Acids. 2018;13:189–197. doi:10.1016/j.omtn.2018.09.001
   PubMedGoogle Scholar
• McCrink KA, Maning J, Vu A, et al. Cardiac βarrestin2 improves contractility and adverse remodeling in heart failure, but is underexpressed in humans. J Am Coll Cardiol. 2017;70(23):2948–2949. doi:10.1016/j.jacc.2017.10.008
   PubMed Web of Science ®Google Scholar
• Maning J, McCrink KA, Pollard CM, et al. Antagonistic roles of GRK2 and GRK5 in cardiac aldosterone signaling reveal GRK5-mediated cardioprotection via mineralocorticoid receptor inhibition. Int J Mol Sci. 2020;21(8):2868. doi:10.3390/ijms21082868
   PubMed Web of Science ®Google Scholar
• Zhang J, Li R, Man K, Yang XB. Enhancing osteogenic potential of hDPSCs by resveratrol through reducing oxidative stress via the Sirt1/Nrf2 pathway. Pharm Biol. 2022;60(1):501–508. doi:10.1080/13880209.2022.2037664
   PubMed Web of Science ®Google Scholar
• Carbone AM, Borges JI, Suster MS, et al. Regulator of G-protein signaling-4 attenuates cardiac adverse remodeling and neuronal norepinephrine release-promoting free fatty acid receptor FFAR3 signaling. Int J Mol Sci. 2022;23(10):5803. doi:10.3390/ijms23105803
   PubMed Web of Science ®Google Scholar
• Lai L, Yan L, Gao S, et al. Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway. Circulation. 2013;127(16):1692–1701. doi:10.1161/CIRCULATIONAHA.112.001212
   PubMed Web of Science ®Google Scholar
• Vatner SF, Pachon RE, Vatner DE. Inhibition of adenylyl cyclase type 5 increases longevity and healthful aging through oxidative stress protection. Oxid Med Cell Longev. 2015;2015:250310. doi:10.1155/2015/250310
   PubMed Web of Science ®Google Scholar
• Yan L, Vatner DE, Jp O, et al. Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell. 2007;130(2):247–258. doi:10.1016/j.cell.2007.05.038
   PubMed Web of Science ®Google Scholar
• Gao Y, Usha Raj J. Effects of SQ 22536, an adenylyl cyclase inhibitor, on isoproterenol-induced cyclic AMP elevation and relaxation in newborn ovine pulmonary veins. Eur J Pharmacol. 2002;436(3):227–233. doi:10.1016/s0014-2999(02)01261-x
   PubMed Web of Science ®Google Scholar
• Brodde OE, Michel MC. Adrenergic and muscarinic receptors in the human heart. Pharmacol Rev. 1999;51(4):651–690.
   PubMed Web of Science ®Google Scholar
• Hein L, Altman JD, Kobilka BK. Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission. Nature. 1999;402(6758):181–184. doi:10.1038/46040
   PubMed Web of Science ®Google Scholar
• Weng X, Zhang X, Lu X, Wu J, Li S. Reduced mitochondrial response sensitivity is involved in the anti-apoptotic effect of dexmedetomidine pretreatment in cardiomyocytes. Int J Mol Med. 2018;41(4):2328–2338. doi:10.3892/ijmm.2018.3384
   PubMed Web of Science ®Google Scholar
• Cora N, Ghandour J, Pollard CM, et al. Nicotine-induced adrenal beta-arrestin1 upregulation mediates tobacco-related hyperaldosteronism leading to cardiac dysfunction. World J Cardiol. 2020;12(5):192–202. doi:10.4330/wjc.v12.i5.192
   PubMed Web of Science ®Google Scholar
• Solesio ME, Mitaishvili E, Lymperopoulos A. Adrenal βarrestin1 targeting for tobacco-associated cardiac dysfunction treatment: aldosterone production as the mechanistic link. Pharmacol Res Perspect. 2019;7(4):e00497. doi:10.1002/prp2.497
   PubMed Web of Science ®Google Scholar
• Kumar S, Appukuttan A, Maghnouj A, Hahn S, Peter Reusch H, Ladilov Y. Suppression of soluble adenylyl cyclase protects smooth muscle cells against oxidative stress-induced apoptosis. Apoptosis. 2014;19(7):1069–1079. doi:10.1007/s10495-014-0989-9
   PubMed Web of Science ®Google Scholar
• Vatner SF, Yan L, Ishikawa Y, Vatner DE, Sadoshima J. Adenylyl cyclase type 5 disruption prolongs longevity and protects the heart against stress. Circ J. 2009;73(2):195–200. doi:10.1253/circj.cj-08-0957
   PubMed Web of Science ®Google Scholar
• Zhang J, Xiao H, Shen J, Wang N, Zhang Y. Different roles of β-arrestin and the PKA pathway in mitochondrial ROS production induced by acute β-adrenergic receptor stimulation in neonatal mouse cardiomyocytes. Biochem Biophys Res Commun. 2017;489(4):393–398. doi:10.1016/j.bbrc.2017.05.140
   PubMed Web of Science ®Google Scholar
• Tan CM, Xenoyannis S, Feldman RD. Oxidant stress enhances adenylyl cyclase activation. Circ Res. 1995;77(4):710–717. doi:10.1161/01.res.77.4.710
   PubMed Web of Science ®Google Scholar
• Mishima K, Baba A, Matsuo M, Itoh Y, Oishi R. Protective effect of cyclic AMP against cisplatin-induced nephrotoxicity. Free Radic Biol Med. 2006;40(9):1564–1577. doi:10.1016/j.freeradbiomed.2005.12.025
   PubMed Web of Science ®Google Scholar
• Yamada H, Adachi T, Fukatsu A, et al. Extracellular superoxide dismutase and glomerular mesangial cells: its production and regulation. FEBS Lett. 2002;519(1–3):77–81. doi:10.1016/s0014-5793(02)02714-x
   PubMed Web of Science ®Google Scholar
• Kroviarski Y, Debbabi M, Bachoual R, et al. Phosphorylation of NADPH oxidase activator 1 (NOXA1) on serine 282 by MAP kinases and on serine 172 by protein kinase C and protein kinase A prevents NOX1 hyperactivation. FASEB J. 2010;24(6):2077–2092. doi:10.1096/fj.09-147629
   PubMed Web of Science ®Google Scholar
• Maning J, Desimine VL, Pollard CM, Ghandour J, Lymperopoulos A. Carvedilol selectively stimulates βarrestin2-dependent SERCA2a activity in cardiomyocytes to augment contractility. Int J Mol Sci. 2022;23(19):11315. doi:10.3390/ijms231911315
   PubMed Web of Science ®Google Scholar