Bibliometric and Visualization Analysis of Stem Cell Therapy for Erectile Dysfunction

References

• Quilter M, Hodges L, von Hurst P, Borman B, Coad J. Male sexual function in New Zealand: a population-based cross-sectional survey of the prevalence of erectile dysfunction in men aged 40–70 years. J Sex Med. 2017;14(7):928–936. doi:10.1016/j.jsxm.2017.05.011
   PubMed Web of Science ®Google Scholar
• Corona G, Lee DM, Forti G, et al. Age-related changes in general and sexual health in middle-aged and older men: results from the European Male Ageing Study (EMAS). J Sex Med. 2010;7(4 Pt 1):1362–1380. doi:10.1111/j.1743-6109.2009.01601.x
   PubMed Web of Science ®Google Scholar
• Ayta IA, McKinlay JB, Krane RJ. The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. BJU Int. 1999;84(1):50–56. doi:10.1046/j.1464-410x.1999.00142.x
   PubMed Web of Science ®Google Scholar
• Yafi FA, Jenkins L, Albersen M, et al. Erectile dysfunction. Nat Rev Dis Primers. 2016;2:16003. doi:10.1038/nrdp.2016.3
   PubMed Web of Science ®Google Scholar
• Gandaglia G, Briganti A, Jackson G, et al. A systematic review of the association between erectile dysfunction and cardiovascular disease. Eur Urol. 2014;65(5):968–978. doi:10.1016/j.eururo.2013.08.023
   PubMed Web of Science ®Google Scholar
• Shamloul R, Ghanem H. Erectile dysfunction. Lancet. 2013;381(9861):153–165. doi:10.1016/S0140-6736(12)60520-0
   PubMed Web of Science ®Google Scholar
• Allen MS, Walter EE. Erectile dysfunction: an umbrella review of meta-analyses of risk-factors, treatment, and prevalence outcomes. J Sex Med. 2019;16(4):531–541. doi:10.1016/j.jsxm.2019.01.314
   PubMed Web of Science ®Google Scholar
• Sun T, Xu W, Wang J, et al. Saxagliptin alleviates erectile dysfunction through increasing stromal cell-derived factor-1 in diabetes mellitus. Andrology. 2023;11(2):295–306. doi:10.1111/andr.13296
   PubMed Web of Science ®Google Scholar
• Fink HA, Mac Donald R, Rutks IR, Nelson DB, Wilt TJ. Sildenafil for male erectile dysfunction: a systematic review and meta-analysis. Arch Intern Med. 2002;162(12):1349–1360. doi:10.1001/archinte.162.12.1349
   PubMedGoogle Scholar
• Wani MM, Rai BP, Webb WR, Madaan S. Is there a role for stem cell therapy in erectile dysfunction secondary to cavernous nerve injury? Network meta-analysis from animal studies and human trials. Ther Adv Urol. 2022;14:17562872221086999. doi:10.1177/17562872221086999
   Web of Science ®Google Scholar
• Castiglione F, Cakir OO, Satchi M, et al. The current role and implications of stem cell therapy in erectile dysfunction: a transformation from caterpillar to butterfly is required. Eur Urol Focus. 2023;9(1):28–31. doi:10.1016/j.euf.2022.11.009
   PubMedGoogle Scholar
• Sarkar A, Saha S, Paul A, Maji A, Roy P, Maity TK. Understanding stem cells and its pivotal role in regenerative medicine. Life Sci. 2021;273:119270. doi:10.1016/j.lfs.2021.119270
   PubMed Web of Science ®Google Scholar
• Campbell JD, Milenkovic U, Usta MF, Albersen M, Bivalacqua TJ. The good, bad, and the ugly of regenerative therapies for erectile dysfunction. Transl Androl Urol. 2020;9(Suppl 2):S252–S261. doi:10.21037/tau.2019.10.06
   PubMedGoogle Scholar
• Vasuri F, Fittipaldi S, Pasquinelli G. Arterial calcification: finger-pointing at resident and circulating stem cells. World J Stem Cells. 2014;6(5):540–551. doi:10.4252/wjsc.v6.i5.540
   PubMedGoogle Scholar
• Zakrzewski W, Dobrzynski M, Szymonowicz M, Rybak Z. Stem cells: past, present, and future. Stem Cell Res Ther. 2019;10(1):68. doi:10.1186/s13287-019-1165-5
   PubMedGoogle Scholar
• Pakpahan C, Ibrahim R, William W, et al. Stem cell therapy and diabetic erectile dysfunction: a critical review. World J Stem Cells. 2021;13(10):1549–1563. doi:10.4252/wjsc.v13.i10.1549
   PubMed Web of Science ®Google Scholar
• Wang B, Gao W, Zheng MY, Lin G, Lue TF. Recent advances in stem cell therapy for erectile dysfunction: a narrative review. Expert Opin Biol Ther. 2023;23(6):565–573. doi:10.1080/14712598.2023.2203811
   PubMed Web of Science ®Google Scholar
• Gur S, Abdel-Mageed AB, Sikka SC, Hellstrom WJG. Advances in stem cell therapy for erectile dysfunction. Expert Opin Biol Ther. 2018;18(11):1137–1150. doi:10.1080/14712598.2018.1534955
   PubMed Web of Science ®Google Scholar
• Yang J, Zhang Y, Zang G, et al. Adipose-derived stem cells improve erectile function partially through the secretion of IGF-1, bFGF, and VEGF in aged rats. Andrology. 2018;6(3):498–509. doi:10.1111/andr.12483
   PubMed Web of Science ®Google Scholar
• Sun T, Xu W, Tu B, et al. Engineered adipose-derived stem cells overexpressing RXFP1 via CRISPR activation ameliorate erectile dysfunction in diabetic rats. Antioxidants. 2023;12(1):171. doi:10.3390/antiox12010171
   Web of Science ®Google Scholar
• Yang Y, Chen Y, Liu Y, et al. Mesenchymal stem cells and pulmonary fibrosis: a bibliometric and visualization analysis of literature published between 2002 and 2021. Front Pharmacol. 2023;14:1136761. doi:10.3389/fphar.2023.1136761
   PubMed Web of Science ®Google Scholar
• Zhou W, Hu S, Wu Y, et al. A bibliometric analysis of mesenchymal stem cell-derived exosomes in acute lung injury/acute respiratory distress syndrome from 2013 to 2022. Drug Des Devel Ther. 2023;17:2165–2181. doi:10.2147/DDDT.S415659
   PubMed Web of Science ®Google Scholar
• van Eck NJ, Waltman L. Software survey: vOSviewer, a computer program for bibliometric mapping. Scientometrics. 2010;84(2):523–538. doi:10.1007/s11192-009-0146-3
   PubMed Web of Science ®Google Scholar
• Hassan-Montero Y, De-Moya-Anegón F, Guerrero-Bote VP. SCImago Graphica: a new tool for exploring and visually communicating data. Profes De La Inform. 2022;31:5.
   Web of Science ®Google Scholar
• Chen C. Searching for intellectual turning points: progressive knowledge domain visualization. Proc Natl Acad Sci U S A. 2004;101(Suppl 1):5303–5310. doi:10.1073/pnas.0307513100
   PubMed Web of Science ®Google Scholar
• Chen C, Chen Y. Searching for clinical evidence in CiteSpace. AMIA Annu Symp Proc. 2005;2005:121–125.
   PubMedGoogle Scholar
• Gonzalez-Cadavid NF, Rajfer J. Therapy of erectile dysfunction: potential future treatments. Endocrine. 2004;23(2–3):167–176. doi:10.1385/ENDO:23:2-3:167
   PubMed Web of Science ®Google Scholar
• Chen C. Leydesdorff LJJotafis, technology. Patterns of connections and movements in dual‐map overlays: a new method of publication portfolio analysis. J Assoc Inform Sci Technol. 2014;65(2):334–351. doi:10.1002/asi.22968
   Web of Science ®Google Scholar
• Albersen M, Fandel TM, Lin G, et al. Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury. J Sex Med. 2010;7(10):3331–3340. doi:10.1111/j.1743-6109.2010.01875.x
   PubMed Web of Science ®Google Scholar
• Bivalacqua TJ, Deng W, Kendirci M, et al. Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction. Am J Physiol Heart Circ Physiol. 2007;292:3.
   Web of Science ®Google Scholar
• Haahr MK, Jensen CH, Toyserkani NM, et al. Safety and potential effect of a single intracavernous injection of autologous adipose-derived regenerative cells in patients with erectile dysfunction following radical prostatectomy: an open-label phase i clinical trial. EBioMedicine. 2016;5:204–210. doi:10.1016/j.ebiom.2016.01.024
   PubMed Web of Science ®Google Scholar
• Yiou R, Hamidou L, Birebent B, et al. Safety of intracavernous bone marrow-mononuclear cells for postradical prostatectomy erectile dysfunction: an open dose-escalation pilot study. Eur Urol. 2016;69(6):988–991. doi:10.1016/j.eururo.2015.09.026
   PubMed Web of Science ®Google Scholar
• Levy JA, Marchand M, Iorio L, Cassini W, Zahalsky MP. Determining the feasibility of managing erectile dysfunction in humans with placental-derived stem cells. J Am Osteopath Assoc. 2016;116(1):e1–5. doi:10.7556/jaoa.2016.007
   PubMed Web of Science ®Google Scholar
• Al Demour S, Jafar H, Adwan S, et al. Safety and potential therapeutic effect of two intracavernous autologous bone marrow derived mesenchymal stem cells injections in diabetic patients with erectile dysfunction: an open label phase I clinical trial. Urol Int. 2018;101(3):358–365. doi:10.1159/000492120
   PubMed Web of Science ®Google Scholar
• Burnett AL, Nehra A, Breau RH, et al. Erectile Dysfunction: AUA Guideline. J Urol. 2018;200(3):633–641. doi:10.1016/j.juro.2018.05.004
   PubMed Web of Science ®Google Scholar
• Matz EL, Terlecki R, Zhang Y, Jackson J, Atala A. Stem cell therapy for erectile dysfunction. Sex Med Rev. 2019;7(2):321–328. doi:10.1016/j.sxmr.2017.12.008
   PubMed Web of Science ®Google Scholar
• Foresta C, Caretta N, Lana A, Cabrelle A, Palu G, Ferlin A. Circulating endothelial progenitor cells in subjects with erectile dysfunction. Int J Impot Res. 2005;17(3):288–290. doi:10.1038/sj.ijir.3901311
   PubMed Web of Science ®Google Scholar
• Garcia MM, Fandel TM, Lin G, et al. Treatment of erectile dysfunction in the obese type 2 diabetic ZDF rat with adipose tissue-derived stem cells. J Sex Med. 2010;7(1 Pt 1):89–98. doi:10.1111/j.1743-6109.2009.01541.x
   PubMed Web of Science ®Google Scholar
• Huang YC, Ning H, Shindel AW, et al. The effect of intracavernous injection of adipose tissue-derived stem cells on hyperlipidemia-associated erectile dysfunction in a rat model. J Sex Med. 2010;7(4 Pt 1):1391–1400. doi:10.1111/j.1743-6109.2009.01697.x
   PubMed Web of Science ®Google Scholar
• Kendirci M, Trost L, Bakondi B, Whitney MJ, Hellstrom WJ, Spees JL. Transplantation of nonhematopoietic adult bone marrow stem/progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury. J Urol. 2010;184(4):1560–1566. doi:10.1016/j.juro.2010.05.088
   PubMed Web of Science ®Google Scholar
• Qiu X, Lin H, Wang Y, et al. Intracavernous transplantation of bone marrow-derived mesenchymal stem cells restores erectile function of streptozocin-induced diabetic rats. J Sex Med. 2011;8(2):427–436. doi:10.1111/j.1743-6109.2010.02118.x
   PubMed Web of Science ®Google Scholar
• Fandel TM, Albersen M, Lin G, et al. Recruitment of intracavernously injected adipose-derived stem cells to the major pelvic ganglion improves erectile function in a rat model of cavernous nerve injury. Eur Urol. 2012;61(1):201–210. doi:10.1016/j.eururo.2011.07.061
   PubMed Web of Science ®Google Scholar
• Lin CS, Xin ZC, Wang Z, et al. Stem cell therapy for erectile dysfunction: a critical review. Stem Cells Dev. 2012;21(3):343–351. doi:10.1089/scd.2011.0303
   PubMed Web of Science ®Google Scholar
• Qiu X, Fandel TM, Ferretti L, et al. Both immediate and delayed intracavernous injection of autologous adipose-derived stromal vascular fraction enhances recovery of erectile function in a rat model of cavernous nerve injury. Eur Urol. 2012;62(4):720–727. doi:10.1016/j.eururo.2012.02.003
   PubMed Web of Science ®Google Scholar
• Liu G, Sun X, Bian J, et al. Correction of diabetic erectile dysfunction with adipose derived stem cells modified with the vascular endothelial growth factor gene in a rodent diabetic model. PLoS One. 2013;8:8.
   Web of Science ®Google Scholar
• Alwaal A, Zaid UB, Lin CS, Lue TF. Stem cell treatment of erectile dysfunction. Adv Drug Deliv Rev. 2015;82–83:137–144. doi:10.1016/j.addr.2014.11.012
   PubMed Web of Science ®Google Scholar
• Chen F, Zhang H, Wang Z, et al. Adipose-derived stem cell-derived exosomes ameliorate erectile dysfunction in a rat model of type 2 diabetes. J Sex Med. 2017;14(9):1084–1094. doi:10.1016/j.jsxm.2017.07.005
   PubMed Web of Science ®Google Scholar
• Soebadi MA, Milenkovic U, Weyne E, Castiglione F, Albersen M. Stem cells in male sexual dysfunction: are we getting somewhere? Sex Med Rev. 2017;5(2):222–235. doi:10.1016/j.sxmr.2016.11.002
   PubMed Web of Science ®Google Scholar
• Feng H, Liu Q, Deng Z, et al. Human umbilical cord mesenchymal stem cells ameliorate erectile dysfunction in rats with diabetes mellitus through the attenuation of ferroptosis. Stem Cell Res Ther. 2022;13(1):450. doi:10.1186/s13287-022-03147-w
   PubMed Web of Science ®Google Scholar
• Zhang Z, Nie P, Yang W, Ma X, Chen Z, Wei H. Lipopolysaccharide-preconditioned allogeneic adipose-derived stem cells improve erectile function in a rat model of bilateral cavernous nerve injury. Basic Clin Androl. 2022;32(1):5. doi:10.1186/s12610-022-00156-w
   PubMed Web of Science ®Google Scholar
• Castela A, Costa C. Molecular mechanisms associated with diabetic endothelial-erectile dysfunction. Nat Rev Urol. 2016;13(5):266–274. doi:10.1038/nrurol.2016.23
   PubMed Web of Science ®Google Scholar
• Liu S, Jiang C, Hu J, Chen H, Han B, Xia S. Low-intensity pulsed ultrasound enhanced adipose-derived stem cell-mediated angiogenesis in the treatment of diabetic erectile dysfunction through the Piezo-ERK-VEGF axis. Stem Cells Int. 2022;2022:6202842. doi:10.1155/2022/6202842
   PubMed Web of Science ®Google Scholar
• Qiu X, Lin G, Xin Z, et al. Effects of low-energy shockwave therapy on the erectile function and tissue of a diabetic rat model. J Sex Med. 2013;10(3):738–746. doi:10.1111/jsm.12024
   PubMed Web of Science ®Google Scholar
• Li M, Li H, Ruan Y, Wang T, Liu J. Stem cell therapy for diabetic erectile dysfunction in rats: a meta-analysis. PLoS One. 2016;11:4.
   Web of Science ®Google Scholar
• Shan H, Chen F, Zhang T, He S, Xu L, Wei A. Stem cell therapy for erectile dysfunction of cavernous nerve injury rats: a systematic review and meta-analysis. PLoS One. 2015;10(4):e0121428. doi:10.1371/journal.pone.0121428
   PubMed Web of Science ®Google Scholar
• Xia J, Minamino S, Kuwabara K, Arai S. Stem cell secretome as a new booster for regenerative medicine. Biosci Trends. 2019;13(4):299–307. doi:10.5582/bst.2019.01226
   PubMed Web of Science ®Google Scholar
• Liu S, Li R, Dou K, Li K, Zhou Q, Fu Q. Injectable thermo-sensitive hydrogel containing ADSC-derived exosomes for the treatment of cavernous nerve injury. Carbohydr Polym. 2023;300:120226. doi:10.1016/j.carbpol.2022.120226
   PubMed Web of Science ®Google Scholar
• An G, Guo F, Liu X, et al. Functional reconstruction of injured corpus cavernosa using 3D-printed hydrogel scaffolds seeded with HIF-1alpha-expressing stem cells. Nat Commun. 2020;11(1):2687. doi:10.1038/s41467-020-16192-x
   PubMed Web of Science ®Google Scholar
• Hansen ST, Lund M, Ostergaard LD, Lund L. Role of regenerative therapies on erectile dysfunction after radical prostatectomy. Int J Impot Res. 2021;33(4):488–496. doi:10.1038/s41443-020-00406-3
   PubMed Web of Science ®Google Scholar
• Zhu Y, Jiang T, Yao C, et al. Effects of stem cell-derived exosome therapy on erectile dysfunction: a systematic review and meta-analysis of preclinical studies. Sex Med. 2023;11(2):qfac019. doi:10.1093/sexmed/qfac019
   PubMed Web of Science ®Google Scholar
• He C, Zheng S, Luo Y, Wang B. Exosome theranostics: biology and translational medicine. Theranostics. 2018;8(1):237–255. doi:10.7150/thno.21945
   PubMed Web of Science ®Google Scholar
• Ouyang B, Sun X, Han D, et al. Human urine-derived stem cells alone or genetically-modified with FGF2 Improve type 2 diabetic erectile dysfunction in a rat model. PLoS One. 2014;9(3):e92825. doi:10.1371/journal.pone.0092825
   PubMed Web of Science ®Google Scholar
• Jeon SH, Zhu GQ, Bae WJ, et al. Engineered mesenchymal stem cells expressing stromal cell-derived factor-1 improve erectile dysfunction in streptozotocin-induced diabetic rats. Int J Mol Sci. 2018;19(12):3730. doi:10.3390/ijms19123730
   PubMed Web of Science ®Google Scholar
• Zhou J, Yin Y, Yang Y, et al. Knockdown of miR-423-5p simultaneously upgrades the eNOS and VEGFa pathways in ADSCs and improves erectile function in diabetic rats. J Cell Mol Med. 2021;25(20):9796–9804. doi:10.1111/jcmm.16927
   PubMed Web of Science ®Google Scholar
• Liu Q, Cui Y, Lin H, et al. MicroRNA-145 engineered bone marrow-derived mesenchymal stem cells alleviated erectile dysfunction in aged rats. Stem Cell Res Ther. 2019;10(1):398. doi:10.1186/s13287-019-1509-1
   PubMed Web of Science ®Google Scholar
• Li L, Zhang D, Li P, Damaser M, Zhang Y. Virus integration and genome influence in approaches to stem cell based therapy for andro-urology. Adv Drug Deliv Rev. 2015;82–83:12–21. doi:10.1016/j.addr.2014.10.012
   PubMed Web of Science ®Google Scholar
• Yan H, Rong L, Xiao D, et al. Injectable and self-healing hydrogel as a stem cells carrier for treatment of diabetic erectile dysfunction. Mater Sci Eng C Mater Biol Appl. 2020;116:111214. doi:10.1016/j.msec.2020.111214
   PubMed Web of Science ®Google Scholar
• Lin H, Dhanani N, Tseng H, et al. Nanoparticle improved stem cell therapy for erectile dysfunction in a rat model of cavernous nerve injury. J Urol. 2016;195(3):788–795. doi:10.1016/j.juro.2015.10.129
   PubMed Web of Science ®Google Scholar
• Zheng T, Zhang T, Zhang W, et al. Icariside II facilitates the differentiation of ADSCs to Schwann cells and restores erectile dysfunction through regulation of miR-33/GDNF axis. Biomed Pharmacother. 2020;125:109888. doi:10.1016/j.biopha.2020.109888
   PubMed Web of Science ®Google Scholar