59
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

A Novel Tetramethylpyrazine Chalcone Hybrid- HCTMPPK, as a Potential Anti-Lung Cancer Agent by Downregulating MELK

, , , , , , , , , & show all
Pages 1531-1546 | Received 20 Nov 2023, Accepted 30 Apr 2024, Published online: 06 May 2024

References

  • Salehi-Rad R, Li R, Paul MK, Dubinett SM, Liu B. The biology of lung cancer: development of more effective methods for prevention, diagnosis, and treatment. Clin Chest Med. 2020;41(1):25–38. doi:10.1016/j.ccm.2019.10.003
  • Rafei H, El-Bahesh E, Finianos A, Nassereddine S, Tabbara I. Immune-based therapies for non-small cell lung cancer. Anticancer Res. 2017;37(2):377–387. doi:10.21873/anticanres.11330
  • Lu T, Yang X, Huang Y, et al. Trends in the incidence, treatment, and survival of patients with lung cancer in the last four decades. Cancer Manag Res. 2019;11:943–953. doi:10.2147/cmar.S187317
  • Chen P, Liu Y, Wen Y, Zhou C. Non-small cell lung cancer in China. Cancer Commun. 2022;42(10):937–970. doi:10.1002/cac2.12359
  • Nagasaka M, Gadgeel SM. Role of chemotherapy and targeted therapy in early-stage non-small cell lung cancer. Expert Rev Anticancer Ther. 2018;18(1):63–70. doi:10.1080/14737140.2018.1409624
  • Pirker R. Chemotherapy remains a cornerstone in the treatment of nonsmall cell lung cancer. Curr Opin Oncol. 2020;32(1):63–67. doi:10.1097/cco.0000000000000592
  • Wang S, Zimmermann S, Parikh K, Mansfield AS, Adjei AA. Current diagnosis and management of small-cell lung cancer. Mayo Clin Proc. 2019;94(8):1599–1622. doi:10.1016/j.mayocp.2019.01.034
  • Constantinescu T, Lungu CN. Anticancer activity of natural and synthetic chalcones. Int J Mol Sci. 2021;22(21):11306.
  • Zhai B, Zhang N, Han X, et al. Molecular targets of β-elemene, a herbal extract used in traditional Chinese medicine, and its potential role in cancer therapy: a review. Biomed Pharmacother. 2019;114:108812. doi:10.1016/j.biopha.2019.108812
  • Yang A-Y, Liu H-L, Yang Y-F. Study on the mechanism of action of Scutellaria barbata on hepatocellular carcinoma based on network pharmacology and bioinformatics. Front Pharmacol. 2022;13:1072547. doi:10.3389/fphar.2022.1072547
  • Luo H, Vong CT, Chen H, et al. Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine. Chin Med. 2019;14:48. doi:10.1186/s13020-019-0270-9
  • Ouyang Y, Li J, Chen X, Fu X, Sun S, Wu Q. Chalcone derivatives: role in anticancer therapy. Biomolecules. 2021;11(6):894.
  • Dong Y, Yang Y, Wei Y, Gao Y, Jiang W, Wang G. Ligustrazine eases lung cancer by regulating PTEN and Wnt/β-catenin pathway. Transl Cancer Res. 2020;9(3):1742–1751. doi:10.21037/tcr.2020.03.26
  • Ma X, Ruan Q, Ji X, Yang J, Peng H. Ligustrazine alleviates cyclophosphamide-induced hepatotoxicity via the inhibition of Txnip/Trx/NF-κB pathway. Life Sci. 2021;274:119331. doi:10.1016/j.lfs.2021.119331
  • Zou Y, Zhao D, Yan C, et al. Correction to novel ligustrazine-based analogs of piperlongumine potently suppress proliferation and metastasis of colorectal cancer cells in vitro and in vivo. J Med Chem. 2020;63(2):880–881. doi:10.1021/acs.jmedchem.9b02072
  • Qian J, Xu Z, Zhu P, et al. A derivative of piperlongumine and ligustrazine as a potential thioredoxin reductase inhibitor in drug-resistant hepatocellular carcinoma. J Nat Prod. 2021;84(12):3161–3168. doi:10.1021/acs.jnatprod.1c00618
  • Liu YL, Yan ZX, Xia Y, et al. Ligustrazine reverts anthracycline chemotherapy resistance of human breast cancer by inhibiting JAK2/STAT3 signaling and decreasing fibrinogen gamma chain (FGG) expression. Am J Cancer Res. 2020;10(3):939–952.
  • Gao F, Huang G, Xiao J. Chalcone hybrids as potential anticancer agents: current development, mechanism of action, and structure-activity relationship. Med Res Rev. 2020;40(5):2049–2084. doi:10.1002/med.21698
  • Luo Y, Wu W, Zha D, et al. Synthesis and biological evaluation of novel ligustrazine-chalcone derivatives as potential anti-triple negative breast cancer agents. Bioorg Med Chem Lett. 2021;47:128230. doi:10.1016/j.bmcl.2021.128230
  • Feng LS, Xu Z, Chang L, et al. Hybrid molecules with potential in vitro antiplasmodial and in vivo antimalarial activity against drug-resistant Plasmodium falciparum. Med Res Rev. 2020;40(3):931–971. doi:10.1002/med.21643
  • Li Z, Yulei J, Yaqing J, et al. Protective effects of tetramethylpyrazine analogue Z-11 on cerebral ischemia reperfusion injury. Eur J Pharmacol. 2019;844:156–164. doi:10.1016/j.ejphar.2018.11.031
  • Das A, Prajapati A, Karna A, et al. Structure-based virtual screening of chemical libraries as potential MELK inhibitors and their therapeutic evaluation against breast cancer. Chem Biol Interact. 2023;376:110443. doi:10.1016/j.cbi.2023.110443
  • Ye J, Deng W, Zhong Y, et al. MELK predicts poor prognosis and promotes metastasis in esophageal squamous cell carcinoma via activating the NF‑κB pathway. Int J Oncol. 2022;61(2):1–5.
  • Mahasenan KV, Li C. Novel inhibitor discovery through virtual screening against multiple protein conformations generated via ligand-directed modeling: a maternal embryonic leucine zipper kinase example. J Chem Inf Model. 2012;52(5):1345–1355. doi:10.1021/ci300040c
  • Yang H, Zhou H, Wang G, et al. MELK is a prognostic biomarker and correlated with immune infiltration in glioma. Front Neurol. 2022;13:977180. doi:10.3389/fneur.2022.977180
  • Tang BF, Yan RC, Wang SW, Zeng ZC, Du SS. Maternal embryonic leucine zipper kinase in tumor cells and tumor microenvironment: an emerging player and promising therapeutic opportunity. Cancer Lett. 2023;560:216126. doi:10.1016/j.canlet.2023.216126
  • Wang Z, Castro N, Bernstein AM, Wolosin JM. TGFβ1-driven SMAD2/3 phosphorylation and myofibroblast emergence are fully dependent on the TGFβ1 pre-activation of MAPKs and controlled by maternal leucine zipper kinase. Cell Signal. 2024;113:110963. doi:10.1016/j.cellsig.2023.110963
  • Nakano I, Paucar AA, Bajpai R, et al. Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. J Cell Biol. 2005;170(3):413–427. doi:10.1083/jcb.200412115
  • Hu Z, Li L, Li M, et al. miR-21-5p inhibits ferroptosis in hepatocellular carcinoma cells by regulating the AKT/mTOR signaling pathway through MELK. J Immunol Res. 2023;2023:8929525. doi:10.1155/2023/8929525
  • Tang Q, Li W, Zheng X, et al. MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma. Signal Transduct Target Ther. 2020;5(1):279. doi:10.1038/s41392-020-00288-3
  • Shannon P, Markiel A, Ozier O, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498–2504. doi:10.1101/gr.1239303
  • Chin CH, Chen SH, Wu HH, Ho CW, Ko MT, Lin CY. cytoHubba: identifying hub objects and sub-networks from complex interactome. BMC Syst Biol. 2014;8(Suppl 4):S11. doi:10.1186/1752-0509-8-s4-s11
  • Dong D, Xu Z, Zhong W, Peng S. Parallelization of molecular docking: a review. Curr Top Med Chem. 2018;18(12):1015–1028. doi:10.2174/1568026618666180821145215
  • Guney E, Menche J, Vidal M, Barábasi AL. Network-based in silico drug efficacy screening. Nat Commun. 2016;7:10331. doi:10.1038/ncomms10331
  • Vodenkova S, Buchler T, Cervena K, Veskrnova V, Vodicka P, Vymetalkova V. 5-fluorouracil and other fluoropyrimidines in colorectal cancer: past, present and future. Pharmacol Ther. 2020;206:107447. doi:10.1016/j.pharmthera.2019.107447
  • Jiang R, Xu J, Zhang Y, et al. Ligustrazine alleviates psoriasis-like inflammation through inhibiting TRAF6/c-JUN/NFκB signaling pathway in keratinocyte. Biomed Pharmacother. 2022;150:113010. doi:10.1016/j.biopha.2022.113010
  • Huang HH, Liu FB, Ruan Z, Zheng J, Su YJ, Wang J. Tetramethylpyrazine (TMPZ) triggers S-phase arrest and mitochondria-dependent apoptosis in lung cancer cells. Neoplasma. 2018;65(3):367–375. doi:10.4149/neo_2018_170112N26
  • Yang S, Wu S, Dai W, et al. Tetramethylpyrazine: a review of its antitumor potential and mechanisms. Front Pharmacol. 2021;12:764331. doi:10.3389/fphar.2021.764331
  • Lu HY, Zu YX, Jiang XW, et al. Novel ADAM-17 inhibitor ZLDI-8 inhibits the proliferation and metastasis of chemo-resistant non-small-cell lung cancer by reversing Notch and epithelial mesenchymal transition in vitro and in vivo. Pharmacol Res. 2019;148:104406. doi:10.1016/j.phrs.2019.104406
  • Gielecińska A, Kciuk M, Yahya EB, Ainane T, Mujwar S, Kontek R. Apoptosis, necroptosis, and pyroptosis as alternative cell death pathways induced by chemotherapeutic agents? Biochim Biophys Acta Rev Cancer. 2023;1878(6):189024. doi:10.1016/j.bbcan.2023.189024
  • Wang H, Zhang W, Cheng Y, et al. Design, synthesis and biological evaluation of ligustrazine-flavonoid derivatives as potential anti-tumor agents. Molecules. 2018;23(9):2187.
  • Moradipour A, Dariushnejad H, Ahmadizadeh C, Lashgarian HE. Dietary flavonoid carvacrol triggers the apoptosis of human breast cancer MCF-7 cells via the p53/Bax/Bcl-2 axis. Med Oncol. 2022;40(1):46. doi:10.1007/s12032-022-01918-2
  • Kramer N, Walzl A, Unger C, et al. In vitro cell migration and invasion assays. Mutat Res. 2013;752(1):10–24. doi:10.1016/j.mrrev.2012.08.001
  • Rajasinghe LD, Pindiprolu RH, Gupta SV. Delta-tocotrienol inhibits non-small-cell lung cancer cell invasion via the inhibition of NF-κB, uPA activator, and MMP-9. Onco Targets Ther. 2018;11:4301–4314. doi:10.2147/ott.S160163
  • Eberhardt J, Santos-Martins D, Tillack AF, Forli S. AutoDock Vina 1.2.0: new docking methods, expanded force field, and python bindings. J Chem Inf Model. 2021;61(8):3891–3898. doi:10.1021/acs.jcim.1c00203
  • Badouel C, Chartrain I, Blot J, Tassan JP. Maternal embryonic leucine zipper kinase is stabilized in mitosis by phosphorylation and is partially degraded upon mitotic exit. Exp Cell Res. 2010;316(13):2166–2173. doi:10.1016/j.yexcr.2010.04.019
  • Janostiak R, Rauniyar N, Lam TT, et al. MELK promotes melanoma growth by stimulating the NF-κB pathway. Cell Rep. 2017;21(10):2829–2841. doi:10.1016/j.celrep.2017.11.033
  • Xu Q, Ge Q, Zhou Y, et al. MELK promotes Endometrial carcinoma progression via activating mTOR signaling pathway. EBioMedicine. 2020;51:102609. doi:10.1016/j.ebiom.2019.102609