Natural and Synthetic Drugs Approached for the Treatment of Recurrent Aphthous Stomatitis Over the Last Decade

References

• Jurge S, Kuffer R, Scully C, Porter SR. Mucosal disease series. Number VI. Recurrent aphthous stomatitis. Oral Dis. 2006;12(1):1–21. doi:10.1111/j.1601-0825.2005.01143.x
   PubMed Web of Science ®Google Scholar
• Cui RZ, Bruce AJ, Rogers RS. Recurrent aphthous stomatitis. Clin Dermatol. 2016;34(4):475–481. doi:10.1016/J.CLINDERMATOL.2016.02.020
   PubMed Web of Science ®Google Scholar
• Ślebioda Z, Szponar E, Kowalska A. Etiopathogenesis of recurrent aphthous stomatitis and the role of immunologic aspects: literature review. Arch Immunol Ther Exp. 2014;62(3):205–215. doi:10.1007/S00005-013-0261-Y/TABLES/3
   PubMed Web of Science ®Google Scholar
• Hussein A, Darwazeh Azmi MG, Al-Jundi S. Prevalence of oral lesions among Jordanian children. Saudi J Oral Sci. 2017;4(1):12. doi:10.4103/1658-6816.200135
   Google Scholar
• Zhu Z, He Z, Xie G, Fan Y, Shao T. Altered oral microbiota composition associated with recurrent aphthous stomatitis in young females. Medicine. 2021;100(10):E24742. doi:10.1097/MD.0000000000024742
   PubMed Web of Science ®Google Scholar
• Bankvall M, Sjöberg F, Gale G, Wold A, Jontell M, Östman S. The oral microbiota of patients with recurrent aphthous stomatitis. J Oral Microbiol. 2014;6:1–11. doi:10.3402/jom.v6.25739
   Web of Science ®Google Scholar
• Gomes VB, Porter S. Review Ulcerative Lesions of the Mouth: an Update. Int J Med. 2007;62(6):769–780.
   Google Scholar
• Mandasari M, Rahmayanti F. Identification of stress as a predisposing factor in minor recurrent aphthous stomatitis: a case report. J Case Rep Dental Med. 2022;4:56–59. doi:10.20956/jcrdm.v4i3.213
   Google Scholar
• Belenguer-Guallar I, Jiménez-Soriano Y, Claramunt-Lozano A. Treatment of recurrent aphthous stomatitis. A literature review. J Clin Exp Dent. 2014;6(2):168–174. doi:10.4317/jced.51401
   PubMedGoogle Scholar
• Vitamia C, Iftinan GN, Latarissa IR, et al. α-Mangostin hydrogel film with chitosan alginate base for recurrent aphthous stomatitis (RAS) treatment: study protocol for double-blind randomized controlled trial. Front Pharmacol. 2024:15. doi:10.3389/FPHAR.2024.1353503
   Google Scholar
• Minervini G, Franco R, Marrapodi MM, et al. Correlation between Temporomandibular Disorders (TMD) and Posture Evaluated trough the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD): a Systematic Review with Meta-Analysis. J Clin Med. 2023;12(7). doi:10.3390/jcm12072652
   Web of Science ®Google Scholar
• Messadi DV, Younai F. Aphthous ulcers. Dermatol Ther. 2010;23(3):281–290. doi:10.1111/j.1529-8019.2010.01324.x
   PubMed Web of Science ®Google Scholar
• Rattan J, Schneider M, Arber N, Gorsky M, Dayan D. Sucralfate suspension as a treatment of recurrent aphthous stomatitis. J Intern Med. 1994;236(3):341–343. doi:10.1111/j.1365-2796.1994.tb00805.x
   PubMed Web of Science ®Google Scholar
• Liu X, Guan X, Chen R, Hua H, Liu Y, Yan Z. Repurposing of Yunnan Baiyao as an alternative therapy for minor recurrent aphthous stomatitis. Evid Based Complement Alternat Med. 2012;2012:284620. doi:10.1155/2012/284620
   PubMed Web of Science ®Google Scholar
• Huo X, Han N, Liu L. Effect of different treatments on recurrent aphthous stomatitis: laser versus medication. Lasers Med Sci. 2021;36(5):1095–1100. doi:10.1007/s10103-020-03166-0
   PubMed Web of Science ®Google Scholar
• Yilmaz HG, Albaba MR, Caygur A, Cengiz E, Boke-Karacaoglu F, Tumer H. Treatment of recurrent aphthous stomatitis with Er, Cr:YSGG laser irradiation: a randomized controlled split mouth clinical study. J Photochem Photobiol B. 2017;170:1–5. doi:10.1016/j.jphotobiol.2017.03.011
   PubMed Web of Science ®Google Scholar
• Albrektson M, Hedström L, Bergh H. Recurrent aphthous stomatitis and pain management with low-level laser therapy: a randomized controlled trial. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117(5):590–594. doi:10.1016/j.oooo.2014.01.228
   PubMed Web of Science ®Google Scholar
• Barrons RW. Treatment strategies for recurrent oral aphthous ulcers. Am J Health Syst Pharm. 2001;58(1):41–43.
   PubMed Web of Science ®Google Scholar
• Lavaee F, Ghasemi M, Amiri MA, Farshidfar N. The Comparative Effects of Rhus Coriaria and Triamcinolone in Patients with Recurrent Aphthous Stomatitis: a Single-Blinded Randomized Controlled Clinical Trial. Biomed Res Int. 2022;2022:5067. doi:10.1155/2022/5855067
   Web of Science ®Google Scholar
• Bakhshi M, Mahboubi A, Jaafari MR, Ebrahimi F, Tofangchiha M, Alizadeh A. Comparative Efficacy of 1% Curcumin Nanomicelle Gel and 2% Curcumin Gel for Treatment of Recurrent Aphthous Stomatitis: a Double-Blind Randomized Clinical Trial. J Evidence-Based Dental Practice. 2022;22(2):101708. doi:10.1016/j.jebdp.2022.101708
   PubMed Web of Science ®Google Scholar
• Raman P, Pity R, Krithika CL, Anand SN, Subramani GP. Topical Curcumin and Triamcinolone Acetonide in Recurrent Minor Aphthous Ulcers: a Pilot Trial. Journal of Contemporary Dental Practice. 2020;21(8):884–890. doi:10.5005/JP-JOURNALS-10024-2901
   PubMedGoogle Scholar
• Deshmukh R, Bagewadi A. Comparison of effectiveness of curcumin with triamcinolone acetonide in the gel form in treatment of minor recurrent aphthous stomatitis: a randomized clinical trial. Int J Pharm Investig. 2014;4(3):138. doi:10.4103/2230-973x.138346
   PubMedGoogle Scholar
• Shao Y, Zhou H. Clinical evaluation of an oral mucoadhesive film containing chitosan for the treatment of recurrent aphthous stomatitis: a randomized, double-blind study. J Dermatological Treat. 2020;31(7):739–743. doi:10.1080/09546634.2019.1610548
   PubMed Web of Science ®Google Scholar
• Rahmani F, Moghadamnia AA, Kazemi S, Shirzad A, Motallebnejad M. Effect of 0.5% Chitosan mouthwash on recurrent aphthous stomatitis: a randomized double-blind crossover clinical trial. Electron Physician. 2018;10(6):6912–6919. doi:10.19082/6912
   PubMedGoogle Scholar
• Abbasi F, Rasoulzadeh Z, Yavari A. The effect of sage (Salvizan gel) compared to triamcinolone acetonide on the treatment of recurrent aphthous stomatitis: a double-blinded randomized clinical trial. BMC Oral Health. 2023;23(1):1–5. doi:10.1186/s12903-023-02861-y
   PubMed Web of Science ®Google Scholar
• Aggour RL, Mahmoud SH, Abdelwhab A. Evaluation of the effect of probiotic lozenges in the treatment of recurrent aphthous stomatitis: a randomized, controlled clinical trial. Clin Oral Investig. 2021;25(4):2151–2158. doi:10.1007/s00784-020-03527-7
   PubMed Web of Science ®Google Scholar
• Molania T, Malekzadeh Shafaroudi A, Saeedi M, et al. Evaluation of cinnamaldehyde mucoadhesive patches on minor recurrent aphthous stomatitis: a randomized, double-blind, placebo-controlled clinical trial. BMC Oral Health. 2022;22(1):1–7. doi:10.1186/s12903-022-02248-5
   PubMed Web of Science ®Google Scholar
• Nosratzehi T, Akar A. Efficacy of Omega-3 in Treatment of Recurrent Aphthous Stomatitis: a Randomised, Double-blind, Placebo-controlled Study. Chin J Dent Res. 2016;19(3):159–164. doi:10.3290/j.cjdr.a36681
   PubMedGoogle Scholar
• Hadian Z, Moghadamnia AA, Kazemi S, Shirzad A. Effect of Omega-3 on Recurrent Aphthous Stomatitis and Improvement Quality of Life. Int J Dent. 2021;2021:7575. doi:10.1155/2021/6617575
   Web of Science ®Google Scholar
• El Khouli AM, El-Gendy EA. Efficacy of omega-3 in treatment of recurrent aphthous stomatitis and improvement of quality of life: a randomized, double-blind, placebo-controlled study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117(2):191–196. doi:10.1016/j.oooo.2013.09.003
   PubMed Web of Science ®Google Scholar
• Rogulj AA, Alajbeg IZ, Brailo V, et al. Topical NAVS naphthalan for the treatment of oral lichen planus and recurrent aphthous stomatitis: a double blind, randomized, parallel group study. PLoS One. 2021;16(4 April):1–14. doi:10.1371/journal.pone.0249862
   Web of Science ®Google Scholar
• Kürklü-Gürleyen E, Öğüt-Erişen M, Çakır O, Uysal Ö, Ak G. Quality of life in patients with recurrent aphthous stomatitis treated with a mucoadhesive patch containing citrus essential oil. Patient Prefer Adherence. 2016;10:967–973. doi:10.2147/PPA.S106530
   PubMed Web of Science ®Google Scholar
• Arafa MG, Ghalwash D, El-Kersh DM, Elmazar MM. Propolis-based niosomes as oromuco-adhesive films: a randomized clinical trial of a therapeutic drug delivery platform for the treatment of oral recurrent aphthous ulcers. Sci Rep. 2018;8(1):1–14. doi:10.1038/s41598-018-37157-7
   PubMed Web of Science ®Google Scholar
• Gavanji S, Larki B, Bakhtari A. The effect of extract of Punica granatum var. pleniflora for treatment of minor recurrent aphthous stomatitis. Integr Med Res. 2014;3(2):83–90. doi:10.1016/j.imr.2014.03.001
   PubMedGoogle Scholar
• Darakhshan S, Malmir M, Bagheri F, et al. The effects of pomegranate peel extract on recurrent aphthous stomatitis. Curr Issues Pharm Med Sci. 2019;32(3):115–120. doi:10.2478/cipms-2019-0021
   Web of Science ®Google Scholar
• Tavangar A, Soleymani B, Ghalayani P, Zolfaghary B, Farhad A. The efficacy of Punica granatum extract in the management of recurrent aphthous stomatitis. J Res Pharm Pract. 2013;2(2):88. doi:10.4103/2279-042x.117389
   PubMedGoogle Scholar
• Tavangar A, Aslani A, Nikbakht N. Comparative Study of Punica granatum Gel and Triadent Oral Paste Effect on Recurrent Aphthous Stomatitis, a Double Blind Clinical Trial. J Dent. 2019;20(3):184–189. doi:10.30476/DENTJODS.2019.44913
   Google Scholar
• El-Haddad SA, Asiri FY, Al-Qahtani HH, Al-Ghmlas AS. Efficacy of honey in comparison to topical corticosteroid for treatment of recurrent minor aphthous ulceration: a randomized, blind, controlled, parallel, double-center clinical trial. Quintessence Int. 2014;45(8):691–701. doi:10.3290/j.qi.a32241
   PubMed Web of Science ®Google Scholar
• Romero-Cerecero O, Zamilpa A, Tortoriello J. Pilot study that evaluated the clinical effectiveness and safety of a phytopharmaceutical elaborated with an extract of Ageratina pichinchensis in patients with minor recurrent aphthous stomatitis. J Ethnopharmacol. 2015;173:225–230. doi:10.1016/j.jep.2015.06.021
   PubMed Web of Science ®Google Scholar
• Umpreecha C, Bhalang K, Charnvanich D, Luckanagul J. Efficacy and safety of topical 0.1% cannabidiol for managing recurrent aphthous ulcers: a randomized controlled trial. BMC Complement Med Ther. 2023;23(1):1–11. doi:10.1186/s12906-023-03886-0
   Google Scholar
• Pedersen AML, Bukkehave KH, Bennett EP, Twetman S. Effect of Lozenges Containing Lactobacillus reuteri on the Severity of Recurrent Aphthous Ulcers: a Pilot Study. Probiotics Antimicrob Proteins. 2020;12(3):819–823. doi:10.1007/s12602-019-09586-x
   PubMed Web of Science ®Google Scholar
• Vaziri S, Mojarrab M, Osein FMH, Najafi F, Ghobadi A. Evaluation of anti-aphthous activity of decoction of Nicotiana tabacum leaves as a mouthwash: a placebo-controlled clinical study. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan / sponsored by All-China Association of Traditional Chinese Medicine. Acad Traditional Chine Med. 2016;36(2):160–164. doi:10.1016/s0254-6272(16)30022-x
   PubMed Web of Science ®Google Scholar
• Rafieian N, Abdolsamadi H, Moghadamnia A, et al. Efficacy of alum for treatment of recurrent aphthous stomatitis. Caspian J Intern Med. 2016;7(3):201–206.
   PubMedGoogle Scholar
• Puspa Dewi SR, Karina Ginting MP, Anggraini NR, Parisa N, Handayani P, Chairani S. Evaluation of the effect of gambier (Uncaria gambier) extract for treatment of recurrent aphthous stomatitis. International Research Journal of Pharmacy. 2020;11(1):27–31. doi:10.7897/2230-8407.11015
   Google Scholar
• Du Q, Ni S, Guo L, et al. Effects of Zingiber officinalis (WILLD.) ROSC. Membranes on minor recurrent aphthous stomatitis: a randomized pragmatic trial. J Traditional Chine Med Sci. 2018;5(1):58–63. doi:10.1016/j.jtcms.2018.02.004
   Google Scholar
• Haghpanah P, Moghadamnia AA, Zarghami A, Motallebnejad M. Muco-bioadhesive containing ginger officinale extract in the management of recurrent aphthous stomatitis: a randomized clinical study. Caspian J Intern Med. 2015;6(1):3–8.
   PubMedGoogle Scholar
• Yousef NJ, Aljoujou AA, Mashlah AM, Hajeer MY. Assessment of the Effectiveness of Aloe vera Versus Amlexanox in the Treatment of Recurrent Aphthous Ulcers: a Three-Arm Placebo-Controlled Randomized Clinical Trial. Cureus. 2022;14(10):1–8. doi:10.7759/cureus.30693
   Web of Science ®Google Scholar
• Mansour G, Ouda S, Shaker A, Abdallah HM. Clinical efficacy of new aloe vera- and myrrh-based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: a randomized, double-blind, vehicle-controlled study. J Oral Pathol Med. 2014;43(6):405–409. doi:10.1111/jop.12130
   PubMed Web of Science ®Google Scholar
• Halim DS, Abdullah NA, Alam MK, Samsee SNB, May TS. Comparison of the effectiveness between virgin coconut oil (VCO) and triamcinolone for treatment of minor recurrent aphthous stomatitis (RAS). International Medical Journal. 2014;21(3):319–320.
   Google Scholar
• Jiang XW, Zhang Y, Zhu YL, et al. Effects of berberine gelatin on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial in a Chinese cohort. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;115(2):212–217. doi:10.1016/j.oooo.2012.09.009
   PubMed Web of Science ®Google Scholar
• Elamrousy WA, Mortada A, Shoukheba M. Evaluation of Novel Topical Camel Whey Protein Gel for the Treatment of Recurrent Aphthous Stomatitis: randomized Clinical Study. J Int Soc Prev Community Dent. 2021;11(5):574–581. doi:10.4103/jispcd.JISPCD_172_21
   PubMed Web of Science ®Google Scholar
• Ansari M, Hashemipour M, Farsinejad A, et al. Clinical efficacy of a buccoadhesive paste from Fenugreek seeds (Trigonella foenum graecum L.) on recurrent aphthous stomatitis: in-vitro assessment of non-toxic concentration and pilot trial. Adv Integr Med. 2022;9(1):17–21. doi:10.1016/j.aimed.2021.06.001
   Web of Science ®Google Scholar
• Raeesi V, Arbabi-Kalati F, Akbari N, Hamishekar H. Comparison effectiveness of the bioadhesive paste containing licorice 5% with bioadhesive paste without drug in the management of recurrent aphthous stomatitis. Acta Med Mediterr. 2015;31(7):1331–1335.
   Google Scholar
• Seyyedi SA, Sanatkhani M, Pakfetrat A, Olyaee P. The therapeutic effects of chamomilla tincture mouthwash on oral aphthae: a randomized clinical trial. J Clin Exp Dent. 2014;6(5):e535–e538. doi:10.4317/jced.51472
   PubMedGoogle Scholar
• Andishe Tadbir A, Pourshahidi S, Ebrahimi H, Hajipour Z, Memarzade MR, Shirazian S. The effect of Matricaria chamomilla (chamomile) extract in Orabase on minor aphthous stomatitis, a randomized clinical trial. J Herb Med. 2015;5(2):71–76. doi:10.1016/j.hermed.2015.05.001
   Web of Science ®Google Scholar
• Ghorbani A, Akbari J, Boorboor M, Nekoukar Z, Eslami G. Evaluation of zinc sulfate mucoadhesive formulation on recurrent aphthous stomatitis: a randomized double-blind, placebo-controlled clinical trial. BMC Oral Health. 2020;20(1):1–6. doi:10.1186/s12903-020-01194-4
   Web of Science ®Google Scholar
• Al-Oudah GA, AL-Ameedee AH, Shwailiya SAS. Activity of zinc oral dispersible tablet on marjory clinical type of recurrent aphthous stomatitis ulceration, a clinical trial human study. Ann Trop Med Public Health. 2020;23(12). doi:10.36295/ASRO.2020.231201
   Google Scholar
• Habibzadeh S, Sheikh Rahimi M, Edalatkhah H, Piri H, Maleki N. Effectiveness of booster dose of tetanus and diphtheria toxoids (Td) vaccine in management of recurrent aphthous stomatitis: a prospective, randomized, triple-blind and placebo-controlled clinical trial. J Dermatological Treat. 2021;32(3):361–366. doi:10.1080/09546634.2019.1654597
   PubMed Web of Science ®Google Scholar
• Sharda N, Shashikanth MC, Kant P, Jain M. Levamisole and low-dose prednisolone in the treatment of recurrent aphthous stomatitis. J Oral Pathol Med. 2014;43(4):309–316. doi:10.1111/jop.12126
   PubMed Web of Science ®Google Scholar
• Vijayabala GS, Kalappanavar AN, Annigeri RG, Sudarshan R, Shettar SS. Single application of topical doxycycline hyclate in the management of recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116(4):440–446. doi:10.1016/j.oooo.2013.06.015
   PubMed Web of Science ®Google Scholar
• Shrivastava K, Naidu G, Deshpande A, Handa H, Raghuvanshi V, Gupta M. Comparative evaluation of the efficacy of topical amlexanox 5% oral paste and triamcinolone acetonide 0.1% oral paste in the treatment of Recurrent Aphthous Stomatitis (RAS). J Indian Acad Oral Med Radiol. 2018;30(3):235–240. doi:10.4103/jiaomr.jiaomr_40_18
   Google Scholar
• Alsahaf S, Alkurdi KA, Challacombe SJ, Tappuni AR. Topical betamethasone and systemic colchicine for treatment of recurrent aphthous stomatitis: a randomised clinical trial. BMC Oral Health. 2023;23(1):709. doi:10.1186/s12903-023-03335-x
   PubMed Web of Science ®Google Scholar
• Halboub E, Alkadasi B, Alakhali M, et al. N-acetylcysteine versus chlorhexidine in treatment of aphthous ulcers: a preliminary clinical trial. J Dermatological Treat. 2021;32(6):649–653. doi:10.1080/09546634.2019.1688231
   PubMed Web of Science ®Google Scholar
• Eslami G, Ghorbani A, Akbari J, Farmoudeh A, Faghih F, Moghimi M. Efficacy of Oral Mucoadhesive N-acetylcysteine Tablets in Treatment of Recurrent Aphthous Stomatitis: a Randomized Double-Blind, Placebo-Controlled Clinical Trial. Front Dent. 2023;20:1–8. doi:10.18502/fid.v20i18.12824
   PubMedGoogle Scholar
• El-Wakeel NM, Dawoud MHS. Topical insulin-liposomal formulation in management of recurrent aphthous ulcers: a randomized placebo-controlled trial. J Investig Clin Dent. 2019;10(4):1–6. doi:10.1111/jicd.12437
   Web of Science ®Google Scholar
• Zeng Q, Shi X, Yang J, et al. The efficacy and safety of thalidomide on the recurrence interval of continuous recurrent aphthous ulceration: a randomized controlled clinical trial. J Oral Pathol Med. 2020;49(4):357–364. doi:10.1111/jop.12960
   PubMed Web of Science ®Google Scholar
• Borhan-Mojabi K, Mirmiran F, Nassiri-Asl M, Nazeman P, Jahanihashemi H. Therapeutic Effects of “Ibuprofen, Diphenhydramine and Aluminium MgS” on Recurrent Aphthous Stomatitis: a Randomized Controlled Trial. J Dent (Tehran). 2014;11(2):167–171.
   PubMedGoogle Scholar
• Yarom N, Zelig K, Epstein JB, Gorsky M. The efficacy of minocycline mouth rinses on the symptoms associated with recurrent aphthous stomatitis: a randomized, double-blind, crossover study assessing different doses of oral rinse. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123(6):675–679. doi:10.1016/j.oooo.2017.02.013
   PubMed Web of Science ®Google Scholar
• Ofluoglu D, Ergun S, Warnakulasuriya S, Namdar-Pekiner F, Tanyeri H. An evaluation of the efficacy of a topical gel with Triester Glycerol Oxide (TGO) in the treatment of minor recurrent aphthous stomatitis in a Turkish cohort: a randomized, double-blind, placebo-controlled clinical trial. Med Oral Patol Oral Cir Bucal. 2017;22(2):e159–e166. doi:10.4317/medoral.21469
   PubMed Web of Science ®Google Scholar
• Parvathi Devi MK, Dnsv R, Koppal S, Byatnal AR, Rukmangada T, Byatnal AA. Efficacy of rebamipide and levamisole in the treatment of patients with recurrent aphthous ulcer - A comparative study. Journal of Clinical and Diagnostic Research. 2014;8(11):ZC119–ZC122. doi:10.7860/JCDR/2014/10295.5202
   PubMedGoogle Scholar
• Owlia M, Mirzadeh M, Mehrpoor G. Penicillin in oral aphthosis, new insight for an old drug: a randomized, double-blind, controlled clinical trial. J Res Med Sci. 2020;25:95. doi:10.4103/jrms.JRMS_748_19
   PubMed Web of Science ®Google Scholar
• Suhandi C, Alfathonah SS, Hasanah AN. Potency of Xanthone Derivatives from Garcinia mangostana L. for COVID-19 Treatment through Angiotensin-Converting Enzyme 2 and Main Protease Blockade: a Computational Study. Molecules. 2023;28(13). doi:10.3390/MOLECULES28135187
   Web of Science ®Google Scholar
• Dhama K, Karthik K, Khandia R, et al. Medicinal and Therapeutic Potential of Herbs and Plant Metabolites / Extracts Countering Viral Pathogens – current Knowledge and Future Prospects. Curr Drug Metab. 2018;19. doi:10.2174/1389200219666180129145252
   Web of Science ®Google Scholar
• Kaileh M, Vanden Berghe W, Boone E, Essawi T, Haegeman G. Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity. J Ethnopharmacol. 2007;113(3):510–516. doi:10.1016/j.jep.2007.07.008
   PubMed Web of Science ®Google Scholar
• Eisen D, Lynch DP. Selecting topical and systemic agents for recurrent aphthous stomatitis. Cutis. 2001;68(3):201–206.
   PubMed Web of Science ®Google Scholar
• Delgado DA, Lambert BS, Boutris N, et al. Validation of Digital Visual Analog Scale Pain Scoring With a Traditional Paper-based Visual Analog Scale in Adults. J Am Acad Orthop Surg Glob Res Rev. 2018;2(3):e088. doi:10.5435/JAAOSGlobal-D-17-00088
   PubMedGoogle Scholar
• Karimi A, Majlesi M, Rafieian-Kopaei M. Herbal versus synthetic drugs; beliefs and facts. J Nephropharmacol. 2015;4(1):27–30.
   PubMedGoogle Scholar
• Furnham AF. Alternative and Complementary Healing Practices. International Encyclopedia of the Social & Behavioral Sciences. 2001;404–407. doi:10.1016/B0-08-043076-7/03905-X
   Google Scholar
• Lau SH, Herman H, Rahmat M. Studi perbandingan tingkat pengetahuan masyarakat tentang obat herbal dan obat sintetik di campagayya kelurahan panaikang Kota makassar. Jurnal Farmasi Sandi Karsa. 2019;5(1):33.
   Google Scholar
• Femiano F, Lanza A, Buonaiuto C, et al. Guidelines for diagnosis and management of aphthous stomatitis. Pediatr Infect Dis J. 2007;26(8):728–732. doi:10.1097/INF.0b013e31806215f9
   PubMed Web of Science ®Google Scholar
• Messier C, Epifano F, Genovese S, Grenier D. Licorice and its potential beneficial effects in common oro-dental diseases. Oral Dis. 2012;18(1):32–39. doi:10.1111/j.1601-0825.2011.01842.x
   PubMed Web of Science ®Google Scholar
• Chaudhuri K, Nair KK, Ashok L. Salivary levels of TNF-α in patients with recurrent aphthous stomatitis: a cross-sectional study. J Dent Res Dent Clin Dent Prospects. 2018;12(1):45–48. doi:10.15171/joddd.2018.007
   PubMedGoogle Scholar
• Kovalik AC, Bisetto P, Pochapski MT, Campagnoli EB, Pilatti GL, Santos FA. Effects of an orabase formulation with ethanolic extract of Malva sylvestris L. in oral wound healing in rats. J Med Food. 2014;17(5):618–624. doi:10.1089/jmf.2013.0001
   PubMed Web of Science ®Google Scholar
• Suhandi C, Wilar G, Lesmana R, et al. Propolis-Based Nanostructured Lipid Carriers for α-Mangostin Delivery: formulation, Characterization, and In Vitro Antioxidant Activity Evaluation. Molecules. 2023;28(16). doi:10.3390/MOLECULES28166057
   Web of Science ®Google Scholar
• Mohammed S, Abdulraheem S. Evaluate the efficiency of sage (Salvia officinalis) and curcumin mouthwash in the treatment of recurrent aphthous stomatitis)(comparative study). Al-Rafidain Dental Journal. 2021;48.
   Google Scholar
• Abdulrab S, Halboub E, Barngkgei I, Al-hebshi N. N-Acetylcysteine as a Candidate Therapeutic for Recurrent Aphthous and Aphthous-Like Ulcers. Dent Hypotheses. 2017;8:17–22. doi:10.4103/2155-8213.202028
   Google Scholar
• A M. Etiology and pathophysiology of recurrent aphthous stomatitis: a review. Int J Curr Res Rev. 2014;6:16–22.
   Google Scholar
• Moraes TM, Kushima H, Moleiro FC, et al. Effects of limonene and essential oil from Citrus aurantium on gastric mucosa: role of prostaglandins and gastric mucus secretion. Chem Biol Interact. 2009;180(3):499–505. doi:10.1016/j.cbi.2009.04.006
   PubMed Web of Science ®Google Scholar
• Kudur MH, Hulmani M. Rebamipide: a Novel Agent in the Treatment of Recurrent Aphthous Ulcer and Behcet’s Syndrome. Indian J Dermatol. 2013;58(5):352–354. doi:10.4103/0019-5154.117298
   PubMedGoogle Scholar
• Rodu B, Mattingly G. Oral mucosal ulcers: diagnosis and management. J Am Dent Assoc. 1992;123(10):83–86. doi:10.14219/jada.archive.1992.0268
   PubMed Web of Science ®Google Scholar
• ALtaei TS, AI-Jubouri RH. Evaluation of the efficacy of alum suspension in treatment of recurrent ulcerative ulceration. J Baghdad College Dentistry. 2005;17(2):45–48.
   Google Scholar
• Attia EAS, Belal DMI, El Samahy MH, El Hamamsy MH. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: impact on quality of life. Wound Repair Regen. 2014;22(1):52–57. doi:10.1111/wrr.12122
   PubMed Web of Science ®Google Scholar
• Negut I, Grumezescu V, Grumezescu AM. Treatment Strategies for Infected Wounds. Molecules. 2018;23(9). doi:10.3390/molecules23092392
   PubMed Web of Science ®Google Scholar
• Tarakji B, Gazal G, Al-Maweri SA, Azzeghaiby SN, Alaizari N. Guideline for the diagnosis and treatment of recurrent aphthous stomatitis for dental practitioners. J Int Oral Health. 2015;7(5):74–80.
   PubMedGoogle Scholar
• Tsuchiya H. Membrane Interactions of Phytochemicals as Their Molecular Mechanism Applicable to the Discovery of Drug Leads from Plants. Molecules. 2015;20(10):18923–18966. doi:10.3390/molecules201018923
   PubMed Web of Science ®Google Scholar
• Suhandi C, Mohammed AFA, Wilar G, El-Rayyes A, Wathoni N. Effectiveness of Mesenchymal Stem Cell Secretome on Wound Healing: a Systematic Review and Meta-analysis. Tissue Eng Regen Med. 2023;20(7):1053–1062. doi:10.1007/S13770-023-00570-9
   PubMed Web of Science ®Google Scholar
• Suharyani I, Fouad Abdelwahab Mohammed A, Muchtaridi M, Wathoni N, Abdassah M. Evolution of Drug Delivery Systems for Recurrent Aphthous Stomatitis. Drug Des Devel Ther. 2021;15:4071–4089. doi:10.2147/DDDT.S328371
   PubMed Web of Science ®Google Scholar
• Boddupalli BM, Mohammed ZNK, Nath RA, Banji D. Mucoadhesive drug delivery system: an overview. J Adv Pharm Technol Res. 2010;1(4):381–387. doi:10.4103/0110-5558.76436
   PubMedGoogle Scholar
• Shaikh R, Raj Singh TR, Garland MJ, Woolfson AD, Donnelly RF. Mucoadhesive drug delivery systems. J Pharm Bioallied Sci. 2011;3(1):89–100. doi:10.4103/0975-7406.76478
   PubMed Web of Science ®Google Scholar
• Bakhshi M, Gholami S, Mahboubi A, Jaafari MR, Namdari M. Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: a Randomized Double-Blind Placebo Controlled Clinical Trial. Dermatol Res Pract. 2020;2020:4298193. doi:10.1155/2020/4298193
   PubMed Web of Science ®Google Scholar
• Ossama M, Lamie C, Tarek M, Wagdy HA, Attia DA, Elmazar MM. Management of recurrent aphthous ulcers exploiting polymer-based Muco-adhesive sponges: in-vitro and in-vivo evaluation. Drug Deliv. 2021;28(1):87–99. doi:10.1080/10717544.2020.1858999
   PubMed Web of Science ®Google Scholar
• Wathoni N, Yuniarsih N, Cahyanto A, Muhctaridi M. Α-Mangostin Hydrogel Film Based Chitosan-Alginate for Recurrent Aphthous Stomatitis. Applied Sciences. 2019;9(23). doi:10.3390/app9235235
   Google Scholar
• Laffleur F, Küppers P. Adhesive alginate for buccal delivery in aphthous stomatitis. Carbohydr Res. 2019;477:51–57. doi:10.1016/j.carres.2019.03.009
   PubMed Web of Science ®Google Scholar
• Farid RM, Wen MM. Promote Recurrent Aphthous Ulcer Healing with Low Dose Prednisolone Bilayer Mucoadhesive Buccal Film. Curr Drug Deliv. 2017;14(1):123–135. doi:10.2174/1567201813666160316122548
   PubMed Web of Science ®Google Scholar
• Sharma A, Yadav N, Ram Murti SS, Author C, Ram MS. Review On Mucoadhesive Buccal Drug Delivery For The Treatment Of Aphthous Ulcers. J Pharmaceutical Negative Results. 2022;13(9). doi:10.47750/pnr.2022.13.S09.1297
   Google Scholar
• Sizílio RH, Galvão JG, Trindade GGG, et al. Chitosan/pvp-based mucoadhesive membranes as a promising delivery system of betamethasone-17-valerate for aphthous stomatitis. Carbohydr Polym. 2018;190:339–345. doi:10.1016/j.carbpol.2018.02.079
   PubMed Web of Science ®Google Scholar
• Colley HE, Said Z, Santocildes-Romero ME, et al. Pre-clinical evaluation of novel mucoadhesive bilayer patches for local delivery of clobetasol-17-propionate to the oral mucosa. Biomaterials. 2018;178:134–146. doi:10.1016/j.biomaterials.2018.06.009
   PubMed Web of Science ®Google Scholar
• Li CL, Huang HL, Wang WC, Hua H. Efficacy and safety of topical herbal medicine treatment on recurrent aphthous stomatitis: a systemic review. Drug Des Devel Ther. 2015;10:107–115. doi:10.2147/DDDT.S96589
   PubMed Web of Science ®Google Scholar
• Chinna Reddy P, Chaitanya KSC, Madhusudan Rao Y. A review on bioadhesive buccal drug delivery systems: current status of formulation and evaluation methods. Daru. 2011;19(6):385–403.
   PubMed Web of Science ®Google Scholar
• Milanda T, Cindana Mo’o FR, Mohammed AFA, et al. Alginate/Chitosan-Based Hydrogel Film Containing α-Mangostin for Recurrent Aphthous Stomatitis Therapy in Rats. Pharmaceutics. 2022;14(8). doi:10.3390/pharmaceutics14081709
   PubMed Web of Science ®Google Scholar