Dexmedetomidine Prolongs Lidocaine Intravenous Regional Anesthesia in Rats by Blocking the Hyperpolarization-Activated Cation Current

References

• van Zundert A, Helmstädter A, Goerig M, Mortier E. Centennial of intravenous regional anesthesiaBier’s Block (1908–2008). Reg Anesth Pain Med. 2008;33(5):483–489. doi:10.1097/00115550-200809000-00014
   Web of Science ®Google Scholar
• Nijs K, Lismont A, De Wachter G, et al. The analgesic efficacy of forearm versus upper arm intravenous regional anesthesia (Bier’s block): A randomized controlled non-inferiority trial. J Clin Anesth. 2021;73:110329. doi:10.1016/j.jclinane.2021.110329
   PubMed Web of Science ®Google Scholar
• Bosdotter Enroth S, Rystedt A, Covaciu L, et al. Bilateral forearm intravenous regional anesthesia with prilocaine for botulinum toxin treatment of palmar hyperhidrosis. J Am Acad Dermatol. 2010;63(3):466–474. doi:10.1016/j.jaad.2009.10.034
   Web of Science ®Google Scholar
• Guay J. Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications. J Clin Anesth. 2009;21(8):585–594. doi:10.1016/j.jclinane.2009.01.015
   PubMed Web of Science ®Google Scholar
• Goh AXC, Yeo JW, Gao JF, et al. Comparative efficacy of anesthetic methods for closed reduction of pediatric forearm fractures: a systematic review. Emerg Med J. 2022;39(12):888–896. doi:10.1136/emermed-2021-212108
   Web of Science ®Google Scholar
• Bakri MH, Ismail EA, Abd-Elshafy SK. Analgesic effect of nalbuphine when added to intravenous regional anesthesia: a randomized control trial. Pain Physician. 2016;19(8):575–581.
   PubMed Web of Science ®Google Scholar
• Viscomi CM, Friend A, Parker C, Murphy T, Yarnell M. Ketamine as an adjuvant in lidocaine intravenous regional anesthesia: a randomized, double-blind, systemic control trial. Reg Anesth Pain Med. 2009;34(2):130–133. doi:10.1097/AAP.0b013e31819bb006
   Web of Science ®Google Scholar
• Memiş D, Turan A, Karamanlioğlu B, Pamukçu Z, Kurt I. Adding dexmedetomidine to lidocaine for intravenous regional anesthesia. Anesth Analg. 2004;98(3):835–840. doi:10.1213/01.ane.0000100680.77978.66
   PubMed Web of Science ®Google Scholar
• Karmaniolou I, Staikou C, Surda P. The role of dexmedetomidine as an additive to intravenous regional anesthesia: a systematic review and meta-analysis. Balkan Med J. 2021;38(3):156–164. doi:10.5152/balkanmedj.2021.20076
   PubMed Web of Science ®Google Scholar
• Weerink MAS, Struys MMRF, Hannivoort LN, Barends CRM, Absalom AR, Colin P. Clinical pharmacokinetics and pharmacodynamics of dexmedetomidine. Clin Pharmacokinet. 2017;56(8):893–913. doi:10.1007/s40262-017-0507-7
   PubMed Web of Science ®Google Scholar
• Fairbanks CA, Stone LS, Wilcox GL. Pharmacological profiles of alpha 2 adrenergic receptor agonists identified using genetically altered mice and isobolographic analysis. Pharmacol Ther. 2009;123(2):224–238. doi:10.1016/j.pharmthera.2009.04.001
   PubMed Web of Science ®Google Scholar
• Brummett CM, Hong EK, Janda AM, Amodeo FS, Lydic R. Perineural dexmedetomidine added to ropivacaine for sciatic nerve block in rats prolongs the duration of analgesia by blocking the hyperpolarization-activated cation current. Anesthesiology. 2011;115(4):836–843. doi:10.1097/ALN.0b013e318221fcc9
   PubMed Web of Science ®Google Scholar
• Kroin JS, Buvanendran A, Beck DR, Topic JE, Watts DE, Tuman KJ. Clonidine prolongation of lidocaine analgesia after sciatic nerve block in rats Is mediated via the hyperpolarization-activated cation current, not by alpha-adrenoreceptors. Anesthesiology. 2004;101(2):488–494. doi:10.1097/00000542-200408000-00031
   PubMed Web of Science ®Google Scholar
• Benarroch EE. HCN channels: function and clinical implications. Neurology. 2013;80(3):304–310. doi:10.1212/WNL.0b013e31827dec42
   PubMed Web of Science ®Google Scholar
• Combe CL, Gasparini S. Ih from synapses to networks: HCN channel functions and modulation in neurons. Prog Biophys Mol Biol. 2021;166:119–132. doi:10.1016/j.pbiomolbio.2021.06.002
   Web of Science ®Google Scholar
• Zhao W, Liang P, Liu J, et al. Capsazepine prolongation of the duration of lidocaine block of sensory transmission in mice may be mediated by modulation of HCN channel currents. PeerJ. 2019;7:e7111.
   Web of Science ®Google Scholar
• Luo WJ, Chai YF, Liu J, et al. A model of intravenous regional anesthesia in rats. Anesth Analg. 2010;110(4):1227–1232. doi:10.1213/ANE.0b013e3181ce1f84
   Web of Science ®Google Scholar
• Mizrak A, Gul R, Erkutlu I, Alptekin M, Oner U. Premedication with dexmedetomidine alone or together with 0.5% lidocaine for IVRA. J Surg Res. 2010;164(2):242–247. doi:10.1016/j.jss.2009.03.005
   PubMed Web of Science ®Google Scholar
• Yang YC, Meng QT, Pan X, Xia ZY, Chen XD. Dexmedetomidine produced analgesic effect via inhibition of HCN currents. Eur. J Pharmacol. 2014;740:560–564.
   Google Scholar
• Yoshitomi T, Kohjitani A, Maeda S, Higuchi H, Shimada M, Miyawaki T. Dexmedetomidine enhances the local anesthetic action of lidocaine via an alpha-2A adrenoceptor. Anesth Analg. 2008;107(1):96–101. doi:10.1213/ane.0b013e318176be73
   Web of Science ®Google Scholar
• Yam MF, Loh YC, Tan CS, Khadijah Adam S, Abdul Manan N, Basir R. General pathways of pain sensation and the major neurotransmitters involved in pain regulation. Int J Mol Sci. 2018;19(8):2164. doi:10.3390/ijms19082164
   PubMed Web of Science ®Google Scholar
• Zhou C, Ke B, Zhao Y, et al. Hyperpolarization-activated cyclic nucleotide-gated channels may contribute to regional anesthetic effects of lidocaine. Anesthesiology. 2015;122(3):606–618. doi:10.1097/ALN.0000000000000557
   PubMed Web of Science ®Google Scholar
• Arnold EC, McMurray C, Gray R, Johnston D. Epilepsy-induced reduction in HCN channel expression contributes to an increased excitability in dorsal, but not ventral, hippocampal CA1 neurons. eNeuro. 2019;6(2):36. doi:10.1523/ENEURO.0036-19.2019
   Web of Science ®Google Scholar
• Sartiani L, Mannaioni G, Masi A, Novella Romanelli M, Cerbai E, Garland CJ. The hyperpolarization-activated cyclic nucleotide-gated channels: from biophysics to pharmacology of a unique family of ion channels. Pharmacol Rev. 2017;69(4):354–395. doi:10.1124/pr.117.014035
   PubMed Web of Science ®Google Scholar
• Cao Y, Pang J, Zhou P. HCN channel as therapeutic targets for heart failure and pain. Curr Top Med Chem. 2016;16(16):1855–1861. doi:10.2174/1568026616666151215104058
   PubMed Web of Science ®Google Scholar
• Tanaka S, Ishida T, Ishida K, et al. A randomized, double-blinded, placebo-controlled, crossover study of the HCN channel blocker ivabradine in a capsaicin-induced pain model in healthy volunteers. Sci Rep. 2022;12(1):17246. doi:10.1038/s41598-022-22309-7
   Google Scholar
• Lee S. Dexmedetomidine: present and future directions. Korean J Anesthesiol. 2019;72(4):323–330. doi:10.4097/kja.19259
   PubMed Web of Science ®Google Scholar
• Buckley MS, Agarwal SK, MacLaren R, Kane-Gill SL. Adverse hemodynamic events associated with concomitant dexmedetomidine and propofol for sedation in mechanically ventilated ICU patients. J Intensive Care Med. 2020;35(12):1536–1545. doi:10.1177/0885066619884548
   Web of Science ®Google Scholar
• Lu TL, Lu TJ, Wu SN. Effectiveness in block by dexmedetomidine of hyperpolarization-activated cation current, independent of Its agonistic effect on α2-adrenergic receptors. Int J Mol Sci. 2020;21(23):9110. doi:10.3390/ijms21239110
   Web of Science ®Google Scholar
• Chen CS, So EC, Wu SN. Modulating hyperpolarization-activated cation currents through small molecule perturbations: magnitude and gating control. Biomedicines. 2023;11(8):2177.
   Web of Science ®Google Scholar