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ORIGINAL RESEARCH

Obacunone Alleviates Inflammatory Pain by Promoting M2 Microglial Polarization and by Activating Nrf2/HO-1 Signaling Pathway

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Pages 1265-1275 | Received 22 Nov 2023, Accepted 11 Apr 2024, Published online: 17 Apr 2024

References

  • Kidd BL, Urban LA. Mechanisms of inflammatory pain. Br J Anaesth. 2001;87(1):3–11. doi:10.1093/bja/87.1.3
  • Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell. 2009;139(2):267–284. doi:10.1016/j.cell.2009.09.028
  • Boettger MK, Uceyler N, Zelenka M, et al. Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient mice. Eur J Pain. 2007;11(7):810–818. doi:10.1016/j.ejpain.2006.12.008
  • Geboes L, De Klerck B, Van Balen M, et al. Freund’s complete adjuvant induces arthritis in mice lacking a functional interferon-gamma receptor by triggering tumor necrosis factor alpha-driven osteoclastogenesis. Arthritis Rheum. 2007;56(8):2595–2607. doi:10.1002/art.22791
  • Ahmed O, Fahim H, Mahmoud A, Ahmed E. Bee venom and hesperidin effectively mitigate complete Freund’s adjuvant-induced arthritis via immunomodulation and enhancement of antioxidant defense system. Arch Rheumatol. 2018;33(2):198–212. doi:10.5606/ArchRheumatol.2018.6519
  • Han K, Zhang A, Mo Y, et al. Islet-cell autoantigen 69 mediates the antihyperalgesic effects of electroacupuncture on inflammatory pain by regulating spinal glutamate receptor subunit 2 phosphorylation through protein interacting with C-kinase 1 in mice. Pain. 2019;160(3):712–723. doi:10.1097/j.pain.0000000000001450
  • Chen O, Luo X, Ji RR . Macrophages and microglia in inflammation and neuroinflammation underlying different pain states. Med Rev (2021). 2023;3(5):381 407. doi:10.1515/mr-2023-0034
  • Calvo M, Bennett DL. The mechanisms of microgliosis and pain following peripheral nerve injury. Exp Neurol. 2012;234(2):271–282. doi:10.1016/j.expneurol.2011.08.018
  • Chen G, Zhang YQ, Qadri YJ, Serhan CN, Ji RR. Microglia in pain: detrimental and protective roles in pathogenesis and resolution of pain. Neuron. 2018;100(6):1292–1311. doi:10.1016/j.neuron.2018.11.009
  • Jassam YN, Izzy S, Whalen M, McGavern DB, El Khoury J. Neuroimmunology of traumatic brain injury: time for a paradigm shift. Neuron. 2017;95(6):1246–1265. doi:10.1016/j.neuron.2017.07.010
  • Pisanu A, Lecca D, Mulas G, et al. Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-γ agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson’s disease. Neurobiol Dis. 2014;71:280–291. doi:10.1016/j.nbd.2014.08.011
  • Piotrowska A, Kwiatkowski K, Rojewska E, Makuch W, Mika J. Maraviroc reduces neuropathic pain through polarization of microglia and astroglia — evidence from in vivo and in vitro studies. Neuropharmacology. 2016;108:207–219. doi:10.1016/j.neuropharm.2016.04.024
  • Gui X, Wang H, Wu L, et al. Botulinum toxin type A promotes microglial M2 polarization and suppresses chronic constriction injury-induced neuropathic pain through the P2X7 receptor. Cell Biosci. 2020;10(1):45. doi:10.1186/s13578-020-00405-3
  • Jiang Y, Wang J, Li H, Xia L. IL-35 promotes microglial M2 polarization in a rat model of diabetic neuropathic pain. Arch Biochem Biophys. 2020;685:108330. doi:10.1016/j.abb.2020.108330
  • Vasavda C, Xu R, Liew J, et al. Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain. Sci Adv. 2022;8(31):eabo5633. doi:10.1126/sciadv.abo5633
  • Farina M, Vieira LE, Buttari B, Profumo E, Saso L. The Nrf2 pathway in ischemic stroke: a review. Molecules. 2021;26(16):5001. doi:10.3390/molecules26165001
  • Shen Y, Liu X, Shi J, Wu X. Involvement of Nrf2 in myocardial ischemia and reperfusion injury. Int J Biol Macromol. 2019;125:496–502.
  • Landis RC, Quimby KR, Greenidge AR. M1/M2 macrophages in diabetic nephropathy: nrf2/HO-1 as therapeutic targets. Curr Pharm Des. 2018;24(20):2241–2249. doi:10.2174/1381612824666180716163845
  • Subedi L, Lee JH, Yumnam S, Ji E, Kim SY. Anti-Inflammatory effect of sulforaphane on LPS-activated microglia potentially through JNK/AP-1/NF-κB Inhibition and Nrf2/HO-1 activation. Cells. 2019;8(2):194. doi:10.3390/cells8020194
  • Bi F, Zhang Y, Liu W, Xie K. Sinomenine activation of Nrf2 signaling prevents inflammation and cerebral injury in a mouse model of ischemic stroke. Exp Ther Med. 2021;21(6):647. doi:10.3892/etm.2021.10079
  • Mobasheri A, Spring-Charles A, Gamaleri FC, McSwan J, Garg M, Sethi VS. Evidence-Based Opinions from Multidisciplinary Experts on Use of Naturopathic Herbal Remedies in Pain Management. J Pain Res. 2022;17:599–608. doi:10.2147/JPR.S432090
  • Gao Y, Hou R, Liu F, et al. Obacunone causes sustained expression of MKP-1 thus inactivating p38 MAPK to suppress pro-inflammatory mediators through intracellular MIF. J Cell Biochem. 2018;119(1):837–849. doi:10.1002/jcb.26248
  • Xu S, Chen W, Xie Q, Xu Y. Obacunone activates the Nrf2-dependent antioxidant responses. Protein Cell. 2016;7(9):684–688. doi:10.1007/s13238-016-0297-y
  • Li J, Deng SH, Li J, et al. Obacunone alleviates ferroptosis during lipopolysaccharide-induced acute lung injury by upregulating Nrf2-dependent antioxidant responses. Cell Mol Biol Lett. 2022;27(1):29. doi:10.1186/s11658-022-00318-8
  • Tao W, Hu Y, Chen Z, Dai Y, Hu Y, Qi M. Magnolol attenuates depressive-like behaviors by polarizing microglia towards the M2 phenotype through the regulation of Nrf2/HO-1/NLRP3 signaling pathway. Phytomedicine. 2021;91:153692. doi:10.1016/j.phymed.2021.153692
  • Singh A, Venkannagari S, Oh KH, et al. Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-deficient NSCLC tumors. ACS Chem Biol. 2016;11(11):3214–3225. doi:10.1021/acschembio.6b00651
  • Guo S, Wang H, Yin Y. Microglia Polarization From M1 to M2 in Neurodegenerative Diseases. Front Aging Neurosci. 2022;14:815347. doi:10.3389/fnagi.2022.815347
  • Wu Q, Zheng Y, Yu J, et al. Electroacupuncture alleviates neuropathic pain caused by SNL by promoting M2 microglia polarization through PD-L1. Int Immunopharmacol. 2023;123:110764. doi:10.1016/j.intimp.2023.110764
  • Qiu Z, Lu P, Wang K, et al. Dexmedetomidine Inhibits Neuroinflammation by Altering Microglial M1/M2 Polarization Through MAPK/ERK Pathway. Neurochem Res. 2020;45(2):345–353. doi:10.1007/s11064-019-02922-1
  • Zhang Y, Liu M, Zhang Y, et al. Urolithin A alleviates acute kidney injury induced by renal ischemia reperfusion through the p62-Keap1-Nrf2 signaling pathway. Phytother Res. 2022;36(2):984–995. doi:10.1002/ptr.7370
  • Rojo de la Vega M, Chapman E, Zhang DD. NRF2 and the Hallmarks of Cancer. Cancer Cell. 2018;34(1):21–43. doi:10.1016/j.ccell.2018.03.022
  • Wang N, Nie H, Zhang Y, et al. Dexmedetomidine exerts cerebral protective effects against cerebral ischemic injury by promoting the polarization of M2 microglia via the Nrf2/HO-1/NLRP3 pathway. Inflamm Res. 2022;71(1):93–106. doi:10.1007/s00011-021-01515-5
  • He D, Fu S, Zhou A, et al. Camptothecin Regulates Microglia Polarization and Exerts Neuroprotective Effects via Activating AKT/Nrf2/HO-1 and Inhibiting NF-κB Pathways In Vivo and In Vitro. Front Immunol. 2021;12:619761. doi:10.3389/fimmu.2021.619761