192
Views
0
CrossRef citations to date
0
Altmetric
CLINICAL TRIAL REPORT

Beneficial Effects of Low-Dose Intravenous Dexmedetomidine Premedication in Patient Undergoing Laparoscopic Cholecystectomy Under General Anesthesia: A Prospective, Double-Blind, Randomized Controlled Trial

ORCID Icon, , , , , , , & show all
Pages 443-452 | Received 27 Nov 2023, Accepted 01 Feb 2024, Published online: 14 Feb 2024

References

  • Sun F, Zheng S, Wu J. Quality of information in gallstone disease videos on tiktok: cross-sectional study. J Med Internet Res. 2023;25:e39162. doi:10.2196/39162
  • Kim HY, Choi JB, Min SK, Chang MY, Lim GM, Kim JE. A randomized clinical trial on the effect of a lidocaine patch on shoulder pain relief in laparoscopic cholecystectomy. Sci Rep. 2021;11(1):1052. doi:10.1038/s41598-020-80289-y
  • Zhang B, Xu Z, Gu W, et al. Postoperative complications and short-term prognosis of laparoscopic pancreaticoduodenectomy vs. open pancreaticoduodenectomy for treating pancreatic ductal adenocarcinoma: a retrospective cohort study. World J Surg Oncol. 2023;21(1):26. doi:10.1186/s12957-023-02909-x
  • Kong H, Li M, Deng CM, Wu YJ, He ST, Mu DL. A comprehensive overview of clinical research on dexmedetomidine in the past 2 decades: a bibliometric analysis. Front Pharmacol. 2023;14:1043956. doi:10.3389/fphar.2023.1043956
  • Hu J, Lv B, West R, et al. Comparison between dexmedetomidine and propofol on outcomes after coronary artery bypass graft surgery: a retrospective study. BMC Anesthes. 2022;22(1):51. doi:10.1186/s12871-022-01589-6
  • Prathapadas U, Hrishi AP, Appavoo A, Vimala S, Sethuraman M. Effect of low-dose dexmedetomidine on the anesthetic and recovery profile of sevoflurane-based anesthesia in patients presenting for supratentorial neurosurgeries: a randomized double-blind placebo-controlled trial. J Neurosci Rural Pract. 2020;11(2):267–273. doi:10.1055/s-0040-1703968
  • Jiang X, Tang X, Liu S, Liu L. Effects of dexmedetomidine on evoked potentials in spinal surgery under combined intravenous inhalation anesthesia: a randomized controlled trial. BMC Anesthes. 2023;23(1):36. doi:10.3892/ijmm.2020.4584
  • Choi EK, Seo Y, Lim DG, Park S. Postoperative nausea and vomiting after thyroidectomy: a comparison between dexmedetomidine and remifentanil as part of balanced anesthesia. Korean J Anesthes. 2017;70(3):299–304. doi:10.4097/kjae.2017.70.3.299
  • Bedirli N, Akçabay M, Emik U. Tramadol vs dexmedetomidine for emergence agitation control in pediatric patients undergoing adenotonsillectomy with sevoflurane anesthesia: prospective randomized controlled clinical study. BMC Anesthes. 2017;17(1):41. doi:10.1186/s12871-017-0332-4
  • Gao PF, Li SY, Li Y, Zhao L, Luo Q, Ji Y. The comparison of ketamine-dexmedetomidine (ketadex) and ketamine-propofol (ketofol) for procedural sedation in pediatric patients: a meta-analysis of randomized controlled trials. Heliyon. 2022;8(10):e11166. doi:10.1016/j.heliyon.2022.e11166
  • Chen Y, Bian W, Xu B. Pretreatment with dexmedetomidine alleviates lung injury in a rat model of intestinal ischemia reperfusion. Mol Med Rep. 2020;21(3):1233–1241. doi:10.3892/mmr.2020.10942
  • Silpa AR, Koshy KA, Subramanian A, Pradeep KK. Comparison of the efficacy of two doses of dexmedetomidine in attenuating the hemodynamic response to intubation in patients undergoing elective cardiac surgery: a randomized double-blinded study. J Anaes Clin Pharmacol. 2020;36(1):83–87. doi:10.4103/joacp.JOACP_235_18
  • Miyazaki H, Miura D, Koguchi Y, Takamatsu C, Sakaguchi Y. Intraoperative serum catecholamine levels in a pregnant woman with pheochromocytoma undergoing cesarean delivery with combined spinal-epidural anesthesia: a case report. Cureus. 2022;14(5):e24727. doi:10.7759/cureus.24727
  • Yu P, Zhang J, Zou Y, Wang J. Effect of preventive analgesia with nalbuphine and dexmedetomidine in endoscopic sinus surgery. Pain Res Manag. 2022;2022:2344733. doi:10.1155/2022/2344733
  • Gu Y, Yang F, Zhang Y, et al. The effects of different doses of dexmedetomidine on the requirements for propofol for loss of consciousness in patients monitored via the bispectral index: a double-blind, placebo-controlled trial. BMC Anesthes. 2020;20(1):96. doi:10.1186/s12871-020-01013-x
  • Dutta A, Sethi N, Sood J, et al. The effect of dexmedetomidine on propofol requirements during anesthesia administered by bispectral index-guided closed-loop anesthesia delivery system: a randomized controlled study. Anesth Analg. 2019;129(1):84–91. doi:10.1213/ANE.0000000000003470
  • Kim SH, Kim N, Kim EH, Suh S, Choi SH. Propofol requirement in patients with growth hormone-secreting pituitary tumors undergoing transsphenoidal surgery. J Clin Med. 2019;8(5):571. doi:10.3390/jcm8050571
  • Kang FC, Chen YC, Wang SC, So EC, Huang BM. Propofol induces apoptosis by activating caspases and the MAPK pathways, and inhibiting the akt pathway in tm3 mouse leydig stem/progenitor cells. Int J Mol Med. 2020;46(1):439–448. doi:10.3892/ijmm.2020.4584
  • Yoo H, Iirola T, Vilo S, et al. Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects. Eur J Clin Pharmacol. 2015;71(10):1197–1207. doi:10.1007/s00228-015-1913-0
  • Yeo J, Park S. Effect of dexmedetomidine on the development of mechanical allodynia and central sensitization in chronic post-ischemia pain rats. J Pain Res. 2018;11:3025–3030. doi:10.2147/JPR.S184621
  • Kong D, Bai J, Ma S, Li C, Yang L, Kong X. Effects of dexmedetomidine hydrochloride on hemodynamics, postoperative analgesia and cognition in cesarean section. Exp Ther Med. 2018;16(3):1778–1783. doi:10.3892/etm.2018.6363
  • Ye Q, Wang F, Xu H, Wu L, Gao X. Effects of dexmedetomidine on intraoperative hemodynamics, recovery profile and postoperative pain in patients undergoing laparoscopic cholecystectomy: a randomized controlled trial. BMC Anesthes. 2021;21(1):63. doi:10.1186/s12871-021-01283-z
  • Hu S, Li Y, Wang S, Xu S, Ju X, Ma L. Effects of intravenous infusion of lidocaine and dexmedetomidine on inhibiting cough during the tracheal extubation period after thyroid surgery. BMC Anesthes. 2019;19(1):66. doi:10.1186/s12871-019-0739-1
  • Aouad MT, Zeeni C, Al Nawwar R, et al. Dexmedetomidine for improved quality of emergence from general anesthesia: a dose-finding study. Anesth Analg. 2019;129(6):1504–1511. doi:10.1213/ANE.0000000000002763
  • Kim JH, Ham SY, Kim DH, Chang CH, Lee JS. Efficacy of single-dose dexmedetomidine combined with low-dose remifentanil infusion for cough suppression compared to high-dose remifentanil infusion: a randomized, controlled, non-inferiority trial. Int J Med Sci. 2019;16(3):376–383. doi:10.7150/ijms.30227
  • Di M, Han Y, Yang Z, et al. Tracheal extubation in deeply anesthetized pediatric patients after tonsillectomy: a comparison of high-concentration sevoflurane alone and low-concentration sevoflurane in combination with dexmedetomidine pre-medication. BMC Anesthes. 2017;17(1):28. doi:10.1186/s12871-017-0317-3
  • Qiu G, Wu Y, Yang Z, et al. Dexmedetomidine activation of dopamine neurons in the ventral tegmental area attenuates the depth of sedation in mice. Anesthesiology. 2020;133(2):377–392. doi:10.1097/ALN.0000000000003347
  • Zhu SJ, Wang KR, Zhang XX, Zhu SM. Relationship between genetic variation in the α2A-adrenergic receptor and the cardiovascular effects of dexmedetomidine in the Chinese Han population. J Zhejiang Univ Sci B. 2019;20(7):598–604. doi:10.1631/jzus.B1800647
  • Sairaku A, Nakano Y, Suenari K, et al. Dexmedetomidine depresses sinoatrial and atrioventricular nodal function without any change in atrial fibrillation inducibility. J Cardiovasc Pharmacol. 2016;68(6):473–478. doi:10.1097/FJC.0000000000000434
  • Tan C, Yan S, Shen J, et al. Effects of dexmedetomidine on cardiac electrophysiology in patients undergoing general anesthesia during perioperative period: a randomized controlled trial. BMC Anesthes. 2022;22(1):271. doi:10.1186/s12871-022-01811-5
  • Chen Z, Shao DH, Ma XD, Mao ZM. Dexmedetomidine aggravates hypotension following mesenteric traction during total gastrectomy: a randomized controlled trial. Ann Saudi Med. 2020;40(3):183–190. doi:10.5144/0256-4947.2020.183
  • Ruder TL, Donahue KR, Colavecchia AC, Putney D, Al-Saadi M. Hemodynamic effects of dexmedetomidine in adults with reduced ejection fraction heart failure. J Intensive Care Med. 2021;36(8):893–899. doi:10.1177/0885066620934416
  • Li J, Tang H, Tu W. Mechanism of dexmedetomidine preconditioning on spinal cord analgesia in rats with functional chronic visceral pain. Acta Cir Bras. 2022;37(2):e370203. doi:10.1590/acb370203
  • Koo JM, Chung YJ, Lee M, Moon YE. Efficacy of dexmedetomidine vs. remifentanil for postoperative analgesia and opioid-related side effects after gynecological laparoscopy: a prospective randomized controlled trial. J Clin Med. 2023;12(1):350. doi:10.3390/jcm12010350
  • Xie C, Zhang C, Sun H, Lu Y. Effects of dexmedetomidine on postoperative nausea and vomiting in adult patients undergoing ambulatory thyroidectomy: a randomized clinical trial. Front Med Lausanne. 2021;8:781689. doi:10.3389/fmed.2021.781689
  • Song J, Liu S, Fan B, Li G, Sun Q. Perioperative dexmedetomidine reduces emergence agitation without increasing the oculocardiac reflex in children: a systematic review and meta-analysis. Medicine. 2021;100(18):e25717. doi:10.1097/MD.0000000000025717
  • Tang Y, Song Y, Tian W, Chen G, Gu Y. A systematic review and meta-analysis on the efficacy and safety of dexmedetomidine combined with sevoflurane anesthesia on emergence agitation in children. Transl Pediatr. 2022;11(7):1156–1170. doi:10.21037/tp-22-172