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CLINICAL TRIAL REPORT

Dose-Response Study of Phenylephrine for Preventing Spinal-Induced Hypotension During Cesarean Delivery with Combined Spinal-Epidural Anesthesia Under the Effect of Prophylactic Intravenous Ondansetron

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Pages 1459-1467 | Received 02 Dec 2023, Accepted 15 Apr 2024, Published online: 01 May 2024

References

  • Ngan Kee WD, Khaw KS, Ng FF, Lee BB. Prophylactic phenylephrine infusion for preventing hypotension during spinal anesthesia for cesarean delivery. Anesth Analg. 2004;98:815–821. doi:10.1213/01.ANE.0000099782.78002.30
  • Choudhary M, Bajaj JK. Study Comparing Phenylephrine Bolus and Infusion for Maternal Hypotension and Neonatal Outcome during Cesarean Section under Spinal Anesthesia. Anesth Essays Res. 2018;12(2):446–451. doi:10.4103/aer.AER_23_18
  • George RB, McKeen DM, Dominguez JE, Allen TK, Doyle PA, Habib AS. A randomized trial of phenylephrine infusion versus bolus dosing for nausea and vomiting during Cesarean delivery in obese women. Can J Anaesth. 2018;65(3):254–262. doi:10.1007/s12630-017-1034-6
  • Campbell JP, Stocks GM. Management of hypotension with vasopressors at caesarean section under spinal anaesthesia - have we found the Holy Grail of obstetric anaesthesia? Anaesthesia. 2018;73(1):3–6. doi:10.1111/anae.14114
  • Ngan Kee WD. The use of vasopressors during spinal anaesthesia for caesarean section. Curr Opin Anaesthesiol. 2017;30(3):319–325. doi:10.1097/ACO.0000000000000453
  • Stewart A, Fernando R, McDonald S, Hignett R, Jones T, Columb M. The dose-dependent effects of phenylephrine for elective cesarean delivery under spinal anesthesia. Anesth Analg. 2010;111(5):1230–1237. doi:10.1213/ANE.0b013e3181f2eae1
  • Xiao F, Wei C, Chang X, et al. A Prospective, Randomized, Double-Blinded Study of the Effect of Intravenous Ondansetron on the Effective Dose in 50% of Subjects of Prophylactic Phenylephrine Infusions for Preventing Spinal Anesthesia-Induced Hypotension During Cesarean Delivery. Anesth Analg. 2020;131(2):564–569. doi:10.1213/ANE.0000000000004534
  • Qian J, Liu L, Zheng X, Xiao F. Does an Earlier or Late Intravenous Injection of Ondansetron Affect the Dose of Phenylephrine Needed to Prevent Spinal-Anesthesia Induced Hypotension in Cesarean Sections? Drug Des Devel Ther. 2020;14:2789–2795. doi:10.2147/DDDT.S257880
  • Oofuvong M, Kunapaisal T, Karnjanawanichkul O, Dilokrattanaphijit N, Leeratiwong J. Minimal effective weight-based dosing of ondansetron to reduce hypotension in cesarean section under spinal anesthesia: a randomized controlled superiority trial. BMC Anesthesiol. 2018;18(1):105. doi:10.1186/s12871-018-0568-7
  • Heesen M, Klimek M, Hoeks SE, Rossaint R. Prevention of spinal anesthesia-induced hypotension during cesarean delivery by 5-Hydroxytryptamine-3 receptor antagonists: a systematic review and meta-analysis and meta-regression. Anesth Analg. 2016;123(4):977–988. doi:10.1213/ANE.0000000000001511
  • Allen TK, George RB, White WD, Muir HA, Habib AS. A double-blind, placebo-controlled trial of four fixed rate infusion regimens of phenylephrine for hemodynamic support during spinal anesthesia for cesarean delivery. Anesth Analg. 2010;111(5):1221–1229. doi:10.1213/ANE.0b013e3181e1db21
  • Xiao F, Shen B, Xu WP, Feng Y, Ngan Kee WD, Chen XZ. Dose-Response Study of 4 Weight-Based Phenylephrine Infusion Regimens for Preventing Hypotension During Cesarean Delivery Under Combined Spinal-Epidural Anesthesia. Anesth Analg. 2020;130(1):187–193. doi:10.1213/ANE.0000000000004092
  • El Khouly NI, Meligy AM. Randomized controlled trial comparing ondansetron and placebo for the reduction of spinal anesthesia-induced hypotension during elective cesarean delivery in Egypt. Int J Gynaecol Obstet. 2016;135(2):205–209. doi:10.1016/j.ijgo.2016.06.012
  • Sahoo T, SenDasgupta C, Goswami A, Hazra A. Reduction in spinal-induced hypotension with ondansetron in parturients undergoing caesarean section: a double-blind randomised, placebo-controlled study. Int J Obstet Anesth. 2012;21(1):24–28. doi:10.1016/j.ijoa.2011.08.002
  • Wang M, Zhuo L, Wang Q, et al. Efficacy of prophylactic intravenous ondansetron on the prevention of hypotension during cesarean delivery: a dose-dependent study. Int J Clin Exp Med. 2014;7(12):5210–5216.
  • Terkawi AS, Tiouririne M, Mehta SH, Hackworth JM, Tsang S, Durieux ME. Ondansetron Does Not Attenuate Hemodynamic Changes in Patients Undergoing Elective Cesarean Delivery Using Subarachnoid Anesthesia: a Double-Blind, Placebo-Controlled, Randomized Trial. Reg Anesth Pain Med. 2015;40(4):344–348. doi:10.1097/AAP.0000000000000274
  • Ortiz-Gómez JR, Palacio-Abizanda FJ, Morillas-Ramirez F, Fornet-Ruiz I, Lorenzo-Jiménez A, Bermejo-Albares ML. The effect of intravenous ondansetron on maternal haemodynamics during elective caesarean delivery under spinal anaesthesia: a double-blind, randomised, placebo-controlled trial. Int J Obstet Anesth. 2014;23(2):138–143. doi:10.1016/j.ijoa.2014.01.005
  • Terkawi AS, Mavridis D, Flood P, et al. Does Ondansetron Modify Sympathectomy Due to Subarachnoid Anesthesia?: meta-analysis, Meta-regression, and Trial Sequential Analysis. Anesthesiology. 2016;124(4):846–869. doi:10.1097/ALN.0000000000001039
  • He K, Zhao H, Zhou HC. Efficiency and safety of ondansetron in preventing postanaesthesia shivering. Ann R Coll Surg Engl. 2016;98(6):358–366. doi:10.1308/rcsann.2016.0152
  • Trabelsi W, Romdhani C, Elaskri H, et al. Effect of Ondansetron on the Occurrence of Hypotension and on Neonatal Parameters during Spinal Anesthesia for Elective Caesarean Section: a Prospective, Randomized, Controlled, Double-Blind Study. Anesthesiol Res Pract. 2015;2015:158061. doi:10.1155/2015/158061