Clinical Application and Research Progress of Remimazolam for Pediatric Patients

References

• Agre F. Preoperative anxiety in children predictors and outcomes. Arch Pediatr Adolesc Med. 1997;151(6):636. doi:10.1001/archpedi.1997.02170430102029
   PubMedGoogle Scholar
• Antonik LJ, Goldwater DR, Kilpatrick GJ, et al. A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): part I. Safety, efficacy, and basic pharmacokinetics. Anesth Analg. 2012;115(2):274–283. doi:10.1213/ANE.0b013e31823f0c28
   PubMed Web of Science ®Google Scholar
• Kam PCA, Cardone D. Propofol infusion syndrome. Anaesthesia. 2007;62(7):690–701. doi:10.1111/j.1365-2044.2007.05055.x
   PubMed Web of Science ®Google Scholar
• Cooper L, Candiotti K, Gallagher C, et al. A randomized, controlled trial on dexmedetomidine for providing adequate sedation and hemodynamic control for awake, diagnostic transesophageal echocardiography. J Cardiothorac Vasc Anesth. 2011;25(2):233–237. doi:10.1053/j.jvca.2010.06.006
   PubMed Web of Science ®Google Scholar
• Shen F, Zhang Q, Xu Y, et al. Effect of intranasal dexmedetomidine or midazolam for premedication on the occurrence of respiratory adverse events in children undergoing tonsillectomy and adenoidectomy: a randomized clinical trial. JAMA Network Open. 2022;5(8):e2225473. doi:10.1001/jamanetworkopen.2022.25473
   PubMed Web of Science ®Google Scholar
• Mo T, Bai Q, Zhang FC, et al. Effect of remimazolam on emergence agitation in children undergoing tooth decay treatment after sevoflurane anesthesia. J Xuzhou Med Univ. 2023;43(5):362–366. doi:10.3969/j.issn.2096-3882.2023.05.010
   Google Scholar
• Nelson JH, Kaplan RF. Anesthetic management of two pediatric patients with concurrent diagnoses of mitochondrial disease and malignant hyperthermia susceptibility: a case report. Case Rep. 2017;9(7):204–206. doi:10.1213/XAA.0000000000000565
   Google Scholar
• Masui K, Stöhr T, Pesic M, Tonai T. A population pharmacokinetic model of remimazolam for general anaesthesia and consideration of remimazolam dose in clinical practice. J Anesth. 2022;36(4):493–505. doi:10.1007/s00540-022-03079-y
   PubMed Web of Science ®Google Scholar
• Upton RN, Martinez AM, Grant C. A dose escalation study in sheep of the effects of the benzodiazepine CNS 7056 on sedation, the EEG and the respiratory and cardiovascular systems. Br J Pharmacol. 2008;155(1):52–61. doi:10.1038/bjp.2008.228
   PubMed Web of Science ®Google Scholar
• Kilpatrick GJ. Remimazolam: non-clinical and clinical profile of a new sedative/anesthetic agent. Front Pharmacol. 2021;12:690875. doi:10.3389/fphar.2021.690875
   PubMed Web of Science ®Google Scholar
• Kilpatrick GJ, Pacofsky GJ, Collins H. A Novel Ultra–short-acting Benzodiazepine. Anesthesiology. 2007;107:60–66. doi:10.1097/01.anes.0000267503.85085.c0
   PubMed Web of Science ®Google Scholar
• Gao YQ, Ihmsen H, Hu ZY, et al. Pharmacokinetics of remimazolam after intravenous infusion in anaesthetised children. Br J Anaesth. 2023;131(5):914–920. doi:10.1016/j.bja.2023.08.019
   PubMed Web of Science ®Google Scholar
• Wiltshire HR, Kilpatrick GJ, Tilbrook GS, et al. A Placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): part II. population pharmacokinetic and pharmacodynamic modeling and simulation. Anesth Analg. 2012;115(2):284–296. doi:10.1213/ANE.0b013e318241f68a
   PubMed Web of Science ®Google Scholar
• Kimoto Y, Hirano T, Kuratani N, et al. Remimazolam as an adjunct to general anaesthesia in children: adverse events and outcomes in a large cohort of 418 cases. J Clin Med. 2023;12(12):3930. doi:10.3390/jcm12123930
   PubMed Web of Science ®Google Scholar
• Schüttler J, Eisenried A, Lerch M, et al. Pharmacokinetics and pharmacodynamics of remimazolam (CNS 7056) after continuous infusion in healthy male volunteers. Anesthesiology. 2020;132(4):636–651. doi:10.1097/ALN.0000000000003103
   PubMed Web of Science ®Google Scholar
• Pesic M, Schippers F, Saunders R, et al. Pharmacokinetics and pharmacodynamics of intranasal remimazolam—a randomized controlled clinical trial. Eur J Clin Pharmacol. 2020;76(11):1505–1516. doi:10.1007/s00228-020-02984-z
   PubMed Web of Science ®Google Scholar
• Long X, xia WL, Yang H, et al. ED95 of remimazolam in nasal administration for attenuating preoperative anxiety in children. Front Med. 2023;10:1253738. doi:10.3389/fmed.2023.1253738
   Web of Science ®Google Scholar
• Nakajima K, Hirai S, Morio T, et al. Benzodiazepines induce sequelae in immature mice with inflammation-induced status epilepticus. Epilepsy Behav. 2015;52:180–186. doi:10.1016/j.yebeh.2015.08.012
   PubMed Web of Science ®Google Scholar
• Choi JY, Lee HS, Kim JY, et al. Comparison of remimazolam-based and propofol-based total intravenous anaesthesia on postoperative quality of recovery: a randomized non-inferiority trial. J Clin Anesth. 2022;82:110955. doi:10.1016/j.jclinane.2022.110955
   PubMed Web of Science ®Google Scholar
• Hasegawa G, Hirata N, Yoshikawa Y, et al. Differential effects of remimazolam and propofol on heart rate variability during anaesthesia induction. J Anesth. 2022;36(2):239–245. doi:10.1007/s00540-022-03037-8
   PubMed Web of Science ®Google Scholar
• Lauder GR. Total intravenous anaesthesia will supercede inhalational anaesthesia in pediatric anesthetic practice. Pediatr Anesth. 2015;25(1):52–64. doi:10.1111/pan.12553
   PubMed Web of Science ®Google Scholar
• Yang X, Lin C, Chen S, et al. Remimazolam for the prevention of emergence delirium in children following tonsillectomy and adenoidectomy under sevoflurane anaesthesia: a randomized controlled study. Drug Des Devel Ther. 2022;16:3413–3420. doi:10.2147/DDDT.S381611
   PubMed Web of Science ®Google Scholar
• Fang YB, Wang CY, Gao YQ, et al. The safety and efficacy of remimazolam tosylate for induction and maintenance of general anaesthesia in pediatric patients undergoing elective surgery: study protocol for a multicenter, randomized, single-blind, positive-controlled clinical trial. Front Pharmacol. 2023;14:1090608. doi:10.3389/fphar.2023.1090608
   PubMed Web of Science ®Google Scholar
• Yamadori Y, Yamagami Y, Matsumoto Y, et al. General anaesthesia with remimazolam for a pediatric patient with MELAS and recurrent epilepsy: a case report. JA Clin Rep. 2022;8(1):75. doi:10.1186/s40981-022-00564-x
   PubMed Web of Science ®Google Scholar
• Watanabe T, Miyoshi H, Noda Y, et al. Effects of remimazolam and propofol on Ca2+ regulation by ryanodine receptor 1 with malignant hyperthermia mutation. BioMed Res Int. 2021;2021:1–11. doi:10.1155/2021/8845129
   PubMed Web of Science ®Google Scholar
• Petkus H, Willer BL, Tobias JD. Remimazolam in a pediatric patient with a suspected family history of malignant hyperthermia. J Med Cases. 2022;13(8):386–390. doi:10.14740/jmc3977
   PubMedGoogle Scholar
• Wang AC, Than KD, Etame AB, et al. Impact of anaesthesia on transcranial electric motor evoked potential monitoring during spine surgery: a review of the literature. Neurosurg Focus. 2009;27(4):E7. doi:10.3171/2009.8.FOCUS09145
   PubMed Web of Science ®Google Scholar
• Arashiro A, Shinzato H, Kamizato K, et al. Spinal fusion with motor evoked potential monitoring using remimazolam in Alström syndrome: a case report. Medicine. 2021;100(47):e27990. doi:10.1097/MD.0000000000027990
   PubMed Web of Science ®Google Scholar
• Kamata K, Asagi S, Shimoda Y, et al. Successful recording of direct cortical motor-evoked potential from a pediatric patient under remimazolam anaesthesia: a case report. JA Clin Rep. 2022;8(1):66. doi:10.1186/s40981-022-00555-y
   PubMed Web of Science ®Google Scholar
• Morimoto Y, Yoshimatsu A, Yoshimura M. Anesthetic management for a patient with myotonic dystrophy with remimazolam. JA Clin Rep. 2021;7(1):10. doi:10.1186/s40981-021-00413-3
   PubMed Web of Science ®Google Scholar
• Horikoshi Y, Kuratani N, Tateno K, et al. Anesthetic management with remimazolam for a pediatric patient with Duchenne muscular dystrophy. Medicine. 2021;100(49):e28209. doi:10.1097/MD.0000000000028209
   PubMed Web of Science ®Google Scholar
• Kiyokawa M, Saito J, Nakai K, et al. A Remimazolam and remifentanil anesthetic for a pediatric patient with a medium-chain Acyl-CoA dehydrogenase deficiency: a case report. AA Pract. 2022;16(12):e01646. doi:10.1213/XAA.0000000000001646
   Google Scholar
• Shi CC, Sun J, Zhang YF. Application of remimazolam in children during painless gastroscopy. J Clin Pathol Res. 2021;41(12):2918–2922. doi:10.3978/j.issn.2095-6959.2021.12.027
   Google Scholar
• Garrett A, Flowers J, Ng V, et al. Remimazolam for sedation during upper gastrointestinal endoscopy in an adolescent. J Med Cases. 2022;13(10):495–498. doi:10.14740/jmc4013
   PubMedGoogle Scholar
• Zhao ZQ, Yang YY, Chen L, et al. The feasibility and safety of remimazolam combined with laryngeal mask for pediatric patients undergoing bronchoscopic lavage. Matern Child World. 2022;16(3):81–83.
   Google Scholar
• Zhou YY, Yang ST, Duan KM, et al. Efficacy and safety of remimazolam besylate in bronchoscopy for adults: a multicenter, randomized, double-blind, positive-controlled clinical study. Front Pharmacol. 2022;13:1005367. doi:10.3389/fphar.2022.1005367
   PubMed Web of Science ®Google Scholar
• Hughes M, Maves G, Tobias JD. Remimazolam for sedation during fiberoptic intubation in an adolescent. J Med Cases. 2023;14(8):289–292. doi:10.14740/jmc4137
   PubMedGoogle Scholar
• Yang HK, Sun J, Wang Q, et al. Application comparison between remimazolam and dexmedetomidine sedation in infantile echocardiographic examination. Chongqing Med. 2021;50(23):4062–4064. doi:10.3969/j.issn.1671-8348.2021.23.022
   Google Scholar
• Zhang T, Xing F, Li Y, Wang X, Liu L, Xing N. Efficacy of remimazolam combined with propofol for sedation in pediatric patients undergoing outpatient dental root canal treatment. Chin J Anesthesiol. 2022;42(2):213–216. doi:10.3760/cma.j.cn131073.20211018.00219
   Google Scholar
• Lyu S, Deng Q, Lin W, et al. Randomized controlled trial for anaesthesia during gastroscopy: interactions between remimazolam and propofol in combination with sufentanil. Int J Clin Pharm. 2023;45(4):857–863. doi:10.1007/s11096-023-01568-y
   PubMed Web of Science ®Google Scholar
• Doi M, Morita K, Takeda J, et al. Efficacy and safety of remimazolam versus propofol for general anaesthesia: a multicenter, single-blind, randomized, parallel-group, phase IIb/III trial. J Anesth. 2020;34(4):543–553. doi:10.1007/s00540-020-02788-6
   PubMed Web of Science ®Google Scholar
• Shannon M, Albers G, Burkhart K, et al.; The Flumazenil Pediatric Study Group. Safety and efficacy of flumazenil in the reversal of benzodiazepine-induced conscious sedation. J Pediatr. 1997;131(4):582–586. doi:10.1016/s0022-3476(97)70066-0
   PubMed Web of Science ®Google Scholar
• Schnider T, Minto C. Context sensitive decrement times of remimazolam. Anesth Analg. 2013;117(1):285. doi:10.1213/ANE.0b013e3182942954
   PubMed Web of Science ®Google Scholar
• Yamamoto T, Kurabe M, Kamiya Y. Re-sleeping after reversal of remimazolam by flumazenil. J Anesth. 2021;35(2):322. doi:10.1007/s00540-021-02915-x
   PubMed Web of Science ®Google Scholar
• Shirozu K, Nobukuni K, Tsumura S, et al. Neurological sedative indicators during general anaesthesia with remimazolam. J Anesth. 2022;36(2):194–200. doi:10.1007/s00540-021-03030-7
   PubMed Web of Science ®Google Scholar
• Lee JM, Akeju O, Terzakis K, et al. A prospective study of age-dependent changes in propofol-induced electroencephalogram oscillations in children. Anesthesiology. 2017;127(2):293–306. doi:10.1097/ALN.0000000000001717
   PubMed Web of Science ®Google Scholar
• Pesic M, Stöhr T, Ossig J, et al. Remimazolam has low oral bioavailability and no potential for misuse in drug-facilitated sexual assaults, with or without alcohol: results from two randomised clinical trials. Drugs RD. 2020;20(3):267–277. doi:10.1007/s40268-020-00317-0
   PubMed Web of Science ®Google Scholar
• Wilton NC, Leigh J, Rosen DR, et al. Preanesthetic sedation of preschool children using intranasal midazolam. Anesthesiology. 1988;69(6):972–975. doi:10.1097/00000542-198812000-00032
   PubMed Web of Science ®Google Scholar
• Keam SJ. Remimazolam: first Approval. Drugs. 2020;80(6):625–633. doi:10.1007/s40265-020-01299-8
   PubMed Web of Science ®Google Scholar
• Jeong H, Kim H, Ahn HJ. An adequate infusion rate of remimazolam for induction of general anaesthesia in adult patients: a prospective up-and-down dose-finding study. J Clin Med. 2023;12(5):1763. doi:10.3390/jcm12051763
   PubMed Web of Science ®Google Scholar
• Dai G, Pei L, Duan F, et al. Safety and efficacy of remimazolam compared with propofol in induction of general anaesthesia. Minerva Anestesiol. 2021;87(10). doi:10.23736/S0375-9393.21.15517-8
   PubMed Web of Science ®Google Scholar
• Lin OS, La Selva D, Kozarek RA, et al. Computer-assisted propofol sedation for esophagogastroduodenoscopy is effective, efficient, and safe. Dig Dis Sci. 2019;64(12):3549–3556. doi:10.1007/s10620-019-05685-5
   PubMed Web of Science ®Google Scholar
• Louvet N, Rigouzzo A, Sabourdin N, Constant I. Bispectral index under propofol anaesthesia in children: a comparative randomized study between TIVA and TCI. Pediatr Anesth. 2016;26(9):899–908. doi:10.1111/pan.12957
   PubMed Web of Science ®Google Scholar
• Hirano T, Kimoto Y, Kuratani N, et al. Remimazolam for pediatric procedural sedation: results of an institutional pilot program. J Clin Med. 2023;12(18):5937. doi:10.3390/jcm12185937
   PubMed Web of Science ®Google Scholar
• Minto CF, Schnider TW, Short TG, et al. Response surface model for anesthetic drug interactions. Anesthesiology. 2000;92(6):1603–1616. doi:10.1097/00000542-200006000-00017
   PubMed Web of Science ®Google Scholar
• Yildirim SA, Dogan L, Sarikaya ZT, et al. Hypotension after anaesthesia induction: target-controlled infusion versus manual anaesthesia induction of propofol. J Clin Med. 2023;12(16):5280. doi:10.3390/jcm12165280
   PubMed Web of Science ®Google Scholar
• Kops MS, Pesic M, Petersen KU, et al. Impact of concurrent remifentanil on the sedative effects of remimazolam, midazolam and propofol in cynomolgus monkeys. Eur J Pharmacol. 2021;890:173639. doi:10.1016/j.ejphar.2020.173639
   PubMed Web of Science ®Google Scholar
• Rizzi S, Carter LB, Ori C, et al. Research Article: clinical anaesthesia causes permanent damage to the fetal guinea pig brain. Brain Pathol. 2008;18(2):198–210. doi:10.1111/j.1750-3639.2007.00116.x
   PubMed Web of Science ®Google Scholar