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Case reports

Acute Liver Failure Caused by Secondary Hemophagocytic Lymphohistiocytosis After COVID-19 Vaccination – Case Report and Literature Review

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Pages 449-455 | Received 26 May 2023, Accepted 22 Jul 2023, Published online: 07 Aug 2023

References

  • Kumar R, Anand U, Priyadarshi RN. Liver transplantation in acute liver failure: dilemmas and challenges. World J Transplant. 2021;11(6):187–202. doi:10.5500/wjt.v11.i6.187
  • Bernal W, Wendon J. Acute liver failure. N Engl J Med. 2013;369:2525–2534. doi:10.1056/NEJMra1208937
  • Lin S, Li Y, Long J, Liu Q, Yang F, He Y. Acute liver failure caused by hemophagocytic lymphohistiocytosis in adults: a case report and review of the literature. Medicine. 2016;95(47):e5431. doi:10.1097/MD.0000000000005431
  • Gee J, Marquez P, Su J, et al. First Month of COVID-19 vaccine safety monitoring - United States, December 14, 2020-January 13, 2021. MMWR Morb Mortal Wkly Rep. 2021;70(8):283–288. doi:10.15585/mmwr.mm7008e3
  • Bae S, Lee YW, Lim SY, et al. Adverse Reactions Following the First Dose of ChAdOx1 nCoV-19 Vaccine and BNT162b2 Vaccine for Healthcare Workers in South Korea. J Korean Med Sci. 2021;36(17):e115. doi:10.3346/jkms.2021.36.e115
  • COVID-19 vaccine tracker. European center for disease prevention and control; 2023. Available from: https://vaccinetracker.ecdc.europa.eu/public/extensions/COVID-19/vaccine-tracker.html#distribution-tab. Accessed June 16, 2023.
  • Nune A, Iyengar KP, Goddard C, Ahmed AE. Multisystem inflammatory syndrome in an adult following the SARS-CoV-2 vaccine (MIS-V). BMJ Case Rep. 2021;14(7):e243888. doi:10.1136/bcr-2021-243888
  • Greinacher A, Thiele T, Warkentin TE, Weisser K, Kyrle PA, Eichinger S. Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination. N Engl J Med. 2021;384(22):2092–2101. doi:10.1056/NEJMoa2104840
  • Griffin G, Shenoi S, Hughes GC. Hemophagocytic lymphohistiocytosis: an update on pathogenesis, diagnosis, and therapy. Best Pract Res Clin Rheumatol. 2020;34(4):101515. doi:10.1016/j.berh.2020.101515
  • La Rosée P, Horne A, Hines M, et al. Recommendations for the management of hemophagocytic lymphohistiocytosis in adults. Blood. 2019;133(23):2465–2477. doi:10.1182/blood.2018894618
  • Henter JI, Horne A, Aricó M, et al. HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2007;48(2):124–131.
  • Fardet L, Galicier L, Lambotte O, et al. Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome. Arthritis Rheumatol. 2014;66(9):2613–2620. doi:10.1002/art.38690
  • Kumar D, Rostad CA, Jaggi P, et al. Distinguishing immune activation and inflammatory signatures of multisystem inflammatory syndrome in children (MIS-C) versus hemophagocytic lymphohistiocytosis (HLH). J Allergy Clin Immunol. 2022;149(5):1592–606.e16. doi:10.1016/j.jaci.2022.02.028
  • Vogel TP, Top KA, Karatzios C, et al. Multisystem inflammatory syndrome in children and adults (MIS-C/ A): case definition & guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine. 2021;39(22):3037–3049. doi:10.1016/j.vaccine.2021.01.054
  • Brown M, Garbajs NZ, Zec S, et al. A case of adult multisystem inflammatory syndrome following COVID-19 vaccine. J Community Hosp Intern Med Perspect. 2022;12(4):7–13. doi:10.55729/2000-9666.1087
  • Li J, Wang Q, Zheng W, et al. Hemophagocytic lymphohistiocytosis: clinical analysis of 103 adult patients. Medicine. 2014;93:100–105. doi:10.1097/MD.0000000000000022
  • Otrock ZK, Eby CS. Clinical characteristics, prognostic factors, and outcomes of adult patients with hemophagocytic lymphohistiocytosis. Am J Hematol. 2015;90:220–224. doi:10.1002/ajh.23911
  • Mayordomo-Colunga J, Rey C, Gonzalez S, et al. Multiorgan failure due to hemophagocytic syndrome: a case report. Cases J. 2008;1:209. doi:10.1186/1757-1626-1-209
  • Li F, Yang Y, Jin F, et al. Clinical characteristics and prognostic factors of adult hemophagocytic syndrome patients: a retrospective study of increasing awareness of a disease from a single-center in China. Orphanet J Rare Dis. 2015;10:20. doi:10.1186/s13023-015-0224-y
  • Ost A, Nilsson-Ardnor S, Henter JI. Autopsy findings in 27 children with haemophagocytic lymphohistiocytosis. Histopathology. 1998;32(4):310–316. doi:10.1046/j.1365-2559.1998.00377.x
  • Wright G, Wilmore S, Makanyanga J, et al. Liver transplant for adult hemophagocytic lymphohistiocytosis: case report and literature review. Exp Clin Transplant. 2012;10(5):508–512. doi:10.6002/ect.2011.0204
  • Boldig K, Kiamos A, Agrawal A, Reddy P. Hemophagocytic lymphohistiocytosis and clostridium difficile infection: a diagnostic dilemma. Cureus. 2023;15(1):e33865. doi:10.7759/cureus.33865
  • Ramos-Casals M, Brito-Zerón P, López-Guillermo A, Khamashta MA, Bosch X. Adult haemophagocytic syndrome. Lancet. 2014;383(9927):1503–1516. doi:10.1016/S0140-6736(13)61048-X
  • Park HW, Min GJ, Kim TY, Cho SG. A case of hemophagocytic lymphohistiocytosis following second dose of COVID-19 Vaccination. Acta Haematol. 2023;146(1):65–71. doi:10.1159/000526980
  • Ai S, Awford A, Roncolato F. Hemophagocytic lymphohistiocytosis following ChAdOx1 nCov- 19 vaccination. J Med Virol. 2022;94(1):14–16. doi:10.1002/jmv.27279
  • Tang LV, Hu Y. Hemophagocytic lymphohistiocytosis after COVID-19 vaccination. J Hematol Oncol. 2021;14(1):87. doi:10.1186/s13045-021-01100-7
  • Cory P, Lawrence H, Abdulrahim H, Mahmood-Rao H, Hussein A, Gane J. Lessons of the month 3: haemophagocytic lymphohistiocytosis following COVID-19 vaccination (ChAdOx1 nCoV-19). Clin Med. 2021;21(6):e677–9. doi:10.7861/clinmed.2021-0564
  • Baek DW, Hwang S, Kim J, et al. Patients presenting high fever with lymphadenopathy after COVID-19 vaccination were diagnosed with hemophagocytic lymphohistiocytosis. Infect Dis. 2022;54(4):303–307. doi:10.1080/23744235.2021.2010801
  • Attwell L, Zaw T, McCormick J, Marks J, Mc-Carthy H. Haemophagocytic lymphohistiocytosis after ChAdOx1 nCoV-19 vaccination. J Clin Pathol. 2022;75(4):282–284. doi:10.1136/jclinpath-2021-207760
  • Sassi M, Khefacha L, Merzigui R, Rakez R, Boukhriss S, Laatiri MA. Haemophagocytosis and atypical vacuolated lymphocytes in bone marrow and blood films after SARS-CoV-2 vaccination. Br J Haematol. 2021;195(5):649. doi:10.1111/bjh.17660
  • Rocco JM, Mallarino-Haeger C, Randolph AH, et al. Hyperinflammatory syndromes after severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) messenger RNA vaccination in individuals with underlying immune dysregulation. Clin Infect Dis. 2022;75(1):e912–5. doi:10.1093/cid/ciab1024
  • Caocci G, Fanni D, Porru M, et al. Kikuchi–Fujimoto disease associated with hemophagocytic lymphohistiocytosis following the BNT162b2 mRNA COVID-19 vaccination. Haematologica. 2022;107(5):1222–1225. doi:10.3324/haematol.2021.280239
  • Hieber ML, Sprute R, Eichenauer DA, Hallek M, Jachimowicz RD. Hemophagocytic lymphohistiocytosis after SARS-CoV-2 vaccination. Infection. 2022;50:1399–1404. doi:10.1007/s15010-022-01786-y
  • Awan RU, Rashid S, Nabeel A, Samant H. COVID-19 vaccination-related hemophagocytic lymphohistiocytosis presenting as acute liver failure. Proc Bayl Univ Med Cent. 2022;36(1):78–80. doi:10.1080/08998280.2022.2123665
  • Vanaparthy R, Mohan G, Vasireddy D, Atluri P. Review of COVID-19 viral vector-based vaccines and COVID-19 variants. Infez Med. 2021;29(3):328–338.