A Case of Genital and Extragenital Warts Unresponsive to Immunotherapy Using Measles, Mumps, Rubella Vaccine

References

• Gilson R, Nugent D, Werner RN, Ballesteros J, Ross J. 2019 IUSTI‐Europe guideline for the management of anogenital warts. J Eur Acad Dermatology Venereol. 2020;34(8):1644–1653. doi:10.1111/jdv.16522
   PubMed Web of Science ®Google Scholar
• Tyros G, Mastraftsi S, Gregoriou S, Nicolaidou E. Incidence of anogenital warts: epidemiological risk factors and real-life impact of human papillomavirus vaccination. Int J STD AIDS. 2021;32(1):4–13. doi:10.1177/0956462420958577
   PubMed Web of Science ®Google Scholar
• Diorio GJ, Giulano AR. The role of human papillomavirus in penile carcinogenesis and preneoplastic lesions a potential target for vaccination and treatment strategies. Uro Clin North Am. 2016;43(4):419–425. doi:10.1016/j.ucl.2016.06.003
   PubMed Web of Science ®Google Scholar
• Dillner J, Mijer CJ, Von Krogh G, Horenblas S. Epidemiology of human papillomavirus infection. Scand J Urol Nephrol Suppl. 2000;205:194–200. doi:10.1080/003655900750016580
   Google Scholar
• Centers for Disease Control and Prevention. Sexually transmitted infections at a glance; 2021. Available from: https://www.cdc.gov/std/statistics/prevalence-2020-at-a-glance.htm. Accessed September 6, 2023.
   Google Scholar
• Winer R, Koutsky L. Genital human papillomavirus infection. In: Dalam Holmes K, Sparling P, Stamm W, Piot P, Wasserheit J, Corey L, editors. Sexually Transmitted Diseases. New York: McGraw-Hill; 2008:489–501.
   Google Scholar
• Patel H, Wagner M, Singhal P, Kothari S. Systematic review of the incidence and prevalence of genital warts. BMC Infect Dis. 2013;13:39. doi:10.1186/1471-2334-13-39
   PubMed Web of Science ®Google Scholar
• Vela S, Videla S, Ornelas A, et al. Effectiveness of physically ablative and pharmacological treatments for anal condyloma in HIV-infected men. PLoS One. 2018;13(8):e0199033. doi:10.1371/journal.pone.0199033
   PubMed Web of Science ®Google Scholar
• Hsu T, Nahmias ZP, Rosman IS, Sheinbein D. Extragenital condyloma acuminatum in the left axillary vault. JAAD Case Rep. 2018;4(9):947–949. doi:10.1016/j.jdcr.2018.07.022
   PubMedGoogle Scholar
• Chen W, Sun H, Molijn A, et al. The variable characteristics of human papillomavirus in squamous cell carcinoma and adenocarcinoma of cervix in China. J Low Genit Tract Dis. 2018;22(4):355–361. doi:10.1097/LGT.0000000000000408
   PubMed Web of Science ®Google Scholar
• Kumar SD. Circumcision in genital warts-let us not forget. Sex Transm Infect. 2003;79(3):265. doi:10.1136/sti.79.3.265
   PubMed Web of Science ®Google Scholar
• Warkowski KA, Bolan GA. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015;64(RR–03):1–137.
   Google Scholar
• Akhavan S, Mousavi A, Modaresgilani M, Alibakhshi A. Genital warts. J Obstet Gynecol Cancer Res. 2017;2(1):10–13.
   Google Scholar
• Ju HJ, Park HR, Kim JY, Kim GM, Bae JM, Lee JH. Intralesional immunotherapy for non-genital warts: a systematic review and meta-analysis. Indian J Dermatol Venereol Leprol. 2022;88(6):724–737. doi:10.25259/IJDVL_1369_20
   PubMed Web of Science ®Google Scholar
• Freire MP, Pires D, Forjaz R, et al. Genital prevalence of HPV types and co-infection in men. Int Braz J Urol. 2014;40(1):67–71. doi:10.1590/S1677-5538.IBJU.2014.01.10
   PubMed Web of Science ®Google Scholar
• Egelkrout E, Galloway D. The biology of genital human papillomaviruses. In: Holmes K, Sparling P, Stamm W, Piot P, Wasserheit J, Corey L, editors. Sexually Transmitted Diseases. 4th ed. New York: McGraw-Hill; 2008:463–487.
   Google Scholar
• Al-azmi H, Hanafy H. Human papillomavirus: manifestations, prevention and treatment: an overview. Gulf J Dermatology Venereol. 2012;19(1):1–28.
   Google Scholar
• Fathi R, Tsoukas MM. Genital warts and other HPV infections: established and novel therapies. Clin Dermatol. 2014;32(2):299–306. doi:10.1016/j.clindermatol.2013.08.014
   PubMed Web of Science ®Google Scholar
• Googe P, Chung SJ, Simmons J, King R. Giant-sized condyloma of the breast with focal acantholytic changes. J Cutan Pathol. 2000;27(6):319–322. doi:10.1034/j.1600-0560.2000.027006319.x
   PubMed Web of Science ®Google Scholar
• Jovic A, Kocic H, Damiani G, et al. Unusual clinical presentation of giant extragenital condyloma. Acta Dermatovenerologica Croat. 2020;28(4):240–241.
   PubMed Web of Science ®Google Scholar
• Staples CG, Henderson D, Tsongalis GJ, Fernandez M, Krejci-Manwaring J. Condylomata of the pannus on 3 obese patients: a new location for a common disease. Arch Dermatol. 2010;146(5):572–574. doi:10.1001/archdermatol.2010.74
   PubMedGoogle Scholar
• Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. MMWR Recomm Reports. 2021;70(4):1.
   PubMed Web of Science ®Google Scholar
• Yanofsky VR, Patel RV, Goldenberg G. Genital warts: a comprehensive review. J Clin Aesthet Dermatol. 2012;5(6):25.
   PubMedGoogle Scholar
• Thappa D, Chiramel M. Evolving role of immunotherapy in the treatment of refractory warts. Indian Dermatol Online J. 2016;7(5):364. doi:10.4103/2229-5178.190487
   PubMedGoogle Scholar
• Sefcik RS, Burkhart CG. Wart immunotherapies: a short review. Open Dermatol J. 2017;11(1):30–34. doi:10.2174/1874372201711010030
   Google Scholar
• Mohta A, Kushwana R, Agrawal A, Sharma MK, Gautam U, Jain SK. Evaluation of the efficacy of intralesional measles, mumps, and rubella vaccine with intralesional vitamin D3 as immunotherapies in the treatment of recalcitrant cutaneous warts in adult - a randomized placebo-controlled study. Indian Dermatol Online J. 2022;12(6):879–887.
   Google Scholar
• Rezk S, Alkady O, Farag R. The effect of intralesional injection of MMR in treatment of viral warts. Benha J App Sci. 2021;6(1):223–226. doi:10.21608/bjas.2021.169112
   Google Scholar
• Sadegh Rezai M, Ghasempouri H, Asqary Marzidareh O, Yazdani Cherati J, Rahmatpour Rokni G. Intralesional injection of the measles–mumps– rubella vaccine into resistant palmoplantar warts: a randomized controlled trial. Iran J Med Sci. 2019;44(1):10–17. doi:10.1002/path.4496
   PubMed Web of Science ®Google Scholar
• Sharma S, Agarwal S. Intralesional immunotherapy with measles mumps rubella vaccine for the treatment of anogenital warts: an open-label study. J Clin Aesthet Dermatol. 2020;13(8):40–44.
   PubMedGoogle Scholar
• Meena D, Sharma S, Chauhan P. Measles, mumps, and rubella vaccine in genital warts: a case report of two patients. Indian J Sex Transm Dis AIDS. 2018;39(2):133–135. doi:10.4103/ijstd.IJSTD_44_16
   PubMed Web of Science ®Google Scholar
• Awal G, Kaur S. Therapeutic outcome of intralesional immunotherapy in cutaneous warts using the mumps, measles, rubella vaccine: a randomized, placebo-controlled trial. J Clin Aesthet Dermatol. 2018;11(5):15–20.
   PubMedGoogle Scholar
• Al-Qassabi A-M, Al-Farsi F. Intralesional measles-mumps-rubella vaccine for genital warts. Sultan Qaboos Univ Med J. 2022;22(3):413–416. doi:10.18295/squmj.6.2021.093
   PubMedGoogle Scholar
• Amirnia M, Khodaeiani E, Fouladi DF, Masoudnia S. Intralesional immunotherapy with tuberculin purified protein derivative (PPD) in recalcitrant wart: a randomized, placebo-controlled, double-blind clinical trial including an extra group of candidates for cryotherapy. J Dermatolog Treat. 2016;27(2):173–178. doi:10.3109/09546634.2015.1078871
   PubMed Web of Science ®Google Scholar
• Mishra A, Shrestha SK, Karn D, Karn D. A prospective clinical study for safety and efficacy of intralesional tuberculin purified protein derivative in the treatment of palmoplantar verruca. J Nobel Med Coll. 2022;11(1):12–16. doi:10.3126/jonmc.v11i1.45720
   Google Scholar
• Lee J, Sun JM, Lee SH, Ahn JS, Park K, Ahn MJ. Are there any ethnic differences in the efficacy and safety of immune checkpoint inhibitors for the treatment of lung cancer? J Thorac Dis. 2020;12(7):3796–3803. doi:10.21037/jtd.2019.08.29
   PubMed Web of Science ®Google Scholar
• Elkrief A, Derosa L, Kroemer G, Zitvogel L, Routy B. The negative impact of antibiotic on outcomes in cancer patients treated with immunotherapy: a new independent prognostic factor. Ann Oncol. 2019;30(10):1572–1579. doi:10.1093/annonc/mdz206
   PubMed Web of Science ®Google Scholar
• Rayburn ER, Ezell SJ, Zhang R. Anti-Inflammatory Agents for Cancer Therapy. Mol Cell Pharmacol. 2009;1(1):29–43. doi:10.4255/mcpharmacol.09.05
   PubMedGoogle Scholar
• Garcia-Quiroz J, Vazquez-Almazan B, Garcia-Berreca R, Diaz L, Avila E. The interaction of human papillomavirus infection and prostaglandin E2 signaling in carcinogenesis: a focus on cervical cancer therapeutic. Cells. 2002;11:2528. doi:10.3390/cells11162528
   Google Scholar