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Case reports

Clozapine-Induced Severe Toxicity: Exploring the Pharmacokinetic Profile of Clozapine and Its Significance in Hemodynamic Instability – A Case Report

, , , & ORCID Icon
Pages 111-120 | Received 14 Oct 2023, Accepted 01 Feb 2024, Published online: 08 Feb 2024

References

  • Curto M, Girardi N, Lionetto L, et al. Systematic review of clozapine cardiotoxicity. Curr Psychiatry Rep. 2016;18(7). doi:10.1007/s11920-016-0704-3
  • Roberts RJ, Miano TA, Hammond DA, et al. Evaluation of vasopressor exposure and mortality in patients with septic shock. Crit Care Med. 2020;48(10):1445–1453. doi:10.1097/CCM.0000000000004476
  • Antal O, Ștefănescu E, Mleșnițe M, et al. Hemodynamic predictors for sepsis-induced acute kidney injury: a preliminary study. J Clin Med. 2020;9(1):151. doi:10.3390/jcm9010151
  • Daskalakis ZJ, George GTP. Clozapine, GABAB, and the treatment of resistant schizophrenia. Clin Pharmacol Ther. 2009;86(4):442Y446. doi:10.1038/clpt.2009.115
  • Farooq S, Choudry A, Cohen D, et al. Barriers to using clozapine in treatment-resistant schizophrenia: systematic review. Br J Psychiatry. 2019;43(1):8–16.
  • Nielsen J, Young C, Ifteni P, et al. Worldwide differences in regulations of clozapine use. CNS Drugs. 2016;30(2):149–161. doi:10.1007/s40263-016-0311-1
  • Weiner DM, Meltzer HY, Veinbergs I, et al. The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine. Psychopharmacology. 2004;177(1–2):207–216.
  • Seeman P. An update of fast-off dopamine D2 atypical antipsychotics. Am J Psychiatry. 2005;162(10):1984–1985. doi:10.1176/appi.ajp.162.10.1984-a
  • Tauscher J, Hussain T, Agid O, et al. Equivalent occupancy of dopamine D1 and D2 receptors with clozapine: differentiation from other atypical antipsychotics. Am J Psychiatry. 2004;161(9):1620–1625. doi:10.1176/appi.ajp.161.9.1620
  • Renwick AC, Renwick AG, Flanagan RJ, et al. Monitoring of clozapine and norclozapine plasma concentration-time curves in acute overdose. Clin Toxicol. 2000;38:325Y328.
  • Krämer I, Rauber-Lüthy C, Kupferschmidt H, Krähenbühl S, Ceschi A. Minimal dose for severe poisoning and influencing factors in acute human clozapine intoxication: a 13-year retrospective study. Clin Neuropharmacol. 2010;33(5):230–234. doi:10.1097/WNF.0b013e3181f0ec55
  • Bebawi E, Wakim L, Doré M. Maxime Doré.Clozapine intoxication with severe adverse effects induced by an inflammatory and infectious process: a case report. J Med Case Rep. 2021;15(1):47. doi:10.1186/s13256-020-02660-x
  • Yartsev A, Peisah C. Caffeine-clozapine interaction associated with severe toxicity and multiorgan system failure: a case report. BMC Psychiatry. 2021;21(1):192. doi:10.1186/s12888-021-03199-x
  • Damkier P, Videbech P. The safety of second-generation antipsychotics during pregnancy: a clinically focused review. CNS Drugs. 2018;32(4):351–366. doi:10.1007/s40263-018-0517-5
  • Beex-Oosterhuis MM, Samb A, Heerdink ER, et al. Safety of clozapine use during pregnancy: analysis of international pharmacovigilance data. Pharmacoepidemiol Drug Saf. 2020;29(6):725–735. doi:10.1002/pds.5016
  • Mehta TM, Van Lieshout RJ. A review of the safety of clozapine during pregnancy and lactation. Arch Womens Ment Health. 2017;20(1):1–9. doi:10.1007/s00737-016-0670-0
  • Rohde C, Polcwiartek C, Kragholm K, et al. Adverse cardiac events in outpatients initiating clozapine treatment: a nationwide register-based study. Acta Psychiatr Scand. 2018;137:47–53. doi:10.1111/acps.12827
  • Hollingworth SA, Winckel K, Saiepour N, et al. Clozapine-related neutropenia, myocarditis and cardiomyopathy adverse event reports in Australia 1993–2014. Psychopharmacology. 2018;235:1915–1921. doi:10.1007/s00213-018-4881-0
  • Crumb WJ, Ekins S, Sarazan RD, et al. Effects of antipsychotic drugs on I (to), I (Na), I (sus), I (K1), and hERG: QT prolongation, structure activity relationship, and network analysis. Pharm Res. 2006;23:1133Y1143.
  • Knoph KN, Morgan RJ, Palmer BA, et al. Clozapine-induced cardiomyopathy and myocarditis monitoring: a systematic review. Schizophr Res. 2018;199:17–30. doi:10.1016/j.schres.2018.03.006
  • Schulte PF, Cohen D, Bogers JP, et al. A Dutch guideline for the use of clozapine. Aust N Z J Psychiatry. 2010;44(11):1055–1056.
  • Nelson LS, Lewin NA, Howland MA, Hoffman RS, Goldfrank LR, Flomenbaum NE. Goldfrank’s Toxicologic Emergencies. New York: McGraw-Hill Professional; 2011.
  • Burns MJ. The pharmacology and toxicology of atypical antipsychotic agents. J Toxicol Clin Toxicol. 2001;39:1–14. doi:10.1081/CLT-100102873
  • Jia-Li H, Xiang Y-T, Li W-B, Cai Z-J, Ungvari GS. Hemoperfusion in the treatment of acute clozapine intoxication in China. J Clin Psychopharmacol. 2007;27(6):667–671. doi:10.1097/jcp.0b013e31815a5881
  • Hanafy Mahmoud S, Buhler J, Chu E, et al. Drug dosing in patients undergoing therapeutic plasma exchange. Neurocrit Care. 2021;34(1):301–311.