481
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Effect of Moringa oleifera Leaf Powder on Hematological Profile of Male Wistar Rats

, , , , &
Pages 477-485 | Received 10 Feb 2023, Accepted 11 Aug 2023, Published online: 23 Aug 2023

References

  • Kim JH, Kismali G, Gupta SC. Natural products for the prevention and treatment of chronic inflammatory diseases: integrating traditional medicine into modern chronic diseases care. Evid Based Complement Alternat Med. 2018;2018:1–2. doi:10.1155/2018/9837863
  • Salmerón-Manzano E, Garrido-Cardenas JA, Manzano-Agugliaro F. Worldwide research trends on medicinal plants. Int J Environ Res Public Health. 2020;17(10):3376. doi:10.3390/ijerph17103376
  • Adnan A, Navia ZI, Silvia M, et al. Diversity of herbs and spices plants and their importance in traditional medicine in the South Aceh district, Indonesia. Biodiversitas. 2022;23(7):3836–3843. doi:10.13057/biodiv/d230761
  • Putri YA, Djamal EC, Ilyas R. Identification of medicinal plant leaves using convolutional neural network. J Phys Conf Ser. 2021;1845(1):012026. doi:10.1088/1742-6596/1845/1/012026
  • Sinaga RM, Zuska F, Sitorus P. Indegenous healer knowledge about illness and the way to make traditional medicine. Indonesia J Med Anthropology. 2021;2(1):43–47. doi:10.32734/ijma.v2i1.5297
  • Parisa N, Kamaluddin MT, Saleh MI, et al. Counseling of the use of herbal medicines for health care to the community. Indo Com Empowerment J. 2022;2(1):144–150.
  • El-Dahiyat F, Rashrash M, Abuhamdah S, Abu Farha R, Babar ZUD. Herbal medicines: a cross-sectional study to evaluate the prevalence and predictors of use among Jordanian adults. J Pharm Policy Pract. 2020;13(1):2. doi:10.1186/s40545-019-0200-3
  • Fatimah SF, Darmawan E, Narwanti I, Dzulhaifa D, Wulandari IA, Salma RP. Subchronic toxicity test on combination of extracted Phyllanthus niruri and Centella asiatica on haematology in rats. J Ilmu Kedokt Kesehat. 2019;10(3):255–264. doi:10.20885/JKKI.Vol10.Iss3.art8
  • Flora SJS, Pachauri V. Moringa (Moringa oleifera) seed extract and the prevention of oxidative stress. In: Nuts and Seeds in Health and Disease Prevention. Elsevier; 2011:775–785. doi:10.1016/B978-0-12-375688-6.10092-1
  • Kuete V. Moringa oleifera. In: Medicinal Spices and Vegetables from Africa. Elsevier; 2017:485–496. doi:10.1016/B978-0-12-809286-6.00022-4
  • Irawan H, Patricio RC, Patricio RC. Indonesian consumers’ perceptions of daun kelor (Moringa oleifera). Acta Hortic. 2017;1158:391–396. doi:10.17660/ActaHortic.2017.1158.44
  • Liu Y, Wang X, Wei X, Gao Z, Han J. Values, properties and utility of different parts of Moringa oleifera: an overview. Chin Herb Med. 2018;10(4):371–378. doi:10.1016/j.chmed.2018.09.002
  • Gopalakrishnan L, Doriya K, Kumar DS. Moringa oleifera: a review on nutritive importance and its medicinal application. Food Sci Hum Wellness. 2016;5(2):49–56. doi:10.1016/j.fshw.2016.04.001
  • Mun’im A, Utami Puteri M, Sari SP, A A. Anti-anemia effect of standardized extract of Moringa oleifera Lamk. leaves on aniline induced rats. Pharmacog J. 2016;8(3):255–258. doi:10.5530/pj.2016.3.14
  • Nurmalasari Y, Rafie R, Warganegara E, Desta Wahyuni L. Pengaruh pemberian ekstrak daun kelor terhadap kadar hemoglobin pada tikus putih galur Wistar jantan. J Medika Malahayati. 2021;2021:5.
  • Mahmood KT, Mugal T, Haq IU. Moringa oleifera: a natural gift-a review. J Pharm Sci Res. 2010;2(11):775.
  • Velázquez-Zavala M, Peón-Escalante IE, Zepeda-Bautista R, Jiménez-Arellanes MA. Moringa (Moringa oleifera Lam.): potential uses in agriculture, industry and medicine. Rev Chapingo Ser Hortic. 2016;XXII(2):95–116. doi:10.5154/r.rchsh.2015.07.018
  • Bhattacharya A, Naik MR, Agrawal D, Rath K, Kumar S, Mishra SS. Anti-pyretic, anti-infl ammatory, and analgesic effects of leaf extract of drumstick tree. J Young Pharm. 2014;6(4):20–24. doi:10.5530/jyp.2014.4.4
  • Martínez-González CL, Martínez L, Martínez-Ortiz EJ, et al. Moringa oleifera, a species with potential analgesic and anti-inflammatory activities. Biomed Pharmacother. 2017;87:482–488. doi:10.1016/j.biopha.2016.12.107
  • Lakshmana Prabu S, Umamaheswari A, Puratchikody A. Phytopharmacological potential of the natural gift Moringa oleifera Lam and its therapeutic application: an overview. Asian Pac J Trop Med. 2019;12(11):485. doi:10.4103/1995-7645.271288
  • Chin CY, Jalil J, Ng PY, Ng SF. Development and formulation of Moringa oleifera standardised leaf extract film dressing for wound healing application. J Ethnopharmacol. 2018;212:188–199. doi:10.1016/j.jep.2017.10.016
  • Tshabalala T, Ndhlala AR, Ncube B, Abdelgadir HA, van Staden J. Potential substitution of the root with the leaf in the use of Moringa oleifera for antimicrobial, antidiabetic and antioxidant properties. S Afr J Bot. 2020;129:106–112. doi:10.1016/j.sajb.2019.01.029
  • Suresh S, Chhipa AS, Gupta M, et al. Phytochemical analysis and pharmacological evaluation of methanolic leaf extract of Moringa oleifera Lam. In ovalbumin induced allergic asthma. S Afr J Bot. 2020;130:484–493. doi:10.1016/j.sajb.2020.01.046
  • Suphachai C. Antioxidant and anticancer activities of Moringa oleifera leaves. J Med Plant Res. 2014;8(7):318–325. doi:10.5897/JMPR2013.5353
  • Mahdi HJ, Khan NAK, Asmawi MZ, Mahmud R, Murugaiyah L, Vikneswaran A. In vivo anti-arthritic and anti-nociceptive effects of ethanol extract of Moringa oleifera leaves on complete Freund’s adjuvant (CFA)-induced arthritis in rats. Integr Med Res. 2018;7(1):85–94. doi:10.1016/j.imr.2017.11.002
  • Biswas D, Nandy S, Mukherjee A, Pandey DK, Dey A. Moringa oleifera Lam. and derived phytochemicals as promising antiviral agents: a review. S Afr J Bot. 2020;129:272–282. doi:10.1016/j.sajb.2019.07.049
  • Saleem A, Naureen I. Effect of Moringa olifera on haematology and cholesterol level. Saudi J Biomed Res. 2021;6(12):298–306. doi:10.36348/sjbr.2021.v06i12.004
  • Kashyap P, Kumar S, Riar CS, et al. Recent advances in drumstick (Moringa oleifera) leaves bioactive compounds: composition, health benefits, bioaccessibility, and dietary applications. Antioxidants. 2022;11(2):402. doi:10.3390/antiox11020402
  • Coulibaly A, Boua Gnangoran N, Baptiste N’guessan Oussou J, Bleyere MN. Evaluation of Moringa oleifera Lam leaves (Moringaceae) diets against induced anemia in Wistar rats. J Anim Physiol Anim Nutr. 2020;2020:1. doi:10.36349/easjnfs.2020.v02i03.004
  • Onyekwelu K, Ufelle S, Achukwu P, Ezeh CO, Ghasi S. Haematological effects of leaf extract of Moringa oleifera Lam in normal and myelo-suppressed Wistar rats. Afr J Biomed Res. 2018;21:87–90.
  • Molnar C, Gair J. The circulatory system: components of the blood. In: Concepts of Biology. 1st ed. BCcampus; 2015.
  • Sharma R, Sharma S. Physiology, Blood Volume; 2022.
  • Pretini V, Koenen MH, Kaestner L, et al. Red blood cells: chasing interactions. Front Physiol. 2019;10:10. doi:10.3389/fphys.2019.00945
  • O’Connell KE, Mikkola AM, Stepanek AM, et al. Practical murine hematopathology: a comparative review and implications for research. Comp Med. 2015;65(2):96–113.
  • Shrivastav AB, Singh KP. Tigers blood: haematological and biochemical studies. In: Blood Cell - an Overview of Studies in Hematology. InTech; 2012. doi10.5772/50360
  • Ihedioha JI, Ugwuja JI, Noel-Uneke OA, Udeani IJ, Daniel-Igwe G. Reference values for the haematology profile of conventional grade outbred albino mice (Mus musculus) in Nsukka, Eastern Nigeria. Anim Res Int. 2012;9:1.
  • Onyishi GC, Oguine CC, Nwani SI, Guzie IO, Nwani CD. Haematological parameters dynamics of developing Gallus gallus domesticus. Anim Res Int. 2017;14(2):2769–2776.
  • Fujii T, Asai T, Matsuo T, Okamura K. Effect of resistance exercise on iron status in moderately iron-deficient rats. Biol Trace Elem Res. 2011;144(1–3):983–991. doi:10.1007/s12011-011-9072-3
  • Krisnadi AD. Kelor Super Nutrisi. Blora. 2015;2015:1.
  • Chiabrando D, Mercurio S, Tolosano E. Heme and erythropoieis: more than a structural role. Haematologica. 2014;99(6):973–983. doi:10.3324/haematol.2013.091991
  • Yulianti H, Hadju V, Alasiry E. The effect of Moringa leaf extract on the hemoglobin levels in young women at SMU Muhammadyah Kupang. JST Kesehatan. 2016;6(3):399–404.
  • Jacob Filho W, Lima CC, Paunksnis MRR, et al. Reference database of hematological parameters for growing and aging rats. Aging Male. 2018;21(2):145–148. doi:10.1080/13685538.2017.1350156
  • de Kort M, Weber K, Wimmer B, et al. Historical control data for hematology parameters obtained from toxicity studies performed on different Wistar rat strains: acceptable value ranges, definition of severity degrees, and vehicle effects. Toxicol Res Appl. 2020;4:239784732093148. doi:10.1177/2397847320931484
  • Aghara ID. A Comparative Study of the Effects of Aqueous Leaf Extracts of Moringa Oleifera and Telfairia Occidentalis on Some Biochemical and Haematological Parameters in Wistar Rats. University of Nigeria; 2014.
  • Bolliger AP, Everds N. Haematology of the mouse. In: The Laboratory Mouse. Elsevier; 2012:331–347. doi:10.1016/B978-0-12-382008-2.00014-3
  • Rosita A, Mushawwir A, Latipudin D. Status hematologis (eritrosit, hematokrit, dan hemoglobin) ayam petelur fase layer pada temperature humidity index yang berbeda. Student E J. 2015;4:1.
  • D’Hiru. Live blood analysis setetes darah anda dapat mengungkap status kesehatan dan penyakit yang mengancam anda [Live blood analysis a drop of your blood can reveal the health status and diseases that threaten you]. PT Gramedia Pustaka Umum; 2013. Indonesian
  • Ware AD. The complete blood count and white blood cell differential. In: Contemporary Practice in Clinical Chemistry. Elsevier; 2020:429–444. doi:10.1016/B978-0-12-815499-1.00025-9
  • Doig K, Zhang B. A methodical approach to interpreting the red blood cell parameters of the complete blood count. Am Soc Clin Lab Sci. 2017;30(3):173–185. doi:10.29074/ascls.30.3.173
  • Carrillo JLM, Rodríguez FPC, Coronado OG, García MAM, Cordero JFC. Physiology and pathology of innate immune response against pathogens. In: Physiology and Pathology of Immunology. InTech; 2017. doi10.5772/intechopen.70556
  • Ajugwo AO, Mounbegna PE, Kemajou TS, Ofokansi VC. Effects of Moringa oleifera leaves extract on haematological parameters of phenylhydrazine anaemia induced Wistar rats. Int J Public Health. 2017;2:4.
  • Sembuling K, Sembuling P. Essential of Medical Physiology. 6th ed. New Jaypee Brothers Medical Publishers; 2012.
  • Holinstat M. Normal platelet function. Cancer Metastasis Rev. 2017;36(2):195–198. doi:10.1007/s10555-017-9677-x
  • Silva MF, Nishi L, Farooqi A, Bergamasco R. The many health benefits of Moringa Oleifera. J Med Pharm Innov. 2014;1:3.
  • Bakr S. Hematologic reference values for healthy adult Saudis. Hematol Transfus Cell Ther. 2021;43:S53. doi:10.1016/j.htct.2021.10.1065
  • Silitonga M, Silitonga PM. Haematological Profile of Rats (Rattus Norvegicus) Induced BCG and Provided Leaf Extract of Plectranthus Amboinicus Lour Spreng). AIP Publishing; 2017:090008. doi:10.1063/1.4995200
  • Dawson WR, Whittow GC. Regulation of body temperature. In: Sturkie’s Avian Physiology. Elsevier; 2000:343–390. doi:10.1016/B978-012747605-6/50015-8
  • von Borell EH. The biology of stress and its application to livestock housing and transportation assessment. J Anim Sci. 2001;79:260–267. doi:10.2527/jas2001.79E-SupplE260x
  • Adedapo AA, Mogbojuri OM, Emikpe BO. Safety evaluations of the aqueous extract of the leaves of Moringa oleifera in rats. J Med Plant Res. 2009;3(8):586–591.
  • Gallaher DD, Gallaher CM, Natukunda S, Schoenfuss TC, Mupere E, Cusick SE. Iron bioavailability from Moringa oleifera leaves is very low. FASEB J. 2018;31(S1):786. doi:10.1096/fasebj.31.1_supplement.786.13
  • Ndong M, Uehera M, Katsumata S, Sato S, Suzuki K. Preventive effects of Moringa oleifera (Lam) on hyperlipidemia and hepatocyte ultrastructural changes in iron deficient rats. Biosci Biotechnol Biochem. 2007;71(8):1826–1833. doi:10.1271/bbb.60644
  • Lesjak M, Hoque R, Balesaria S, et al. Quercetin inhibits intestinal iron absorption and ferroportin transporter expression in vivo and in vitro. PLoS One. 2014;9(7):e102900. doi:10.1371/journal.pone.0102900
  • Jain A, Jain S, Singh N, et al. Storage stability of commonly used haematological parameters at 33 °C. Biochem Med (Zagreb). 2018;28(2). doi:10.11613/BM.2018.020901
  • Mazzullo G, Rifici C, Caccamo G, Rizzo M, Piccione G. Effect of different environmental conditions on some haematological parameters in cow. Ann Animal Sci. 2014;14(4):947–954. doi:10.2478/aoas-2014-0049
  • Kodi GM, Mustafa HA, Idris AAA. The effects of Moringa oleifera leaves on complete blood count, renal and liver functions as potential therapy for malnutrition. Mol Cell Biol Sci. 2022;6(2):55. doi:10.21705/mcbs.v6i2.234
  • Amara AK, Goze BN, Bleyere MN, Yapo PA. Moringa oleifera diets effect on haematological parameters of rat (Ratus norvegicus). J Biosci Med. 2020;08(05):20–30. doi:10.4236/jbm.2020.85003