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ORIGINAL RESEARCH

Analgesic and Anti-Inflammatory Activities of 80% Methanol Extract and Solvent Fractions of Ehretia cymosa Thonn (Boraginaceae) Leaves in Rodents

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Pages 63-79 | Received 06 Dec 2022, Accepted 15 Feb 2023, Published online: 23 Feb 2023

References

  • Raja S, Carr D, Cohen M, et al. The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. Pain. 2020;161:1976.
  • Stanton-Hicks M, Jänig W, Hassenbusch S, Haddox J, Boas R, Wilson P. Reflex sympathetic dystrophy: changing concepts and taxonomy. Pain. 1995;63(1):127–133. doi:10.1016/0304-3959(95)00110-E
  • Tracey I, Woolf CJ, Andrews NA. Composite pain biomarker signatures for objective assessment and effective treatment. Neuron. 2019;101(5):783–800. doi:10.1016/j.neuron.2019.02.019
  • Beal BR, Wallace MS. An overview of pharmacologic management of chronic pain. Med Clin. 2016;100(1):65–79. doi:10.1016/j.mcna.2015.08.006
  • Balkrishna A, Ranjan R, Sakat SS, et al. Evaluation of polyherbal ayurvedic formulation ‘Peedantak Vati’for anti-inflammatory and analgesic properties. J Ethnopharmacol. 2019;235:361–374. doi:10.1016/j.jep.2019.01.028
  • Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010;140(6):883–899. doi:10.1016/j.cell.2010.01.025
  • Wu X, Xie J, Qiu L, et al. The anti-inflammatory and analgesic activities of the ethyl acetate extract of Viburnum taitoense Hayata. J Ethnopharmacol. 2021;269:113742. doi:10.1016/j.jep.2020.113742
  • Munn LL. Cancer and inflammation. Wiley Interdiscip Rev Syst Biol Med. 2017;9(2):e1370.
  • Haley RM, von Recum HA. Localized and targeted delivery of NSAIDs for treatment of inflammation: a review. Exp Biol Med. 2019;244(6):433–444. doi:10.1177/1535370218787770
  • Oray M, Abu Samra K, Ebrahimiadib N, Meese H, Foster CS. Long-term side effects of glucocorticoids. Expert Opin Drug Saf. 2016;15(4):457–465. doi:10.1517/14740338.2016.1140743
  • Pahwa R, Goyal A, Bansal P, Jialal I. Chronic inflammation; 2018.
  • Ou Z, Zhao J, Zhu L, et al. Anti-inflammatory effect and potential mechanism of betulinic acid on λ-carrageenan-induced paw edema in mice. Biomed Pharmacother. 2019;118:109347. doi:10.1016/j.biopha.2019.109347
  • Mathew E, Kim E, Zempsky W. Pharmacologic treatment of pain. In: Seminars in Pediatric Neurology. Elsevier; 2016.
  • Yimer T, Birru EM, Adugna M, Geta M, Emiru YK. Evaluation of analgesic and anti-inflammatory activities of 80% methanol root extract of Echinops kebericho M. (Asteraceae). J Inflamm Res. 2020;13:647. doi:10.2147/JIR.S267154
  • Palombo EA. Traditional medicinal plant extracts and natural products with activity against oral bacteria: potential application in the prevention and treatment of oral diseases. Evid Based Complement Alternat Med. 2011;2011:1–15. doi:10.1093/ecam/nep067
  • Mohamed D, Mahmoud E, Abdel-Moniem S, Hassan M. Anti-inflammatory and anti-arthritic activity of some spices extracts on adjuvant induced arthritis in rats. J Appl Sci Res. 2013;9:5303–5312.
  • Yang R, Yuan B-C, Ma Y-S, Zhou S, Liu Y. The anti-inflammatory activity of licorice, a widely used Chinese herb. Pharm Biol. 2017;55(1):5–18. doi:10.1080/13880209.2016.1225775
  • Velu G, Palanichamy V, Rajan AP. Phytochemical and pharmacological importance of plant secondary metabolites in modern medicine. In: Bioorganic Phase in Natural Food: An Overview. Springer; 2018:135–156.
  • Tesfaye S, Belete A, Engidawork E, Gedif T, Asres K. Ethnobotanical study of medicinal plants used by traditional healers to treat cancer-like symptoms in eleven districts, Ethiopia. Evid Based Complement Alternat Med. 2020;2020:1–23. doi:10.1155/2020/7683450
  • Kassaye KD, Amberbir A, Getachew B, Mussema Y. A historical overview of traditional medicine practices and policy in Ethiopia. Ethiop J Health Dev. 2006;20(2):127–134.
  • Sarkodie J, Squire S, Oppong Bekoe E, et al. The antihyperglycemic, antioxidant and antimicrobial activities of Ehretia cymosa. J Pharmacognosy Phytother. 2015;4(3):105–111.
  • Ogundajo AL, Nnaemeka CO, Olawunmi RO, Ogunwande IA. Chemical constituents of essential oil of Ethretia cymosa Thonn. Br J Appl Sci Technol. 2016;14(4):1–6. doi:10.9734/BJAST/2016/24240
  • Etana B Ethnobotanical Study of Traditional Medicinal Plants of Goma Wereda, Jimma Zone of Oromia Region, Ethiopia. Ethiopia: Addis Ababa University Repository;2010.
  • Alemayehu G, Asfaw Z, Kelbessa E. Ethnobotanical study of medicinal plants used by local communities of Minjar-Shenkora District, North Shewa Zone of Amhara Region, Ethiopia. J Med Plants Stud. 2015;3(6):1–11.
  • Fassil A, Gashaw G. An ethnobotanical study of medicinal plants in chiro district, West Hararghe, Ethiopia. Afr J Plant Sci. 2019;13(11):309–323. doi:10.5897/AJPS2019.1911
  • Couto M, Cates C. Laboratory guidelines for animal care. In: Vertebrate Embryogenesis. Springer; 2019:407–430.
  • Neto A, Costa J, Belati C, et al. Analgesic and anti-inflammatory activity of a crude root extract of Pfaffia glomerata (Spreng) Pedersen. J Ethnopharmacol. 2005;96(1–2):87–91. doi:10.1016/j.jep.2004.08.035
  • Afsar S, Kumar KR, Gopal JV, Raveesha P. Assessment of anti-inflammatory activity of Artemisia vulgaris leaves by cotton pellet granuloma method in Wistar albino rats. J Pharm Res. 2013;7(6):463–467. doi:10.1016/j.jopr.2013.04.056
  • Shi P, Du W, Wang Y, Teng X, Chen X, Ye L. Total phenolic, flavonoid content, and antioxidant activity of bulbs, leaves, and flowers made from Eleutherine bulbosa (Mill.) Urb. Food Sci Nutr. 2019;7(1):148–154. doi:10.1002/fsn3.834
  • Nigatu H, Belay A, Ayalew H, et al. In vitro antileishmanial activity of some Ethiopian medicinal plants. J Exp Pharmacol. 2021;13:15. doi:10.2147/JEP.S285079
  • Ajanal M, Gundkalle MB, Nayak SU. Estimation of total alkaloid in Chitrakadivati by UV-spectrophotometer. Anc Sci Life. 2012;31(4):198. doi:10.4103/0257-7941.107361
  • Jan S, Khan MR. Antipyretic, analgesic and anti-inflammatory effects of Kickxia ramosissima. J Ethnopharmacol. 2016;182:90–100. doi:10.1016/j.jep.2016.02.020
  • Olela B, Mbaria J, Wachira T, Moriasi G. Acute oral toxicity and anti-inflammatory and analgesic effects of aqueous and methanolic stem bark extracts of Piliostigma thonningii (Schumach.). Evid Based Complement Alternat Med. 2020;2020:1–10. doi:10.1155/2020/5651390
  • Yasmen N, Aziz M, Tajmim A, Akter M, Hazra AK, Rahman S. Analgesic and anti-inflammatory activities of Diethyl Ether and n-Hexane extract of Polyalthia suberosa leaves. Evid Based Complement Alternat Med. 2018;2018:1–8. doi:10.1155/2018/5617234
  • Azab A, Nassar A, Azab AN. Anti-inflammatory activity of natural products. Molecules. 2016;21(10):1321. doi:10.3390/molecules21101321
  • Gawade S. Acetic acid induced painful endogenous infliction in writhing test on mice. J Pharmacol Pharmacother. 2012;3(4):348. doi:10.4103/0976-500X.103699
  • Villaseñor IM, Canlas AP, Faustino KM, Plana KG. Evaluation of the bioactivity of triterpene mixture isolated from Carmona retusa (Vahl.) Masam leaves. J Ethnopharmacol. 2004;92(1):53–56. doi:10.1016/j.jep.2004.01.017
  • Shojaii A, Motaghinejad M, Norouzi S, Motevalian M. Evaluation of anti-inflammatory and analgesic activity of the extract and fractions of Astragalus hamosus in animal models. Iran J Pharm Res. 2015;14(1):263.
  • Tamrat Y, Nedi T, Assefa S, Teklehaymanot T, Shibeshi W. Anti-inflammatory and analgesic activities of solvent fractions of the leaves of Moringa stenopetala Bak. (Moringaceae) in mice models. BMC Complement Altern Med. 2017;17(1):1–10. doi:10.1186/s12906-017-1982-y
  • Verdam MC, Guilhon-Simplicio F, de Andrade KC, et al. Analgesic, anti-inflammatory, and antioxidant activities of Byrsonima duckeana W. R. Anderson (Malpighiaceae). Sci World J. 2017;2017:8367042. doi:10.1155/2017/8367042
  • Khan MS, Maalik A. Evaluation of antinociceptive potential of methanolic extract of different parts of Ehretia serrata Roxb and Ehretia obtusifolia in vivo. Biomed Res. 2018;29(9):1792–1796.
  • Brito T, Silva A, Cunha RXD, et al. Anti-inflammatory, hypoglycemic, hypolipidemic, and analgesic activities of Plinia cauliflora (Mart.) Kausel (Brazilian grape) epicarp. J Ethnopharmacol. 2021;268:113611. doi:10.1016/j.jep.2020.113611
  • Karbab A, Mokhnache K, Ouhida S, et al. Anti-inflammatory, analgesic activity, and toxicity of Pituranthos scoparius stem extract: an ethnopharmacological study in rat and mouse models. J Ethnopharmacol. 2020;258:112936. doi:10.1016/j.jep.2020.112936
  • Kifayatullah M, Rahim H, Jan NU, Chishti KA, Ullah I, Abbas S. In vivo analgesic, antipyretic and anti-inflammatory activities of ethanol extract of pericampylus glaucus in experimental animals. Sains Malaysiana. 2019;48(3):629–635. doi:10.17576/jsm-2019-4803-16
  • Jyothirmai N, Nagaraju B, Kumar JS. Evaluation of anti-inflammatory and anti- bacterial activities of different solvent extracts of Ehretia laevis Roxb. J Pharm Sci Res. 2016;8(8):715.
  • Sharma P, Shri R, Ntie-Kang F, Kumar S. Phytochemical and ethnopharmacological perspectives of Ehretia laevis. Molecules. 2021;26(12):3489. doi:10.3390/molecules26123489
  • Sharma VC, Kaushik A, Dey YN, Srivastava B, Wanjari M, Jaiswal B. Analgesic, anti-inflammatory and antipyretic activities of ethanolic extract of stem bark of Anogeissus latifolia Roxb. Clin Phytoscience. 2020;6(1):1–9. doi:10.1186/s40816-020-00171-2
  • Asif M, Saadullah M, Yaseen HS, et al. Evaluation of in vivo anti-inflammatory and anti-angiogenic attributes of methanolic extract of Launaea spinosa. Inflammopharmacology. 2020;28(4):993–1008. doi:10.1007/s10787-020-00687-6
  • Pingsusaen P, Kunanusorn P, Khonsung P, Chiranthanut N, Panthong A, Rujjanawate C. Investigation of anti-inflammatory, antinociceptive and antipyretic activities of Stahlianthus involucratus rhizome ethanol extract. J Ethnopharmacol. 2015;162:199–206. doi:10.1016/j.jep.2014.10.060
  • Patil KR, Patil CR. Anti-inflammatory activity of bartogenic acid containing fraction of fruits of Barringtonia racemosa Roxb. in acute and chronic animal models of inflammation. J Tradit Complement Med. 2017;7(1):86–93. doi:10.1016/j.jtcme.2016.02.001
  • Wilches I, Tobar V, Peñaherrera E, et al. Evaluation of anti-inflammatory activity of the methanolic extract from Jungia rugosa leaves in rodents. J Ethnopharmacol. 2015;173:166–171. doi:10.1016/j.jep.2015.07.004
  • Ma J, Guo C, Pan Y, Lin D, Qiu L, Wen L. Antioxidant and anti‑inflammatory activities of ethyl acetate extract of Gynura formosana (Kitam) leaves. Exp Ther Med. 2017;14(3):2303–2309. doi:10.3892/etm.2017.4757
  • Pranitha D, Ch MR. Inflammation lowering property of Pistacia atlantica in cotton pellet granuloma. Int J Rev Life Sci. 2019;9(2):14–17. doi:10.26452/ijrls.v9i2.1329
  • Ogundajo A, Ashafa AT. Phytochemical compositions and in vitro assessments of antioxidant and antidiabetic potentials of fractions from Ehretia cymosa Thonn. Pharmacogn Mag. 2017;13(Suppl 3):S470. doi:10.4103/pm.pm_118_17