Analgesic and Anti-Inflammatory Effects of 80% Methanol Extract and Solvent Fractions of the Leaves of Vernonia auriculifera Hiern. (Asteraceae)

References

• Lalan BK, Hiray R, Ghongane B. Evaluation of analgesic and anti-inflammatory activity of extract of Holoptelea integrifolia and Argyreia speciosa in animal models. J Clin Diagnostic Res. 2015;9(7):FF01. doi:10.7860/JCDR/2015/12059.6200
   PubMedGoogle Scholar
• Peters ML. Emotional and cognitive influences on pain experience. Pain Psychiatric Disorders. 2015;30:138–152.
   Google Scholar
• Michaelides A, Zis P. Depression, anxiety and acute pain: links and management challenges. Postgrad Med. 2019;131(7):438–444. doi:10.1080/00325481.2019.1663705
   PubMed Web of Science ®Google Scholar
• Agnihotri S, Wakode S, Agnihotri A. An overview on anti-inflammatory properties and chemo-profiles of plants used in traditional medicine. Indian J Natural Products Resources. 2010;1:150.
   Google Scholar
• Achar KC, Hosamani KM, Seetharamareddy HR. In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives. Eur J Med Chem. 2010;45(5):2048–2054. doi:10.1016/j.ejmech.2010.01.029
   PubMed Web of Science ®Google Scholar
• Lande AA, Ambavade SD, Swami US, Adkar PP, Ambavade PD, Waghamare AB. Saponins isolated from roots of Chlorophytum borivilianum reduce acute and chronic inflammation and histone deacetylase. J Integr Med. 2015;13(1):25–33. doi:10.1016/S2095-4964(15)60157-1
   PubMedGoogle Scholar
• Pahwa R, Goyal A, Jialal I. Chronic Inflammation. StatPearls [Internet]; 2021.
   Google Scholar
• Deng J-S, Chi C-S, Huang -S-S, Shie P-H, Lin T-H, Huang G-J. Antioxidant, analgesic, and anti-inflammatory activities of the ethanolic extracts of Taxillus liquidambaricola. J Ethnopharmacol. 2011;137(3):1161–1171. doi:10.1016/j.jep.2011.07.041
   PubMed Web of Science ®Google Scholar
• García-Lafuente A, Guillamón E, Villares A, Rostagno MA, Martínez JA. Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflammation Res. 2009;58(9):537–552. doi:10.1007/s00011-009-0037-3
   PubMed Web of Science ®Google Scholar
• Keeley SC, Jones SB. Distribution of pollen types in Vernonia (Vernonieae: compositae). Systematic Botany. 1979;4(3):195–202. doi:10.2307/2418418
   Web of Science ®Google Scholar
• Toyang NJ, Verpoorte R. A review of the medicinal potentials of plants of the genus Vernonia (Asteraceae). J Ethnopharmacol. 2013;146(3):681–723. doi:10.1016/j.jep.2013.01.040
   PubMed Web of Science ®Google Scholar
• Wado TE, Suleman S, Mohammed T. Antimicrobial Evaluation of Sequentially extracted Leaf of Vernonia auriculifera Hiern (Rejicho). BMC Complementary Med Therapies. 2022;22(1):1–10. doi:10.1186/s12906-022-03690-2
   PubMedGoogle Scholar
• Sobrinho ACN, de Souza EB. A review on antimicrobial potential of species of the genus Vernonia (Asteraceae). J Med Plants Res. 2015;9(31):838–850. doi:10.5897/JMPR2015.5868
   Google Scholar
• Albejo B, Endale M, Kibret B, Anza M. Phytochemical investigation and antimicrobial activity of leaves extract of Vernonia auriculifera Hiern. J Pharm Pharmacognosy Res. 2015;3(6):141–147.
   Google Scholar
• Alam B, Akter F, Parvin N, et al. Antioxidant, analgesic and anti-inflammatory activities of the methanolic extract of Piper betle leaves. Avicenna j Phytomed. 2013;3(2):112.
   PubMedGoogle Scholar
• Ferraz CR, Carvalho TT, Manchope MF, et al. Therapeutic potential of flavonoids in pain and inflammation: mechanisms of action, pre-clinical and clinical data, and pharmaceutical development. Molecules. 2020;25(3):762. doi:10.3390/molecules25030762
   PubMed Web of Science ®Google Scholar
• NRCoN A. Guide for the Care and Use of Laboratory Animals Eighth Edition. Washington: The; 2011.
   Google Scholar
• Koster R. Acetic Acid for Analgesic Screening. InFed Proc. 1959;18:412.
   Google Scholar
• Eddy NB, Leimbach D. Synthetic analgesics. II. Dithienylbutenyl-and dithienylbutylamines. J Pharmacol Exp Therapeutics. 1953;107(3):385–393.
   PubMed Web of Science ®Google Scholar
• Winter CA, Risley EA, Nuss GW. Carrageenin-induced edema in hind paw of the rat as an assay for antiinflammatory drugs. Proce Soc Exp Biol Med. 1962;111(3):544–547. doi:10.3181/00379727-111-27849
   PubMed Web of Science ®Google Scholar
• Winter CA, Porter CC. Effect of alterations in side chain upon anti-inflammatory and liver glycogen activities of hydrocortisone esters. J Am Pharmaceutical Assoc. 1957;46(9):515–519. doi:10.1002/jps.3030460902
   Google Scholar
• Tatiya AU, Saluja AK, Kalaskar MG, Surana SJ, Patil PH. Evaluation of analgesic and anti-inflammatory activity of Bridelia retusa (Spreng) bark. J Traditional Complementary Med. 2017;7(4):441–451. doi:10.1016/j.jtcme.2016.12.009
   PubMedGoogle Scholar
• Mansouri MT, Hemmati AA, Naghizadeh B, Mard SA, Rezaie A, Ghorbanzadeh B. A study of the mechanisms underlying the anti-inflammatory effect of ellagic acid in carrageenan-induced paw edema in rats. Indian J Pharmacol. 2015;47(3):292. doi:10.4103/0253-7613.157127
   PubMed Web of Science ®Google Scholar
• Laavola M, Leppänen T, Eräsalo H, Hämäläinen M, Nieminen R, Moilanen E. Anti-inflammatory effects of nortrachelogenin in murine J774 macrophages and in carrageenan-induced paw edema model in the mouse. Planta Med. 2017;234(06):519–526.
   Google Scholar
• Md Idris MH, Mohd Amin SN, Mohd Amin SN, et al. Flavonoids as dual inhibitors of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX): molecular docking and in vitro studies. Beni-Suef Univ J Basic Appl Sci. 2022;11(1):1–9. doi:10.1186/s43088-022-00296-y
   Google Scholar
• Lambebo MK, Kifle ZD, Gurji TB, Yesuf JS. Evaluation of Wound Healing Activity of Methanolic Crude Extract and Solvent Fractions of the Leaves of Vernonia auriculifera Hiern (Asteraceae) in Mice. J Exp Pharmacol. 2021;13:677. doi:10.2147/JEP.S308303
   PubMedGoogle Scholar
• Nirmal SA, Pal SC, Mandal SC, Patil AN. Analgesic and anti-inflammatory activity of β-sitosterol isolated from Nyctanthes arbortristis leaves. Inflammopharmacology. 2012;20(4):219–224. doi:10.1007/s10787-011-0110-8
   PubMedGoogle Scholar
• Ambavade SD, Misar AV, Ambavade PD. Pharmacological, nutritional, and analytical aspects of β-sitosterol: a review. Orient Pharm Exp Med. 2014;14(3):193–211. doi:10.1007/s13596-014-0151-9
   Google Scholar
• Villaseñor IM, Angelada J, Canlas AP, Echegoyen D. Bioactivity studies on β‐sitosterol and its glucoside. Phytotherapy Res. 2002;16(5):417–421. doi:10.1002/ptr.910
   PubMed Web of Science ®Google Scholar
• Joyce JK, Neil AK, Hafizah C. Triterpenoids from Vernonia auriculifera Hiern exhibit antimicrobial activity. Af J Pharmacy Pharmacol. 2011;5(8):1150–1156.
   Google Scholar
• Kayani WK, Dilshad E, Ahmed T, Ismail H, Mirza B. Evaluation of Ajuga bracteosa for antioxidant, anti-inflammatory, analgesic, antidepressant and anticoagulant activities. BMC Complement Altern Med. 2016;16(1):1–13. doi:10.1186/s12906-016-1363-y
   PubMedGoogle Scholar
• Oliveira RN, Mancini MC, Oliveira F, et al. FTIR analysis and quantification of phenols and flavonoids of five commercially available plants extracts used in wound healing. Matéria. 2016;21:767–779. doi:10.1590/S1517-707620160003.0072
   Google Scholar
• Nijveldt RJ, Van Nood E, Van Hoorn DE, Boelens PG, Van Norren K, Van Leeuwen PA. Flavonoids: a review of probable mechanisms of action and potential applications. Am J Clin Nutr. 2001;74(4):418–425. doi:10.1093/ajcn/74.4.418
   PubMed Web of Science ®Google Scholar
• Garelnabi EA, Mohammed MS, Osman WJ, et al. Secondary metabolites as anti-inflammatory agents. J Phytopharmacol. 2014;3(4):275.
   Google Scholar
• Govindappa M, Poojashri M. Antimicrobial, antioxidant and in vitro anti-inflammatory activity of ethanol extract and active phytochemical screening of Wedelia trilobata (L.) Hitchc. J Pharmacognosy Phytother. 2011;3(3):43–51.
   Google Scholar
• Yang D, Wang T, Long M, Li P. Quercetin: its main pharmacological activity and potential application in clinical medicine. Oxid Med Cell Longev. 2020;2020. doi:10.1155/2020/8825387
   Web of Science ®Google Scholar
• Kumar KP, Naik VS, Chandra VB, Lavanya R, Narendra K. Evaluation of in vitro and in vivo anti-inflammatory activity of aqueous extract of Gliricidia sepium flowers in rats. Int J Pharmacognosy Phytochem Res. 2014;6:477–481.
   Google Scholar
• Muthu S, Durairaj B. Evaluation of antioxidant and free radical scavenging activity of Annona muricata. Eur J Exp Biol. 2015;5(3):39–45.
   Google Scholar