262
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Anti-Diabetic Effects of the 80% Methanolic Extract of Datura Stramonium Linn (Solanaceae) Leaves in Streptozotocin- Induced Diabetic Mice

, ORCID Icon, , ORCID Icon &
Pages 375-389 | Received 19 Jul 2023, Accepted 13 Oct 2023, Published online: 18 Oct 2023

References

  • World Health Organization. Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycaemia: Report of a WHO/IDF Consultation. World Health Organization; 2006.
  • Sun H, Saeedi P, Karuranga S, et al. IDF Diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022;183:109119. doi:10.1016/j.diabres.2021.109119
  • Bishu KG, Jenkins C, Yebyo HG, Atsbha M, Wubayehu T, Gebregziabher M. Diabetes in Ethiopia: a systematic review of prevalence, risk factors, complications, and cost. Obes Med. 2019;15:100132. doi:10.1016/j.obmed.2019.100132
  • Care D. Standards of medical care in diabetes 2019. Diabetes Care. 2019;42(Suppl 1):S124–S38.
  • Papatheodorou K, Banach M, Bekiari E, Rizzo M, Edmonds M. Complications of Diabetes 2017. Hindawi; 2018.
  • Silver B, Ramaiya K, Andrew SB, et al. EADSG guidelines: insulin therapy in diabetes. Diabetes Ther. 2018;9(2):449–492. doi:10.1007/s13300-018-0384-6
  • Brutsaert EF. Diabetes mellitus (DM). Merck Manual; 2017.
  • Alamgir A. Therapeutic Use of Medicinal Plants and Their Extracts. Vol. 1. Springer; 2017.
  • Shanmugam KR, Shanmugam B, Subbaiah GV, Ravi S, Reddy KS. Medicinal plants and bioactive compounds for diabetes management: important advances in drug discovery. Curr Pharm Des. 2021;27(6):763–774. doi:10.2174/1381612826666200928160357
  • Suleman S, Alemu T. A survey on utilization of ethnomedicinal plants in Nekemte town, East Wellega (Oromia), Ethiopia. J Herbs Spices Med Plants. 2012;18(1):34–57. doi:10.1080/10496475.2011.645188
  • Al-Snafi AE. Medical importance of Datura fastuosa (syn: datura metel) and Datura stramonium-A review. IOSR J Pharm. 2017;7(2):43–58.
  • Belayneh YM, Birhanu Z, Birru EM, Getenet G. Evaluation of in vivo antidiabetic, antidyslipidemic, and in vitro antioxidant activities of hydromethanolic root extract of Datura stramonium L.(Solanaceae). J Exp Pharmacol. 2019;11:29. doi:10.2147/JEP.S192264
  • Melaku BC, Amare GG. Evaluation of antidiabetic and antioxidant potential of hydromethanolic seed extract of Datura stramonium Linn (Solanaceae). J Exp Pharmacol. 2020;12:181. doi:10.2147/JEP.S258522
  • Shobha G, Soumya C, Shashidhara K, Moses V. Phytochemical profile, antibacterial and antidiabetic effects of crude aqueous leaf extract of Datura stramonium. Pharmacophore. 2014;5(2):273–278.
  • Geresu GD, Umer S, Arayaselassie M, Ashebir G, Makonnen E, Fan Y-C. Hepatoprotective Effects of Crude Stem Bark Extracts and Solvent Fractions of Cordia africana against Acetaminophen-Induced Liver Injury in Rats. Can J Gastroenterol Hepatol. 2022;2022. doi:10.1155/2022/1449286
  • Pandey A, Tripathi S. Concept of standardization, extraction and pre phytochemical screening strategies for herbal drug. J Pharmacogn Phytochem. 2014;2(5).1.
  • Hara K, Someya T, Sano K, Sagane Y, Watanabe T, Wijesekara R. Antioxidant activities of traditional plants in Sri Lanka by DPPH free radical-scavenging assay. Data Br. 2018;17:870–875. doi:10.1016/j.dib.2018.02.013
  • Deeds M, Anderson J, Armstrong A, et al. Single dose streptozotocin-induced diabetes: considerations for study design in islet transplantation models. Lab Anim. 2011;45(3):131–140. doi:10.1258/la.2010.010090
  • Toxicity–Up AO. OECD guideline for testing of chemicals; 2001.
  • Tegegne BA, Mekuria AB, Birru EM. Evaluation of anti-diabetic and anti-hyperlipidemic activities of hydro-alcoholic crude extract of the shoot tips of crinum abyssinicum Hochst. ex A. Rich (Amaryllidaceae) in Mice. J Exp Pharmacol. 2022;14:27. doi:10.2147/JEP.S335650
  • Nasir B, Khan AU, Baig MW, Althobaiti YS, Faheem M, Haq I-U. Datura stramonium leaf extract exhibits anti-inflammatory activity in CCL4-Induced hepatic injury model by modulating oxidative stress markers and iNOS/Nrf2 Expression. Biomed Res Int. 2022;2022:1–20. doi:10.1155/2022/1382878
  • Toma A, Makonnen E, Mekonnen Y, Debella A, Adisakwattana S. Antidiabetic activities of aqueous ethanol and n-butanol fraction of Moringa stenopetala leaves in streptozotocin-induced diabetic rats. BMC Complement Altern Med. 2015;15(1):1–8. doi:10.1186/s12906-015-0779-0
  • Dadi DW, Emire SA, Hagos AD, et al. Antihyperglycemic, vasodilator, and diuretic activities of microencapsulated bioactive product from moringa stenopetala leaves extract. J Food Qual. 2020;2020:1–8. doi:10.1155/2020/8882042
  • Karthikeyan R Evaluation and characterization of herbal extract of Halodule uninervis and its anti diabetic activity: KM College of Pharmacy, Madurai; 2018.
  • Sharma M, Dhaliwal I, Rana K, Delta AK, Kaushik P. Phytochemistry, pharmacology, and toxicology of datura species—a review. Antioxidants. 2021;10(8):1291. doi:10.3390/antiox10081291
  • Bharti SK, Krishnan S, Kumar A, Kumar A. Antidiabetic phytoconstituents and their mode of action on metabolic pathways. Ther Adv Endocrinol Metab. 2018;9(3):81–100. doi:10.1177/2042018818755019
  • Iqbal S, Sivaraj C, Gunasekaran K. Antioxidant and Anticancer activities of methanol extract of seeds of datura stramonium l. Free Radic Antioxid. 2017;7(2):184–189. doi:10.5530/fra.2017.2.28
  • Bhardwaj K, Kumar S, Ojha S. Antioxidant activity and FT-IR analysis of datura innoxia and datura metel leaf and seed methanolic extracts. Afr J Tradit Complement Altern Med. 2016;13(5):7–16. doi:10.21010/ajtcam.v13i5.2
  • Santos-Sánchez NF, Salas-Coronado R, Villanueva-Cañongo C, Hernández-Carlos B. Antioxidant compounds and their antioxidant mechanism. Antioxidants. 2019;10:1–29.
  • Mbida H, Tsala D, Aboubakar S, et al. Antioxidant activity of aqueous extract of leaves and seeds of datura metel (Solanaceae) in frog’s heart failure model. Evid Based Complement Alternat Med. 2022;2022:1–8. doi:10.1155/2022/5318117
  • Kifle ZD, Belayneh YM. Antidiabetic and anti-hyperlipidemic effects of the crude hydromethanol extract of Hagenia abyssinica (Rosaceae) leaves in streptozotocin-induced diabetic mice. Diabetes Metab Syndr Obes. 2020;13:4085. doi:10.2147/DMSO.S279475
  • Sundaram R, Nandhakumar E, Haseena Banu H. Hesperidin, a citrus flavonoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats. Toxicol Mech Methods. 2019;29(9):644–653. doi:10.1080/15376516.2019.1646370
  • Tian H-L, Wei L, Xu Z, Zhao R, Jin D, Gao J. Correlations between blood glucose level and diabetes signs in streptozotocin-induced diabetic mice. Glob J Pharmacol. 2010;4(3):111–116.
  • Oladipo I, Lateef A, Azeez M, et al. Antidiabetic properties of phytosynthesized gold nanoparticles (AuNPs) from Datura stramonium seed. IOP Conference Series: Materials Science and Engineering. IOP Publishing; 2020.
  • Arowora KA, Imo C, Ezeonu CS, Muhammad ZI. Effects of ethanolic extracts of Datura metel on blood lipid profile of male albino rats. Int J. 2016;2(10):248.
  • Jadna Silva Frederico M, Jhonatan Gomes Castro A, Menegaz D, et al. Mechanism of action of novel glibenclamide derivatives on potassium and calcium channels for insulin secretion. Curr Drug Targets. 2017;18(6):641–650. doi:10.2174/1389450117666160615084752
  • Al Nahdi AM, John A, Raza H. Elucidation of molecular mechanisms of streptozotocin-induced oxidative stress, apoptosis, and mitochondrial dysfunction in Rin-5F Pancreatic β -Cells. Oxid Med Cell Longev. 2017;2017:1–15. doi:10.1155/2017/7054272
  • Gaikwad B, Krishna Mohan S, Sandhya Rani M. Phytochemicals for diabetes management. Pharm Crops. 2014;5(1):11–28. doi:10.2174/2210290601405010011
  • Babby A, Elanchezhiyan C, Suhasini S, Chandirasegaran G. Antihyperglycemic effect of tannic acid in streptozotocin induced diabetic rats. Int J Curr Res. 2014;6(3):5396–5398.
  • Ramírez-Espinosa JJ, Rios MY, López-Martínez S, et al. Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP–1B: in vitro, in silico, and in vivo approaches. Eur J Med Chem. 2011;46(6):2243–2251. doi:10.1016/j.ejmech.2011.03.005
  • Kansal S, Kamble T. Lipid profile in prediabetes. J Assoc Physicians India. 2016;64(3):18–21.
  • Vergès B. Pathophysiology of diabetic dyslipidaemia: where are we? Diabetologia. 2015;58(5):886–899. doi:10.1007/s00125-015-3525-8
  • Sosale A, Saboo B, Sosale B. Saroglitazar for the treatment of hypertrig-lyceridemia in patients with type 2 diabetes: current evidence. Diabetes Metab Syndr Obes. 2015;8:189. doi:10.2147/DMSO.S49592
  • Borle AL, Chhari N, Gupta G, Bathma V. Study of prevalence and pattern of dyslipidaemia in type 2 diabetes mellitus patients attending rural health training centre of medical college in Bhopal, Madhya Pradesh, India. Int J Community Med Public Health. 2016;3(1):140–144. doi:10.18203/2394-6040.ijcmph20151549
  • Taskinen M-R, Borén J. New insights into the pathophysiology of dyslipidemia in type 2 diabetes. Atherosclerosis. 2015;239(2):483–495. doi:10.1016/j.atherosclerosis.2015.01.039
  • Jiang S-Y, Li H, Tang -J-J, et al. Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol. Nat Commun. 2018;9(1):1–13. doi:10.1038/s41467-018-07590-3
  • Chang Y, Robidoux J. Dyslipidemia management update. Curr Opin Pharmacol. 2017;33:47–55. doi:10.1016/j.coph.2017.04.005
  • Rousset X, Vaisman B, Amar M, Sethi AA, Remaley AT. Lecithin: cholesterol acyltransferase: from biochemistry to role in cardiovascular disease. Curr Opin Endocrinol Diabetes Obes. 2009;16(2):163. doi:10.1097/MED.0b013e328329233b
  • Young SG, Fong LG. Lowering plasma cholesterol by raising LDL receptors—revisited. N Engl J Med. 2012;366(12):1154. doi:10.1056/NEJMe1202168
  • Albus U. Guide for the Care and Use of Laboratory Animals. 8th ed. UK London, England: SAGE Publications; 2012.