Evaluation of Anti-Diarrheal Activities of the 80% Methanol Extract and Solvent Fractions of Maesa lanceolata Forssk (Myrsinaceae) Leaves in Mice

References

• World Health Organization. Diarrheal disease fact sheet [Internet]. World Health Organization Media Center; 2022:1–4. Available from: https://www.who.int/news-room/fact-sheets/detail/diarrhoeal-disease. Accessed October 2, 2023.
   Google Scholar
• Nemeth V, Pfleghaar N. Diarrhea - StatPearls - NCBI Bookshelf. StatPearls Publishing; 2021.
   Google Scholar
• Poitras P. The digestive system: from basic sciences to clinical practice; 2022.
   Google Scholar
• Dereje B, Yibabie S, Keno Z, Megersa A. Antibiotic utilization pattern in treatment of acute diarrheal diseases: the case of Hiwot Fana Specialized University Hospital, Harar, Ethiopia. J Pharm Policy Pract. 2023;16(62):1–10. doi:10.1186/s40545-023-00568-7
   PubMedGoogle Scholar
• Feleke DG, Chanie ES, Admasu FT, Bahir S, Amare AT, Abate HK. Two-week prevalence of acute diarrhea and associated factors among under five years’ children in Simada Woreda, South Gondar Zone, Northwest Ethiopia, 2021: a multi-central community based cross-sectional study. Pan Afr Med J. 2022;42:12. doi:10.11604/pamj.2022.42.12.32599
   PubMed Web of Science ®Google Scholar
• Mahyar A, Ayazi P, Shaftaroni MR, Oveisi S, Dalirani R, Esmaeili S. The effect of adding honey to zinc in the treatment of diarrhea in children. Korean J Fam Med. 2022;43(3):188–192. doi:10.4082/kjfm.21.0080
   PubMed Web of Science ®Google Scholar
• Colston JM, Faruque ASG, Hossain MJ, et al. Associations between household-level exposures and all-cause diarrhea and pathogen-specific enteric infections in children enrolled in five sentinel surveillance studies. Int J Environ Res Public Health. 2020;17(21):8078. doi:10.3390/ijerph17218078
   PubMed Web of Science ®Google Scholar
• Öner SZ, Kaleli İ, Demi RM, Mete E, Çalişkan A. Rotavirus and adenovirus prevalence in patients with acute viral gastroenteritis in Denizli, Turkey, 2017–2021. J Med Virol. 2022;94(8):3857–3862. doi:10.1002/jmv.27834
   PubMed Web of Science ®Google Scholar
• Reintam Blaser A, Deane AM, Fruhwald S. Diarrhoea in the critically ill. Curr Opin Crit Care. 2015;21(2):142–153. doi:10.1097/MCC.0000000000000188
   PubMed Web of Science ®Google Scholar
• Keely SJ, Barrett KE. Intestinal secretory mechanisms and diarrhea. Am J Physiol Gastrointest Liver Physiol. 2022;322(4):G405–20. doi:10.1152/ajpgi.00316.2021
   PubMed Web of Science ®Google Scholar
• Estella OU, Nneoma UT, Patrick O, Ikenna C. Quantitative phytochemical analysis and antidiarrhoeal activity of methanol leaf extract of Combretum Bauchiense Hutch. World J Pharm Res. 2021;11(1):1607–1622.
   Google Scholar
• Nigam Y, Knight J, Williams N. Gastrointestinal tract 5: the anatomy and functions of the large intestine. Nurs Times. 2019;115(10):50–53.
   Google Scholar
• Anbazhagan AN, Priyamvada S, Alrefai WA, Dudeja PK. Pathophysiology of IBD associated diarrhea. Tissue Barriers. 2018;6(2):e1463897. doi:10.1080/21688370.2018.1463897
   PubMed Web of Science ®Google Scholar
• Bruzzese E, Giannattasio A, Guarino A. Antibiotic treatment of acute gastroenteritis in children. F1000Research. 2018;7:193. doi:10.12688/f1000research.12328.1
   PubMedGoogle Scholar
• Feng X, Zhuang L, Chen L, Zhao H, Huang R, Guo Z. Comparison of different probiotics in the treatment of acute diarrhea in children: a protocol for systematic review and network meta-analysis. Medicine (Baltimore). 2022;101(11):e28899.
   PubMed Web of Science ®Google Scholar
• Stefano G, Anil D. Textbook of Pediatric Gastroenterology, Hepatology and Nutrition. 2nd ed. Springer Cham; 2021:1095.
   Google Scholar
• Shankar S, Rosenbaum J. Chronic diarrhoea in children: a practical algorithm-based approach. J Paediatr Child Health. 2020;56(7):1029–1038. doi:10.1111/jpc.14986
   PubMed Web of Science ®Google Scholar
• Apers S, Baronikova S, Sindambiwe JB, et al. Antiviral, haemolytic and molluscicidal activities of triterpenoid saponins from Maesa lanceolata: establishment of structure-activity relationships. Planta Med. 2001;67(6):528–532. doi:10.1055/s-2001-16489
   PubMed Web of Science ®Google Scholar
• Katuura E, Waako P, Ogwal-Okeng J, Bukenya-Ziraba R. Traditional treatment of malaria in Mbarara District, western Uganda. Afr J Ecol. 2007;45(SUPPL. 1):48–51. doi:10.1111/j.1365-2028.2007.00737.x
   Google Scholar
• Julius G. Some pharmacological effects of the leaf extracts of Vernonia lasiopus and maesa lanceolata: plants traditionally used to treat common ailments in humans in East Africa. Am J Res Commun. 2009;5:12–42. doi:10.1016/j.jhydrol.2017.11.003
   Google Scholar
• Abdela G, Girma Z, Awas T. Ethnobotanical study of medicinal plant species in Nensebo District, south-eastern Ethiopia. Ethnobot Res Appl. 2022;24:1–25.
   Google Scholar
• Mercy GT, Amon A, Patrick EO, Casim UT, Clement OA, Esther K. Medicinal plants used in gynecological procedures in Uganda. J Med Plants Res. 2020;14(4):185–194. doi:10.5897/JMPR2019.6847
   Google Scholar
• Haile A. Ethnobotanical study of medicinal plants used by local people of Mojana Wadera Woreda, North Shewa Zone, Amhara Region, Ethiopia. Asian J Ethnobiol. 2022;5(1):35–43. doi:10.13057/asianjethnobiol/y050104
   Google Scholar
• Agize M, Asfaw Z, Nemomissa S, Gebre T. Ethnobotany of traditional medicinal plants and associated indigenous knowledge in Dawuro Zone of Southwestern Ethiopia. J Ethnobiol Ethnomed. 2022;18(1):48. doi:10.1186/s13002-022-00546-4
   PubMed Web of Science ®Google Scholar
• Tadesse D, Eguale T, Giday M, Mussa A. Ovicidal and larvicidal activity of crude extracts of Maesa lanceolata and Plectranthus punctatus against Haemonchus contortus. J Ethnopharmacol. 2009;122(2):240–244. doi:10.1016/j.jep.2009.01.014
   PubMed Web of Science ®Google Scholar
• Sindambiwe JB, Calomme M, Geerts S, Pieters L, Vlietinck AJ, Vanden Berghe DA. Evaluation of biological activities of triterpenoid saponins from Maesa lanceolata. J Nat Prod. 1998;61(5):585–590. doi:10.1021/np9705165
   PubMed Web of Science ®Google Scholar
• Fokam Tagne MA, Tchoffo A, Noubissi PA, et al. Effects of hydro-ethanolic extract of leaves of Maesa lanceolata (Mursinaceae) on acetic acid-induced ulcerative colitis in rats. Inflammopharmacology. 2021;29(4):1211–1223. doi:10.1007/s10787-021-00825-8
   PubMed Web of Science ®Google Scholar
• Mekonnen Bayisa Y, Seid Bultum M. Extraction of oil from Maesa lanceolata seeds and evaluation of its antimicrobial activities. S Afr J Chem Eng. 2022;40:126–133. doi:10.1016/j.sajce.2022.02.007
   Google Scholar
• Okemo PO, Bais HP, Vivanco JM. In vitro activities of Maesa lanceolata extracts against fungal plant pathogens. Fitoterapia. 2003;74(3):312–316. doi:10.1016/S0367-326X(03)00039-X
   PubMed Web of Science ®Google Scholar
• Shin SY, Dekebo A, Dinku W, et al. Identification of an anticancer compound contained in seeds of Maesa lanceolata, a medicinal plant in Ethiopia. J Korean Soc Appl Biol Chem. 2014;57(4):519–522. doi:10.1007/s13765-014-4177-y
   Google Scholar
• Katuura E, Waako P, Tabuti JRS, Bukenya-Ziraba R, Ogwal-Okeng J. Antiplasmodial activity of extracts of selected medicinal plants used by local communities in western Uganda for treatment of malaria. Afr J Ecol. 2007;45:94–98. doi:10.1111/j.1365-2028.2007.00864.x
   Web of Science ®Google Scholar
• Lulekal E, Asfaw Z, Kelbessa E, Van Damme P. Ethnomedicinal study of plants used for human ailments in Ankober District, North Shewa Zone, Amhara Region, Ethiopia. J Ethnobiol Ethnomed. 2013;9(1):1–13. doi:10.1186/1746-4269-9-63
   PubMedGoogle Scholar
• Kumar S, Rajput MK, Tickoo SB. Laws, regulations, policies and guidelines governing the care and use of laboratory animals. In: Nagarajan P, Gudde R, Srinivasan R, editors. Essentials of Laboratory Animal Science: Principles and Practices [Internet]. Singapore: Springer Singapore; 2021:23–38. doi:10.1007/978-981-16-0987-9_2
   Google Scholar
• Walum E. Acute oral toxicity. Environ Health Perspect. 1998;106 Suppl(Suppl 2):497–503.
   Google Scholar
• Rabiu Abubakar A, Sani IH, Malami S, Yaro AH. Quantitative determination of secondary metabolites of fractions obtained from Solanum aethiopicum (L.) Fruit. Dutse J Pure Appl Sci. 2020;6(3):25–33.
   Google Scholar
• Mosisa Gudeta B, Melesie Taye G, Abula T, Alemayehu Gadisa D. Evaluation of anti-diarrheal activity of 80% methanol extracts of Vernonia amygdalina Delile (Asteraceae) leaves in mice. J Exp Pharmacol. 2020;12:455–462. doi:10.2147/JEP.S282669
   PubMedGoogle Scholar
• Shaikh JR, Patil M. Qualitative tests for preliminary phytochemical screening: an overview. Int J Chem Stud. 2020;8(2):603–608. doi:10.22271/chemi.2020.v8.i2i.8834
   Google Scholar
• OECD. Organization of economic corporation and development‟s guideline for the testing of chemical No; 425. Manual. 2008;3(October):27.
   Google Scholar
• Patil VP, Hugar S, Sukanya Pramod P, Hanakunti Math N, Pampanagouda Patil V. Evaluation of antidiarrhoeal activity of extract of Moringa Oleifera Pods. Artic Int J Pharm Phytopharm Res. 2019;9(3):128–134.
   Google Scholar
• Birru EM, Asrie AB, Adinew GM, Tsegaw A. Antidiarrheal activity of crude methanolic root extract of Idigofera spicata Forssk.(Fabaceae). BMC Complement Altern Med. 2016;16:272. doi:10.1186/s12906-016-1252-4
   PubMed Web of Science ®Google Scholar
• Sisay M, Engidawork E, Shibeshi W. Evaluation of the antidiarrheal activity of the leaf extracts of Myrtus communis Linn (Myrtaceae) in mice model. BMC Complement Altern Med. 2017;17(1):103. doi:10.1186/s12906-017-1625-3
   PubMedGoogle Scholar
• Timothy C, Lizzy M, Richard K, Angela M, Christine B. Antimicrobial activity and safety of Maesa lanceolata for the treatment and management of selected bacterial pathogens. J Adv Microbiol. 2018;8(3):1–8. doi:10.9734/JAMB/2018/39450
   Google Scholar
• Nortjie E, Basitere M, Moyo D, Nyamukamba P. Extraction methods, quantitative and qualitative phytochemical screening of medicinal plants for antimicrobial textiles: a review. Plants(Basel, Switzerland). 2022;11(15). doi:10.3390/plants11152011
   Google Scholar
• Erhirhie E, Emudainohwo T, Igboeme S, et al. Preclinical screening techniques for antidiarrheal drugs: a comprehensive review. Am J Physiol Biochem Pharmacol. 2018;7(2):61. doi:10.5455/ajpbp.20180329014330
   Google Scholar
• Ogunro OB, Ofeniforo EB. Ethanol extract of Spondias mombin L. Leaves exhibits antidiarrhoeal activity by stimulation of Na+–K+ ATPase, inhibition of prostaglandins or suppression of nitric oxide; 2021.
   Google Scholar
• Araújo TSL, de Oliveira TM, de Sousa NA, et al. Biopolymer extracted from Anadenanthera colubrina (Red Angico Gum) exerts therapeutic potential in mice: antidiarrheal activity and safety assessment. Pharmaceuticals (Basel). 2020;13(1):17. doi:10.3390/ph13010017
   PubMedGoogle Scholar
• Shahed-Al-Mahmud M, Shawon MJA, Islam T, Rahman MM, Rahman MR. In vivo anti-diarrheal activity of methanolic extract of Streblus asper leaves stimulating the Na(+)/K(+)-ATPase in Swiss Albino Rats. Indian J Clin Biochem. 2020;35(1):72–79. doi:10.1007/s12291-018-0781-7
   PubMed Web of Science ®Google Scholar
• Ahmed MU, Arise RO, Umaru IJ, Mohammed A. Antidiarheal activity of catechol and ethyl 5, 8,11,14,17 - icosapentanoate-rich fraction of Annona senegalensis stem bark. J Tradit Complement Med. 2022;12(2):190–194. doi:10.1016/j.jtcme.2021.07.007
   PubMedGoogle Scholar
• Dong CL, Qin Y, Ma JX, et al. The active ingredients identification and antidiarrheal mechanism analysis of Plantago asiatica L. Superfine powder. Front Pharmacol. 2020;11:612478. doi:10.3389/fphar.2020.612478
   PubMed Web of Science ®Google Scholar
• Ukwuani-Kwaja AN, Yakubu IL, Mustapha AS, Makun B. Antidiarrhoeal effects of hydromethanolic leaves Extract of Ipomea asarifolia in Albino Rat Model. J Complement Altern Med Res. 2019;1–7. doi:10.9734/jocamr/2019/v7i430106
   Google Scholar
• Njideka F, Chidinma F, Nnah S, Ebaimoh F. Antimicrobial activity and anti-diarrheal potentials ofAntimicrobial activity and anti-diarrheal potentials of Psidium guajava Linn leaf extract in experimental rat models. Anim Res International. 2022;19(2):4530–4542.
   Google Scholar
• Sarkar KK, Mitra T, Rahman MA, et al. In vivo bioactivities of Hoya parasitica (Wall.) and in silico study against Cyclooxygenase Enzymes. Biomed Res Int. 2022;2022:1331758. doi:10.1155/2022/1331758
   PubMed Web of Science ®Google Scholar
• Elgorashi EE, McGaw LJ. African plants with in vitro anti-inflammatory activities: a review. South African J Bot. 2019;126:142–169. doi:10.1016/j.sajb.2019.06.034
   Web of Science ®Google Scholar
• Olanrewaju Oyindamola J, Christian Akuodor G, Ifeanyi Obi M, Ogochukwu Nwachukwu E, Chilaka KC, Irinmwinuwa OE. Comparative assessment of the anti-diarrhoeal effects of the ethanol leaf and stem extracts of lantana camara in Wistar rats. Magna Sci Adv Res Rev. 2021;3(1):035–45. doi:10.30574/msarr.2021.3.1.0059
   Google Scholar
• Degu A, Engidawork E, Shibeshi W. Evaluation of the anti-diarrheal activity of the leaf extract of Croton macrostachyus Hocsht. ex Del. (Euphorbiaceae) in mice model. BMC Complement Altern Med. 2016;16(1):379. doi:10.1186/s12906-016-1357-9
   PubMed Web of Science ®Google Scholar
• Ferede YA, Zewdu WS, Zeleke MM, Alemu MA. Evaluation of antidiarrheal activity of 80% methanolic extract of the leaves of Cordia africana (Lamiaceae) in mice. Evid Based Complement Alternat Med. 2021;2021:3627878. doi:10.1155/2021/3627878
   PubMed Web of Science ®Google Scholar
• Elisha IL, Dzoyem JP, McGaw LJ, Botha FS, Eloff JN. The anti-arthritic, anti-inflammatory, antioxidant activity and relationships with total phenolics and total flavonoids of nine South African plants used traditionally to treat arthritis. BMC Complement Altern Med. 2016;16(1):307. doi:10.1186/s12906-016-1301-z
   PubMedGoogle Scholar
• Adebayo SA, Amoo SO. South African botanical resources: a gold mine of natural pro-inflammatory enzyme inhibitors? South African J Bot. 2019;123:214–227. doi:10.1016/j.sajb.2019.03.020
   Web of Science ®Google Scholar
• Zhao SR, Ni XM, Zhang XA, Tian H. Effect of cognitive behavior therapy combined with exercise intervention on the cognitive bias and coping styles of diarrhea-predominant irritable bowel syndrome patients. World J Clin Cases. 2019;7(21):3446–3462. doi:10.12998/wjcc.v7.i21.3446
   PubMed Web of Science ®Google Scholar
• Anggraeni R, Aljaberi MAA, Nisha Nambiar N, Sansuwito TB, Wati NL. The relationship of supplementary feeding, breast milk (MP-ASI) to infants with the event of diarrhea. Int J Nurs Inf. 2022;1(1):1–9.
   Google Scholar
• Obioma Obiorah E, Obu DC, Ezeanosike OB, Akuodor GC, Anusiem CA, Okorie AU. Ethanol leaf extract of Dialium guineense produces anti-diarrhoeal and gastrointestinal motility slowing activities in Wistar rats. Magna Sci Adv Res Rev. 2022;5(1):018–24. doi:10.30574/msarr.2022.5.1.0088
   Google Scholar
• Douho Djimeli RC, Nchouwet ML, Poualeu Kamani SL, Tchoumba Tchoumi LM, Kamanyi A, Wansi Ngnokam SL. Antisecretory and spasmolytic activities of aqueous and ethanolic stem bark extracts of Nauclea diderrichii in Wistar rats. Biomed Res Int. 2022;2022:7569848. doi:10.1155/2022/7569848
   PubMed Web of Science ®Google Scholar
• Ahmad MH, Usman AG, Abba SI. Comparative performance of extreme learning machine and Hammerstein-Weiner models for modelling the intestinal hyper-motility and secretory inhibitory effects of methanolic leaf extract of Combretumhypopilinum Diels (Combretaceae). In Silico Pharmacol. 2021;9(1):31. doi:10.1007/s40203-021-00090-1
   PubMedGoogle Scholar
• Desta GT, Adela Alemu M, Tsegaw A, Belete TM, Adugna BY. Antidiarrheal effect of 80% methanol extract and fractions of Clerodendrum myricoides (Hochst.) Vatke (Lamiaceae) Leaf in Swiss Albino Mice. Evid Based Complement Alternat Med. 2021;2021:9369173. doi:10.1155/2021/9369173
   PubMed Web of Science ®Google Scholar
• Bulbul IJ, Shanta AP, Rashid MA. Evaluation of antidiarrheal activity of Leea aequata L. (Family: Vitaceae) in mice models. Bangladesh Pharm J. 2022;25(2):180–187. doi:10.3329/bpj.v25i2.60969
   Google Scholar
• Akter S, Roy R, Basher DMA. Methanolic extract of Pycreus polystachyos possesses potent antidiarrheal activity that varies in male and female mice. J Pharmacogn Phytochem. 2022;11(2):151–154. doi:10.22271/phyto.2022.v11.i2b.14381
   Google Scholar
• Andargie Y, Sisay W, Molla M, Adela M. Evaluation of In vivo antidiarrheal activity of hydro-methanolic extract of the root of Rumex nepalensis in Swiss Albino mice. Metab Open. 2022;15:100197. doi:10.1016/j.metop.2022.100197
   PubMedGoogle Scholar
• Mekonnen B, Asrie AB, Wubneh ZB. Antidiarrheal activity of 80% methanolic leaf extract of Justicia schimperiana. Evid Based Complement Alternat Med. 2018;2018:3037120. doi:10.1155/2018/3037120
   PubMed Web of Science ®Google Scholar
• National Research Council. Guide for the Care and Use of Laboratory Animals. 8th ed.; 2011:246.
   Google Scholar