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ORIGINAL RESEARCH

Acute and Sub-Acute Toxicity Evaluation of the Crude Methanolic Extract of Justicia schimperiana Leaf in Wistar Albino Rats

ORCID Icon, , , , & ORCID Icon
Pages 467-483 | Received 12 Oct 2023, Accepted 09 Nov 2023, Published online: 17 Nov 2023

References

  • Abebe D. Traditional medicine in Ethiopia: the attempts being made to promote it for effective and better utilization. SINET. 1986;9:61–69.
  • Bannerman RH, Burton J. Traditional medicine and health care coverage. J Mod Afr Stud. 1984;22(4):695–696. doi:10.1017/S0022278X00056421
  • Desta B. Ethiopian traditional herbal drugs: potentiality and appropriate utilization. In: 8th International Conference of Ethiopian Studies. Addis Ababa; 1984:763–766.
  • Abebe W. Traditional pharmaceutical practice in Gondar region, northwestern Ethiopia. J Ethnopharmacol. 1984;11(1):33–47. doi:10.1016/0378-8741(84)90094-1
  • Abebe D. Proceedings of the workshop on development and utilization of herbal remedies in Ethiopia. Addis Ababa: Ethiopian Health and Nutrition Research Institute; 1996.
  • Bekele-Tesemma A. Useful Trees and Shrubs of Ethiopia: Identification, Propagation and Management for 17 Agroclimatic Zones; 2007.
  • Corrêa GM, de Alcântara AFC. Chemical constituents and biological activities of species of Justicia: a review. Rev Bras Farmacogn. 2012;22(1):220–238. doi:10.1590/S0102-695X2011005000196
  • Abera B. Medicinal plants used in traditional medicine by Oromo people, Ghimbi District, Southwest Ethiopia. J Ethnobiol Ethnomed. 2014;10(1):40. doi:10.1186/1746-4269-10-40
  • Yineger H, Kelbessa E, Bekele T, Lulekal E. Plants used in traditional management of human ailments at Bale Mountains National Park, Southeastern Ethiopia. J Med Plants Res. 2008;2(6):132–153.
  • Chekole G, Asfaw Z, Kelbessa E. Ethnobotanical study of medicinal plants in the environs of Tara-gedam and Amba remnant forests of Libo Kemkem District, northwest Ethiopia. J Ethnobiol Ethnomed. 2015;11(1). doi:10.1186/1746-4269-11-4
  • Teklehaymanot T, Giday M. Ethnobotanical study of medicinal plants used by people in Zegie Peninsula, Northwestern Ethiopia. J Ethnobiol Ethnomed. 2007;3:3. doi:10.1186/1746-4269-3-12
  • Limenew A, Tadesse M. Phytochemical screening and peroxide value determination of methanolic extract of four traditional medicinal plants from Debre Tabor Town, Ethiopia. J Med Plants Res. 2018;12(16):203–208. doi:10.5897/jmpr2018.6579
  • Mekonnen B, Asrie AB, Wubneh ZB. Antidiarrheal Activity of 80% Methanolic Leaf Extract of Justicia schimperiana. Evid Based Complement Alternat Med. 2018;2018:1–10. doi:10.1155/2018/3037120
  • Gizaw A, Marami LM, Teshome I, et al. Phytochemical screening and in vitro antifungal activity of selected medicinal plants against candida albicans and Aspergillus Niger in West Shewa Zone, Ethiopia. Adv Pharmacol Pharm Sci. 2022;2022:1–8. doi:10.1155/2022/3299146
  • Abdela JE, Engidawork E, Shibeshi W. In vivo antimalarial activity of solvent fractions of the leaf of Justicia schimperiana Hochst. Ex Nees (Acanthaceae) against Plasmodium berghei in mice. Ethiop Pharm J. 2014;30(October 2015):95–108. doi:10.4314/epj.v30i2.3
  • Tesera Y, Desalegn A, Tadele A, et al. Phytochemical screening, acute toxicity and anti-rabies activities of extracts of selected Ethiopian traditional medicinal plants. J Pharm Res. 2022;7(150). doi:10.33140/JPR.07.01.06
  • Gebrewoled S, Giorgis G, Ambikar D, Tsegaw A, Belayneh YM. Wound healing activity of 80% methanolic crude extract and solvent fractions of the leaves of justicia schimperiana (Hochst. ex Nees) T. Anderson (Acanthaceae) in Mice. J Exp Pharmacol. 2022. doi:10.2147/JEP.S340177
  • Asfere Y, Zinabu D, Kebede A, Aiello F. In-vitro antimicrobial activities and phytochemical screening of selected plant extracts against some medically and agriculturally important pathogens. European J Med Plants. 2020;31(10):167–189. doi:10.9734/ejmp/2020/v31i1030293
  • Abebe H, Kibret B, Haile A. Phytochemical investigation on leaf extract of Adhatoda schimperiana, Ethiopia. J Med Plants Stud. 2014;2(2):23–31.
  • Tafesse T. Chemical composition and antimicrobial activity study of root extracts of Justicia schimperiana; 2017.
  • Carneiro MRB, Sallum LO, Martins JLR, de Peixoto JC, Napolitano HB, Rosseto LP. Overview of the justicia genus: insights into its chemical diversity and biological potential. Molecules. 2023;28(3):1190. doi:10.3390/molecules28031190
  • Abebe W, Zhang W, Zhang S, Xie G. Chemical composition and antimicrobial activity of essential oil from justicia schimperiana. J Pharmacogn Nat Prod. 2018;04(02):6–8. doi:10.4172/2472-0992.1000154
  • Bobasa EM, Alemu BG, Berkessa ST, et al. Antimalarial activity of selected Ethiopian medicinal plants in mice. J Pharm Pharmacogn Res. 2018;6(1):57–64.
  • Petros Z, Melaku D. In vivo anti-plasmodial activity of Adhatoda schimperiana leaf extract in mice. PhramacologyOnline. 2012;3:95–103.
  • Tesfaye A, Makonnen E, Gedamu S. Hypoglycemic and antihyperglycemic activity of aqueous extract of Justicia Schimperiana leaves in normal and streptozotocin-induced diabetic mice. Int J Pharma Sci Res. 2016;7(2):110–113.
  • Umer S, Asres K, Veeresham C. Hepatoprotective activities of two Ethiopian medicinal plants. Pharm Biol. 2010;48(4):461–468. doi:10.3109/13880200903173593
  • Petros Z, Makonnen E, Debella A. Tracheal relaxant effect of column chromatographic elutes of chloroform fraction of Adhatoda schimperiana leaves in Guinea-pigs. Pharmacogn Mag. 2009;5(17):86.
  • Petros Z, Makonnen E, Debella A. Bronchodilatory and respiratory distress protective effect of fractions isolated from Adhatoda schimperiana in Guinea-pigs. Pharmacologyonline. 2008;2:889–900.
  • Assefa A, Urga K, Melaku D, Guta M, Mekonnen W. Bronchodilator and anti-inflammatory activities of Adhatoda schimperiana. Ethiop J Health Sci. 2016;18(2). doi:10.4314/ejhs.v18i2
  • Seshathri K. Antimicrobial properties of Ethiopian chewing sticks against Candida albicans. J Appl Pharm Sci. 2012;02(01):45–50.
  • Zewde D, Dawo F, Hurisa B, Mengesha A, Tadele A. Determination of anti-rabies virus activities of crude extracts from some traditionally used medicinal plants in East Wollega, Ethiopia. Int J Basic Appl Virol. 2019;8(2):28–37. doi:10.5829/idosi.ijbav.2019.28.37
  • Ekor M. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol. 2014;4. doi:10.3389/FPHAR.2013.00177/ABSTRACT
  • Aydin A, Aktay G, Yesilada E. A guidance manual for the toxicity assessment of traditional herbal medicines. Nat Prod Commun. 2016;11(11):1763–1773. doi:10.1177/1934578x1601101131
  • ScienceDirect Topics. Acute Toxicity Study - an overview. Available from: https://www.sciencedirect.com/topics/medicine-and-dentistry/acute-toxicity-study. Accessed November 1, 2023.
  • Rhiouani H, El-Hilaly J, Israili ZH, Lyoussi B. Acute and sub-chronic toxicity of an aqueous extract of the leaves of Herniaria glabra in rodents. J Ethnopharmacol. 2008;118(3):378–386. doi:10.1016/j.jep.2008.05.009
  • OECD. OECD Guidelines for the Testing of Chemicals: Acute Oral Toxicity - Acute Toxic Class Method-423. OECD; 2002.
  • OECD. OECD Guidelines for the testing of chemicals: repeated Dose 28-day Oral Toxicity Study in Rodents-407. In: OECD Guidelines for the Testing of Chemicals, Section 4. 2008; Paris:OECD Publishing. doi:10.1787/9789264070684-en
  • Cassileth B, Ladenheim D, Mccarthy T, et al. Evaluating the safety of herbal medicines: integrated toxicological approaches. Science. 2014;2014:(S):47–49.
  • OECD. OECD Guidelines for the Testing of Chemicals: Acute Oral Toxicity-Up-and-Down-Procedure-425. OECD; 2001.
  • Oladotun AO, Michael O, Daniyan Gbola O. Biochemical, hematological and histopathological evaluation of the toxicity potential of the leaf extract of Stachytarpheta cayennensis in rats. J Tradit Complement Med. 2020;10(6):544–554. doi:10.1016/j.jtcme.2019.05.001
  • American Veterinary Medical Association (AVMA). AVMA Guidelines for the Euthanasia of Animals: 2020. Schaumburg: American Veterinary Medical Association; 1931. Available from: https://www.avma.org. Accessed November 10, 2023.
  • Hodge A, Sterner B. Toxicity classes in: Canadian Center for occupational health and safety; 2005.
  • Tan PV, Mezui C, Enow-Orock G, Njikam N, Dimo T, Bitolog P. Teratogenic effects, acute and sub chronic toxicity of the leaf aqueous extract of Ocimum suave Wild (Lamiaceae) in rats. J Ethnopharmacol. 2008;115(2):232–237. doi:10.1016/j.jep.2007.09.022
  • Nirogi R, Goyal VK, Jana S, Pandey SK, Gothi A. What suits best for organ weight Analysis: review of relationship between organ weight and body/brain weight for rodent toxicity studies. Int J Pharm Sci Res. 2014;5(4):1525–1532.
  • Michael B, Yano B, Sellers RS, et al. Evaluation of organ weights for rodent and non-rodent toxicity studies: a review of regulatory guidelines and a survey of current practices. Int J Pharm Sci Res. 2007;35(5):742–750. doi:10.1080/01926230701595292
  • Piao Y, Liu Y, Xie X. Change trends of organ weight background data in Sprague Dawley rats at different ages. J Toxicol Pathol. 2013;26(1):29–34. doi:10.1293/tox.26.29
  • Akintimehin ES, Karigidi KO, Omogunwa TS, Adetuyi FO. Safety assessment of oral administration of ethanol extract of Justicia carnea leaf in healthy Wistar rats: hematology, antioxidative and histology studies. Clin Phytoscience. 2021;7(1). doi:10.1186/s40816-020-00234-4
  • A-S OA, E-H TM, A-M AA. Effect of prolonged vigabatrin treatment on hematological and biochemical parameters in plasma, liver and kidney of Swiss albino mice. Sci Pharm. 2002;70(2):135–145. doi:10.3797/scipharm.aut-02-16
  • Akpamu U, Nwaopara AO, Izunya AM, et al. A comparative study on the acute and chronic effect of oral administration of Yaji (a complex Nigerian meat sauce) on some hematological parameters. Br J Pharmacol Toxicol. 2011;2(3):108–112.
  • Vigneshwar R, Arivuchelvan A, Mekala P, Imayarasi K. Sex-specific reference intervals for Wistar albino rats: hematology and clinical biochemistry. Indian J Anim Heal. 2021;60(1):58–65. doi:10.36062/ijah.60.1.2021.58-65
  • Jacobson-Kram D, Keller KA. Toxicological testing handbook: principles, applications and data interpretation. Informa Health Care. 2006;2006:1.
  • Rahman MF, Siddiqui MKJ, Jamil K. Effects of Vepacide (Azadirachta indica) on asp artate and al anine aminotransferase profiles in a subchronic study with rats. Hum Exp Toxicol. 2001;20(5):243–249. doi:10.1191/096032701678227730
  • Thapa BR, Walia A. Liver function tests and their interpretation. Indian J Pediatr. 2007;74:663–671. doi:10.1007/s12098-007-0118-7