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ORIGINAL RESEARCH

Dapagliflozin Pretreatment Prevents Cardiac Electrophysiological Changes in a Diet and Streptozotocin Induction of Type 2 Diabetes in Rats: A Potential New First-Line?

ORCID Icon, ORCID Icon, &
Pages 123-133 | Received 15 Oct 2023, Accepted 22 Feb 2024, Published online: 19 Mar 2024

References

  • Maejima Y. SGLT2 inhibitors play a salutary role in heart failure via modulation of the mitochondrial function. Front Cardiovasc Med. 2020;6. doi:10.3389/fcvm.2019.00186
  • Ferrini M, Johansson I, Aboyans V. Heart failure and its complications in patients with diabetes: mounting evidence for a growing burden. Eur J Prev Cardiol. 2019;26(2_suppl):106–113. doi:10.1177/2047487319885461
  • Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L. Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence. Nat Rev Cardiol. 2020;17(9):585–607. doi:10.1038/s41569-020-0339-2
  • Borghetti G, Von Lewinski D, Eaton DM, Sourij H, Houser SR, Wallner M. Diabetic cardiomyopathy: current and future therapies. Beyond glycemic control. Front Physiol. 2018;9:1–15. doi:10.3389/fphys.2018.01514
  • Filardi T, Ghinassi B, Di Baldassarre A, et al. Cardiomyopathy associated with diabetes: the central role of the cardiomyocyte. Int J Mol Sci. 2019;20(13):3299. doi:10.3390/ijms20133299
  • Varma U, Koutsifeli P, Benson VL, Mellor KM, Delbridge LMD. Molecular mechanisms of cardiac pathology in diabetes – experimental insights. Biochim Biophys Acta Mol Basis Dis. 2018;1864(5):1949–1959. doi:10.1016/j.bbadis.2017.10.035
  • Zhang Y, Wang Y, Yanni J, et al. Electrical conduction system remodeling in streptozotocin-induced diabetes mellitus rat heart. Front Physiol. 2019;10:1–15. doi:10.3389/fphys.2019.00826
  • Stern S, Sclarowsky S. The ecg in diabetes mellitus. Circulation. 2009;120(16):1633–1636. doi:10.1161/CIRCULATIONAHA.109.897496
  • Konopelski P, Ufnal M. Electrocardiography in rats: a comparison to human. Physiol Res. 2016;65(5):717–725. doi:10.33549/physiolres.933270
  • Pabon MA, Manocha K, Cheung JW, Lo JC. Linking arrhythmias and adipocytes: insights, mechanisms, and future directions. Front Physiol. 2018;9:1–12. doi:10.3389/fphys.2018.01752
  • Patel KHK, Hwang T, Liebers CS, Ng FS. Epicardial adipose tissue as a mediator of cardiac arrhythmias. Am J Physiol Heart Circ Physiol. 2022;322(2):H129–H144. doi:10.1152/ajpheart.00565.2021
  • Filippatos TD, Liontos A, Papakitsou I, Elisaf MS. SGLT2 inhibitors and cardioprotection: a matter of debate and multiple hypotheses. Postgrad Med. 2019;131(2):82–88. doi:10.1080/00325481.2019.1581971
  • Wiviott SD, Raz I, Bonaca MP, et al. Dapagliflozin and cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2019;380(4):347–357. doi:10.1056/NEJMoa1812389
  • Ni L, Yuan C, Chen G, et al. SGLT2i: beyond the glucose-lowering effect. Cardiovasc Diabetol. 2020;19(1). doi:10.1186/s12933-020-01071-y
  • Driver C, Bamitale KDS, Kazi A, Olla M, Nyane NA, Owira PMO. Cardioprotective Effects of Metformin. J Cardiovasc Pharmacol. 2018;72(2):121–127. doi:10.1097/FJC.0000000000000599
  • Ye Y, Bajaj M, Yang HC, Perez-Polo JR, Birnbaum Y. SGLT-2 inhibition with dapagliflozin reduces the activation of the Nlrp3/ASC inflammasome and attenuates the development of diabetic cardiomyopathy in mice with type 2 diabetes. further augmentation of the effects with saxagliptin, a DPP4 inhibitor. Cardiovasc Drugs Ther. 2017;31(2):119–132. doi:10.1007/s10557-017-6725-2
  • Nair A, Jacob S. A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm. 2016;7(2):27. doi:10.4103/0976-0105.177703
  • Argun M, Üzüm K, Sönmez MF, et al. Cardioprotective effect of metformin against doxorubicin cardiotoxicity in rats. Anatol J Cardiol. 2016;16(4):234–241. doi:10.5152/akd.2015.6185
  • Chege BM, Waweru MP, Frederick B, Nyaga NM. The freeze-dried extracts of Rotheca myricoides (Hochst.) Steane & Mabb possess hypoglycemic, hypolipidemic and hypoinsulinemic on type 2 diabetes rat model. J Ethnopharmacol. 2019;232:244. doi:10.1016/j.jep.2019.112077
  • Novelli ELB, Diniz YS, Galhardi CM, et al. Anthropometrical parameters and markers of obesity in rats. Lab Anim. 2007;41(1):111–119. doi:10.1258/002367707779399518
  • Ayala JE, Samuel VT, Morton GJ, et al. Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice. DMM Dis Models Mech. 2010;3(9–10):525–534. doi:10.1242/dmm.006239
  • Mutiso SK, Rono DK, Bukachi F. Relationship between anthropometric measures and early electrocardiographic changes in obese rats. BMC Res Notes. 2014;7(1). doi:10.1186/1756-0500-7-931
  • Kumar AHS. Effectively communicating the 5R’s (replace, reduce, refine, reuse, and rehabilitate) of research ethics, biomedical waste, personalized medicines and the rest. J Nat Sci Biol Med. 2012;3(1):1–2. doi:10.4103/0976-9668.95932
  • Mauricio D, Alonso N, Gratacòs M. Chronic Diabetes Complications: the Need to Move beyond Classical Concepts. Trends Endocrinol Metab. 2020;31(4):287–295. doi:10.1016/j.tem.2020.01.007
  • Chen HY, Huang JY, Siao WZ, Jong GP. The association between SGLT2 inhibitors and new-onset arrhythmias: a nationwide population-based longitudinal cohort study. Cardiovasc Diabetol. 2020;19(1). doi:10.1186/s12933-020-01048-x
  • Gupta S, Gupta RK, Kulshrestha M, Chaudhary RR. Evaluation of ECG abnormalities in patients with asymptomatic type 2 diabetes mellitus. J Clin Diagn Res. 2017;11(4):OC39–OC41. doi:10.7860/JCDR/2017/24882.9740
  • Ring A, Brand T, Macha S, et al. The sodium glucose cotransporter 2 inhibitor empagliflozin does not prolong QT interval in a thorough QT (TQT) study. Cardiovasc Diabetol. 2013;12(1):70. doi:10.1186/1475-2840-12-70
  • Zhang Y, Post WS, Blasco-Colmenares E, Dalal D, Tomaselli GF, Guallara E. Electrocardiographic QT interval and mortality: a meta-analysis. Epidemiology. 2011;22(5):660–670. doi:10.1097/EDE.0b013e318225768b
  • Siscovick DS, Sotoodehnia N, Rea TD, Raghunathan TE, Jouven X, Lemaitre R. Type 2 diabetes mellitus and the risk of sudden cardiac arrest in the community. Rev Endocr Metab Disord. 2012;11(1):53–59. doi:10.1007/s11154-010-9133-5.Type
  • Carlson GF, Tou CKP, Parikh S, Birmingham BK, Butler K. Evaluation of the effect of dapagliflozin on cardiac repolarization: a thorough QT/QTc study. Diabetes Therapy. 2011;2(3):123–132. doi:10.1007/s13300-011-0003-2
  • Dhingra R, Pencina MJ, Wang TJ, et al. Electrocardiographic QRS duration and the risk of congestive heart failure: the Framingham heart study. Hypertension. 2006;47(5):861–867. doi:10.1161/01.HYP.0000217141.20163.23
  • Nantsupawat T, Wongcharoen W, Chattipakorn SC, Chattipakorn N. Effects of metformin on atrial and ventricular arrhythmias: evidence from cell to patient. Cardiovasc Diabetol. 2020;19(1):198. doi:10.1186/S12933-020-01176-4
  • Okin PM, Devereux RB, Lee ET, Galloway JM, Howard BV. Electrocardiographic repolarization complexity and abnormality predict all-cause and cardiovascular mortality in diabetes: the strong heart study. Diabetes. 2004;53(2):434–440. doi:10.2337/diabetes.53.2.434
  • Solomon SD, Zelenkofske S, Mcmurray JJ, et al. Sudden death in patients with myocardial infarction and left ventricular dysfunction, heart failure, or both. N Engl J Med. 2005;352(25):2581–2588.
  • Sato T, Aizawa Y, Yuasa S, et al. The effect of dapagliflozin treatment on epicardial adipose tissue volume. Cardiovasc Diabetol. 2018;17(1):1–9. doi:10.1186/s12933-017-0658-8
  • Yagi S, Hirata Y, Ise T, et al. Canagliflozin reduces epicardial fat in patients with type 2 diabetes mellitus. Diabetol Metab Syndr. 2017;9(1):1–7. doi:10.1186/s13098-017-0275-4
  • Paneni F, Costantino S, Hamdani N. Regression of left ventricular hypertrophy with SGLT2 inhibitors. Eur Heart J. 2020;41(36):3433–3436. doi:10.1093/eurheartj/ehaa530
  • Oikonomou EK, Antoniades C. The role of adipose tissue in cardiovascular health and disease. Nat Rev Cardiol. 2019;16(2):83–99. doi:10.1038/s41569-018-0097-6
  • Tsimihodimos V, Panagiotopoulou T, Tzavella E, Elisaf M. Clinical pharmacology of sodium glucose cotransporter 2 inhibitors. Hellenic J Atherosc. 2017;8(2):61–72.
  • Daniele G, Xiong J, Solis-Herrera C, et al. Dapagliflozin enhances fat oxidation and ketone production in patients with type 2 diabetes. Diabetes Care. 2016;39(11):2036–2041. doi:10.2337/dc15-2688
  • Ritchie RH, Dale Abel E. Basic mechanisms of diabetic heart disease. Circ Res. 2020;126(11):1501–1525. doi:10.1161/CIRCRESAHA.120.315913
  • Drzewoski J, Kasznicki J, Trojanowski Z. The role of “metabolic memory” in the natural history of diabetes mellitus. Pol Arch Med Wewn. 2009;119(7–8):493–500. doi:10.20452/PAMW.747
  • Testa R, Bonfigli AR, Prattichizzo F, La Sala L, De Nigris V, Ceriello A. The “Metabolic Memory” theory and the early treatment of hyperglycemia in prevention of diabetic complications. Nutrients. 2017;9(5):437. doi:10.3390/nu9050437
  • Jia G, Hill MA, Sowers JR. Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity. Circ Res. 2018;122(4):624–638. doi:10.1161/CIRCRESAHA.117.311586