References
- Meara JG, Leather AJ, Hagander L, et al. Global surgery 2030: evidence and solutions for achieving health, welfare, and economic development. Surgery. 2015;158(1):3–6. doi:10.1016/j.surg.2015.04.011
- Glare P, Aubrey KR, Myles PS. Transition from acute to chronic pain after surgery. Lancet. 2019;393(10180):1537–1546. doi:10.1016/S0140-6736(19)30352-6
- Goebel A, Birklein F, Brunner F, et al. The Valencia consensus-based adaptation of the IASP complex regional pain syndrome diagnostic criteria. Pain. 2021;162(9):2346–2348. doi:10.1097/j.pain.0000000000002245
- Carley ME, Chaparro LE, Choiniere M, et al. Pharmacotherapy for the prevention of chronic pain after surgery in adults: an updated systematic review and meta-analysis. Anesthesiology. 2021;135(2):304–325. doi:10.1097/ALN.0000000000003837
- Li Z, Tseng PY, Tiwari V, et al. Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain. Proc Natl Acad Sci U S A. 2017;114(10):E1996–E2005. doi:10.1073/pnas.1615255114
- Tiwari V, Anderson M, Yang F, et al. Peripherally acting mu-opioid receptor agonists attenuate ongoing pain-associated behavior and spontaneous neuronal activity after nerve injury in rats. Anesthesiology. 2018;128(6):1220–1236. doi:10.1097/ALN.0000000000002191
- Tiwari V, He SQ, Huang Q, et al. Activation of micro-delta opioid receptor heteromers inhibits neuropathic pain behavior in rodents. Pain. 2020;161(4):842–855. doi:10.1097/j.pain.0000000000001768
- Vaidya S, Shantanu PA, Tiwari V. Attenuation of ongoing neuropathic pain by peripheral acting opioid involves activation of central dopaminergic neurocircuitry. Neurosci Lett. 2021;754:135751. doi:10.1016/j.neulet.2021.135751
- Kang S, Lee D, Theusch BE, Arpey CJ, Brennan TJ. Wound hypoxia in deep tissue after incision in rats. Wound Repair Regen. 2013;21(5):730–739. doi:10.1111/wrr.12081
- Kim TJ, Freml L, Park SS, Brennan TJ. Lactate concentrations in incisions indicate ischemic-like conditions may contribute to postoperative pain. J Pain. 2007;8(1):59–66. doi:10.1016/j.jpain.2006.06.003
- Kido K, Gautam M, Benson CJ, Gu H, Brennan TJ. Effect of deep tissue incision on pH responses of afferent fibers and dorsal root ganglia innervating muscle. Anesthesiology. 2013;119(5):1186–1197. doi:10.1097/ALN.0b013e31829bd791
- Sugiyama D, Kang S, Brennan TJ, Binshtok A. Muscle Reactive Oxygen Species (ROS) contribute to post-incisional guarding via the TRPA1 receptor. PLoS One. 2017;12(1):e0170410. doi:10.1371/journal.pone.0170410
- Koban M, Leis S, Schultze-Mosgau S, Birklein F. Tissue hypoxia in complex regional pain syndrome. Pain. 2003;104(1):149–157. doi:10.1016/s0304-3959(02)00484-0
- Watts ER, Walmsley SR. Inflammation and hypoxia: HIF and PHD isoform selectivity. Trends Mol Med. 2019;25(1):33–46. doi:10.1016/j.molmed.2018.10.006
- Bernhardt WM, Gottmann U, Doyon F, et al. Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model. Proc Natl Acad Sci U S A. 2009;106(50):21276–21281. doi:10.1073/pnas.0903978106
- Deguchi H, Ikeda M, Ide T, et al. Roxadustat markedly reduces myocardial ischemia reperfusion injury in mice. Circ J. 2020;84(6):1028–1033. doi:10.1253/circj.CJ-19-1039
- Puzio M, Moreton N, O’Connor JJ. Neuroprotective strategies for acute ischemic stroke: targeting oxidative stress and prolyl hydroxylase domain inhibition in synaptic signalling. Brain Disord. 2022;5:100030. doi:10.1016/j.dscb.2022.100030
- Banik RK, Woo YC, Park SS, Brennan TJ. Strain and sex influence on pain sensitivity after plantar incision in the mouse. Anesthesiology. 2006;105(6):1246–1253. doi:10.1097/00000542-200612000-00025
- Wu K, Zhou K, Wang Y, et al. Stabilization of HIF-1 alpha by FG-4592 promotes functional recovery and neural protection in experimental spinal cord injury. Brain Res. 2016;1632:19–26. doi:10.1016/j.brainres.2015.12.017
- Lu F, Kato J, Toramaru T, Sugai M, Zhang M, Morisaki H. Objective and quantitative evaluation of spontaneous pain-like behaviors using dynamic weight-bearing system in mouse models of postsurgical pain. J Pain Res. 2022;15:1601–1612. doi:10.2147/JPR.S359220
- Hama H, Hioki H, Namiki K, et al. ScaleS: an optical clearing palette for biological imaging. Nat Neurosci. 2015;18(10):1518–1529. doi:10.1038/nn.4107
- Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39(2):175–191. doi:10.3758/bf03193146
- Dhillon S. Roxadustat: first global approval. Drugs. 2019;79(5):563–572. doi:10.1007/s40265-019-01077-1
- Crowther M, Brown NJ, Bishop ET, Lewis CE. Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors. J Leukoc Biol. 2001;70(4):478–490. doi:10.1189/jlb.70.4.478
- Schreml S, Szeimies RM, Prantl L, Karrer S, Landthaler M, Babilas P. Oxygen in acute and chronic wound healing. Br J Dermatol. 2010;163(2):257–268. doi:10.1111/j.1365-2133.2010.09804.x
- Lim TK, Shi XQ, Johnson JM, et al. Peripheral nerve injury induces persistent vascular dysfunction and endoneurial hypoxia, contributing to the genesis of neuropathic pain. J Neurosci. 2015;35(8):3346–3359. doi:10.1523/jneurosci.4040-14.2015
- Kanngiesser M, Mair N, Lim HY, et al. Hypoxia-inducible factor 1 regulates heat and cold pain sensitivity and persistence. Antioxid Redox Signal. 2014;20(16):2555–2571. doi:10.1089/ars.2013.5494
- Miyake T, Nakamura S, Zhao M, et al. Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS. Nat Commun. 2016;7:12840. doi:10.1038/ncomms12840
- Memtsoudis SG, Stundner O, Yoo D, et al. Does limb preconditioning reduce pain after total knee arthroplasty? A randomized, double-blind study. Clin Orthop Relat Res. 2014;472(5):1467–1474. doi:10.1007/s11999-013-3106-4
- Orban JC, Levraut J, Gindre S, et al. Effects of acetylcysteine and ischaemic preconditioning on muscular function and postoperative pain after orthopaedic surgery using a pneumatic tourniquet. Eur J Anaesthesiol. 2006;23(12):1025–1030. doi:10.1017/s026502150600086x
- Pogatzki-Zahn EM, Segelcke D, Schug SA. Postoperative pain-from mechanisms to treatment. Pain Rep. 2017;2(2):e588. doi:10.1097/PR9.0000000000000588
- Guhl C, Birklein F, Hirsch S. Sweating disorders in mice with and without nerve lesions. Eur J Pain. 2019;23(4):835–842. doi:10.1002/ejp.1352
- Schnell PO, Ignacak ML, Bauer AL, Striet JB, Paulding WR, Czyzyk-Krzeska MF. Regulation of tyrosine hydroxylase promoter activity by the von Hippel-Lindau tumor suppressor protein and hypoxia-inducible transcription factors. J Neurochem. 2003;85(2):483–491. doi:10.1046/j.1471-4159.2003.01696.x
- Bohuslavova R, Cerychova R, Papousek F, et al. HIF-1 alpha is required for development of the sympathetic nervous system. Proc Natl Acad Sci U S A. 2019;116(27):13414–13423. doi:10.1073/pnas.1903510116
- Smaila BD, Holland SD, Babaeijandaghi F, Henderson HG, Rossi FMV, Ramer MS. Systemic hypoxia mimicry enhances axonal regeneration and functional recovery following peripheral nerve injury. Exp Neurol. 2020;334:113436. doi:10.1016/j.expneurol.2020.113436
- Singh A, Wilson JW, Schofield CJ, Chen R. Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model. Sci Rep. 2020;10(1):1597. doi:10.1038/s41598-020-58482-w
- Johansen JL, Sager TN, Lotharius J, et al. HIF prolyl hydroxylase inhibition increases cell viability and potentiates dopamine release in dopaminergic cells. J Neurochem. 2010;115(1):209–219. doi:10.1111/j.1471-4159.2010.06917.x
- Albrecht PJ, Hines S, Eisenberg E, et al. Pathologic alterations of cutaneous innervation and vasculature in affected limbs from patients with complex regional pain syndrome. Pain. 2006;120(3):244–266. doi:10.1016/j.pain.2005.10.035
- Geertzen JH, Bodde MI, van den Dungen JJ, Dijkstra PU, den Dunnen WF. Peripheral nerve pathology in patients with severely affected complex regional pain syndrome type I. Int J Rehabil Res. 2015;38(2):121–130. doi:10.1097/mrr.0000000000000096
- Coderre TJ, Bennett GJ. Objectifying CRPS-I. Pain. 2008;138(1):3–4. doi:10.1016/j.pain.2008.06.006
- Foxler DE, Bridge KS, Foster JG, et al. A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia. EMBO Mol Med. 2018;10(8). doi:10.15252/emmm.201708304
- Yu J, Wang S, Shi W, et al. Roxadustat prevents Ang II hypertension by targeting angiotensin receptors and eNOS. JCI Insight. 2021;6(18). doi:10.1172/jci.insight.133690
- Abdelazeem B, Shehata J, Abbas KS, et al. The efficacy and safety of roxadustat for the treatment of anemia in non-dialysis dependent chronic kidney disease patients: an updated systematic review and meta-analysis of randomized clinical trials. PLoS One. 2022;17(4):e0266243. doi:10.1371/journal.pone.0266243
- Gandecka A, Araszkiewicz A, Pilacinski S, Wierusz-Wysocka B, Zozulinska-Ziolkiewicz D. The relationship between sudomotor function and skin microvascular reactivity in individuals with type 1 diabetes of long duration. Microvasc Res. 2018;120:84–89. doi:10.1016/j.mvr.2018.07.002
- Goh EL, Chidambaram S, Ma D. Complex regional pain syndrome: a recent update. Burns Trauma. 2017;5:2. doi:10.1186/s41038-016-0066-4
- Kamberov YG, Karlsson EK, Kamberova GL, et al. A genetic basis of variation in eccrine sweat gland and hair follicle density. Proc Natl Acad Sci U S A. 2015;112(32):9932–9937. doi:10.1073/pnas.1511680112
- Ratko M, Habek N, Kordic M, Dugandzic A. The use of infrared technology as a novel approach for studies with female laboratory animals. Croat Med J. 2020;61(4):346–353. doi:10.3325/cmj.2020.61.346
- Godet I, Doctorman S, Wu F, Gilkes DM. Detection of hypoxia in cancer models: significance, challenges, and advances. Cells. 2022;11(4):686. doi:10.3390/cells11040686
- Rosenberger C, Solovan C, Rosenberger AD, et al. Upregulation of hypoxia-inducible factors in normal and psoriatic skin. J Invest Dermatol. 2007;127(10):2445–2452. doi:10.1038/sj.jid.5700874