Role of Sensory Pathway Injury in Central Post-Stroke Pain: A Narrative Review of Its Pathogenetic Mechanism

References

• Watson JC, Sandroni P. Central neuropathic pain syndromes. Mayo Clin Proc. 2016;91(3):372–385. doi:10.1016/j.mayocp.2016.01.017
   PubMedGoogle Scholar
• Westerlind E, Singh R, Persson HC, Sunnerhagen KS. Experienced pain after stroke: a cross-sectional 5-year follow-up study. BMC Neurol. 2020;20(1):4. doi:10.1186/s12883-019-1584-z
   PubMed Web of Science ®Google Scholar
• Harrison RA, Field TS. Post stroke pain: identification, assessment, and therapy. Cerebrovasc Dis. 2015;39(3–4):190–201. doi:10.1159/000375397
   PubMed Web of Science ®Google Scholar
• Treister AK, Hatch MN, Cramer SC, Chang EY. Demystifying poststroke pain: from etiology to treatment. PM R. 2017;9(1):63–75. doi:10.1016/j.pmrj.2016.05.015
   PubMedGoogle Scholar
• Klit H, Finnerup NB, Jensen TS. Central post-stroke pain: clinical characteristics, pathophysiology, and management. Lancet Neurol. 2009;8(9):857–868. doi:10.1016/S1474-4422(09)70176-0
   PubMed Web of Science ®Google Scholar
• Leijon G, Boivie J, Johansson I. Central post-stroke pain--neurological symptoms and pain characteristics. Pain. 1989;36(1):13–25. doi:10.1016/0304-3959(89)90107-3
   PubMed Web of Science ®Google Scholar
• Şahin-Onat Ş, Ünsal-Delialioğlu S, Kulaklı F, Özel S. The effects of central post-stroke pain on quality of life and depression in patients with stroke. J Phys Ther Sci. 2016;28(1):96–101. doi:10.1589/jpts.28.96
   PubMedGoogle Scholar
• Treede RD. Spinothalamic and thalamocortical nociceptive pathways. J Pain. 2002;3(2):109–114. doi:10.1054/jpai.2002.122951
   PubMedGoogle Scholar
• D’Mello R, Dickenson AH. Spinal cord mechanisms of pain. Br J Anaesth. 2008;101(1):8–16. doi:10.1093/bja/aen088
   PubMed Web of Science ®Google Scholar
• Haroutounian S, Ford AL, Frey K, et al. How central is central poststroke pain? The role of afferent input in poststroke neuropathic pain: a prospective, open-label pilot study. Pain. 2018;159(7):1317–1324. doi:10.1097/j.pain.0000000000001213
   PubMed Web of Science ®Google Scholar
• Kretzschmar M, Reining M. Dorsal root ganglion stimulation for treatment of central poststroke pain in the lower extremity after medullary infarction. Pain. 2021;162(11):2682–2685. doi:10.1097/j.pain.0000000000002439
   PubMedGoogle Scholar
• Heijmans L, Joosten EA. Mechanisms and mode of action of spinal cord stimulation in chronic neuropathic pain. Postgrad Med. 2020;132(sup3):17–21. doi:10.1080/00325481.2020.1769393
   PubMed Web of Science ®Google Scholar
• Takami K, Fujita-Hamabe W, Harada S, Tokuyama S. Aβ and Aδ but not C-fibres are involved in stroke related pain and allodynia: an experimental study in mice. J Pharm Pharmacol. 2011;63(3):452–456. doi:10.1111/j.2042-7158.2010.01231.x
   PubMedGoogle Scholar
• Hyakkoku K, Umeda N, Shimada S, et al. Post-stroke pain caused by peripheral sensory hypersensitization after transient focal cerebral ischemia in rats. Brain Res. 2019;1715:35–40. doi:10.1016/j.brainres.2019.03.019
   PubMedGoogle Scholar
• Dang G, Chen X, Zhao Y, et al. Alterations in the spinal cord and ventral root after cerebral infarction in non-human primates. Restor Neurol Neurosci. 2018;36(6):729–740. doi:10.3233/RNN-180854
   PubMedGoogle Scholar
• Liang T, Chen XF, Yang Y, et al. Secondary damage and neuroinflammation in the spinal dorsal horn mediate post-thalamic hemorrhagic stroke pain hypersensitivity: SDF1-CXCR4 signaling mediation. Front Mol Neurosci. 2022;15(911476). doi:10.3389/fnmol.2022.911476
   Google Scholar
• Matsuura W, Harada S, Liu K, Nishibori M, Tokuyama S. Evidence of a role for spinal HMGB1 in ischemic stress-induced mechanical allodynia in mice. Brain Res. 2018;1687:1–10. doi:10.1016/j.brainres.2018.02.026
   PubMed Web of Science ®Google Scholar
• Yang F, Luo WJ, Sun W, et al. SDF1-CXCR4 signaling maintains central post-stroke pain through mediation of glial-neuronal interactions. Front Mol Neurosci. 2017;10:226. doi:10.3389/fnmol.2017.00226
   PubMed Web of Science ®Google Scholar
• Matsuura W, Nakamoto K, Tokuyama S. The involvement of DDAH1 in the activation of spinal NOS signaling in early stage of mechanical allodynia induced by exposure to ischemic stress in mice. Biol Pharm Bull. 2019;42(9):1569–1574. doi:10.1248/bpb.b19-00371
   PubMedGoogle Scholar
• Harada S, Matsuura W, Takano M, Tokuyama S. Proteomic profiling in the spinal cord and sciatic nerve in a global cerebral ischemia-induced mechanical allodynia mouse model. Biol Pharm Bull. 2016;39(2):230–238. doi:10.1248/bpb.b15-00647
   PubMedGoogle Scholar
• Montoya-Filardi A, García-Junco Albacete M, Ortolá Fortes P, Carreres Polo J. Imaging secondary neuronal degeneration. Radiologia. 2022;64(2):145–155. doi:10.1016/j.rxeng.2022.01.001
   PubMedGoogle Scholar
• Willis WD, Westlund KN. Neuroanatomy of the pain system and of the pathways that modulate pain. J Clin Neurophysiol. 1997;14(1):2–31. doi:10.1097/00004691-199701000-00002
   PubMed Web of Science ®Google Scholar
• Boivie J. Chapter 48 central post-stroke pain. Handb Clin Neurol. 2006;81:715–730. doi:10.1016/S0072-9752(06)80052-7
   PubMedGoogle Scholar
• Garcia-Larrea L, Hagiwara K. Electrophysiology in diagnosis and management of neuropathic pain. Rev Neurol. 2019;175(1–2):26–37. doi:10.1016/j.neurol.2018.09.015
   PubMedGoogle Scholar
• Garcia-Larrea L, Convers P, Magnin M, et al. Laser-evoked potential abnormalities in central pain patients: the influence of spontaneous and provoked pain. Brain. 2002;125(Pt 12):2766–2781. doi:10.1093/brain/awf275
   PubMedGoogle Scholar
• Veciana M, Valls-Solé J, Rubio F, Callén A, Robles B. Laser evoked potentials and prepulse inhibition of the blink reflex in patients with Wallenberg’s syndrome. Pain. 2005;117(3):443–449. doi:10.1016/j.pain.2005.07.013
   PubMedGoogle Scholar
• Casey KL, Beydoun A, Boivie J, et al. Laser-evoked cerebral potentials and sensory function in patients with central pain. Pain. 1996;64(3):485–491. doi:10.1016/0304-3959(95)00143-3
   PubMedGoogle Scholar
• Convers P, Creac’h C, Beschet A, Laurent B, Garcia-Larrea L, Peyron R. A hidden mesencephalic variant of central pain. Eur J Pain. 2020;24(7):1393–1399. doi:10.1002/ejp.1588
   PubMedGoogle Scholar
• Kamali A, Kramer LA, Butler IJ, Hasan KM. Diffusion tensor tractography of the somatosensory system in the human brainstem: initial findings using high isotropic spatial resolution at 3.0 T. Eur Radiol. 2009;19(6):1480–1488. doi:10.1007/s00330-009-1305-x
   PubMedGoogle Scholar
• Jang SH, Seo JP. Anatomical location of the spinothalamic tract in the subcortical white matter in the human brain: a diffusion tensor imaging study. Clin Anat. 2021;34(5):736–741. doi:10.1002/ca.23709
   PubMedGoogle Scholar
• Jang SH, Seo JP, Lee SJ. Diffusion tensor tractography studies of central post-stroke pain due to the spinothalamic tract injury: a mini-review. Front Neurol. 2019;10:787. doi:10.3389/fneur.2019.00787
   PubMedGoogle Scholar
• Hong JH, Choi BY, Chang CH, et al. The prevalence of central poststroke pain according to the integrity of the spino-thalamo-cortical pathway. Eur Neurol. 2012;67(1):12–17. doi:10.1159/000333012
   PubMedGoogle Scholar
• Wasner G, Lee BB, Engel S, McLachlan E. Residual spinothalamic tract pathways predict development of central pain after spinal cord injury. Brain. 2008;131(Pt 9):2387–2400. doi:10.1093/brain/awn169
   PubMedGoogle Scholar
• Wang G, Thompson SM. Maladaptive homeostatic plasticity in a rodent model of central pain syndrome: thalamic hyperexcitability after spinothalamic tract lesions. J Neurosci. 2008;28(46):11959–11969. doi:10.1523/JNEUROSCI.3296-08.2008
   PubMedGoogle Scholar
• Navarro-Orozco D, Bollu PC. Neuroanatomy, medial lemniscus (Reils band, reils ribbon). In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2021.
   Google Scholar
• Kim JS, Choi-Kwon S. Sensory sequelae of medullary infarction: differences between lateral and medial medullary syndrome. Stroke. 1999;30(12):2697–2703. doi:10.1161/01.str.30.12.2697
   PubMedGoogle Scholar
• Melzack R, Wall PD. Pain mechanisms: a new theory. Science. 1965;150(3699):971–979. doi:10.1126/science.150.3699.971
   PubMed Web of Science ®Google Scholar
• Liampas A, Velidakis N, Georgiou T, et al. Prevalence and management challenges in central post-stroke neuropathic pain: a systematic review and meta-analysis. Adv Ther. 2020;37(7):3278–3291. doi:10.1007/s12325-020-01388-w
   PubMed Web of Science ®Google Scholar
• Krause T, Brunecker P, Pittl S, et al. Thalamic sensory strokes with and without pain: differences in lesion patterns in the ventral posterior thalamus. J Neurol Neurosurg Psychiatry. 2012;83(8):776–784. doi:10.1136/jnnp-2011-301936
   PubMed Web of Science ®Google Scholar
• Sprenger T, Seifert CL, Valet M, et al. Assessing the risk of central post-stroke pain of thalamic origin by lesion mapping. Brain. 2012;135(Pt 8):2536–2545. doi:10.1093/brain/aws153
   PubMedGoogle Scholar
• Vartiainen N, Perchet C, Magnin M, et al. Thalamic pain: anatomical and physiological indices of prediction. Brain. 2016;139(Pt 3):708–722. doi:10.1093/brain/awv389
   PubMedGoogle Scholar
• Wasserman JK, Koeberle PD. Development and characterization of a hemorrhagic rat model of central post-stroke pain. Neuroscience. 2009;161(1):173–183. doi:10.1016/j.neuroscience.2009.03.042
   PubMedGoogle Scholar
• Anttila JE, Pöyhönen S, Airavaara M. Secondary pathology of the thalamus after focal cortical stroke in rats is not associated with thermal or mechanical hypersensitivity and is not alleviated by intra-thalamic post-stroke delivery of recombinant CDNF or MANF. Cell Transplant. 2019;28(4):425–438. doi:10.1177/0963689719837915
   PubMedGoogle Scholar
• Hiraga SI, Itokazu T, Hoshiko M, Takaya H, Nishibe M, Yamashita T. Microglial depletion under thalamic hemorrhage ameliorates mechanical allodynia and suppresses aberrant axonal sprouting. JCI Insight. 2020;5(3):e131801. doi:10.1172/jci.insight.131801
   PubMedGoogle Scholar
• Brickley SG, Mody I. Extrasynaptic GABA(A) receptors: their function in the CNS and implications for disease. Neuron. 2012;73(1):23–34. doi:10.1016/j.neuron.2011.12.012
   PubMed Web of Science ®Google Scholar
• Zhou LJ, Peng J, Xu YN, et al. Microglia are indispensable for synaptic plasticity in the spinal dorsal horn and chronic pain. Cell Rep. 2019;27(13):3844–3859.e6. doi:10.1016/j.celrep.2019.05.087
   PubMed Web of Science ®Google Scholar
• Lu J, Guo X, Yan M, et al. P2X4R contributes to central disinhibition via TNF-α/TNFR1/GABAaR pathway in post-stroke pain rats. J Pain. 2021;22(8):968–980. doi:10.1016/j.jpain.2021.02.013
   PubMedGoogle Scholar
• Kuan YH, Shih HC, Tang SC, Jeng JS, Shyu BC. Targeting P(2)X(7) receptor for the treatment of central post-stroke pain in a rodent model. Neurobiol Dis. 2015;78:134–145. doi:10.1016/j.nbd.2015.02.028
   PubMedGoogle Scholar
• Inoue K, Tsuda M. Nociceptive signaling mediated by P2X3, P2X4 and P2X7 receptors. Biochem Pharmacol. 2021;187:114309. doi:10.1016/j.bcp.2020.114309
   PubMedGoogle Scholar
• Fu G, Du S, Huang T, et al. FTO (Fat-mass and obesity-associated protein) participates in hemorrhage-induced thalamic pain by stabilizing toll-like receptor 4 expression in thalamic neurons. Stroke. 2021;52(7):2393–2403. doi:10.1161/STROKEAHA.121.034173
   PubMedGoogle Scholar
• Leresche N, Lambert RC. GABA receptors and T-type Ca2+ channels crosstalk in thalamic networks. Neuropharmacology. 2018;136(PtA):37–45. doi:10.1016/j.neuropharm.2017.06.006
   PubMedGoogle Scholar
• Yu J, Wang DS, Bonin RP, et al. Gabapentin increases expression of δ subunit-containing GABAA receptors. EBioMedicine. 2019;42:203–213. doi:10.1016/j.ebiom.2019.03.008
   PubMed Web of Science ®Google Scholar
• Yang Y, Yang F, Yang F, et al. Gabapentinoid insensitivity after repeated administration is associated with down-regulation of the α(2)δ-1 subunit in rats with central post-stroke pain hypersensitivity. Neurosci Bull. 2016;32(1):41–50. doi:10.1007/s12264-015-0008-3
   PubMedGoogle Scholar
• Cui W, Wu H, Yu X, Song T, Xu X, Xu F. The calcium channel α2δ1 subunit: interactional targets in primary sensory neurons and role in neuropathic pain. Front Cell Neurosci. 2021;15(699731). doi:10.3389/fncel.2021.699731
   Google Scholar
• Chen X, Li Z, Zhang B, et al. Alleviation of mechanical allodynia by 14,15-epoxyeicosatrienoic acid in a central poststroke pain model: possible role of allopregnanolone and δ-subunit-containing gamma-aminobutyric acid a receptors. J Pain. 2019;20(5):577–591. doi:10.1016/j.jpain.2018.11.006
   PubMedGoogle Scholar
• Cai W, Wu S, Pan Z, et al. Disrupting interaction of PSD-95 with nNOS attenuates hemorrhage-induced thalamic pain. Neuropharmacology. 2018;141:238–248. doi:10.1016/j.neuropharm.2018.09.003
   PubMedGoogle Scholar
• Frese A, Husstedt IW, Ringelstein EB, Evers S. Pharmacologic treatment of central post-stroke pain. Clin J Pain. 2006;22(3):252–260. doi:10.1097/01.ajp.0000173020.10483.13
   PubMedGoogle Scholar
• Infantino R, Schiano C, Luongo L, et al. MED1/BDNF/TrkB pathway is involved in thalamic hemorrhage-induced pain and depression by regulating microglia. Neurobiol Dis. 2022;164:105611. doi:10.1016/j.nbd.2022.105611
   PubMed Web of Science ®Google Scholar
• Varendi K, Kumar A, Härma MA, Andressoo JO. miR-1, miR-10b, miR-155, and miR-191 are novel regulators of BDNF. Cell Mol Life Sci. 2014;71(22):4443–4456. doi:10.1007/s00018-014-1628-x
   PubMed Web of Science ®Google Scholar
• Krause T, Asseyer S, Taskin B, et al. The cortical signature of central poststroke pain: gray matter decreases in somatosensory, insular, and prefrontal cortices. Cereb Cortex. 2016;26(1):80–88. doi:10.1093/cercor/bhu177
   PubMedGoogle Scholar
• Craig AD, Chen K, Bandy D, Reiman EM. Thermosensory activation of insular cortex. Nat Neurosci. 2000;3(2):184–190. doi:10.1038/72131
   PubMed Web of Science ®Google Scholar
• Nagasaka K, Takashima I, Matsuda K, Higo N. Pharmacological inactivation of the primate posterior insular/secondary somatosensory cortices attenuates thermal hyperalgesia. Eur J Pain. 2022;26(8):1723–1731. doi:10.1002/ejp.1996
   PubMedGoogle Scholar
• Kadono Y, Koguchi K, Okada KI, et al. Repetitive transcranial magnetic stimulation restores altered functional connectivity of central poststroke pain model monkeys. Sci Rep. 2021;11(1):6126. doi:10.1038/s41598-021-85409-w
   PubMedGoogle Scholar
• Rainville P, Duncan GH, Price DD, Carrier B, Bushnell MC. Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science. 1997;277(5328):968–971. doi:10.1126/science.277.5328.968
   PubMed Web of Science ®Google Scholar
• Seghier ML, Lazeyras F, Vuilleumier P, Schnider A, Carota A. Functional magnetic resonance imaging and diffusion tensor imaging in a case of central poststroke pain. J Pain. 2005;6(3):208–212. doi:10.1016/j.jpain.2004.11.004
   PubMedGoogle Scholar
• Lu HC, Chang WJ, Kuan YH, Huang AC, Shyu BC. A [14C]iodoantipyrine study of inter-regional correlations of neural substrates following central post-stroke pain in rats. Mol Pain. 2015;11:9. doi:10.1186/s12990-015-0006-5
   PubMedGoogle Scholar
• Head H, Holmes G. Sensory disturbances from cerebral lesions. Brain. 1911;34(2–3):102–254. doi:10.1093/brain/34.2-3.102
   Google Scholar
• Hong JH, Bai DS, Jeong JY, et al. Injury of the spino-thalamo-cortical pathway is necessary for central post-stroke pain. Eur Neurol. 2010;64(3):163–168. doi:10.1159/000319040
   PubMedGoogle Scholar
• Jang SH, Chang CH, Jung YJ, Lee HD. Delayed-onset central pain due to degeneration of ischemic transcallosal fibers after corpus callosum hemorrhage. Am J Phys Med Rehabil. 2017;96(10):e177–e180. doi:10.1097/PHM.0000000000000693
   PubMedGoogle Scholar
• Jang SH, Lee J, Yeo SS. Central post-stroke pain due to injury of the spinothalamic tract in patients with cerebral infarction: a diffusion tensor tractography imaging study. Neural Regen Res. 2017;12(12):2021–2024. doi:10.4103/1673-5374.221159
   PubMedGoogle Scholar
• Jang SH, Kim J, Lee HD. Delayed-onset central poststroke pain due to degeneration of the spinothalamic tract following thalamic hemorrhage: a case report. Medicine. 2018;97(50):e13533. doi:10.1097/MD.0000000000013533
   PubMedGoogle Scholar
• Huang T, Fu G, Gao J, et al. Fgr contributes to hemorrhage-induced thalamic pain by activating NF-κB/ERK1/2 pathways. JCI Insight. 2020;5(20):e139987. doi:10.1172/jci.insight.139987
   PubMedGoogle Scholar
• Shih HC, Kuan YH, Shyu BC. Targeting brain-derived neurotrophic factor in the medial thalamus for the treatment of central poststroke pain in a rodent model. Pain. 2017;158(7):1302–1313. doi:10.1097/j.pain.0000000000000915
   PubMedGoogle Scholar
• Saini V, Guada L, Yavagal DR. Global epidemiology of stroke and access to acute ischemic stroke interventions. Neurology. 2021;97(20 Suppl 2):S6–S16. doi:10.1212/WNL.0000000000012781
   PubMedGoogle Scholar