288
Views
0
CrossRef citations to date
0
Altmetric
CLINICAL TRIAL REPORT

The Effects and Potential Mechanisms of Moxibustion for Rheumatoid Arthritis-Related Pain: A Randomized, Controlled Trial

ORCID Icon, , , , , , & show all
Pages 1739-1749 | Received 15 Mar 2023, Accepted 09 May 2023, Published online: 26 May 2023

References

  • Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis. Lancet. 2016;388(10055):2023–2038. doi:10.1016/S0140-6736(16)30173-8
  • Firestein GS. Evolving concepts of rheumatoid arthritis. Nature. 2003;423(6937):356–361. doi:10.1038/nature01661
  • Tedeschi SK, Bermas B, Costenbader KH. Sexual disparities in the incidence and course of SLE and RA. Clin Immunol. 2013;149(2):211–218. doi:10.1016/j.clim.2013.03.003
  • Kwiatkowska B, Klak A, Raciborski F, et al. The prevalence of depression and insomnia symptoms among patients with rheumatoid arthritis and osteoarthritis in Poland: a case control study. Psychol Health Med. 2019;24(3):333–343. doi:10.1080/13548506.2018.1529325
  • Uguz F, Kucuk A, Cicek E, et al. Quality of life in rheumatological patients: the impact of personality disorders. Int J Psychiatry Med. 2015;49(3):199–207. doi:10.1177/0091217415582183
  • Ovayolu N, Ovayolu O, Karadag G. Health-related quality of life in ankylosing spondylitis, fibromyalgia syndrome, and rheumatoid arthritis: a comparison with a selected sample of healthy individuals. Clin Immunol. 2011;30(5):655–664. doi:10.1007/s10067-010-1604-2
  • Covic T, Cumming SR, Pallant JF, et al. Depression and anxiety in patients with rheumatoid arthritis: prevalence rates based on a comparison of the Depression, Anxiety and Stress Scale (DASS) and the hospital, Anxiety and Depression Scale (Hads). BMC Psychiatry. 2012;12:6. doi:10.1186/1471-244X-12-6
  • Machin AR, Babatunde O, Haththotuwa R, et al. The association between anxiety and disease activity and quality of life in rheumatoid arthritis: a systematic review and meta-analysis. Clin Rheumatol. 2020;39(5):1471–1482. doi:10.1007/s10067-019-04900-y
  • Rawla P. Cardiac and vascular complications in rheumatoid arthritis. Reumatologia. 2019;57(1):27–36. doi:10.5114/reum.2019.83236
  • Xing L, Yufeng Y, Bin M, et al. Clinical study of 157 rheumatoid arthritis patients’combination and complication. Chin J Dis Control Prevention. 2016;20(02):201–203.
  • Spagnolo P, Lee JS, Sverzellati N, et al. The lung in rheumatoid arthritis: focus on interstitial lung disease. Arthritis Rheumatol. 2018;70(10):1544–1554. doi:10.1002/art.40574
  • Kaeley N, Ahmad S, Pathania M, et al. Prevalence and patterns of peripheral neuropathy in patients of rheumatoid arthritis. J Family Med Primary Care. 2019;8(1):22–26. doi:10.4103/jfmpc.jfmpc_260_18
  • Drosos AA, Pelechas E, Kaltsonoudis E, et al. Therapeutic options and cost-effectiveness for rheumatoid arthritis treatment. Curr Rheumatol Rep. 2020;22(8):44. doi:10.1007/s11926-020-00921-8
  • Scheiman JM. NSAID-induced gastrointestinal injury: a focused update for clinicians. J Clin Gastroenterol. 2016;50(1):5–10. doi:10.1097/MCG.0000000000000432
  • Koike T, Harigai M, Inokuma S, et al. Effectiveness and safety of tocilizumab: postmarketing surveillance of 7901 patients with rheumatoid arthritis in Japan. J Rheumatol. 2014;41(1):15–23. doi:10.3899/jrheum.130466
  • Hwang YG, Saag K. The safety of low-dose glucocorticoids in rheumatic diseases: results from observational studies. Neuroimmunomodulation. 2015;22(1–2):72–82. doi:10.1159/000362727
  • Negrei C, Bojinca V, Balanescu A, et al. Management of rheumatoid arthritis: impact and risks of various therapeutic approaches. Exp Ther Med. 2016;11(4):1177–1183. doi:10.3892/etm.2016.3045
  • Chen Y, Li H, Luo X, et al. Moxibustion of Zusanli (ST36) and Shenshu (BL23) alleviates cartilage degradation through RANKL/OPG signaling in a rabbit model of rheumatoid arthritis. Evid Based Complement Alternat Med. 2019;2019:6436420. doi:10.1155/2019/6436420
  • Zhidan L, Xiaoyan L, Chuang Z, et al. Effects of moxibustion on Treg/Th17 cell and its signal pathway in mice with rheumatoid arthritis. Chinese Acupuncture & Moxibustion. 2017;37(10):1083–1092. doi:10.13703/j.0255-2930.2017.10.015
  • Jigang R, Xuguang L, Xiao L, et al. Study on the anti-inflammatory effect and the expression of mPD-1 in synovial tissue of RA model with moxibustion therapy. Lishizhen Med Materia Med Res. 2017;28(12):3048–3050.
  • Zhang C, Tang Z. Progress of mechanism study on rheumatoid arthritis treated by moxibustion. J Acupuncture Tuina Sci. 2009;7(2):65–70. doi:10.1007/s11726-009-0065-0
  • Xie X, Lei Q. Observation on therapeutic effect of the spreading moxibustion on rheumatoid arthritis. Chinese Acupuncture & Moxibustion. 2008;1(10):730–732.
  • Shen B, Sun Q, Chen H, et al. Effects of moxibustion on pain behaviors in patients with rheumatoid arthritis: a meta-analysis. Medicine. 2019;98(30):e16413. doi:10.1097/MD.0000000000016413
  • Wan R, Fan Y, Zhao A, et al. Comparison of efficacy of acupuncture-related therapy in the treatment of rheumatoid arthritis: a network meta-analysis of randomized controlled trials. Front Immunol. 2022;13:829409. doi:10.3389/fimmu.2022.829409
  • Aletaha D, Neogi T, Silman AJ, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis. 2010;62(9):2569–2581. doi:10.1002/art.27584
  • Smolen JS, Landewe R, Bijlsma J, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update. Ann Rheum Dis. 2017;76(6):960–977. doi:10.1136/annrheumdis-2016-210715
  • Gong Y, Yu Z, Wang Y, et al. Effect of moxibustion on HIF-1 alpha and VEGF levels in patients with rheumatoid arthritis. Pain Res Management. 2019;2019:4705247. doi:10.1155/2019/4705247
  • Katz J, Melzack R. Measurement of pain. Surg Clin North Am. 1999;79(2):231–252. doi:10.1016/s0039-6109(05)70381-9
  • Jensen MP, Chen C, Brugger AM. Interpretation of visual analog scale ratings and change scores: a reanalysis of two clinical trials of postoperative pain. J Pain. 2003;4(7):407–414. doi:10.1016/s1526-5900(03)00716-8
  • Prevoo ML, Kuper HH. Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheumatism. 1995;38(1):44–48. doi:10.1002/art.1780380107
  • Fransen J, Creemers MC, Van Riel PL. Remission in rheumatoid arthritis: agreement of the disease activity score (DAS28) with the ARA preliminary remission criteria. Rheumatology. 2004;43(10):1252–1255. doi:10.1093/rheumatology/keh297
  • Smolen JS, Breedveld FC, Schiff MH, et al. A simplified disease activity index for rheumatoid arthritis for use in clinical practice. Rheumatology. 2003;42(2):244–257. doi:10.1093/rheumatology/keg072
  • Aletaha D, Nell VP, Stamm T, et al. Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score. Arthritis Res Ther. 2005;7(4):R796–806. doi:10.1186/ar1740
  • Aletaha D, Martinez-Avila J, Kvien TK, et al. Definition of treatment response in rheumatoid arthritis based on the simplified and the clinical disease activity index. Ann Rheum Dis. 2012;71(7):1190–1196. doi:10.1136/annrheumdis-2012-201491
  • Bruce B, Fries JF. The Stanford Health Assessment Questionnaire: a review of its history, issues, progress, and documentation. J Rheumatol. 2003;30(1):167–178.
  • Felson DT, Anderson JJ, Boers M, et al. American College of Rheumatology. Preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum. 1995;38(6):727–735. doi:10.1002/art.1780380602
  • Yang H, Liu X, Yang X, et al. Effect of different types of moxibustion intervention on expression of inflammatory cytokines IL-1 and TNF-α in rabbits with rheumatoid arthritis. Acupuncture Res. 2013;38(02):134–139. doi:10.13702/j.1000-0607.2013.02.009
  • Gao X, Wang X, Liu X, et al. Effects of different moxibustion on the function of HPAA in rabbits with rheumatoid arthritis. J Basic Chine Med. 2015;21(09):1140–1142. doi:10.19945/j.cnki.issn.1006-3250.2015.09.036
  • Yu X, Zhang F, Zhang J. Effect of transcutaneous electrical acupuncture point stimulation on expression of p-JNK in the dorsal root ganglion in a rat model of myofascial pain syndrome. Acupunct Med. 2019;37(5):312–318. doi:10.1136/acupmed-2017-011536
  • Mitidieri AMS, Baltazar M, da Silva APM, et al. Ashi acupuncture versus local anesthetic trigger point injections in the treatment of abdominal myofascial pain syndrome: a randomized clinical trial. Pain Physician. 2020;23(5):507–518.
  • Wei J, Shen X, Ding G, et al. Investigation of pathway and mechanism of heat stimulating action of sandwiched moxibustion. Chinese Acupuncture & Moxibustion. 2007;3(5):391–393.
  • Xu S, Zhang H, Gu Y. Progress of research on mechanisms of moxibustion intervention underlying improvement of blood circulation. Acupuncture Res. 2018;43(11):738–743. doi:10.13702/j.1000-0607.170309
  • Orange DE, Blachere NE, DiCarlo EF, et al. Rheumatoid arthritis morning stiffness is associated with synovial fibrin and neutrophils. Arthritis Rheumatol. 2020;72(4):557–564. doi:10.1002/art.41141
  • Zhang M, Zhao C, Jiang L, et al. Clinical effect and mechanism of moxibustion combined with western medication for rheumatoid arthritis of liver-kidney deficiency. Chinese Acupuncture & Moxibustion. 2021;41(5):489–92+524. doi:10.13703/j.0255-2930.20200519-k0005
  • Wang S, Ye G, Zhang Y, et al. Flipping moxibustion of Hui medicine combined with western medication for rheumatoid arthritis with cold dampness bi syndrome. Chinese Acupuncture & Moxibustion. 2017;37(10):1047–1051. doi:10.13703/j.0255-2930.2017.10.006
  • Yu H, Zhu Y, Pan Y, et al. Clinical efficacy of moxibustion as supplement on rheumatoid arthritis and the exploration on its mechanism. Chinese Acupuncture & Moxibustion. 2016;36(01):17–20. doi:10.13703/j.0255-2930.2016.01.005
  • Gao F, Xiang HC, Li HP, et al. Electroacupuncture inhibits NLRP3 inflammasome activation through CB2 receptors in inflammatory pain. Brain Behav Immun. 2018;67:91–100. doi:10.1016/j.bbi.2017.08.004
  • Su TF, Zhao YQ, Zhang LH, et al. Electroacupuncture reduces the expression of proinflammatory cytokines in inflamed skin tissues through activation of cannabinoid CB2 receptors. Eur J Pain. 2012;16(5):624–635. doi:10.1002/j.1532-2149.2011.00055.x
  • Takano S, Uchida K, Inoue G, et al. Vascular endothelial growth factor expression and their action in the synovial membranes of patients with painful knee osteoarthritis. BMC Musculoskelet Disord. 2018;19(1):204. doi:10.1186/s12891-018-2127-2
  • Juarez M, Filer A, Buckley CD. Fibroblasts as therapeutic targets in rheumatoid arthritis and cancer. Swiss Med Wkly. 2012;142:w13529. doi:10.4414/smw.2012.13529
  • Moelants EA, Mortier A, Van Damme J, et al. Regulation of TNF-alpha with a focus on rheumatoid arthritis. Immunol Cell Biol. 2013;91(6):393–401. doi:10.1038/icb.2013.15
  • Kim HR, Kim KW, Kim BM, et al. The effect of vascular endothelial growth factor on osteoclastogenesis in rheumatoid arthritis. PLoS One. 2015;10(4):e0124909. doi:10.1371/journal.pone.0124909
  • Alshevskaya AA, Lopatnikova JA, Shkaruba NS, et al. Differences of IL-1 beta receptors expression by immunocompetent cells subsets in rheumatoid arthritis. Mediators Inflamm. 2015;2015:948393. doi:10.1155/2015/948393
  • Zheng Y, Sun L, Jiang T, et al. TNFalpha promotes Th17 cell differentiation through IL-6 and IL-1 beta produced by monocytes in rheumatoid arthritis. J Immunol Res. 2014;2014:385352. doi:10.1155/2014/385352
  • Paradowska-Gorycka A, Pawlik A, Romanowska-Prochnicka K, et al. Relationship between VEGF gene polymorphisms and serum VEGF protein levels in patients with rheumatoid arthritis. PLoS One. 2016;11(8):e0160769. doi:10.1371/journal.pone.0160769
  • Clavel G, Bessis N, Lemeiter D, et al. Angiogenesis markers (VEGF, soluble receptor of VEGF and angiopoietin-1) in very early arthritis and their association with inflammation and joint destruction. Clin Immunol. 2007;124(2):158–164. doi:10.1016/j.clim.2007.04.014
  • Zhong YM, Cheng B, Zhang LL, et al. Effect of moxibustion on inflammatory cytokines in animals with rheumatoid arthritis: a systematic review and meta-analysis. Evid Based Complement Alternat Med. 2020;2020:6108619. doi:10.1155/2020/6108619