Pulsed Radiofrequency Decreases pERK and Affects Intracellular Ca²⁺ Influx, Cytosolic ATP Level, and Mitochondrial Membrane Potential in the Sensitized Dorsal Root Ganglion Neuron Induced by N-Methyl D-Aspartate

References

• De SJB, Grossmann E, Perissinotti D, et al. Prevalence of chronic pain, treatments, perception, and interference on life activities: Brazilian population-based survey. Pain Res Manag. 2017;2017. doi:10.1155/2017/4643830
   Web of Science ®Google Scholar
• Goldberg DS, Mcgee SJ. Pain as a global public health priority. BMC Public Health. 2011;11(1):770. doi:10.1186/1471-2458-11-770
   PubMed Web of Science ®Google Scholar
• Tsang A, Von Korff M, Lee S, et al. Common chronic pain conditions in developed and developing countries: gender and age differences and comorbidity with depression-anxiety disorders. J Pain. 2008;9(10):883–891. doi:10.1016/j.jpain.2008.05.005
   PubMed Web of Science ®Google Scholar
• Zhou HY, Chen SR, Pan HL. Targeting N-methyl-D-aspartate receptors for treatment of neuropathic pain. Expert Rev Clin Pharmacol. 2011;4(3):379–388. doi:10.1586/ecp.11.17
   PubMedGoogle Scholar
• Laumet G, Chen SR, Pan HL. NMDA receptors and signaling in chronic neuropathic pain. Receptors. 2017;30:103–119. doi:10.1007/978-3-319-49795-2_6
   Google Scholar
• Youn DH, Gerber G, Sather WA. Ionotropic glutamate receptors and voltage-gated Ca2+ channels in long-term potentiation of spinal dorsal horn synapses and pain hypersensitivity. Neural Plast. 2013;2013. doi:10.1155/2013/654257
   PubMed Web of Science ®Google Scholar
• Ji RR, Gureau IVRW, Malcangio M, Strichartz GR. MAP kinase and pain. Brain Res Rev. 2009;60(1):135–148. doi:10.1016/j.brainresrev.2008.12.011
   PubMedGoogle Scholar
• Bazzari AH, Bazzari FH. Advances in targeting central sensitization and brain plasticity in chronic pain. Egypt J Neurol Psychiatry Neurosurg. 2022;58(1). doi:10.1186/s41983-022-00472-y
   Google Scholar
• Latremoliere A, Woolf C. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Sci Food Agric. 2009;10(9):895–926. doi:10.1016/j.jpain.2009.06.012.Central
   Google Scholar
• Shetty PK, Galeffi F, Turner DA. Cellular links between neuronal activity and energy homeostasis. Front Pharmacol. 2012;3:1–14. doi:10.3389/fphar.2012.00043
   PubMed Web of Science ®Google Scholar
• Natsubori A, Tsunematsu T, Karashima A, et al. Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states. Commun Biol. 2020;3(1):1–5. doi:10.1038/s42003-020-01215-6
   PubMed Web of Science ®Google Scholar
• Berger AA, Liu Y, Possoit H, et al. Dorsal root ganglion (DRG) and chronic pain. Anesthesiol Pain Med. 2021;11(2):1–10. doi:10.5812/aapm.113020
   Google Scholar
• Esposito MF, Malayil R, Hanes M, Deer T. Unique characteristics of the dorsal root ganglion as a target for neuromodulation. Pain Med. 2019;20:S23–S30. doi:10.1093/pm/pnz012
   PubMed Web of Science ®Google Scholar
• Liu CN, Wall PD, Ben-Dor E, Michaelis M, Amir R, Devor M. Tactile allodynia in the absence of C-fiber activation: altered firing properties of DRG neurons following spinal nerve injury. Pain. 2000;85(3):503–521. doi:10.1016/S0304-3959(00)00251-7
   PubMed Web of Science ®Google Scholar
• Cosman ER. A comment on the history of the pulsed radiofrequency technique for pain therapy [2]. Anesthesiology. 2005;103(6):1312. doi:10.1097/00000542-200512000-00028
   PubMed Web of Science ®Google Scholar
• Cho JH, Lee DG. Translocation of ampa receptors in the dorsal horn of the spinal cord corresponding to long-term depression following pulsed radiofrequency stimulation at the dorsal root ganglion. Pain Med. 2020;21(9):1913–1920. doi:10.1093/PM/PNZ307
   PubMed Web of Science ®Google Scholar
• Chua NHL, Vissers KC, Sluijter ME. Pulsed radiofrequency treatment in interventional pain management: mechanisms and potential indications - A review. Acta Neurochir. 2011;153(4):763–771. doi:10.1007/s00701-010-0881-5
   PubMed Web of Science ®Google Scholar
• Kwak SG, Lee DG, Chang MC. Effectiveness of pulsed radiofrequency treatment on cervical radicular pain A meta-analysis. Medicine. 2018;97(31):1–6. doi:10.1097/MD.0000000000011761
   Web of Science ®Google Scholar
• Wu YT, Ho CW, Chen YL, Li TY, Lee KC, Chen LC. Ultrasound-guided pulsed radiofrequency stimulation of the suprascapular nerve for adhesive capsulitis: a prospective, randomized, controlled trial. Anesth Analg. 2014;119(3):686–692. doi:10.1213/ANE.0000000000000354
   PubMed Web of Science ®Google Scholar
• Sam J, Catapano M, Sahni S, Ma F, Abd-Elsayed A, Visnjevac O. Pulsed radiofrequency in interventional pain management: cellular and molecular mechanisms of action – an update and review. Pain Physician. 2021;24(8):525–532.
   PubMed Web of Science ®Google Scholar
• Erdine S, Bilir A, Cosman ER. Ultrastructural changes in axons following exposure to pulsed radiofrequency fields. Pain Pract. 2009;9(6):407–417. doi:10.1111/j.1533-2500.2009.00317.x
   PubMed Web of Science ®Google Scholar
• Chang HR, Kuo CC. The activation gate and gating mechanism of the NMDA receptor. J Neurosci. 2008;28(7):1546–1556. doi:10.1523/JNEUROSCI.3485-07.2008
   PubMed Web of Science ®Google Scholar
• Gao Y-J, Ji -R-R. c-fos or pERK, which is a better marker for neuronal activation and central sensitization after noxious stimulation and tissue injury? Open Pain J. 2009;2(1):11–17. doi:10.2174/1876386300902010011
   PubMedGoogle Scholar
• Platika D, Boulos MH, Baizer L, Fishman MC. Neuronal traits of clonal cell lines derived by fusion of dorsal root ganglia neurons with neuroblastoma cells. Proc Natl Acad Sci U S A. 1985;82(10):3499–3503. doi:10.1073/pnas.82.10.3499
   PubMed Web of Science ®Google Scholar
• Hashemian S, Alhouayek M, Fowler CJ. TLR4 receptor expression and function in F11 dorsal root ganglion × neuroblastoma hybrid cells. Innate Immun. 2017;23(8):687–696. doi:10.1177/1753425917732824
   PubMed Web of Science ®Google Scholar
• Pastori V, D’Aloia A, Blasa S, Lecchi M. Serum-deprived differentiated neuroblastoma F-11 cells express functional dorsal root ganglion neuron properties. PeerJ. 2019;2019(10):1–20. doi:10.7717/peerj.7951
   Google Scholar
• Cahana A, Vutskits L, Muller D. Acute differential modulation of synaptic transmission and cell survival during exposure to pulsed and continuous radiofrequency energy. J Pain. 2003;4(4):197–202. doi:10.1016/S1526-5900(03)00554-6
   PubMed Web of Science ®Google Scholar
• Pan L, Zhang P, Hu F, et al. Hypotonic stress induces fast, reversible degradation of the vimentin cytoskeleton via intracellular calcium release. Adv Sci. 2019;6(18):1–8. doi:10.1002/advs.201900865
   Web of Science ®Google Scholar
• Pendergrass W, Wolf N, Pool M. Efficacy of MitoTracker GreenTM and CMXRosamine to measure changes in mitochondrial membrane potentials in living cells and tissues. Cytom Part A. 2004;61(2):162–169. doi:10.1002/cyto.a.20033
   PubMed Web of Science ®Google Scholar
• Haberberger RV, Barry C, Matusica D. Immortalized dorsal root ganglion neuron cell lines. Front Cell Neurosci. 2020;14. doi:10.3389/fncel.2020.00184
   PubMed Web of Science ®Google Scholar
• Yin K, Baillie GJ, Vetter I. Neuronal cell lines as dorsal root ganglion neurons: a transcriptomic comparison. Mol Pain. 2016;12:1–17. doi:10.1177/1744806916646111
   Web of Science ®Google Scholar
• Martínez AL, Brea J, Monroy X, Merlos M, Burgueño J, Loza MI. A new of sensorial neuron-like cells for HTS of novel analgesics for neuropathic pain. SLAS Discov. 2019;24(2):158–168. doi:10.1177/2472555218810323
   PubMed Web of Science ®Google Scholar
• Vetter I, Lewis RJ. Characterization of endogenous calcium responses in neuronal cell lines. Biochem Pharmacol. 2010;79(6):908–920. doi:10.1016/j.bcp.2009.10.020
   PubMed Web of Science ®Google Scholar
• Fabbretti E. P2X3 ATP, receptors and neuronal sensitization. Front Cell Neurosci. 2013;7:1–6. doi:10.3389/fncel.2013.00236
   PubMed Web of Science ®Google Scholar
• Van Zundert J, Lamé IE, De Louw A, et al. Percutaneous pulsed radiofrequency treatment of the cervical dorsal root ganglion in the treatment of chronic cervical pain syndromes: a clinical audit. Neuromodulation. 2003;6(1):6–14. doi:10.1046/j.1525-1403.2003.03001.x
   PubMed Web of Science ®Google Scholar
• Chao SC, Lee HT, Kao TH, et al. Percutaneous pulsed radiofrequency in the treatment of cervical and lumbar radicular pain. Surg Neurol. 2008;70(1):59–65. doi:10.1016/j.surneu.2007.05.046
   PubMedGoogle Scholar
• Wang F, Zhou Q, Xiao L, et al. A randomized comparative study of pulsed radiofrequency treatment with or without selective nerve root block for chronic cervical radicular pain. Pain Pract. 2017;17(5):589–595. doi:10.1111/papr.12493
   PubMed Web of Science ®Google Scholar
• Vanneste T, Van Lantschoot A, Van Boxem K, Van Zundert J. Pulsed radiofrequency in chronic pain. Curr Opin Anaesthesiol. 2017;30(5):577–582. doi:10.1097/ACO.0000000000000502
   PubMed Web of Science ®Google Scholar
• Erdem Y, Sir E. The efficacy of ultrasound-guided pulsed radiofrequency of genicular nerves in the treatment of chronic knee pain due to severe degenerative disease or previous total knee arthroplasty. Med Sci Monit. 2019;25:1857–1863. doi:10.12659/MSM.915359
   PubMed Web of Science ®Google Scholar
• Napoli A, Alfieri G, Scipione R, Andrani F, Leonardi A, Catalano C. Pulsed radiofrequency for low-back pain and sciatica. Expert Rev Med Devices. 2020;17(2):83–86. doi:10.1080/17434440.2020.1719828
   PubMed Web of Science ®Google Scholar
• Cahana A, Van Zundert J, Macrea L, Van Kleef M, Sluijter M. Pulsed radiofrequency: current clinical and biological literature available. Pain Med. 2006;7(5):411–423. doi:10.1111/j.1526-4637.2006.00148.x
   PubMed Web of Science ®Google Scholar
• Lin ML, Lin WT, Huang RY, et al. Pulsed radiofrequency inhibited activation of spinal mitogen-activated protein kinases and ameliorated early neuropathic pain in rats. Eur J Pain. 2014;18(5):659–670. doi:10.1002/j.1532-2149.2013.00419.x
   PubMed Web of Science ®Google Scholar
• Xu X, Fu S, Shi X, Liu R. Microglial BDNF, PI3K, and p-ERK in the spinal cord are suppressed by pulsed radiofrequency on dorsal root ganglion to ease SNI-induced neuropathic pain in rats. Pain Res Manag. 2019;2019. doi:10.1155/2019/5948686
   Web of Science ®Google Scholar
• Bevilaqua LRM, Cammarota M. PERK, mTORC1 and eEF2 interplay during long term potentiation: an Editorial for ‘Genetic removal of eIF2a kinase PERK in mice enables hippocampal L-LTP independent of mTORC1 activity’ on page 133. J Neurochem. 2018;146(2):119–121. doi:10.1111/jnc.14485
   PubMed Web of Science ®Google Scholar
• Deng M, Chen S, Chen H, Luo Y, Dong Y, Pan H. Mitogen-activated protein kinase signaling mediates opioid- induced presynaptic NMDA receptor activation and analgesic tolerance. J Neurochem. 2019;148(2):275–290. doi:10.1111/jnc.14628.Mitogen-Activated
   PubMed Web of Science ®Google Scholar
• Mercadal B, Vicente R, Ivorra A. Pulsed radiofrequency for chronic pain: in vitro evidence of an electroporation mediated calcium uptake. Bioelectrochemistry. 2020;136:107624. doi:10.1016/j.bioelechem.2020.107624
   PubMed Web of Science ®Google Scholar
• Vergara RC, Jaramillo-Riveri S, Luarte A, et al. The energy homeostasis principle: neuronal energy regulation drives local network dynamics generating behavior. Front Comput Neurosci. 2019;13:1–18. doi:10.3389/fncom.2019.00049
   PubMed Web of Science ®Google Scholar
• Davis GW. Not fade away: mechanisms of neuronal ATP homeostasis. Neuron. 2020;105(4):591–593. doi:10.1016/j.neuron.2020.01.024
   PubMed Web of Science ®Google Scholar
• Baughman JM, Perocchi F, Girgis HS, et al. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature. 2011;476(7360):341–345. doi:10.1038/nature10234
   PubMed Web of Science ®Google Scholar
• Ashrafi G, De J-SJ, Farrell RJ, Ryan TA. ensures metabolic flexibility of neurotransmission. Neuron. 2021;105(4):678–687. doi:10.1016/j.neuron.2019.11.020
   Google Scholar
• Morais VA, Verstreken P, Roethig A, et al. Parkinson’s disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol Med. 2009;1(2):99–111. doi:10.1002/emmm.200900006
   PubMed Web of Science ®Google Scholar
• Wang HL, Chou AH, Wu AS, et al. PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons. Biochim Biophys Acta - Mol Basis Dis. 2011;1812(6):674–684. doi:10.1016/j.bbadis.2011.03.007
   PubMed Web of Science ®Google Scholar
• Gvozdjáková A, de Cabo R, Navas P. Mitochondrial medicine. Recent Adv Mitochondrial Med Coenzyme Q. 2018;1–11. doi:10.1161/circulationaha.108.775163
   Google Scholar
• Zorova L, Popkov V, Plotnikov E, et al. Mitochondrial membrane potential Ljubava. Anal Biochem. 2018;552:50–59. doi:10.1016/j.ab.2017.07.009
   PubMed Web of Science ®Google Scholar