240
Views
0
CrossRef citations to date
0
Altmetric
Pre-Clinical/Scientific

Electroacupuncture Attenuates Neuropathic Pain in a Rat Model of Cervical Spondylotic Radiculopathy: Involvement of Spinal Cord Synaptic Plasticity

ORCID Icon, , , , , , ORCID Icon, & show all
Pages 2447-2460 | Received 30 Mar 2023, Accepted 07 Jul 2023, Published online: 18 Jul 2023

References

  • Hu J, Chen F, Qiu G, et al. Jingshu Keli for treating cervical spondylotic radiculopathy: the first multicenter, randomized, controlled clinical trial. J Orthop Translat. 2021;27:44–56. doi:10.1016/j.jot.2020.10.010
  • Luyao H, Xiaoxiao Y, Tianxiao F, et al. Management of cervical spondylotic radiculopathy: a systematic review. Global Spine J. 2022;12(8):1912–1924. doi:10.1177/21925682221075290
  • Yu CX, Li B, Xu YK, et al. Altered functional connectivity of the periaqueductal gray in chronic neck and shoulder pain. Neuroreport. 2017;28(12):720–725. doi:10.1097/wnr.0000000000000819
  • Liu XH, Du YM, Cong HJ, et al. Effects of continuous epidural injection of dexamethasone on blood glucose, blood lipids, plasma cortisol and ACTH in patients with neuropathic pain. Front Neurol. 2020;11:564643. doi:10.3389/fneur.2020.564643
  • Finnerup NB, Kuner R, Jensen TS. Neuropathic pain: from mechanisms to treatment. Physiol Rev. 2021;101(1):259–301. doi:10.1152/physrev.00045.2019
  • Ju ZY, Wang K, Cui HS, et al. Acupuncture for neuropathic pain in adults. Cochrane Database Syst Rev. 2017;12(12):Cd012057. doi:10.1002/14651858.CD012057.pub2
  • Bai LL, Wang WT, Wang JF, et al. Anterior cervical discectomy and fusion combined with foraminotomy assisted by high-definition 3-dimensional exoscope in the treatment of cervical spondylotic radiculopathy secondary to bony foraminal stenosis. Orthop Surg. 2021;13(8):2318–2326. doi:10.1111/os.13040
  • Zhou LJ, Peng J, Xu YN, et al. Microglia are indispensable for synaptic plasticity in the spinal dorsal horn and chronic pain. Cell Rep. 2019;27(13):3844–3859.e3846. doi:10.1016/j.celrep.2019.05.087
  • Obata K, Yamanaka H, Kobayashi K, et al. Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation. J Neurosci. 2004;24(45):10211–10222. doi:10.1523/jneurosci.3388-04.2004
  • Sun L, Peng C, Joosten E, et al. Spinal cord stimulation and treatment of peripheral or central neuropathic pain: mechanisms and clinical application. Neural Plast. 2021;2021:5607898. doi:10.1155/2021/5607898
  • Gómez de San José N, Massa F, Halbgebauer S, et al. Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration. J Neural Transm. 2022;129(2):207–230. doi:10.1007/s00702-021-02411-2
  • Rothwell JC. Plasticity in the human motor system. Folia Phoniatr Logop. 2010;62(4):153–157. doi:10.1159/000314030
  • Zhang L, Wang G, Ma J, et al. Brain-derived neurotrophic factor (BDNF) in the rostral anterior cingulate cortex (rACC) contributes to neuropathic spontaneous pain-related aversion via NR2B receptors. Brain Res Bull. 2016;127:56–65. doi:10.1016/j.brainresbull.2016.08.016
  • Zhang Z, Ding X, Zhou Z, et al. Sirtuin 1 alleviates diabetic neuropathic pain by regulating synaptic plasticity of spinal dorsal horn neurons. Pain. 2019;160(5):1082–1092. doi:10.1097/j.pain.0000000000001489
  • Ferreira N, Gonçalves NP, Jan A, et al. Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain. Acta Neuropathol Commun. 2021;9(1):31. doi:10.1186/s40478-021-01131-8
  • Dias PA, Guimarães AB, Albuquerque Ade O, et al. Short-term complementary and alternative medicine on quality of life in women with fibromyalgia. J Integr Med. 2016;14(1):29–35. doi:10.1016/S2095-4964(16)60235-2
  • Liu J, Huang Z, Zhang GH. Involvement of NF-κB signal pathway in acupuncture treatment of patients with rheumatoid arthritis. Zhen Ci Yan Jiu. 2020;45(11):914–919. doi:10.13702/j.1000-0607.190848
  • Li JN, Li J, Liu J, et al. Acupuncture with Tiaochong Shugan method by stages for menstrual headache based on syndrome differentiation: a randomized controlled trial. Zhongguo Zhen Jiu. 2022;42(10):1108–1112. doi:10.13703/j.0255-2930.20211203-k0005
  • Lang PM, Stoer J, Schober GM, et al. Bilateral acupuncture analgesia observed by quantitative sensory testing in healthy volunteers. Anesth Analg. 2010;110(5):1448–1456. doi:10.1213/ANE.0b013e3181d3e7ef
  • Zheng Z, Feng SJ, Costa C, et al. Acupuncture analgesia for temporal summation of experimental pain: a randomised controlled study. Eur J Pain. 2010;14(7):725–731. doi:10.1016/j.ejpain.2009.11.006
  • Liu Y, Du J, Fang J, et al. Electroacupuncture inhibits the interaction between peripheral TRPV1 and P2X3 in rats with different pathological pain. Physiol Res. 2021;70(4):635–647. doi:10.33549/physiolres.934649
  • Ali U, Apryani E, Wu HY, et al. Low frequency electroacupuncture alleviates neuropathic pain by activation of spinal microglial IL-10/β-endorphin pathway. Biomed Pharmacother. 2020;125:109898. doi:10.1016/j.biopha.2020.109898
  • Wan J, Nan S, Liu J, et al. Synaptotagmin 1 is involved in neuropathic pain and electroacupuncture-mediated analgesic effect. Int J Mol Sci. 2020;21(3):968. doi:10.3390/ijms21030968
  • Zhou K, Wu Q, Yue J, et al. Electroacupuncture suppresses spinal nerve ligation-induced neuropathic pain via regulation of synaptic plasticity through upregulation of basic fibroblast growth factor expression. Acupunct Med. 2022;40(4):379–388. doi:10.1177/09645284211066499
  • Xing GG, Liu FY, Qu XX, et al. Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain. Exp Neurol. 2007;208(2):323–332. doi:10.1016/j.expneurol.2007.09.004
  • Cai HQ, Lin XY, Chen HY, et al. Direct moxibustion exerts an analgesic effect on cervical spondylotic radiculopathy by increasing autophagy via the Act A/Smads signaling pathway. Brain Behav. 2022;12(4):e2545. doi:10.1002/brb3.2545
  • Shen WS, Li CF, Zhou ZS, et al. MicroRNA-204 silencing relieves pain of cervical spondylotic radiculopathy by targeting GDNF. Gene Ther. 2020;27(6):254–265. doi:10.1038/s41434-019-0114-3
  • Sun W, Zheng K, Liu B, et al. Neuroprotective potential of gentongping in rat model of cervical spondylotic radiculopathy targeting PPAR-γ pathway. J Immunol Res. 2017;2017:9152960. doi:10.1155/2017/9152960
  • Kawakami M, Weinstein JN, Spratt KF, et al.; Experimental lumbar radiculopathy. Immunohistochemical and quantitative demonstrations of pain induced by lumbar nerve root irritation of the rat. Spine. 1994;19(16):1780–1794. doi:10.1097/00007632-199408150-00001
  • Chaplan SR, Bach FW, Pogrel JW, et al. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 1994;53(1):55–63. doi:10.1016/0165-0270(94)90144-9
  • Chen S, Su SY, Huang YL, et al. Effect of electroacupuncture at distal acupoints on expression of JAK1 and STAT3 proteins in local spinal cord tissue of CSR rats. Chin Archiv Trad Chin. 2018;36(05):1154–1156. doi:10.13193/j.issn.1673-7717.2018.05.033
  • Zhou Y, Wang W, Tian K, et al. Efficacy and safety of electroacupuncture in treatment of cervical spondylosis: a protocol of randomized controlled trial. Medicine. 2021;100(18):e25570. doi:10.1097/md.0000000000025570
  • Liao J, Zhang L, Zheng J, et al. Electroacupuncture inhibits annulus fibrosis cell apoptosis in vivo via TNF-α-TNFR1-caspase-8 and integrin β1/Akt signaling pathways. J Tradit Chin Med. 2014;34(6):684–690. doi:10.1016/s0254-6272(15)30083-2
  • Jia YZ, Li HT, Zhang GM, et al. Electroacupuncture alleviates orofacial allodynia and anxiety-like behaviors by regulating synaptic plasticity of the CA1 hippocampal region in a mouse model of trigeminal neuralgia. Front Mol Neurosci. 2022;15:979483. doi:10.3389/fnmol.2022.979483
  • Xu Q, Liu T, Chen S, et al. Correlation between the cumulative analgesic effect of electroacupuncture intervention and synaptic plasticity of hypothalamic paraventricular nucleus neurons in rats with sciatica. Neural Regen Res. 2013;8(3):218–225. doi:10.3969/j.issn.1673-5374.2013.03.003
  • Lv PR, Su YS, He W, et al. Electroacupuncture alleviated referral hindpaw hyperalgesia via suppressing spinal Long-Term Potentiation (LTP) in TNBS-induced colitis rats. Neural Plast. 2019;2019:2098083. doi:10.1155/2019/2098083
  • Song X, Shao X. Effect of annular external fixator-assisted bone transport on clinical healing, pain stress and joint function of traumatic massive bone defect of tibia. Comput Math Methods Med. 2022;2022:9052770. doi:10.1155/2022/9052770
  • Sindrup SH, Graf A, Sfikas N. The NK1-receptor antagonist TKA731 in painful diabetic neuropathy: a randomised, controlled trial. Eur J Pain. 2006;10(6):567–571. doi:10.1016/j.ejpain.2005.08.001
  • Zeilhofer HU. The glycinergic control of spinal pain processing. Cell Mol Life Sci. 2005;62(18):2027–2035. doi:10.1007/s00018-005-5107-2
  • Chen L, Hu Y, Wang S, et al. mTOR-neuropeptide Y signaling sensitizes nociceptors to drive neuropathic pain. JCI Insight. 2022;7(22):e159247. doi:10.1172/jci.insight.159247
  • Sapunar D, Vukojević K, Kostić S, et al. Attenuation of pain-related behavior evoked by injury through blockade of neuropeptide Y Y2 receptor. Pain. 2011;152(5):1173–1181. doi:10.1016/j.pain.2011.01.045
  • Qiao LN, Wang JY, Yang YS, et al. Effect of electroacupuncture intervention on expression of CGRP, SP, COX-1, and PGE2 of dorsal portion of the cervical spinal cord in rats with neck-incision pain. Evid Based Complement Alternat Med. 2013;2013:294091. doi:10.1155/2013/294091
  • Bliss TV, Collingridge GL, Kaang BK, et al. Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain. Nat Rev Neurosci. 2016;17(8):485–496. doi:10.1038/nrn.2016.68
  • Latremoliere A, Woolf CJ. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain. 2009;10(9):895–926. doi:10.1016/j.jpain.2009.06.012
  • Dai WJ, Sun JL, Li C, et al. Involvement of Interleukin-10 in Analgesia of Electroacupuncture on Incision Pain. Evid Based Complement Alternat Med. 2019;2019:8413576. doi:10.1155/2019/8413576
  • Lyu Z, Guo Y, Gong Y, et al. The Role of neuroglial crosstalk and synaptic plasticity-mediated central sensitization in acupuncture analgesia. Neural Plast. 2021;2021:8881557. doi:10.1155/2021/8881557
  • Su DJ, Li LF, Wang SY, et al. Pra-C exerts analgesic effect through inhibiting microglial activation in anterior cingulate cortex in complete Freund’s adjuvant-induced mouse model. Mol Pain. 2021;17:1744806921990934. doi:10.1177/1744806921990934
  • Cheng F, Vivacqua G, Yu S. The role of α-synuclein in neurotransmission and synaptic plasticity. J Chem Neuroanat. 2011;42(4):242–248. doi:10.1016/j.jchemneu.2010.12.001
  • Schmidtko A, Luo C, Gao W, et al. Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn. Pain. 2008;139(3):632–643. doi:10.1016/j.pain.2008.06.018
  • Bogen IL, Jensen V, Hvalby Ø, et al. Glutamatergic neurotransmission in the synapsin I and II double knock-out mouse. Semin Cell Dev Biol. 2011;22(4):400–407. doi:10.1016/j.semcdb.2011.07.004
  • Le S, Xu L, Wen C, et al. PSD95 gene specific siRNAs attenuate neuropathic pain through modulating neuron sensibility and postsynaptic CaMKIIα phosphorylation. Chin Med Sci J. 2011;26(4):201–207. doi:10.1016/s1001-9294(12)60001-7
  • Zhou NB, Wang KG, Fu ZJ. Effect of morphine and a low dose of ketamine on the T cells of patients with refractory cancer pain in vitro. Oncol Lett. 2019;18(4):4230–4236. doi:10.3892/ol.2019.10750
  • Baron R, Binder A, Wasner G. Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment. Lancet Neurol. 2010;9(8):807–819. doi:10.1016/s1474-4422(10)70143-5
  • Dai Y, Zhang Y, Yang M, et al. Electroacupuncture Increases the hippocampal synaptic transmission efficiency and long-term plasticity to improve vascular cognitive impairment. Mediators Inflamm. 2022;2022:5985143. doi:10.1155/2022/5985143