The Relationship Between Chronic Pain and Cognitive Impairment in the Elderly: A Review of Current Evidence

References

• Petersen RC, Lopez O, Armstrong MJ, et al. Practice guideline update summary: mild cognitive impairment: report of the guideline development, dissemination, and implementation subcommittee of the American Academy of Neurology. Neurology. 2018;90(3):126–135. doi:10.1212/WNL.0000000000004826
   PubMed Web of Science ®Google Scholar
• World Alzheimer Report 2018 - the state of the art of dementia research: new frontiers. New Frontiers. 48.
   Google Scholar
• Jia J, Wei C, Chen S, et al. The cost of Alzheimer’s disease in China and re-estimation of costs worldwide. Alzheimers Dement. 2018;14(4):483–491. doi:10.1016/j.jalz.2017.12.006
   PubMed Web of Science ®Google Scholar
• Tom SE, Hubbard RA, Crane PK, et al. Characterization of dementia and Alzheimer’s disease in an older population: updated incidence and life expectancy with and without dementia. Am J Public Health. 2015;105(2):408–413. doi:10.2105/AJPH.2014.301935
   PubMed Web of Science ®Google Scholar
• Pickett J, Brayne C. The scale and profile of global dementia research funding. Lancet. 2019;394(10212):1888–1889. doi:10.1016/S0140-6736(19)32599-1
   PubMed Web of Science ®Google Scholar
• Livingston G, Huntley J, Sommerlad A, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396(10248):413–446. doi:10.1016/S0140-6736(20)30367-6
   PubMed Web of Science ®Google Scholar
• Raja SN, Carr DB, Cohen M, et al. The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. Pain. 2020;161(9):1976–1982. doi:10.1097/j.pain.0000000000001939
   PubMed Web of Science ®Google Scholar
• Cohen SP, Vase L, Hooten WM. Chronic pain: an update on burden, best practices, and new advances. Lancet. 2021;397(10289):2082–2097. doi:10.1016/S0140-6736(21)00393-7
   PubMed Web of Science ®Google Scholar
• Kuner R, Flor H. Structural plasticity and reorganisation in chronic pain. Nat Rev Neurosci. 2017;18(2):113. doi:10.1038/nrn.2017.5
   PubMed Web of Science ®Google Scholar
• Enkvist A, Ekström H, Elmståhl S. Life satisfaction (LS) and symptoms among the oldest-old: results from the longitudinal population study called Good Aging in Skåne (GÅS). Arch Gerontol Geriatr. 2012;54(1):146–150. doi:10.1016/j.archger.2011.05.001
   PubMed Web of Science ®Google Scholar
• Baker KS, Gibson S, Georgiou-Karistianis N, Roth RM, Giummarra MJ. Everyday executive functioning in chronic pain: specific deficits in working memory and emotion control, predicted by mood, medications, and pain interference. Clin J Pain. 2016;32(8):673–680. doi:10.1097/AJP.0000000000000313
   PubMed Web of Science ®Google Scholar
• van der Leeuw G, Leveille SG, Dong Z, et al. Chronic pain and attention in older community-dwelling adults. J Am Geriatr Soc. 2018;66(7):1318–1324. doi:10.1111/jgs.15413
   PubMed Web of Science ®Google Scholar
• Whitlock EL, Diaz-Ramirez LG, Glymour MM, et al. Association between persistent pain and memory decline and dementia in a longitudinal cohort of elders. JAMA Intern Med. 2017;177(8):1146–1153. doi:10.1001/jamainternmed.2017.1622
   PubMed Web of Science ®Google Scholar
• Rouch I, Edjolo A, Laurent B, et al. Association between chronic pain and long-term cognitive decline in a population-based cohort of elderly participants. Pain. 2021;162(2):552–560. doi:10.1097/j.pain.0000000000002047
   PubMed Web of Science ®Google Scholar
• Kao P-H, Fong-Lin J, Chung-Han H, et al. Chronic pain increases the risk of dementia: a nationwide population-based cohort study. Pain Physician. 2021;24:E849–E856.
   PubMed Web of Science ®Google Scholar
• Bushnell MC, Ceko M, Low LA. Cognitive and emotional control of pain and its disruption in chronic pain. Nat Rev Neurosci. 2013;14(7):502–511. doi:10.1038/nrn3516
   PubMed Web of Science ®Google Scholar
• van Kooten J, Binnekade TT, van der Wouden JC, et al. A review of pain prevalence in Alzheimer’s, vascular, frontotemporal and lewy body dementias. Dement Geriatr Cogn Disord. 2016;41(3–4):220–232. doi:10.1159/000444791
   PubMed Web of Science ®Google Scholar
• Abeare CA, Cohen JL, Axelrod BN, et al. Pain, executive functioning, and affect in patients with rheumatoid arthritis. Clin J Pain. 2010;26(8):683–689. doi:10.1097/AJP.0b013e3181ed1762
   PubMed Web of Science ®Google Scholar
• Oosterman JM, Derksen LC, van Wijck AJM, Veldhuijzen DS, Kessels RPC. Memory functions in chronic pain: examining contributions of attention and age to test performance. Clin J Pain. 2011;27(1):70–75. doi:10.1097/AJP.0b013e3181f15cf5
   PubMed Web of Science ®Google Scholar
• Innes KE, Sambamoorthi U. The association of perceived memory loss with osteoarthritis and related joint pain in a large appalachian population. Pain Med. 2018;19(7):1340–1356. doi:10.1093/pm/pnx107
   PubMed Web of Science ®Google Scholar
• Cardoso J, Apagueno B, Lysne P, et al. Pain and the Montreal Cognitive Assessment (MoCA) in aging. Pain Med. 2021;22(8):1776–1783. doi:10.1093/pm/pnab003
   PubMed Web of Science ®Google Scholar
• Bell TR, Sprague BN, Ross LA. Longitudinal associations of pain and cognitive decline in community-dwelling older adults. Psychol Aging. 2022;37(6):715–730. doi:10.1037/pag0000699
   PubMed Web of Science ®Google Scholar
• van der Leeuw G, Ayers E, Leveille SG, et al. The effect of pain on major cognitive impairment in older adults. J Pain. 2018;19(12):1435–1444. doi:10.1016/j.jpain.2018.06.009
   PubMed Web of Science ®Google Scholar
• Ikram M, Innes K, Sambamoorthi U. Association of osteoarthritis and pain with Alzheimer’s Diseases and Related Dementias among older adults in the United States. Osteoarthritis Cartilage. 2019;27(10):1470–1480. doi:10.1016/j.joca.2019.05.021
   PubMed Web of Science ®Google Scholar
• Bell T, Franz CE, Kremen WS. Persistence of pain and cognitive impairment in older adults. J Am Geriatr Soc. 2022;70(2):449–458. doi:10.1111/jgs.17542
   PubMed Web of Science ®Google Scholar
• Zhang X, Gao R, Zhang C, et al. Evidence for cognitive decline in chronic pain: a systematic review and meta-analysis. Front Neurosci. 2021;15:737874. doi:10.3389/fnins.2021.737874
   PubMed Web of Science ®Google Scholar
• de Aguiar GPCG, Saraiva MD, Khazaal EJB, et al. Persistent pain and cognitive decline in older adults: a systematic review and meta-analysis from longitudinal studies. Pain. 2020;161(10):2236–2247. doi:10.1097/j.pain.0000000000001932
   PubMed Web of Science ®Google Scholar
• Pinto TCC, Machado L, Bulgacov TM, et al. Is the Montreal Cognitive Assessment (MoCA) screening superior to the Mini-Mental State Examination (MMSE) in the detection of mild cognitive impairment (MCI) and Alzheimer’s Disease (AD) in the elderly? Int Psychogeriatr. 2019;31(04):491–504. doi:10.1017/S1041610218001370
   PubMedGoogle Scholar
• Oosterman JM, de Vries K, Dijkerman HC, de Haan EHF, Scherder EJA. Exploring the relationship between cognition and self-reported pain in residents of homes for the elderly. Int Psychogeriatr. 2009;21(01):157–163. doi:10.1017/S1041610208007941
   PubMedGoogle Scholar
• Landrø NI, Fors EA, Våpenstad LL, et al. The extent of neurocognitive dysfunction in a multidisciplinary pain centre population. Is there a relation between reported and tested neuropsychological functioning? Pain. 2013;154(7):972–977. doi:10.1016/j.pain.2013.01.013
   PubMed Web of Science ®Google Scholar
• Samartin-Veiga N, González-Villar AJ, Carrillo-de-la-peña MT. Neural correlates of cognitive dysfunction in fibromyalgia patients: reduced brain electrical activity during the execution of a cognitive control task. Neuroimage Clin. 2019;23:101817. doi:10.1016/j.nicl.2019.101817
   PubMed Web of Science ®Google Scholar
• Andrews-Hanna JR, Smallwood J, Spreng RN. The default network and self-generated thought: component processes, dynamic control, and clinical relevance. Ann N Y Acad Sci. 2014;1316(1):29–52. doi:10.1111/nyas.12360
   PubMed Web of Science ®Google Scholar
• Buckner RL, Snyder AZ, Shannon BJ, et al. Molecular, structural, and functional characterization of Alzheimer’s disease: evidence for a relationship between default activity, amyloid, and memory. J Neurosci. 2005;25(34):7709–7717. doi:10.1523/JNEUROSCI.2177-05.2005
   PubMed Web of Science ®Google Scholar
• Peterson BS, Potenza MN, Wang Z, et al. An FMRI study of the effects of psychostimulants on default-mode processing during Stroop task performance in youths with ADHD. Am J Psychiatry. 2009;166(11):1286–1294. doi:10.1176/appi.ajp.2009.08050724
   PubMed Web of Science ®Google Scholar
• Anticevic A, Repovs G, Shulman GL, Barch DM. When less is more: TPJ and default network deactivation during encoding predicts working memory performance. Neuroimage. 2010;49(3):2638–2648. doi:10.1016/j.neuroimage.2009.11.008
   PubMed Web of Science ®Google Scholar
• White TP, Jansen M, Doege K, et al. Theta power during encoding predicts subsequent-memory performance and default mode network deactivation. Hum Brain Mapp. 2013;34(11):2929–2943. doi:10.1002/hbm.22114
   PubMed Web of Science ®Google Scholar
• Baliki MN, Geha PY, Apkarian AV, Chialvo DR. Beyond feeling: chronic pain hurts the brain, disrupting the default-mode network dynamics. J Neurosci. 2008;28(6):1398–1403. doi:10.1523/JNEUROSCI.4123-07.2008
   PubMed Web of Science ®Google Scholar
• Kucyi A, Salomons TV, Davis KD. Mind wandering away from pain dynamically engages antinociceptive and default mode brain networks. Proc Natl Acad Sci U S A. 2013;110(46):18692–18697. doi:10.1073/pnas.1312902110
   PubMed Web of Science ®Google Scholar
• Hemington KS, Rogachov A, Cheng JC, et al. Patients with chronic pain exhibit a complex relationship triad between pain, resilience, and within- and cross-network functional connectivity of the default mode network. Pain. 2018;159(8):1621–1630. doi:10.1097/j.pain.0000000000001252
   PubMed Web of Science ®Google Scholar
• Shi H, Yuan C, Dai Z, Ma H, Sheng L. Gray matter abnormalities associated with fibromyalgia: a meta-analysis of voxel-based morphometric studies. Semin Arthritis Rheum. 2016;46(3):330–337. doi:10.1016/j.semarthrit.2016.06.002
   PubMed Web of Science ®Google Scholar
• Zhou Z, Hui ES, Kranz GS, et al. Potential mechanisms underlying the accelerated cognitive decline in people with chronic low back pain: a scoping review. Ageing Res Rev. 2022;82:101767. doi:10.1016/j.arr.2022.101767
   PubMed Web of Science ®Google Scholar
• Rodriguez-Raecke R, Niemeier A, Ihle K, Ruether W, May A. Brain gray matter decrease in chronic pain is the consequence and not the cause of pain. J Neurosci. 2009;29(44):13746–13750. doi:10.1523/JNEUROSCI.3687-09.2009
   PubMed Web of Science ®Google Scholar
• Seminowicz DA, Shpaner M, Keaser ML, et al. Cognitive-behavioral therapy increases prefrontal cortex gray matter in patients with chronic pain. J Pain. 2013;14(12):1573–1584. doi:10.1016/j.jpain.2013.07.020
   PubMed Web of Science ®Google Scholar
• Pomares FB, Funck T, Feier NA, et al. Histological underpinnings of grey matter changes in fibromyalgia investigated using multimodal brain imaging. J Neurosci. 2017;37(5):1090–1101. doi:10.1523/JNEUROSCI.2619-16.2016
   PubMed Web of Science ®Google Scholar
• Kang D, McAuley JH, Kassem MS, Gatt JM, Gustin SM. What does the grey matter decrease in the medial prefrontal cortex reflect in people with chronic pain? Eur J Pain. 2019;23(2):203–219. doi:10.1002/ejp.1304
   PubMed Web of Science ®Google Scholar
• Franklin TR, Wang Z, Shin J, et al. A VBM study demonstrating ‘apparent’ effects of a single dose of medication on T1-weighted MRIs. Brain Struct Funct. 2013;218(1):97–104. doi:10.1007/s00429-012-0385-6
   PubMed Web of Science ®Google Scholar
• Chen G, Zhang Y-Q, Qadri YJ, Serhan CN, Ji -R-R. Microglia in pain: detrimental and protective roles in pathogenesis and resolution of pain. Neuron. 2018;100(6):1292–1311. doi:10.1016/j.neuron.2018.11.009
   PubMed Web of Science ®Google Scholar
• Orihuela R, McPherson CA, Harry GJ. Microglial M1/M2 polarization and metabolic states. Br J Pharmacol. 2016;173(4):649–665. doi:10.1111/bph.13139
   PubMed Web of Science ®Google Scholar
• Smirnov D, Galasko D. Dynamics of neuroinflammation in AlzheimerAlzheimer’s disease. Lancet Neurol. 2022;21(4):297–298. doi:10.1016/S1474-4422(22)00087-4
   PubMed Web of Science ®Google Scholar
• Loggia ML, Chonde DB, Akeju O, et al. Evidence for brain glial activation in chronic pain patients. Brain. 2015;138(3):604–615. doi:10.1093/brain/awu377
   PubMed Web of Science ®Google Scholar
• Sideris-Lampretsas G, Malcangio M. Microglial heterogeneity in chronic pain. Brain Behav Immun. 2021;96:279–289. doi:10.1016/j.bbi.2021.06.005
   PubMed Web of Science ®Google Scholar
• Vergne-Salle P, Bertin P. Chronic pain and neuroinflammation. Joint Bone Spine. 2021;88(6):105222. doi:10.1016/j.jbspin.2021.105222
   PubMed Web of Science ®Google Scholar
• Ji R-R, Nackley A, Huh Y, Terrando N, Maixner W. Neuroinflammation and Central Sensitization in Chronic and Widespread Pain. Anesthesiology. 2018;129(2):343–366. doi:10.1097/ALN.0000000000002130
   PubMed Web of Science ®Google Scholar
• Meints SM, Edwards RR. Evaluating psychosocial contributions to chronic pain outcomes. Prog Neuropsychopharmacol Biol Psychiatry. 2018;87(Pt B):168–182. doi:10.1016/j.pnpbp.2018.01.017
   PubMed Web of Science ®Google Scholar
• Hall AM, Kamper SJ, Maher CG, et al. Symptoms of depression and stress mediate the effect of pain on disability. Pain. 2011;152(5):1044–1051. doi:10.1016/j.pain.2011.01.014
   PubMed Web of Science ®Google Scholar
• Ilgen MA, Kleinberg F, Ignacio RV, et al. Noncancer pain conditions and risk of suicide. JAMA Psychiatry. 2013;70(7):692–697. doi:10.1001/jamapsychiatry.2013.908
   PubMed Web of Science ®Google Scholar
• Macfarlane GJ, McBeth J, Silman AJ, Crombie IK. Widespread body pain and mortality: prospective population based study. BMJ. 2001;323(7314):662–665. doi:10.1136/bmj.323.7314.662
   PubMedGoogle Scholar
• Almeida OP, Hankey GJ, Yeap BB, Golledge J, Flicker L. Depression as a modifiable factor to decrease the risk of dementia. Transl Psychiatry. 2017;7(5):e1117. doi:10.1038/tp.2017.90
   PubMed Web of Science ®Google Scholar
• Krogh J, Benros ME, Jørgensen MB, et al. The association between depressive symptoms, cognitive function, and inflammation in major depression. Brain Behav Immun. 2014;35:70–76. doi:10.1016/j.bbi.2013.08.014
   PubMed Web of Science ®Google Scholar
• Irwin MR. Sleep and inflammation: partners in sickness and in health. Nat Rev Immunol. 2019;19(11):702–715. doi:10.1038/s41577-019-0190-z
   PubMed Web of Science ®Google Scholar
• Bowman GL, Dayon L, Kirkland R, et al. Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults. Alzheimers Dement. 2018;14(12):1640–1650. doi:10.1016/j.jalz.2018.06.2857
   PubMed Web of Science ®Google Scholar
• Colla M, Kronenberg G, Deuschle M, et al. Hippocampal volume reduction and HPA-system activity in major depression. J Psychiatr Res. 2007;41(7):553–560. doi:10.1016/j.jpsychires.2006.06.011
   PubMed Web of Science ®Google Scholar
• Shoskes DA, Wang H, Polackwich AS, et al. Analysis of gut microbiome reveals significant differences between men with chronic prostatitis/chronic pelvic pain syndrome and controls. J Urol. 2016;196(2):435–441. doi:10.1016/j.juro.2016.02.2959
   PubMed Web of Science ®Google Scholar
• Minerbi A, Gonzalez E, Brereton NJB, et al. Altered microbiome composition in individuals with fibromyalgia. Pain. 2019;160(11):2589–2602. doi:10.1097/j.pain.0000000000001640
   PubMed Web of Science ®Google Scholar
• Freidin MB, Stalteri MA, Wells PM, et al. An association between chronic widespread pain and the gut microbiome. Rheumatology. 2021;60(8):3727–3737. doi:10.1093/rheumatology/keaa847
   PubMed Web of Science ®Google Scholar
• Sánchez Romero EA, Meléndez Oliva E, Alonso Pérez JL, et al. Relationship between the gut microbiome and osteoarthritis pain: review of the literature. Nutrients. 2021;13(3):716. doi:10.3390/nu13030716
   PubMed Web of Science ®Google Scholar
• Minerbi A, Shen S. Gut microbiome in anesthesiology and pain medicine. Anesthesiology. 2022;137(1):93–108. doi:10.1097/ALN.0000000000004204
   PubMed Web of Science ®Google Scholar
• Zhu S, Jiang Y, Xu K, et al. The progress of gut microbiome research related to brain disorders. J Neuroinflammation. 2020;17(1):25. doi:10.1186/s12974-020-1705-z
   PubMed Web of Science ®Google Scholar
• Sun M-F, Shen Y-Q. Dysbiosis of gut microbiota and microbial metabolites in Parkinson’s disease. Ageing Res Rev. 2018;45:53–61. doi:10.1016/j.arr.2018.04.004
   PubMed Web of Science ®Google Scholar
• Bairamian D, Sha S, Rolhion N, et al. Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer’s disease. Mol Neurodegener. 2022;17(1):19. doi:10.1186/s13024-022-00522-2
   PubMed Web of Science ®Google Scholar
• Banks WA, Robinson SM. Minimal penetration of lipopolysaccharide across the murine blood-brain barrier. Brain Behav Immun. 2010;24(1):102–109. doi:10.1016/j.bbi.2009.09.001
   PubMed Web of Science ®Google Scholar
• Wang C, Fan L, Khawaja RR, et al. Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy. Nat Commun. 2022;13(1):1969. doi:10.1038/s41467-022-29552-6
   PubMed Web of Science ®Google Scholar
• Eller-Smith OC, Nicol AL, Christianson JA. Potential mechanisms underlying centralized pain and emerging therapeutic interventions. Front Cell Neurosci. 2018;12:35. doi:10.3389/fncel.2018.00035
   PubMed Web of Science ®Google Scholar
• Hofmann SG, Smits JAJ. Cognitive-behavioral therapy for adult anxiety disorders: a meta-analysis of randomized placebo-controlled trials. J Clin Psychiatry. 2008;69(4):621–632. doi:10.4088/JCP.v69n0415
   PubMed Web of Science ®Google Scholar
• Spector A, Charlesworth G, King M, et al. Cognitive-behavioural therapy for anxiety in dementia: pilot randomised controlled trial. Br J Psychiatry. 2015;206(6):509–516. doi:10.1192/bjp.bp.113.140087
   PubMed Web of Science ®Google Scholar
• Yoshino A, Okamoto Y, Okada G, et al. Changes in resting-state brain networks after cognitive-behavioral therapy for chronic pain. Psychol Med. 2018;48(7):1148–1156. doi:10.1017/S0033291717002598
   PubMed Web of Science ®Google Scholar
• Haight ES, Forman TE, Cordonnier SA, James ML, Tawfik VL. Microglial modulation as a target for chronic pain: from the bench to the bedside and back. Anesth Analg. 2019;128(4):737–746. doi:10.1213/ANE.0000000000004033
   PubMed Web of Science ®Google Scholar
• Zhou Y-Q, Liu D-Q, Chen S-P, et al. Minocycline as a promising therapeutic strategy for chronic pain. Pharmacol Res. 2018;134:305–310. doi:10.1016/j.phrs.2018.07.002
   PubMed Web of Science ®Google Scholar
• Syngle A, Verma I, Krishan P, Garg N, Syngle V. Minocycline improves peripheral and autonomic neuropathy in type 2 diabetes: MIND study. Neurol Sci. 2014;35(7):1067–1073. doi:10.1007/s10072-014-1647-2
   PubMed Web of Science ®Google Scholar
• Younger J, Parkitny L, McLain D. The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain. Clin Rheumatol. 2014;33(4):451–459. doi:10.1007/s10067-014-2517-2
   PubMed Web of Science ®Google Scholar
• Younger J, Mackey S. Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study. Pain Med. 2009;10(4):663–672. doi:10.1111/j.1526-4637.2009.00613.x
   PubMed Web of Science ®Google Scholar
• Snigdha S, Ha K, Tsai P, et al. Probiotics: potential novel therapeutics for microbiota-gut-brain axis dysfunction across gender and lifespan. Pharmacol Ther. 2022;231:107978. doi:10.1016/j.pharmthera.2021.107978
   PubMed Web of Science ®Google Scholar
• Gonzalez-Alvarez ME, Sanchez-Romero EA, Turroni S, Fernandez-Carnero J, Villafañe JH. Correlation between the altered gut microbiome and lifestyle interventions in chronic widespread pain patients: a systematic review. Medicina. 2023;59(2):256. doi:10.3390/medicina59020256
   PubMedGoogle Scholar