193
Views
0
CrossRef citations to date
0
Altmetric
Cancer Pain and Palliative Care

Efficacy and Safety of Naloxegol in Patients with Chronic Non-Cancer Pain Who Experience Opioid-Induced Constipation: A Pooled Analysis of Two Global, Randomized Controlled Studies

, , , , , , , ORCID Icon, & show all
Pages 2943-2953 | Received 09 May 2023, Accepted 18 Aug 2023, Published online: 28 Aug 2023

References

  • Zelaya CE, Dahlhamer JM, Lucas JW, Connor EM. Chronic pain and high-impact chronic pain among U.S. Adults, 2019. NCHS Data Brief. 2020;2020:1–8.
  • Dahlhamer JM, Connor EM, Bose J, Lucas JL, Zelaya CE. Prescription opioid use among adults with chronic pain: United States, 2019. Natl Health Stat Report. 2021;2021:1–9.
  • De Sola H, Duenas M, Salazar A, Ortega-Jimenez P, Failde I. Prevalence of therapeutic use of opioids in chronic non-cancer pain patients and associated factors: a systematic review and meta-analysis. Front Pharmacol. 2020;11:564412. doi:10.3389/fphar.2020.564412
  • Mathieson S, Wertheimer G, Maher CG, et al. What proportion of patients with chronic noncancer pain are prescribed an opioid medicine? Systematic review and meta-regression of observational studies. J Intern Med. 2020;287(5):458–474. doi:10.1111/joim.13026
  • Wertheimer G, Mathieson S, Maher CG, et al. The prevalence of opioid analgesic use in people with chronic noncancer pain: systematic review and meta-analysis of observational studies. Pain Med. 2021;22(2):506–517. doi:10.1093/pm/pnaa322
  • Yong RJ, Mullins PM, Bhattacharyya N. Prevalence of chronic pain among adults in the United States. Pain. 2022;163(2):e328–e332. doi:10.1097/j.pain.0000000000002291
  • Bell TJ, Panchal SJ, Miaskowski C, Bolge SC, Milanova T, Williamson R. The prevalence, severity, and impact of opioid-induced bowel dysfunction: results of a US and European patient survey (PROBE 1). Pain Med. 2009;10(1):35–42. doi:10.1111/j.1526-4637.2008.00495.x
  • Tuteja AK, Biskupiak J, Stoddard GJ, Lipman AG. Opioid-induced bowel disorders and narcotic bowel syndrome in patients with chronic non-cancer pain. Neurogastroenterol Motil. 2010;22(4):424–30, e96. doi:10.1111/j.1365-2982.2009.01458.x
  • Crockett SD, Greer KB, Heidelbaugh JJ, et al. American gastroenterological association institute guideline on the medical management of opioid-induced constipation. Gastroenterology. 2019;156(1):218–226. doi:10.1053/j.gastro.2018.07.016
  • Camilleri M. Opioid-induced constipation: challenges and therapeutic opportunities. Am J Gastroenterol. 2011;106(5):835–842. doi:10.1038/ajg.2011.30
  • Nojkov B, Baker J, Menees S, et al. Is dyssynergic defecation an unrecognized cause of chronic constipation in patients using opioids? Am J Gastroenterol. 2019;114(11):1772–1777. doi:10.14309/ajg.0000000000000413
  • Rachinger-Adam B, Conzen P, Azad SC. Pharmacology of peripheral opioid receptors. Curr Opin Anaesthesiol. 2011;24(4):408–413. doi:10.1097/ACO.0b013e32834873e5
  • Camilleri M, Drossman DA, Becker G, Webster LR, Davies AN, Mawe GM. Emerging treatments in neurogastroenterology: a multidisciplinary working group consensus statement on opioid-induced constipation. Neurogastroenterol Motil. 2014;26(10):1386–1395. doi:10.1111/nmo.12417
  • Coyne KS, Margolis MK, Yeomans K, et al. Opioid-induced constipation among patients with chronic noncancer pain in the United States, Canada, Germany, and the United Kingdom: laxative use, response, and symptom burden over time. Pain Med. 2015;16(8):1551–1565. doi:10.1111/pme.12724
  • Panchal SJ, Muller-Schwefe P, Wurzelmann JI. Opioid-induced bowel dysfunction: prevalence, pathophysiology and burden. Int J Clin Pract. 2007;61(7):1181–1187. doi:10.1111/j.1742-1241.2007.01415.x
  • Argoff CE. Opioid-induced constipation: a review of health-related quality of life, patient burden, practical clinical considerations, and the impact of peripherally acting mu-opioid receptor antagonists. Clin J Pain. 2020;36(9):716–722. doi:10.1097/AJP.0000000000000852
  • Varrassi G, Banerji V, Gianni W, Marinangeli F, Pinto C. Impact and consequences of opioid-induced constipation: a survey of patients. Pain Ther. 2021;10(2):1139–1153. doi:10.1007/s40122-021-00271-y
  • Farmer AD, Drewes AM, Chiarioni G, et al. Pathophysiology and management of opioid-induced constipation: European expert consensus statement. United European Gastroenterol J. 2019;7(1):7–20. doi:10.1177/2050640618818305
  • Chey WD, Webster L, Sostek M, Lappalainen J, Barker PN, Tack J. Naloxegol for opioid-induced constipation in patients with noncancer pain. N Engl J Med. 2014;370(25):2387–2396. doi:10.1056/NEJMoa1310246
  • Chey WR, Bortey E, Almenoff J. Rapid onset of time to first Spontaneous Bowel Movement (SBM) and predictable efficacy of Naloxegol. Pooled Analysis of Two Global Randomized Controlled Trials Poster presented at: Digestive Disease Week; 2021.
  • Tack J, Lappalainen J, Diva U, Tummala R, Sostek M. Efficacy and safety of naloxegol in patients with opioid-induced constipation and laxative-inadequate response. United European Gastroenterol J. 2015;3(5):471–480. doi:10.1177/2050640615604543
  • CDC. 71 CDC clinical practice guideline for prescribing opioids for pain - United States, 2022. CDC; 2022:1–95.