Remifentanil at a Relatively Elevated Dose in Active Phase is Safe and More Suitable Than Fixed Lower Dose for Intravenous Labor Analgesia

References

• Zhang P, Yu Z, Zhai M, et al. Effect and safety of remifentanil patient-controlled analgesia compared with epidural analgesia in labor: an updated meta-analysis of randomized controlled trials. Gynecol Obstet Invest. 2021;86(3):231–238. doi:10.1159/000515531
   PubMed Web of Science ®Google Scholar
• Zhang P, Yu Z, Zhai M, et al. ACOG practice bulletin No. 209: obstetric analgesia and anesthesia. Obstet Gynecol. 2019;2019:e208–e225.
   Google Scholar
• Ching Wong SS, Cheung CW. Analgesic efficacy and adverse effects of meperidine in managing postoperative or labor pain: a narrative review of randomized controlled trials. Pain Phys. 2020;23(2):175–201. doi:10.36076/ppj.2020/23/175
   PubMed Web of Science ®Google Scholar
• Van de Velde M, Carvalho B. Remifentanil for labor analgesia: an evidence-based narrative review. Int J Obstet Anesth. 2016;25:66–74. doi:10.1016/j.ijoa.2015.12.004
   PubMed Web of Science ®Google Scholar
• Lu G, Yao W, Chen X, et al. Remifentanil patient-controlled versus epidural analgesia on intrapartum maternal fever: a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2020;20(1):151. doi:10.1186/s12884-020-2800-y
   PubMed Web of Science ®Google Scholar
• Balki M, Kasodekar S, Dhumne S, et al. Remifentanil patient-controlled analgesia for labour: optimizing drug delivery regimens. Can J Anaesth. 2007;54(8):626–633. doi:10.1007/BF03022956
   Web of Science ®Google Scholar
• Wilson MJA, MacArthur C, Hewitt CA, et al. Intravenous remifentanil patient-controlled analgesia versus intramuscular pethidine for pain relief in labour (RESPITE): an open-label, multicentre, randomised controlled trial. Lancet. 2018;392(10148):662–672. doi:10.1016/S0140-6736(18)31613-1
   PubMed Web of Science ®Google Scholar
• Leong WL, Sng BL, Sia AT. A comparison between remifentanil and meperidine for labor analgesia: a systematic review. Anesth Analg. 2011;113(4):818–825. doi:10.1213/ANE.0b013e3182289fe9
   PubMed Web of Science ®Google Scholar
• Schnabel A, Hahn N, Broscheit J, et al. Remifentanil for labour analgesia: a meta-analysis of randomised controlled trials. Eur J Anaesthesiol. 2012;29(4):177–185. doi:10.1097/EJA.0b013e32834fc260
   PubMed Web of Science ®Google Scholar
• Kranke P, Girard T, Lavand’homme P, et al. Must we press on until a young mother dies? Remifentanil patient controlled analgesia in labour may not be suited as a “poor man’s epidural”. BMC Pregnancy Childbirth. 2013;13(139). doi:10.1186/1471-2393-13-139
   PubMedGoogle Scholar
• Weibel S, Jelting Y, Afshari A, et al. Patient-controlled analgesia with remifentanil versus alternative parenteral methods for pain management in labour. Cochrane Database Syst Rev. 2017;4:CD011989. doi:10.1002/14651858.CD011989.pub2
   PubMedGoogle Scholar
• Hutchison J, Mahdy H, Hutchison J. Stages of Labor. Treasure Island (FL): StatPearls; 2022.
   Google Scholar
• Lim TW, Choi YH, Kim JY, et al. Efficacy of the bispectral index and Observer’s assessment of alertness/sedation scale in monitoring sedation during spinal anesthesia: a randomized clinical trial. J Int Med Res. 2020;48(4):300060519893165. doi:10.1177/0300060519893165
   PubMed Web of Science ®Google Scholar
• Cnattingius S, Norman M, Granath F, et al. Apgar score components at 5 minutes: risks and prediction of neonatal mortality. Paediatr Perinat Epidemiol. 2017;31(4):328–337. doi:10.1111/ppe.12360
   PubMed Web of Science ®Google Scholar
• Macones GA, Hankins GD, Spong CY, et al. The 2008 National Institute of Child Health and Human Development workshop report on electronic fetal monitoring: update on definitions, interpretation, and research guidelines. J Obstet Gynecol Neonatal Nurs. 2008;37(5):510–515. doi:10.1111/j.1552-6909.2008.00284.x
   PubMed Web of Science ®Google Scholar
• Bin D, Chun F, Shan J, et al. Comparison of different administration methods of remifentanil in the intravenous labor analgesia. Shanghai Med J. 2016;39(8):470–475.
   Google Scholar
• Jia Z, Li Y, Jia H, et al. Curative effect of remifentanil on labor analgesia in newborns. J Matern Fetal Neonatal Med. 2020;33(11):1913–1918. doi:10.1080/14767058.2018.1533946
   PubMed Web of Science ®Google Scholar
• Lavand’homme P, Roelants F. Patient-controlled intravenous analgesia as an alternative to epidural analgesia during labor: questioning the use of the short-acting opioid remifentanil. Survey in the French part of Belgium (Wallonia and Brussels). Acta Anaesthesiol Belg. 2009;60(2):75–82.
   PubMedGoogle Scholar
• Schwarz GL, Volmanen P, Albrechtsen S, et al. Remifentanil target-controlled infusion during second stage labour in high-risk parturients: a case series. Acta Anaesthesiol Scand. 2013;57(6):802–808. doi:10.1111/aas.12096
   PubMed Web of Science ®Google Scholar
• Messmer AA, Potts JM, Orlikowski CE. A prospective observational study of maternal oxygenation during remifentanil patient-controlled analgesia use in labour. Anaesthesia. 2016;71(2):171–176. doi:10.1111/anae.13329
   PubMed Web of Science ®Google Scholar
• Devabhakthuni S. Efficacy and safety of remifentanil as an alternative labor analgesic. Clin Med Insights Womens Health. 2013;6:37–49. doi:10.4137/CMWH.S8015
   PubMedGoogle Scholar
• Ohashi Y, Baghirzada L, Sumikura H, et al. Remifentanil for labor analgesia: a comprehensive review. J Anesth. 2016;30(6):1020–1030. doi:10.1007/s00540-016-2233-y
   PubMed Web of Science ®Google Scholar
• Blair JM, Hill DA, Fee JP. Patient-controlled analgesia for labour using remifentanil: a feasibility study. Br J Anaesth. 2001;87(3):415–420. doi:10.1093/bja/87.3.415
   PubMed Web of Science ®Google Scholar
• Moran VH, Thomson G, Cook J, et al. Qualitative exploration of women’s experiences of intramuscular pethidine or remifentanil patient-controlled analgesia for labour pain. BMJ Open. 2019;9(12):e032203. doi:10.1136/bmjopen-2019-032203
   PubMed Web of Science ®Google Scholar
• Volmanen P, Akural EI, Raudaskoski T, et al. Remifentanil in obstetric analgesia: a dose-finding study. Anesth Analg. 2002;94(4):913–917. doi:10.1097/00000539-200204000-00026
   PubMed Web of Science ®Google Scholar
• Tveit TO, Halvorsen A, Seiler S, et al. Efficacy and side effects of intravenous remifentanil patient-controlled analgesia used in a stepwise approach for labour: an observational study. Int J Obstet Anesth. 2013;22(1):19–25. doi:10.1016/j.ijoa.2012.09.003
   PubMed Web of Science ®Google Scholar
• Shen MK, Wu ZF, Zhu AB, et al. Remifentanil for labour analgesia: a double-blinded, randomised controlled trial of maternal and neonatal effects of patient-controlled analgesia versus continuous infusion. Anaesthesia. 2013;68(3):236–244. doi:10.1111/anae.12098
   PubMed Web of Science ®Google Scholar
• Dhileepan S, Stacey RG. A preliminary investigation of remifentanil as a labor analgesic. Anesth Analg. 2001;92(5):1358–1359. doi:10.1097/00000539-200105000-00062
   PubMed Web of Science ®Google Scholar
• Owen MD, Poss MJ, Dean LS, et al. Prolonged intravenous remifentanil infusion for labor analgesia. Anesth Analg. 2002;94(4):918–919. doi:10.1097/00000539-200204000-00027
   PubMed Web of Science ®Google Scholar
• Anderson B. The use of remifentanil as the primary agent for analgesia in parturients. Crit Care Nurs Clin North Am. 2017;29(4):495–517. doi:10.1016/j.cnc.2017.08.009
   PubMed Web of Science ®Google Scholar
• Yin W, Jung F, Adams D, et al. Case report of remifentanil labor analgesia for a pregnant patient with congenital methemoglobinemia type 1. AA Pract. 2021;15(1):e01373. doi:10.1213/XAA.0000000000001373
   Google Scholar