Medical Cannabis: A Review from the American Society of Pain and Neuroscience

References

• American Society of Anesthesiologists Task Force on Acute Pain Management. Practice guidelines for acute pain management in the perioperative setting: an updated report by the American Society of Anesthesiologists task force on acute pain management. Anesthesiology. 2012;116(2):248–273. doi:10.1097/ALN.0b013e31823c1030
   PubMed Web of Science ®Google Scholar
• Colvin AC, Egorova N, Harrison AK, Moskowitz A, Flatow EL. National trends in rotator cuff repair. J Bone Joint Surg Am. 2012;94(3):227–233. doi:10.2106/JBJS.J.00739
   PubMed Web of Science ®Google Scholar
• Wu CL, Raja SN. Treatment of acute postoperative pain. Lancet. 2011;377(9784):2215–2225. doi:10.1016/S0140-6736(11)60245-6
   PubMed Web of Science ®Google Scholar
• Kehlet H, Holte K. Effect of postoperative analgesia on surgical outcome. Br J Anaesth. 2001;87(1):62–72. doi:10.1093/bja/87.1.62
   PubMed Web of Science ®Google Scholar
• Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet. 2006;367(9522):1618–1625. doi:10.1016/S0140-6736(06)68700-X
   PubMed Web of Science ®Google Scholar
• Borgelt LM, Franson KL, Nussbaum AM, Wang GS. The pharmacologic and clinical effects of medical cannabis. Pharmacotherapy. 2013;33(2):195–209. doi:10.1002/phar.1187
   PubMed Web of Science ®Google Scholar
• Klein TW. Cannabinoid-based drugs as anti-inflammatory therapeutics. Nat Rev Immunol. 2005;5(5):400–411. doi:10.1038/nri1602
   PubMed Web of Science ®Google Scholar
• Martin BR, Wiley JL. Mechanism of action of cannabinoids: how it may lead to treatment of cachexia, emesis, and pain. J Support Oncol. 2004;2(4):305–314.
   PubMedGoogle Scholar
• Aggarwal SK. Cannabinergic pain medicine: a concise clinical primer and survey of randomized-controlled trial results. Clin J Pain. 2013;29(2):162–171. doi:10.1097/AJP.0b013e31824c5e4c
   PubMed Web of Science ®Google Scholar
• Abdallah FW, Hussain N, Weaver T, Brull R. Analgesic efficacy of cannabinoids for acute pain management after surgery: a systematic review and meta-analysis. Reg Anesth Pain Med. 2020;45(7):509–519. doi:10.1136/rapm-2020-101340
   PubMed Web of Science ®Google Scholar
• Madden K, van der Hoek N, Chona S, et al. Cannabinoids in the management of musculoskeletal pain: a critical review of the evidence. JBJS Rev. 2018;6(5):e7. doi:10.2106/JBJS.RVW.17.00153
   PubMed Web of Science ®Google Scholar
• Whiting PF, Wolff RF, Deshpande S, et al. Cannabinoids for medical use: a systematic review and meta-analysis. JAMA. 2015;313(24):2456–2473. doi:10.1001/jama.2015.6358
   PubMed Web of Science ®Google Scholar
• Richards BL, Whittle SL, Buchbinder R. Neuromodulators for pain management in rheumatoid arthritis. Cochrane Database Syst Rev. 2012;1(1):CD008921. doi:10.1002/14651858.CD008921.pub2
   PubMedGoogle Scholar
• Stevens AJ, Higgins MD. A systematic review of the analgesic efficacy of cannabinoid medications in the management of acute pain. Acta Anaesthesiol Scand. 2017;61(3):268–280. doi:10.1111/aas.12851
   PubMed Web of Science ®Google Scholar
• Mead A. Legal and regulatory issues governing cannabis and cannabis-derived products in the United States. Front Plant Sci. 2019;10:697. doi:10.3389/fpls.2019.00697
   PubMed Web of Science ®Google Scholar
• Mead A. The legal status of cannabis (marijuana) and cannabidiol (CBD) under U.S. law. Epilepsy Behav. 2017;70(Pt B):288–291. doi:10.1016/j.yebeh.2016.11.021
   PubMedGoogle Scholar
• Hoffmann DE, Weber E. Medical marijuana and the law. N Engl J Med. 2010;362(16):1453–1457. doi:10.1056/NEJMp1000695
   PubMed Web of Science ®Google Scholar
• Annas GJ. Medical marijuana, physicians, and state law. N Engl J Med. 2014;371(11):983–985. doi:10.1056/NEJMp1408965
   PubMed Web of Science ®Google Scholar
• Conant v Walters, 309 F3d 629 (9th Cir 2002); 2002.
   Google Scholar
• Testimony of Amy Abernethy, MD, PhD. Hemp production and the 2018 farm bill: hearing before, senate committee on agriculture, nutrition, and forestry; 2019. Available from: https://www.fda.gov/news-events/congressional-testimony/hemp-production-and-2018-farm-bill-07252019. Accessed November 30, 2023.
   Google Scholar
• The National Academies Collection: Reports funded by National Institutes of Health. The health effects of cannabis and cannabinoids: the current state of evidence and recommendations for research. The National Academies Collection: Reports funded by National Institutes of Health; 2017.
   Google Scholar
• Grbic J, Goddard P, Ryder D. Observations of the role of science in the United States medical cannabis state policies: lessons learnt. Int J Drug Policy. 2017;42:109–114. doi:10.1016/j.drugpo.2016.12.019
   PubMed Web of Science ®Google Scholar
• Taylor SL. Evidence-based policy? The re-medicalization of cannabis and the role of expert committees in the UK, 1972-1982. Int J Drug Policy. 2016;37:129–135. doi:10.1016/j.drugpo.2016.04.014
   PubMed Web of Science ®Google Scholar
• Pardo B. Cannabis policy reforms in the Americas: a comparative analysis of Colorado, Washington, and Uruguay. Int J Drug Policy. 2014;25(4):727–735. doi:10.1016/j.drugpo.2014.05.010
   PubMed Web of Science ®Google Scholar
• Herkenham M, Lynn AB, Little MD, et al. Cannabinoid receptor localization in brain. Proc Natl Acad Sci U S A. 1990;87(5):1932–1936. doi:10.1073/pnas.87.5.1932
   PubMed Web of Science ®Google Scholar
• Devinsky O, Cross JH, Laux L, et al. Trial of cannabidiol for drug-resistant seizures in the Dravet syndrome. N Engl J Med. 2017;376(21):2011–2020. doi:10.1056/NEJMoa1611618
   PubMed Web of Science ®Google Scholar
• Ware MA, Wang T, Shapiro S, et al. Cannabis for the Management of Pain: assessment of Safety Study (COMPASS). J Pain. 2015;16(12):1233–1242. doi:10.1016/j.jpain.2015.07.014
   PubMed Web of Science ®Google Scholar
• Johnson JR, Lossignol D, Burnell-Nugent M, Fallon MT. An open-label extension study to investigate the long-term safety and tolerability of THC/CBD oromucosal spray and oromucosal THC spray in patients with terminal cancer-related pain refractory to strong opioid analgesics. J Pain Symptom Manage. 2013;46(2):207–218. doi:10.1016/j.jpainsymman.2012.07.014
   PubMed Web of Science ®Google Scholar
• Hill KP. Medical marijuana for treatment of chronic pain and other medical and psychiatric problems: a clinical review. JAMA. 2015;313(24):2474–2483. doi:10.1001/jama.2015.6199
   PubMed Web of Science ®Google Scholar
• Millar SA, Stone NL, Yates AS, O’Sullivan SE. A systematic review on the pharmacokinetics of cannabidiol in humans. Front Pharmacol. 2018;9:1365. doi:10.3389/fphar.2018.01365
   PubMed Web of Science ®Google Scholar
• Ujvary I, Hanus L. Human metabolites of cannabidiol: a review on their formation, biological activity, and relevance in therapy. Cannabis Cannabinoid Res. 2016;1(1):90–101. doi:10.1089/can.2015.0012
   PubMedGoogle Scholar
• Cooper ZD, Bedi G, Ramesh D, Balter R, Comer SD, Haney M. Impact of co-administration of oxycodone and smoked cannabis on analgesia and abuse liability. Neuropsychopharmacology. 2018;43(10):2046–2055. doi:10.1038/s41386-018-0011-2
   PubMed Web of Science ®Google Scholar
• Pini LA, Guerzoni S, Cainazzo MM, et al. Nabilone for the treatment of medication overuse headache: results of a preliminary double-blind, active-controlled, randomized trial. J Headache Pain. 2012;13(8):677–684. doi:10.1007/s10194-012-0490-1
   PubMed Web of Science ®Google Scholar
• Cuttler C, Spradlin A, Cleveland MJ, Craft RM. Short- and long-term effects of cannabis on headache and migraine. J Pain. 2020;21(5–6):722–730. doi:10.1016/j.jpain.2019.11.001
   PubMed Web of Science ®Google Scholar
• Rhyne DN, Anderson SL, Gedde M, Borgelt LM. Effects of medical marijuana on migraine headache frequency in an adult population. Pharmacotherapy. 2016;36(5):505–510. doi:10.1002/phar.1673
   PubMed Web of Science ®Google Scholar
• Leroux E, Taifas I, Valade D, Donnet A, Chagnon M, Ducros A. Use of cannabis among 139 cluster headache sufferers. Cephalalgia. 2013;33(3):208–213. doi:10.1177/0333102412468669
   PubMed Web of Science ®Google Scholar
• Consroe P, Musty R, Rein J, Tillery W, Pertwee R. The perceived effects of smoked cannabis on patients with multiple sclerosis. Eur Neurol. 1997;38(1):44–48. doi:10.1159/000112901
   PubMed Web of Science ®Google Scholar
• Aviram J, Vysotski Y, Berman P, Lewitus GM, Eisenberg E, Meiri D. Migraine frequency decrease following prolonged medical cannabis treatment: a cross-sectional study. Brain Sci. 2020;10(6):360. doi:10.3390/brainsci10060360
   PubMed Web of Science ®Google Scholar
• Baron EP, Lucas P, Eades J, Hogue O. Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort. J Headache Pain. 2018;19(1):37. doi:10.1186/s10194-018-0862-2
   PubMedGoogle Scholar
• Zhang N, Woldeamanuel YW. Medication overuse headache in patients with chronic migraine using cannabis: a case-referent study. Headache. 2021;61(8):1234–1244. doi:10.1111/head.14195
   PubMed Web of Science ®Google Scholar
• Stith SS, Diviant JP, Brockelman F, et al. Alleviative effects of Cannabis flower on migraine and headache. J Integr Med. 2020;18(5):416–424. doi:10.1016/j.joim.2020.07.004
   PubMedGoogle Scholar
• Gibson LP, Hitchcock LN, Bryan AD, Bidwell LC. Experience of migraine, its severity, and perceived efficacy of treatments among cannabis users. Complement Ther Med. 2021;56:102619. doi:10.1016/j.ctim.2020.102619
   PubMed Web of Science ®Google Scholar
• Duarte RA, Dahmer S, Sanguinetti SY, Forde G, Duarte DP, Kobak LF. Medical cannabis for headache pain: a primer for clinicians. Curr Pain Headache Rep. 2021;25(10):64. doi:10.1007/s11916-021-00974-z
   PubMed Web of Science ®Google Scholar
• Bagshaw SM, Hagen NA. Medical efficacy of cannabinoids and marijuana: a comprehensive review of the literature. J Palliat Care. 2002;18(2):111–122. doi:10.1177/082585970201800207
   PubMed Web of Science ®Google Scholar
• Johannes CB, Le TK, Zhou X, Johnston JA, Dworkin RH. The prevalence of chronic pain in United States adults: results of an Internet-based survey. J Pain. 2010;11(11):1230–1239. doi:10.1016/j.jpain.2010.07.002
   PubMed Web of Science ®Google Scholar
• Stockings E, Campbell G, Hall WD, et al. Cannabis and cannabinoids for the treatment of people with chronic noncancer pain conditions: a systematic review and meta-analysis of controlled and observational studies. Pain. 2018;159(10):1932–1954. doi:10.1097/j.pain.0000000000001293
   PubMed Web of Science ®Google Scholar
• Patti F, Chisari CG, Fernandez O, et al. A real-world evidence study of nabiximols in multiple sclerosis patients with resistant spasticity: analysis in relation to the newly described ‘spasticity-plus syndrome’. Eur J Neurol. 2022;29(9):2744–2753. doi:10.1111/ene.15412
   PubMed Web of Science ®Google Scholar
• Grossman S, Tan H, Gadiwalla Y. Cannabis and orofacial pain: a systematic review. Br J Oral Maxillofac Surg. 2022;60(5):e677–e690. doi:10.1016/j.bjoms.2021.06.005
   PubMed Web of Science ®Google Scholar
• Lynch ME, Ware MA. Cannabinoids for the treatment of chronic non-cancer pain: an updated systematic review of randomized controlled trials. J Neuroimmune Pharmacol. 2015;10(2):293–301. doi:10.1007/s11481-015-9600-6
   PubMed Web of Science ®Google Scholar
• Bruera E, Kim HN. Cancer pain. JAMA. 2003;290(18):2476–2479. doi:10.1001/jama.290.18.2476
   PubMed Web of Science ®Google Scholar
• Portenoy RK. Treatment of cancer pain. Lancet. 2011;377(9784):2236–2247. doi:10.1016/S0140-6736(11)60236-5
   PubMed Web of Science ®Google Scholar
• Kramer JL. Medical marijuana for cancer. CA Cancer J Clin. 2015;65(2):109–122. doi:10.3322/caac.21260
   PubMed Web of Science ®Google Scholar
• Pawasarat IM, Schultz EM, Frisby JC, et al. The efficacy of medical marijuana in the treatment of cancer-related pain. J Palliat Med. 2020;23(6):809–816. doi:10.1089/jpm.2019.0374
   PubMed Web of Science ®Google Scholar
• National Center for Complementary and Integrative Health. Cannabis (Marijuana) and cannabinoids: what you need to know. Available from: https://www.nccih.nih.gov/health/cannabis-marijuana-and-cannabinoids-what-you-need-to-know. Accessed May 30, 2023.
   Google Scholar
• Pacula RL, Powell D, Heaton P, Sevigny EL. Assessing the effects of medical marijuana laws on marijuana use: the devil is in the details. J Policy Anal Manage. 2015;34(1):7–31. doi:10.1002/pam.21804
   PubMed Web of Science ®Google Scholar
• Pergam SA, Woodfield MC, Lee CM, et al. Cannabis use among patients at a comprehensive cancer center in a state with legalized medicinal and recreational use. Cancer. 2017;123(22):4488–4497. doi:10.1002/cncr.30879
   PubMed Web of Science ®Google Scholar
• Tringale KR, Huynh-Le MP, Salans M, Marshall DC, Shi Y, Hattangadi-Gluth JA. The role of cancer in marijuana and prescription opioid use in the United States: a population-based analysis from 2005 to 2014. Cancer. 2019;125(13):2242–2251. doi:10.1002/cncr.32059
   PubMed Web of Science ®Google Scholar
• Swarm RA, Paice JA, Anghelescu DL, et al. Adult cancer pain, version 3.2019, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2019;17(8):977–1007. doi:10.6004/jnccn.2019.0038
   PubMed Web of Science ®Google Scholar
• Portenoy RK, Ahmed E. Principles of opioid use in cancer pain. J Clin Oncol. 2014;32(16):1662–1670. doi:10.1200/JCO.2013.52.5188
   PubMed Web of Science ®Google Scholar
• Koyyalagunta D, Bruera E, Solanki DR, et al. A systematic review of randomized trials on the effectiveness of opioids for cancer pain. Pain Physician. 2012;15(3 Suppl):1.
   PubMed Web of Science ®Google Scholar
• Braun IM, Wright A, Peteet J, et al. Medical oncologists’ beliefs, practices, and knowledge regarding marijuana used therapeutically: a nationally representative survey study. J Clin Oncol. 2018;36(19):1957–1962. doi:10.1200/JCO.2017.76.1221
   PubMed Web of Science ®Google Scholar
• Fallon M, Giusti R, Aielli F, et al. Management of cancer pain in adult patients: ESMO clinical practice guidelines. Ann Oncol. 2018;29(Suppl 4):iv166–iv191. doi:10.1093/annonc/mdy152
   PubMed Web of Science ®Google Scholar
• Johnson JR, Burnell-Nugent M, Lossignol D, Ganae-Motan ED, Potts R, Fallon MT. Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC: CBD extract and THC extract in patients with intractable cancer-related pain. J Pain Symptom Manage. 2010;39(2):167–179. doi:10.1016/j.jpainsymman.2009.06.008
   PubMed Web of Science ®Google Scholar
• Portenoy RK, Ganae-Motan ED, Allende S, et al. Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial. J Pain. 2012;13(5):438–449. doi:10.1016/j.jpain.2012.01.003
   PubMed Web of Science ®Google Scholar
• Lynch ME, Cesar-Rittenberg P, Hohmann AG. A double-blind, placebo-controlled, crossover pilot trial with extension using an oral mucosal cannabinoid extract for treatment of chemotherapy-induced neuropathic pain. J Pain Symptom Manage. 2014;47(1):166–173. doi:10.1016/j.jpainsymman.2013.02.018
   PubMed Web of Science ®Google Scholar
• Aviram J, Samuelly-Leichtag G. Efficacy of cannabis-based medicines for pain management: a systematic review and meta-analysis of randomized controlled trials. Pain Physician. 2017;20:6.
   Web of Science ®Google Scholar
• Richebe P, Capdevila X, Rivat C. Persistent postsurgical pain: pathophysiology and preventative pharmacologic considerations. Anesthesiology. 2018;129(3):590–607. doi:10.1097/ALN.0000000000002238
   PubMed Web of Science ®Google Scholar
• Haroutiunian S, Nikolajsen L, Finnerup NB, Jensen TS. The neuropathic component in persistent postsurgical pain: a systematic literature review. Pain. 2013;154(1):95–102. doi:10.1016/j.pain.2012.09.010
   PubMed Web of Science ®Google Scholar
• Niraj G, Rowbotham DJ. Persistent postoperative pain: where are we now? Br J Anaesth. 2011;107(1):25–29. doi:10.1093/bja/aer116
   PubMed Web of Science ®Google Scholar
• Chou R, Gordon DB, de Leon-Casasola OA, et al. Management of postoperative pain: a clinical practice guideline from the American Pain Society, the American Society of regional anesthesia and pain medicine, and the American society of anesthesiologists’ committee on regional anesthesia, executive committee, and administrative council. J Pain. 2016;17(2):131–157. doi:10.1016/j.jpain.2015.12.008
   PubMed Web of Science ®Google Scholar
• Pogatzki-Zahn E, Lavandhomme P. Prevention of Chronic Post-Surgical Pain. International Association for the Study of Pain. Available from: https://www.iasp-pain.org/resources/fact-sheets/prevention-of-chronic-post-surgical-pain/. Accessed May 30, 2023.
   Google Scholar
• Adili A, Madden K. Cannabinoids vs. Placebo on persistent post-surgical pain following TKA: a Pilot RCT. ClinicalTrials.gov. Available from: https://clinicaltrials.gov/ct2/show/study/NCT03825965. Accessed November 30, 2023.
   Google Scholar
• Sarzi-Puttini P, Giorgi V, Marotto D, Atzeni F. Fibromyalgia: an update on clinical characteristics, aetiopathogenesis and treatment. Nat Rev Rheumatol. 2020;16(11):645–660. doi:10.1038/s41584-020-00506-w
   PubMed Web of Science ®Google Scholar
• Queiroz LP. Worldwide epidemiology of fibromyalgia. Curr Pain Headache Rep. 2013;17(8):356. doi:10.1007/s11916-013-0356-5
   PubMed Web of Science ®Google Scholar
• Spaeth M. Epidemiology, costs, and the economic burden of fibromyalgia. Arthritis Res Ther. 2009;11(3):117. doi:10.1186/ar2715
   PubMed Web of Science ®Google Scholar
• Wolfe F, Clauw DJ, Fitzcharles MA, et al. 2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum. 2016;46(3):319–329. doi:10.1016/j.semarthrit.2016.08.012
   PubMed Web of Science ®Google Scholar
• Arnold LM, Bennett RM, Crofford LJ, et al. AAPT diagnostic criteria for fibromyalgia. J Pain. 2019;20(6):611–628. doi:10.1016/j.jpain.2018.10.008
   PubMed Web of Science ®Google Scholar
• Ware MA, Fitzcharles MA, Joseph L, Shir Y. The effects of nabilone on sleep in fibromyalgia: results of a randomized controlled trial. Anesth Analg. 2010;110(2):604–610. doi:10.1213/ANE.0b013e3181c76f70
   PubMed Web of Science ®Google Scholar
• Skrabek RQ, Galimova L, Ethans K, Perry D. Nabilone for the treatment of pain in fibromyalgia. J Pain. 2008;9(2):164–173. doi:10.1016/j.jpain.2007.09.002
   PubMed Web of Science ®Google Scholar
• Schley M, Legler A, Skopp G, Schmelz M, Konrad C, Rukwied R. Delta-9-THC based monotherapy in fibromyalgia patients on experimentally induced pain, axon reflex flare, and pain relief. Curr Med Res Opin. 2006;22(7):1269–1276. doi:10.1185/030079906x112651
   PubMed Web of Science ®Google Scholar
• Weber J, Schley M, Casutt M, et al. Tetrahydrocannabinol (Delta 9-THC) treatment in chronic central neuropathic pain and fibromyalgia patients: results of a multicenter survey. Anesthesiol Res Pract. 2009;2009. doi:10.1155/2009/827290
   PubMedGoogle Scholar
• Haanpää M, Treede R-D. Diagnosis and classification of neuropathic pain. Pain Clin Updates. 2010;18(7):1–6.
   Google Scholar
• van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N. Neuropathic pain in the general population: a systematic review of epidemiological studies. Pain. 2014;155(4):654–662. doi:10.1016/j.pain.2013.11.013
   PubMed Web of Science ®Google Scholar
• Cavalli E, Mammana S, Nicoletti F, Bramanti P, Mazzon E. The neuropathic pain: an overview of the current treatment and future therapeutic approaches. Int J Immunopathol Pharmacol. 2019;33:2058738419838383. doi:10.1177/2058738419838383
   Web of Science ®Google Scholar
• Maldonado R, Banos JE, Cabanero D. The endocannabinoid system and neuropathic pain. Pain. 2016;157. doi:10.1097/j.pain.0000000000000428
   PubMed Web of Science ®Google Scholar
• Abrams DI, Jay CA, Shade SB, et al. Cannabis in painful HIV-associated sensory neuropathy: a randomized placebo-controlled trial. Neurology. 2007;68(7):515–521. doi:10.1212/01.wnl.0000253187.66183.9c
   PubMed Web of Science ®Google Scholar
• Ellis RJ, Toperoff W, Vaida F, et al. Smoked medicinal cannabis for neuropathic pain in HIV: a randomized, crossover clinical trial. Neuropsychopharmacology. 2009;34(3):672–680. doi:10.1038/npp.2008.120
   PubMed Web of Science ®Google Scholar
• Wallace MS, Marcotte TD, Umlauf A, et al. Efficacy of inhaled cannabis on painful diabetic neuropathy. J Pain. 2015;16(7):616–627. doi:10.1016/j.jpain.2015.03.008
   PubMed Web of Science ®Google Scholar
• Wilsey B, Marcotte T, Tsodikov A, et al. A randomized, placebo-controlled, crossover trial of cannabis cigarettes in neuropathic pain. J Pain. 2008;9(6):506–521. doi:10.1016/j.jpain.2007.12.010
   PubMed Web of Science ®Google Scholar